{"id":"https://openalex.org/W2803552155","doi":"https://doi.org/10.23736/s0392-0488.17.05742-x","title":"Reducing the oral isotretinoin skin side effects: efficacy of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide cream compound in acne patients","display_name":"Reducing the oral isotretinoin skin side effects: efficacy of 8% omega-ceramides, hydrophilic sugars, 5% niacinamide cream compound in acne patients","publication_year":2018,"publication_date":"2018-03-01","ids":{"openalex":"https://openalex.org/W2803552155","doi":"https://doi.org/10.23736/s0392-0488.17.05742-x","mag":"2803552155","pmid":"https://pubmed.ncbi.nlm.nih.gov/29564872"},"language":"en","primary_location":{"id":"doi:10.23736/s0392-0488.17.05742-x","doi":"https://doi.org/10.23736/s0392-0488.17.05742-x","is_oa":false,"landing_page_url":"https://doi.org/10.23736/s0392-0488.17.05742-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210170121","display_name":"Italian Journal of Dermatology and Venereology","issn_l":"2784-8450","issn":["2784-8450","2784-8671"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4320800528","host_organization_name":"Edizioni Minerva Medica","host_organization_lineage":["https://openalex.org/P4320800528"],"host_organization_lineage_names":["Edizioni Minerva Medica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Italian Journal of Dermatology and Venereology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090667117","display_name":"Maria Vittoria Cannizzaro","orcid":"https://orcid.org/0000-0001-6805-1005","observed_orcids":["https://orcid.org/0000-0001-6805-1005"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria V. Cannizzaro","raw_affiliation_strings":["Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy - mariavittoria.cannizzaro@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy - mariavittoria.cannizzaro@gmail.com","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014765702","display_name":"Annunziata Dattola","orcid":"https://orcid.org/0000-0001-9504-5882","observed_orcids":["https://orcid.org/0000-0001-9504-5882"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annunziata Dattola","raw_affiliation_strings":["Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112555634","display_name":"Virginia Garofalo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Virginia Garofalo","raw_affiliation_strings":["Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008637093","display_name":"Ester DEL DUCA","orcid":"https://orcid.org/0000-0001-7948-8536","observed_orcids":["https://orcid.org/0000-0001-7948-8536"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ester Del Duca","raw_affiliation_strings":["Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004401304","display_name":"Luca Bianchi","orcid":"https://orcid.org/0000-0001-8697-6896","observed_orcids":["https://orcid.org/0000-0001-8697-6896","https://orcid.org/0000-0001-5159-4863"]},"institutions":[{"id":"https://openalex.org/I116067653","display_name":"University of Rome Tor Vergata","ror":"https://ror.org/02p77k626","country_code":"IT","type":"education","lineage":["https://openalex.org/I116067653"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Bianchi","raw_affiliation_strings":["Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology and Venereology, Tor Vergata University of Rome, Rome, Italy","institution_ids":["https://openalex.org/I116067653"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I116067653"],"apc_list":null,"apc_paid":null,"fwci":1.3182,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.79552427,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"153","issue":"2","first_page":"161","last_page":"164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11553","display_name":"Acne and Rosacea Treatments and Effects","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/isotretinoin","display_name":"isotretinoin","score":0.8489999771118164},{"id":"https://openalex.org/keywords/acne-vulgaris","display_name":"acne","score":0.9129999876022339},{"id":"https://openalex.org/keywords/nicotinamide","display_name":"nicotinamide","score":0.9879999756813049},{"id":"https://openalex.org/keywords/topical-cream","display_name":"topical cream","score":0.9490000009536743},{"id":"https://openalex.org/keywords/dry-skin","display_name":"dry skin","score":0.8999999761581421},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.7689999938011169},{"id":"https://openalex.org/keywords/facial-redness","display_name":"facial redness","score":0.7099999785423279},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.8769999742507935},{"id":"https://openalex.org/keywords/nodular-acne","display_name":"nodular acne","score":0.49000000953674316}],"concepts":[{"id":"https://openalex.org/C2777673923","wikidata":"https://www.wikidata.org/wiki/Q79928","display_name":"Acne","level":2,"score":0.8681504726409912},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8504694700241089},{"id":"https://openalex.org/C2776285725","wikidata":"https://www.wikidata.org/wiki/Q287029","display_name":"Isotretinoin","level":3,"score":0.836632251739502},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.7144317626953125},{"id":"https://openalex.org/C2779923671","wikidata":"https://www.wikidata.org/wiki/Q199602","display_name":"Itching","level":2,"score":0.6924744844436646},{"id":"https://openalex.org/C2909408332","wikidata":"https://www.wikidata.org/wiki/Q192423","display_name":"Niacinamide","level":4,"score":0.5526043176651001},{"id":"https://openalex.org/C2777035695","wikidata":"https://www.wikidata.org/wiki/Q1929023","display_name":"Dry skin","level":2,"score":0.5136727690696716},{"id":"https://openalex.org/C2780986958","wikidata":"https://www.wikidata.org/wiki/Q1871151","display_name":"Lotion","level":2,"score":0.47436246275901794},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4669519364833832},{"id":"https://openalex.org/C2777063393","wikidata":"https://www.wikidata.org/wiki/Q77776","display_name":"Irritation","level":2,"score":0.44770246744155884},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.41984957456588745},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3627714514732361},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.1626553237438202},{"id":"https://openalex.org/C2779728014","wikidata":"https://www.wikidata.org/wiki/Q192423","display_name":"Nicotinamide","level":3,"score":0.13105982542037964},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000073893","descriptor_name":"Sugars","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000152","descriptor_name":"Acne Vulgaris","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D000279","descriptor_name":"Administration, Cutaneous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D003879","descriptor_name":"Dermatologic Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015474","descriptor_name":"Isotretinoin","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D015474","descriptor_name":"Isotretinoin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055118","descriptor_name":"Medication Adherence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063465","descriptor_name":"Skin Cream","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.23736/s0392-0488.17.05742-x","doi":"https://doi.org/10.23736/s0392-0488.17.05742-x","is_oa":false,"landing_page_url":"https://doi.org/10.23736/s0392-0488.17.05742-x","pdf_url":null,"source":{"id":"https://openalex.org/S4210170121","display_name":"Italian Journal of Dermatology and Venereology","issn_l":"2784-8450","issn":["2784-8450","2784-8671"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4320800528","host_organization_name":"Edizioni Minerva Medica","host_organization_lineage":["https://openalex.org/P4320800528"],"host_organization_lineage_names":["Edizioni Minerva Medica"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Italian Journal of Dermatology and Venereology","raw_type":"journal-article"},{"id":"pmid:29564872","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29564872","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia","raw_type":"Journal Article"},{"id":"pmh:oai:art.torvergata.it:2108/196838","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2108/196838","pdf_url":null,"source":{"id":"https://openalex.org/S4306400993","display_name":"Cineca Institutional Research Information System (Tor Vergata University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I116067653","host_organization_name":"University of Rome Tor Vergata","host_organization_lineage":["https://openalex.org/I116067653"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1712021","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1712021","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9907000064849854,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4404164086","https://openalex.org/W2411578295","https://openalex.org/W2806302491","https://openalex.org/W7167516283","https://openalex.org/W4412796636","https://openalex.org/W4387823762","https://openalex.org/W3148401363","https://openalex.org/W2167116419","https://openalex.org/W166749112","https://openalex.org/W4411769228"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acne":[1],"vulgaris":[2],"is":[3],"a":[4,70,79,122,165],"chronic":[5],"inflammatory":[6,19],"skin":[7,198],"disease":[8],"that":[9],"manifests":[10],"as":[11,16,18],"open":[12],"and":[13,22,27,42,153,171,197,200],"closed":[14],"comedones":[15],"well":[17],"papules,":[20],"pustules,":[21],"nodules":[23],"localized":[24],"on":[25],"face":[26],"trunk.":[28],"Oral":[29],"isotretinoin":[30,61,89,212],"demonstrated":[31],"to":[32,65,74,85,119,174,209],"be":[33],"effective":[34,193],"in":[35,56,83,95,160,194,204],"controlling":[36],"seborrhea,":[37],"inflammation,":[38],"Propionibacterium":[39],"Acnes":[40],"hyperproliferation":[41],"reducing":[43,62,195],"scarring,":[44],"nevertheless":[45],"muco-cutaneous":[46],"side":[47,90],"effects,":[48],"particularly":[49],"dryness,":[50,93,169],"itching,":[51],"bruising":[52],"are":[53],"commonly":[54],"seen":[55],"patients":[57,96,106,159],"under":[58],"treatment":[59,108,151],"with":[60,109,185],"the":[63,66,76,87,102,149,161,175,178,206,210],"compliance":[64],"treatment.":[67,213],"We":[68],"conducted":[69],"randomized":[71,118],"controlled":[72],"trial":[73],"evaluate":[75],"efficacy":[77],"of":[78,101,125,157,168],"cream":[80,123,139,183],"compound":[81],"formulated":[82,184],"order":[84],"reduce":[86],"oral":[88,211],"effects":[91],"(redness,":[92],"itching)":[94],"affected":[97],"by":[98],"severe":[99],"acne":[100,116],"face.":[103],"METHODS:":[104],"Twenty-seven":[105],"undergoing":[107],"0.5-1":[110],"mg/kg/day":[111],"for":[112],"papulo-pustular":[113],"or":[114,137],"nodulo-cystic":[115],"were":[117],"additionally":[120],"receive":[121],"composed":[124],"8%":[126,186],"omega-ceramides,":[127,187],"hydrophilic":[128,188],"sugars,":[129,189],"5%":[130,190],"niacinamide":[131,191],"applied":[132,142],"twice":[133],"daily":[134],"(group":[135,140],"A)":[136],"placebo":[138,179],"B)":[141],"2":[143],"times":[144],"per":[145],"day.":[146],"RESULTS:":[147],"During":[148],"whole":[150],"period":[152],"after":[154],"6":[155],"months":[156],"treatment,":[158],"group":[162,176],"A":[163],"showed":[164],"greater":[166],"reduction":[167],"itching":[170],"redness":[172],"compared":[173],"receiving":[177],"cream.":[180],"CONCLUSIONS:":[181],"The":[182],"was":[192,201],"xerosis":[196],"irritation,":[199],"also":[202],"successful":[203],"improving":[205],"patients'":[207],"adherence":[208]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":4},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-06-01T00:00:00"}