{"id":"https://openalex.org/W2803544444","doi":"https://doi.org/10.4274/jtgga.2017.0124","title":"A double-blind, placebo-controlled trial of Fennel (Foeniculum vulgare) on menopausal symptoms: A high placebo response","display_name":"A double-blind, placebo-controlled trial of Fennel (Foeniculum vulgare) on menopausal symptoms: A high placebo response","publication_year":2018,"publication_date":"2018-08-06","ids":{"openalex":"https://openalex.org/W2803544444","doi":"https://doi.org/10.4274/jtgga.2017.0124","mag":"2803544444","pmid":"https://pubmed.ncbi.nlm.nih.gov/29755029","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6085528"},"language":"en","primary_location":{"id":"doi:10.4274/jtgga.2017.0124","doi":"https://doi.org/10.4274/jtgga.2017.0124","is_oa":true,"landing_page_url":"https://doi.org/10.4274/jtgga.2017.0124","pdf_url":"https://doi.org/10.4274/jtgga.2017.0124","source":{"id":"https://openalex.org/S4210191485","display_name":"Journal of the Turkish-German Gynecological Association","issn_l":"1309-0380","issn":["1309-0380","1309-0399"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish-German Gynecological Association","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4274/jtgga.2017.0124","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067927283","display_name":"Masumeh Ghazanfarpour","orcid":"https://orcid.org/0000-0003-4639-3711","observed_orcids":["https://orcid.org/0000-0003-4639-3711"]},"institutions":[{"id":"https://openalex.org/I235686326","display_name":"Kerman University of Medical Sciences","ror":"https://ror.org/02kxbqc24","country_code":"IR","type":"education","lineage":["https://openalex.org/I235686326"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Masumeh Ghazanfarpour","raw_affiliation_strings":["Department of Midwifery, School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Midwifery, School of Nursing and Midwifery, Kerman University of Medical Sciences, Kerman, Iran","institution_ids":["https://openalex.org/I235686326"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029672501","display_name":"Mona Najaf Najafi","orcid":"https://orcid.org/0000-0003-4962-6787","observed_orcids":["https://orcid.org/0000-0003-4962-6787","https://orcid.org/0000-0002-2646-7720"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mona Najaf Najafi","raw_affiliation_strings":["Department of Community Medicine, Imam Reza Clinical Research Units, Mashhad University of Medicl Sciences School of Medicine, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Community Medicine, Imam Reza Clinical Research Units, Mashhad University of Medicl Sciences School of Medicine, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040956740","display_name":"Nosrat Baharian Sharghi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nosrat Baharian Sharghi","raw_affiliation_strings":["Midwife, Omolbanin Hospital, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Midwife, Omolbanin Hospital, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051846311","display_name":"Mahsa Sadat Mousavi","orcid":"https://orcid.org/0000-0002-9953-0284","observed_orcids":["https://orcid.org/0000-0002-9953-0284"]},"institutions":[{"id":"https://openalex.org/I2799282979","display_name":"Islamic Azad University, Isfahan","ror":"https://ror.org/039zhhm92","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I2799282979"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mahsa Sadat Mousavi","raw_affiliation_strings":["Department of Midwifery, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Midwifery, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran","institution_ids":["https://openalex.org/I2799282979"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042188619","display_name":"Masoudeh Babakhanian","orcid":"https://orcid.org/0000-0002-6128-8023","observed_orcids":["https://orcid.org/0000-0002-6128-8023"]},"institutions":[{"id":"https://openalex.org/I4210154083","display_name":"Semnan University of Medical Sciences","ror":"https://ror.org/05y44as61","country_code":"IR","type":"education","lineage":["https://openalex.org/I4210154083"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Masoudeh Babakhanian","raw_affiliation_strings":["Social Determinant of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Social Determinant of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran","institution_ids":["https://openalex.org/I4210154083"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017311650","display_name":"Hassan Rakhshandeh","orcid":"https://orcid.org/0000-0002-2118-1096","observed_orcids":["https://orcid.org/0000-0002-2118-1096"]},"institutions":[{"id":"https://openalex.org/I165560825","display_name":"Mashhad University of Medical Sciences","ror":"https://ror.org/04sfka033","country_code":"IR","type":"education","lineage":["https://openalex.org/I165560825"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Hassan Rakhshandeh","raw_affiliation_strings":["Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran","institution_ids":["https://openalex.org/I165560825"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5017311650"],"corresponding_institution_ids":["https://openalex.org/I165560825"],"apc_list":null,"apc_paid":null,"fwci":1.1944,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.79957264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"19","issue":"3","first_page":"122","last_page":"127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10694","display_name":"Menopause: Health Impacts and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10902","display_name":"Complementary and Alternative Medicine Studies","score":0.00139999995008111,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11318","display_name":"Phytoestrogen effects and research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fennel","display_name":"fennel","score":1.0},{"id":"https://openalex.org/keywords/menopausal-symptoms","display_name":"menopausal symptoms","score":0.9860000014305115},{"id":"https://openalex.org/keywords/postmenopausal-women","display_name":"postmenopausal women","score":0.9399999976158142},{"id":"https://openalex.org/keywords/placebo-response","display_name":"placebo response","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hot-flashes","display_name":"hot flashes","score":0.9100000262260437},{"id":"https://openalex.org/keywords/night-sweats","display_name":"night sweats","score":0.9739999771118164},{"id":"https://openalex.org/keywords/anxiety","display_name":"anxiety","score":0.5870000123977661},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.9539999961853027},{"id":"https://openalex.org/keywords/menopause-specific-quality-of-life-questionnaire","display_name":"Menopause-Specific Quality of Life Questionnaire","score":0.746999979019165},{"id":"https://openalex.org/keywords/herbal-medicine","display_name":"herbal medicine","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.9620064496994019},{"id":"https://openalex.org/C2780010996","wikidata":"https://www.wikidata.org/wiki/Q27030","display_name":"Foeniculum","level":2,"score":0.9143906235694885},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5885404348373413},{"id":"https://openalex.org/C2992459003","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo response","level":4,"score":0.58746337890625},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47821328043937683},{"id":"https://openalex.org/C3017583242","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Placebo group","level":4,"score":0.42030632495880127},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2596437335014343},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.4274/jtgga.2017.0124","doi":"https://doi.org/10.4274/jtgga.2017.0124","is_oa":true,"landing_page_url":"https://doi.org/10.4274/jtgga.2017.0124","pdf_url":"https://doi.org/10.4274/jtgga.2017.0124","source":{"id":"https://openalex.org/S4210191485","display_name":"Journal of the Turkish-German Gynecological Association","issn_l":"1309-0380","issn":["1309-0380","1309-0399"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish-German Gynecological Association","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5038090","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6085528","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6085528","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6085528","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Turk Ger Gynecol Assoc","raw_type":"Text"},{"id":"pmid:29755029","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29755029","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish German Gynecological Association","raw_type":"Journal Article"},{"id":"pmh:oai:eprints.kmu.ac.ir:34427","doi":null,"is_oa":false,"landing_page_url":"http://eprints.kmu.ac.ir/34427/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400818","display_name":"Research Information System of Ardabil University of Medical Sciences (Ardabil University of Medical Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I33103891","host_organization_name":"Ardabil University of Medical Sciences","host_organization_lineage":["https://openalex.org/I33103891"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.4274/jtgga.2017.0124","doi":"https://doi.org/10.4274/jtgga.2017.0124","is_oa":true,"landing_page_url":"https://doi.org/10.4274/jtgga.2017.0124","pdf_url":"https://doi.org/10.4274/jtgga.2017.0124","source":{"id":"https://openalex.org/S4210191485","display_name":"Journal of the Turkish-German Gynecological Association","issn_l":"1309-0380","issn":["1309-0380","1309-0399"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","ki-jl-1","poland-40","russia-white-list-3","tr-dizin"],"host_organization":"https://openalex.org/P4310320331","host_organization_name":"Galenos Yayinevi","host_organization_lineage":["https://openalex.org/P4310320331"],"host_organization_lineage_names":["Galenos Yayinevi"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the Turkish-German Gynecological Association","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/randomized-controlled-trial","display_name":"Randomized Controlled Trial"},{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803544444.pdf","grobid_xml":"https://content.openalex.org/works/W2803544444.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W139073085","https://openalex.org/W1525789197","https://openalex.org/W1774724565","https://openalex.org/W1905533266","https://openalex.org/W1951347687","https://openalex.org/W1967469845","https://openalex.org/W1969680120","https://openalex.org/W1971078243","https://openalex.org/W1971931197","https://openalex.org/W1996796076","https://openalex.org/W2016699506","https://openalex.org/W2016819916","https://openalex.org/W2032747942","https://openalex.org/W2055126527","https://openalex.org/W2060807041","https://openalex.org/W2073526412","https://openalex.org/W2124632453","https://openalex.org/W2128384860","https://openalex.org/W2135783033","https://openalex.org/W2137807360","https://openalex.org/W2156059498","https://openalex.org/W2227131322","https://openalex.org/W2227922348","https://openalex.org/W2411235636","https://openalex.org/W2514789316","https://openalex.org/W2573875464","https://openalex.org/W2574385617","https://openalex.org/W2942129259","https://openalex.org/W2993753148","https://openalex.org/W3154082087","https://openalex.org/W3161999510","https://openalex.org/W4234947283","https://openalex.org/W4255829745","https://openalex.org/W4385891454","https://openalex.org/W7074033770"],"related_works":["https://openalex.org/W2922546620","https://openalex.org/W2754827167","https://openalex.org/W3133793701","https://openalex.org/W2750638984","https://openalex.org/W2736919935","https://openalex.org/W2800100904","https://openalex.org/W2801131463","https://openalex.org/W2188539331","https://openalex.org/W2762942404","https://openalex.org/W4293217898"],"abstract_inverted_index":{"Objective:":[0],"The":[1,154],"present":[2],"study":[3,187],"aimed":[4],"to":[5,156,192],"evaluate":[6],"the":[7,55,71,140,194],"effects":[8],"of":[9,39,58,100],"oral":[10],"fennel":[11,40,77,86,94,104,113,125,141],"on":[12,25],"menopausal":[13,137],"symptoms.":[14],"Material":[15],"and":[16,42,50,64,78,87,95,105,114,118,126,142,148],"Methods:":[17],"This":[18],"double-blind,":[19],"randomized,":[20],"placebo-controlled":[21],"trial":[22],"was":[23],"conducted":[24],"50":[26],"postmenopausal":[27],"women":[28],"in":[29,70,135],"Mashhad":[30],"(Iran).":[31],"Patients":[32],"were":[33,46,131],"randomly":[34],"divided":[35],"into":[36],"two":[37],"groups":[38,66],"(n=25)":[41],"placebo":[43,63,143,168,179,195],"(n=25).":[44],"Measurements":[45],"performed":[47],"at":[48],"baseline":[49],"after":[51],"three":[52],"months":[53],"using":[54],"Menopause-Specific":[56],"Quality":[57],"Life":[59],"questionnaire.":[60],"Results:":[61],"Both":[62],"treatment":[65],"revealed":[67],"significant":[68,133,159],"improvements":[69],"hot":[72],"flush":[73],"score":[74],"(p<0.001":[75],"for":[76,80,85,89,93,97,103,107,112,116,124,128,146],"p<0.01":[79,88,96],"placebo),":[81,90,98,108,117],"night":[82],"sweats":[83],"(p=0.007":[84],"sweating":[91],"(p=0.002":[92],"symptoms":[99,138],"anxiety":[101],"(p=0.05":[102],"p=0.001":[106],"feeling":[109],"depressed":[110],"(p<0.01":[111,123],"p=0.006":[115],"impatience":[119],"with":[120,188],"other":[121],"people":[122],"p=0.003":[127],"placebo).":[129],"There":[130],"no":[132],"differences":[134],"any":[136],"between":[139],"groups,":[144],"except":[145],"coughing":[147],"sneezing":[149],"when":[150],"urinating":[151],"(p=0.03).":[152],"Conclusion:":[153],"failure":[155],"indicate":[157],"a":[158,166,178,184],"effect":[160],"may":[161],"have":[162],"been":[163],"caused":[164],"by":[165],"high":[167],"response.":[169],"It":[170],"is":[171],"suggested":[172],"that":[173],"future":[174],"trials":[175],"should":[176],"include":[177],"run-in":[180],"phase":[181],"or":[182],"design":[183],"sequential,":[185],"parallel":[186],"larger":[189],"sample":[190],"sizes":[191],"mitigate":[193],"effect.":[196]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-01T00:00:00"}
