{"id":"https://openalex.org/W2803535501","doi":"https://doi.org/10.3389/fdigh.2018.00013","title":"Big Data: Challenge and Opportunity for Translational and Industrial Research in Healthcare","display_name":"Big Data: Challenge and Opportunity for Translational and Industrial Research in Healthcare","publication_year":2018,"publication_date":"2018-05-31","ids":{"openalex":"https://openalex.org/W2803535501","doi":"https://doi.org/10.3389/fdigh.2018.00013","mag":"2803535501"},"language":"en","primary_location":{"id":"doi:10.3389/fdigh.2018.00013","doi":"https://doi.org/10.3389/fdigh.2018.00013","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdigh.2018.00013","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdigh.2018.00013/pdf","source":{"id":"https://openalex.org/S2596149232","display_name":"Frontiers in Digital Humanities","issn_l":"2297-2668","issn":["2297-2668"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Humanities","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://www.frontiersin.org/articles/10.3389/fdigh.2018.00013/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071602399","display_name":"Riccardo Lorenzo Rossi","orcid":"https://orcid.org/0000-0002-4964-3264","observed_orcids":["https://orcid.org/0000-0002-4964-3264"]},"institutions":[{"id":"https://openalex.org/I4210160365","display_name":"Istituto Nazionale Genetica Molecolare","ror":"https://ror.org/05rb1q636","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210160365"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Riccardo L. Rossi","raw_affiliation_strings":["Bioinformatics, Istituto Nazionale Genetica Molecolare, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics, Istituto Nazionale Genetica Molecolare, Milan, Italy","institution_ids":["https://openalex.org/I4210160365"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016860319","display_name":"Renata Grifantini","orcid":"https://orcid.org/0000-0003-0024-3355","observed_orcids":["https://orcid.org/0000-0003-0024-3355"]},"institutions":[{"id":"https://openalex.org/I4210160365","display_name":"Istituto Nazionale Genetica Molecolare","ror":"https://ror.org/05rb1q636","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210160365"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Renata M. Grifantini","raw_affiliation_strings":["Translational Research, Istituto Nazionale Genetica Molecolare, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Research, Istituto Nazionale Genetica Molecolare, Milan, Italy","institution_ids":["https://openalex.org/I4210160365"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5016860319","https://openalex.org/A5071602399"],"corresponding_institution_ids":["https://openalex.org/I4210160365"],"apc_list":{"value":0,"currency":"USD","value_usd":0},"apc_paid":null,"fwci":1.7742,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.89369704,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"5","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14280","display_name":"Big Data Technologies and Applications","score":0.3303000032901764,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T14280","display_name":"Big Data Technologies and Applications","score":0.3303000032901764,"subfield":{"id":"https://openalex.org/subfields/1802","display_name":"Information Systems and Management"},"field":{"id":"https://openalex.org/fields/18","display_name":"Decision Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.17499999701976776,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.10729999840259552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/big-data-in-healthcare","display_name":"big data in healthcare","score":0.906000018119812},{"id":"https://openalex.org/keywords/translational-research","display_name":"translational research","score":0.921999990940094},{"id":"https://openalex.org/keywords/industrial-research","display_name":"industrial research","score":0.4399999976158142},{"id":"https://openalex.org/keywords/data-annotation","display_name":"data annotation","score":0.7860000133514404},{"id":"https://openalex.org/keywords/data-integration","display_name":"data integration","score":0.8970000147819519},{"id":"https://openalex.org/keywords/data-silos","display_name":"data silos","score":0.7960000038146973},{"id":"https://openalex.org/keywords/omics-data","display_name":"omics data","score":0.7419999837875366},{"id":"https://openalex.org/keywords/machine-learning","display_name":"machine learning","score":0.703000009059906},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.8220000267028809},{"id":"https://openalex.org/keywords/vaccine-development","display_name":"vaccine development","score":0.9750000238418579},{"id":"https://openalex.org/keywords/electronic-health-records","display_name":"electronic health records","score":0.9390000104904175},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.8799999952316284},{"id":"https://openalex.org/keywords/network-analysis","display_name":"network analysis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/in-vitro-assay","display_name":"in vitro assay","score":0.6980000138282776},{"id":"https://openalex.org/keywords/data-driven-decision-making","display_name":"data-driven decision making","score":0.4659999907016754}],"concepts":[{"id":"https://openalex.org/C75684735","wikidata":"https://www.wikidata.org/wiki/Q858810","display_name":"Big data","level":2,"score":0.7989639043807983},{"id":"https://openalex.org/C2780625559","wikidata":"https://www.wikidata.org/wiki/Q5152592","display_name":"Commercialization","level":2,"score":0.7810204029083252},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.6586490869522095},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.6196913123130798},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.5396385788917542},{"id":"https://openalex.org/C160735492","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Health care","level":2,"score":0.5021822452545166},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4715198278427124},{"id":"https://openalex.org/C91632574","wikidata":"https://www.wikidata.org/wiki/Q15088675","display_name":"Data curation","level":2,"score":0.43979620933532715},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.4263764023780823},{"id":"https://openalex.org/C162264550","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Translational medicine","level":2,"score":0.4258999526500702},{"id":"https://openalex.org/C2780440489","wikidata":"https://www.wikidata.org/wiki/Q5227278","display_name":"Data-driven","level":2,"score":0.41991671919822693},{"id":"https://openalex.org/C56739046","wikidata":"https://www.wikidata.org/wiki/Q192060","display_name":"Knowledge management","level":1,"score":0.36269494891166687},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3197363317012787},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.24662885069847107},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.1833280622959137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.18207955360412598},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.16168391704559326},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.13410484790802002},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13226372003555298},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.13082274794578552},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fdigh.2018.00013","doi":"https://doi.org/10.3389/fdigh.2018.00013","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdigh.2018.00013","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdigh.2018.00013/pdf","source":{"id":"https://openalex.org/S2596149232","display_name":"Frontiers in Digital Humanities","issn_l":"2297-2668","issn":["2297-2668"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Humanities","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5adc62e2392c4f14be31958bc5378497","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5adc62e2392c4f14be31958bc5378497","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Digital Humanities, Vol 5 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fdigh.2018.00013","doi":"https://doi.org/10.3389/fdigh.2018.00013","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fdigh.2018.00013","pdf_url":"https://www.frontiersin.org/articles/10.3389/fdigh.2018.00013/pdf","source":{"id":"https://openalex.org/S2596149232","display_name":"Frontiers in Digital Humanities","issn_l":"2297-2668","issn":["2297-2668"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Digital Humanities","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6773999929428101,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"},{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.6100000143051147,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803535501.pdf","grobid_xml":"https://content.openalex.org/works/W2803535501.grobid-xml"},"referenced_works_count":111,"referenced_works":["https://openalex.org/W221337327","https://openalex.org/W1200768482","https://openalex.org/W1515452625","https://openalex.org/W1538202910","https://openalex.org/W1544009106","https://openalex.org/W1590194639","https://openalex.org/W1627599966","https://openalex.org/W1905165981","https://openalex.org/W1972821149","https://openalex.org/W1974971068","https://openalex.org/W1978153508","https://openalex.org/W1979240969","https://openalex.org/W1984165851","https://openalex.org/W1985026129","https://openalex.org/W1992578437","https://openalex.org/W2004910511","https://openalex.org/W2005095482","https://openalex.org/W2006402375","https://openalex.org/W2007347214","https://openalex.org/W2011549181","https://openalex.org/W2013972020","https://openalex.org/W2016963430","https://openalex.org/W2018478612","https://openalex.org/W2028279608","https://openalex.org/W2032821328","https://openalex.org/W2035817047","https://openalex.org/W2037301607","https://openalex.org/W2037409991","https://openalex.org/W2037699447","https://openalex.org/W2040455921","https://openalex.org/W2046452372","https://openalex.org/W2059980695","https://openalex.org/W2060427373","https://openalex.org/W2067263136","https://openalex.org/W2068181924","https://openalex.org/W2068841432","https://openalex.org/W2075068409","https://openalex.org/W2079859830","https://openalex.org/W2080809120","https://openalex.org/W2083045667","https://openalex.org/W2094239525","https://openalex.org/W2096142777","https://openalex.org/W2096562137","https://openalex.org/W2099625540","https://openalex.org/W2099656145","https://openalex.org/W2103368657","https://openalex.org/W2104846587","https://openalex.org/W2105208620","https://openalex.org/W2106966651","https://openalex.org/W2112300874","https://openalex.org/W2113105800","https://openalex.org/W2115792042","https://openalex.org/W2118306668","https://openalex.org/W2119220491","https://openalex.org/W2124757426","https://openalex.org/W2126339385","https://openalex.org/W2127230663","https://openalex.org/W2128232860","https://openalex.org/W2130790725","https://openalex.org/W2131161884","https://openalex.org/W2132074759","https://openalex.org/W2134046693","https://openalex.org/W2134725489","https://openalex.org/W2138178898","https://openalex.org/W2139049032","https://openalex.org/W2144885342","https://openalex.org/W2148757128","https://openalex.org/W2149010238","https://openalex.org/W2153341679","https://openalex.org/W2158939484","https://openalex.org/W2159901125","https://openalex.org/W2160578795","https://openalex.org/W2161604082","https://openalex.org/W2168909179","https://openalex.org/W2169873962","https://openalex.org/W2194366276","https://openalex.org/W2228927609","https://openalex.org/W2229921221","https://openalex.org/W2236421841","https://openalex.org/W2263739890","https://openalex.org/W2302501749","https://openalex.org/W2317648909","https://openalex.org/W2323929490","https://openalex.org/W2324559765","https://openalex.org/W2342276553","https://openalex.org/W2355199334","https://openalex.org/W2412078427","https://openalex.org/W2412600970","https://openalex.org/W2490695200","https://openalex.org/W2512827249","https://openalex.org/W2522775671","https://openalex.org/W2523691760","https://openalex.org/W2557334921","https://openalex.org/W2561772629","https://openalex.org/W2562588878","https://openalex.org/W2575460524","https://openalex.org/W2591434643","https://openalex.org/W2605810679","https://openalex.org/W2606065148","https://openalex.org/W2607382887","https://openalex.org/W2610740470","https://openalex.org/W2619948933","https://openalex.org/W2626089421","https://openalex.org/W2733693942","https://openalex.org/W2738959495","https://openalex.org/W2739319684","https://openalex.org/W2747962007","https://openalex.org/W2761425539","https://openalex.org/W2773787581","https://openalex.org/W3198350258","https://openalex.org/W4235243453"],"related_works":["https://openalex.org/W3128893237","https://openalex.org/W2972967911","https://openalex.org/W2776352206","https://openalex.org/W3205014207","https://openalex.org/W2951635356","https://openalex.org/W4403771504","https://openalex.org/W1770604065","https://openalex.org/W4285254081","https://openalex.org/W7095599191","https://openalex.org/W7098673696"],"abstract_inverted_index":{"Research":[0],"and":[1,12,16,20,35,44,63,78,114,128,189,217,235,238,258,295],"innovation":[2],"are":[3,212],"constant":[4],"imperatives":[5],"for":[6,76,92,99,173,278,292],"the":[7,27,51,65,67,72,74,86,97,100,109,157,166,209,265,279,286,296],"healthcare":[8,45,246],"sector:":[9],"medicine,":[10],"biology":[11],"biotechnology":[13],"support":[14],"it,":[15],"more":[17],"recently":[18],"computational":[19],"data-driven":[21],"disciplines":[22],"gained":[23],"relevance":[24],"to":[25,56,90,111,161,199,250,263],"handle":[26],"massive":[28],"amount":[29],"of":[30,82,102,121,139,153,169,208,242,282,288,298],"data":[31,49,68,89,104,116,131,244],"this":[32],"sector":[33],"is":[34,108,201,249],"will":[36,275],"be":[37,40,57,222,276],"generating.":[38],"To":[39],"effective":[41,113,271,280],"in":[42,50,105,226,245,268],"translational":[43],"industrial":[46,106,154,170,247],"research,":[47],"big":[48,103,140,243],"life":[52],"science":[53],"domain":[54],"need":[55,75],"organized,":[58],"well":[59,230],"annotated,":[60],"catalogued,":[61],"correlated":[62],"integrated:":[64],"biggest":[66],"silos":[69],"at":[70,119],"hand,":[71],"stronger":[73],"organization":[77,84],"tidiness.":[79],"The":[80,194,240],"degree":[81],"such":[83,124,252],"marks":[85],"transition":[87],"from":[88,159,196],"knowledge":[91,260],"strategic":[93],"decision":[94],"making.":[95],"Thus":[96],"challenge":[98],"use":[101,281],"research":[107,155,248],"possibility":[110],"have":[112],"coherent":[115],"annotation,":[117],"aimed":[118],"integration":[120],"heterogeneous":[122],"domains":[123],"as":[125,229,231,262],"different":[126],"OMICs":[127],"non-OMICs":[129],"(traditional)":[130],"sources.":[132],"Holistic":[133],"approaches":[134],"enabling":[135],"an":[136],"acknowledged":[137],"management":[138],"data,":[141],"often":[142,213],"driven":[143],"by":[144,203,215,224,232,254],"machine":[145],"learning":[146],"methods,":[147],"can":[148],"thus":[149],"trigger":[150],"a":[151,269],"change":[152],"accelerating":[156],"process":[158,211,267],"discovery":[160],"product":[162],"delivery.":[163],"For":[164],"instance,":[165],"main":[167],"pillars":[168],"R&D":[171,210],"processes":[172],"vaccines":[174,299],"or":[175],"drug":[176,293],"development,":[177],"include":[178],"initial":[179],"discovery,":[180],"early":[181],"-":[182,192],"late":[183],"pre":[184],"clinics,":[185],"pre-industrialization,":[186],"clinical":[187],"phases":[188],"finally":[190],"registration":[191],"commercialization.":[193],"passage":[195],"one":[197],"step":[198],"another":[200],"regulated":[202],"stringent":[204],"pass/fail":[205],"criteria.":[206],"Bottlenecks":[207],"represented":[214],"animal":[216],"human":[218,301],"studies,":[219],"which":[220],"could":[221],"rationalized":[223],"surrogate":[225],"vitro":[227],"assays":[228],"predictive":[233],"molecular":[234],"cellular":[236],"signatures":[237],"models.":[239],"impact":[241],"address":[251],"bottlenecks":[253],"providing":[255],"actionable":[256],"information":[257],"new":[259],"so":[261],"accelerate":[264],"development":[266,297],"cost":[270],"way.":[272],"Case":[273],"studies":[274],"discussed":[277],"electronic":[283],"health":[284],"records,":[285],"leverage":[287],"network":[289],"analysis":[290],"methods":[291],"repurposing":[294],"towards":[300],"pathologies.":[302]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2018-06-01T00:00:00"}
