{"id":"https://openalex.org/W2803445034","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.444","title":"ALBI-RT: A novel radiation therapy specific hepatotoxicity prediction model for hepatocellular carcinoma patients.","display_name":"ALBI-RT: A novel radiation therapy specific hepatotoxicity prediction model for hepatocellular carcinoma patients.","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W2803445034","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.444","mag":"2803445034"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.4_suppl.444","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.444","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.4_suppl.444","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008305614","display_name":"Stephanie K. Schaub","orcid":"https://orcid.org/0000-0002-5148-379X","observed_orcids":["https://orcid.org/0000-0002-5148-379X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephanie K Schaub","raw_affiliation_strings":["University of Washington, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080374314","display_name":"Stephen R. Bowen","orcid":"https://orcid.org/0000-0001-7581-770X","observed_orcids":["https://orcid.org/0000-0001-7581-770X"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen R. Bowen","raw_affiliation_strings":["University of Washington, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074772724","display_name":"Tobias Robert Chapman","orcid":"https://orcid.org/0000-0002-6841-5558","observed_orcids":["https://orcid.org/0000-0002-6841-5558"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tobias Robert Chapman","raw_affiliation_strings":["University of Washington, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018732676","display_name":"Matthew J. Nyflot","orcid":"https://orcid.org/0000-0002-2356-9422","observed_orcids":["https://orcid.org/0000-0002-2356-9422"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew J. Nyflot","raw_affiliation_strings":["University of Washington, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA;","institution_ids":["https://openalex.org/I201448701"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018262026","display_name":"Smith Apisarnthanarax","orcid":"https://orcid.org/0000-0003-4522-8300","observed_orcids":["https://orcid.org/0000-0003-4522-8300"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Smith Apisarnthanarax","raw_affiliation_strings":["University of Washington, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Washington, Seattle, WA;","institution_ids":["https://openalex.org/I201448701"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I201448701"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"4_suppl","first_page":"444","last_page":"444"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocellular-carcinoma","display_name":"hepatocellular carcinoma","score":0.8529999852180481},{"id":"https://openalex.org/keywords/radiotherapy","display_name":"radiotherapy","score":0.8119999766349792},{"id":"https://openalex.org/keywords/radiation-induced-liver-injury","display_name":"radiation-induced liver injury","score":0.921999990940094},{"id":"https://openalex.org/keywords/hepatotoxicity-prediction","display_name":"hepatotoxicity prediction","score":0.8740000128746033},{"id":"https://openalex.org/keywords/albi-grade","display_name":"ALBI score","score":0.7440000176429749},{"id":"https://openalex.org/keywords/child-pugh-score","display_name":"Child-Pugh score","score":0.9829999804496765},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.8859999775886536},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.8009999990463257},{"id":"https://openalex.org/keywords/liver-function-assessment","display_name":"liver function assessment","score":0.5640000104904175},{"id":"https://openalex.org/keywords/liver-cancer-treatment-outcomes","display_name":"liver cancer treatment outcomes","score":0.31700000166893005},{"id":"https://openalex.org/keywords/child-pugh-a","display_name":"Child-Pugh A","score":0.3540000021457672}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8937304019927979},{"id":"https://openalex.org/C2778019345","wikidata":"https://www.wikidata.org/wiki/Q1148337","display_name":"Hepatocellular carcinoma","level":2,"score":0.8130022287368774},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7798311710357666},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6624380350112915},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.6136130690574646},{"id":"https://openalex.org/C207103383","wikidata":"https://www.wikidata.org/wiki/Q3930246","display_name":"Hazard ratio","level":3,"score":0.5695971250534058},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5099846124649048},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.48044487833976746},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.42713722586631775},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.30838000774383545},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.11387321352958679}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.4_suppl.444","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.444","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.4_suppl.444","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2992087725","https://openalex.org/W4402946569","https://openalex.org/W4416356140","https://openalex.org/W7054754176","https://openalex.org/W2942210387","https://openalex.org/W2892019103","https://openalex.org/W6921227860","https://openalex.org/W3094597888","https://openalex.org/W2797486990","https://openalex.org/W2802599832"],"abstract_inverted_index":{"444":[0],"Background:":[1],"The":[2],"albumin-bilirubin":[3],"(ALBI)":[4],"grade":[5,212,256,306],"system":[6],"was":[7,80,120,132,162],"optimized":[8],"to":[9,20,40,86,90,112,145,239,253,343],"predict":[10],"survival":[11,95,99],"in":[12,355],"hepatocellular":[13],"carcinoma":[14],"(HCC)":[15],"patients;":[16],"however,":[17],"its":[18],"applicability":[19],"patients":[21,53,218,331],"treated":[22,54],"with":[23,55,142,166,296,338],"radiation":[24,73],"therapy":[25],"(RT)":[26],"is":[27,322],"unclear.":[28],"We":[29,47,147],"propose":[30],"a":[31,83,149,167,220,230,240,277,323],"novel":[32],"analysis":[33],"of":[34,103,122,164,169,173,176,208,216,223,301,329,365],"the":[35,361],"ALBI":[36,59,79,151,228,255,275,305,348],"equation,":[37],"designated":[38],"ALBI-RT,":[39],"assess":[41],"hepatotoxicity":[42],"risk":[43,182,207,222,300],"after":[44,336],"RT.":[45],"Methods:":[46],"retrospectively":[48],"reviewed":[49],"48":[50],"consecutive":[51],"HCC":[52,330],"RT":[56,337],"(2013-2016).":[57],"Raw":[58,78],"values":[60],"and":[61,97,105,125,130,134,171,191,238,262,285,312,346,353,363],"Child-Pugh":[62],"(CP)":[63],"scores":[64],"were":[65,70,107,139,294],"calculated.":[66],"Any":[67],"patient":[68],"deaths":[69,141],"examined":[71],"for":[72,93,272,326,332],"induced":[74],"liver":[75],"disease":[76],"(RILD).":[77],"assessed":[81],"as":[82,229,276],"continuous":[84,231,278],"variable":[85,232,279],"perform":[87],"ROC":[88],"analyses":[89],"identify":[91],"cutoffs":[92],"overall":[94],"(OS)":[96],"RILD-specific":[98],"(RILD-SS).":[100],"Univariate":[101],"predictors":[102],"OS":[104,131],"RILD-SS":[106,165,177],"evaluated":[108],"using":[109],"Cox":[110],"regression":[111],"determine":[113],"hazard":[114],"ratios":[115],"(HR).":[116],"Results:":[117],"Patient":[118],"cohort":[119],"comprised":[121],"60%":[123],"CP-A":[124,201],"39%":[126],"CP-B/C.":[127],"Median":[128],"follow-up":[129],"13":[133],"10":[135],"months,":[136],"respectively.":[137],"There":[138],"18":[140],"6":[143],"ascribed":[144],"RILD.":[146,224],"identified":[148,214],"raw":[150,227,274],"cutoff":[152,178],"at":[153,205,219],"-1.70":[154,187,195],"(AUC":[155],"=":[156,159,189,197,236,249,260,268,283,292,310,318],"0.94,":[157],"p":[158,235,248,259,267,282,291,309,317],"0.008)":[160],"that":[161],"predictive":[163],"sensitivity":[168],"100%":[170],"specificity":[172],"71%.":[174],"Dichotimization":[175],"generated":[179],"two":[180],"ALBI-RT":[181,199,211,243,286,321],"categories:":[183],"low-risk":[184],"A":[185,213],"<":[186],"(n":[188,196],"29)":[190],"high-risk":[192],"B":[193,245,288],"\u2265":[194],"18).":[198],"subdivided":[200],"patients,":[202],"identifying":[203],"14%":[204],"increased":[206],"RILD;":[209],"conversely,":[210],"21%":[215],"CP-B/C":[217],"decreased":[221],"For":[225],"OS,":[226],"(HR":[233,246,257,265,280,289,307,315],"3.0,":[234,258],"0.02),":[237],"lesser":[241],"degree":[242],"Grade":[244,287],"2.4,":[247],"0.06),":[250],"performed":[251],"similarly":[252],"traditional":[254,304],"0.01),":[261],"CP":[263,313,345],"score":[264,314],"1.4,":[266],"0.03).":[269],"In":[270],"contrast":[271],"RILD-SS,":[273],"25.1,":[281],"0.01)":[284],"9.9,":[290],"0.04)":[293],"associated":[295],"an":[297,339],"elevated":[298,340],"relative":[299],"RILD":[302],"than":[303],"5.8,":[308],"0.02)":[311],"2.3,":[316],"0.003).":[319],"Conclusions:":[320],"promising":[324],"metric":[325],"pre-treatment":[327],"assessment":[328],"predicting":[333],"RILD-related":[334],"death":[335],"relative-risk":[341],"compared":[342],"both":[344],"conventional":[347],"grades.":[349],"Future":[350],"prospective":[351],"evaluation":[352],"validation":[354],"independent":[356],"data":[357],"sets":[358],"will":[359],"strengthen":[360],"generalizability":[362],"utility":[364],"ALBI-RT.":[366]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-06-01T00:00:00"}
