{"id":"https://openalex.org/W2803374591","doi":null,"title":"Neuroprotective effect of quercetin in a model of Parkinson\u2019s disease in rat: A histochemical analysis","display_name":"Neuroprotective effect of quercetin in a model of Parkinson\u2019s disease in rat: A histochemical analysis","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2803374591","mag":"2803374591"},"language":"en","primary_location":{"id":"pmh:oai:doaj.org/article:399d215b5d0d4bfeae486eeb32a853ed","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/399d215b5d0d4bfeae486eeb32a853ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 1, Iss 1, Pp 3-6 (2009)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doaj.org/article/4d7f1978e0094c8bbd4ed728e4514cef","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067679659","display_name":"Mehdi Mehdizadeh","orcid":"https://orcid.org/0000-0002-9268-7318","observed_orcids":["https://orcid.org/0000-0002-9268-7318"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mehdi Mehdizadeh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007424003","display_name":"Mohammad Taghi Joghataei","orcid":"https://orcid.org/0009-0005-6748-6468","observed_orcids":["https://orcid.org/0009-0005-6748-6468","https://orcid.org/0000-0003-2233-4223","https://orcid.org/0000-0003-4254-6426"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mohammad Taghi Joghataei","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074951513","display_name":"Maliheh Nobakht","orcid":"https://orcid.org/0000-0002-4281-5924","observed_orcids":["https://orcid.org/0000-0002-4281-5924","https://orcid.org/0000-0003-2352-6331"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maliheh Nobakht","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5080535572","display_name":"Roya Aryanpour","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roya Aryanpour","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quercetin","display_name":"quercetin","score":0.9639999866485596},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9929999709129333},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.996999979019165},{"id":"https://openalex.org/keywords/6-ohda-lesion","display_name":"6-hydroxydopamine lesion","score":0.8949999809265137},{"id":"https://openalex.org/keywords/substantia-nigra-pars-compacta","display_name":"substantia nigra pars compacta","score":0.9819999933242798},{"id":"https://openalex.org/keywords/dopaminergic-neuron-degeneration","display_name":"dopaminergic neuron loss","score":0.9440000057220459},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9399999976158142},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.609000027179718},{"id":"https://openalex.org/keywords/striatum","display_name":"striatum","score":0.652999997138977},{"id":"https://openalex.org/keywords/nissl-staining","display_name":"Nissl staining","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.9243730306625366},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6977404356002808},{"id":"https://openalex.org/C2781263971","wikidata":"https://www.wikidata.org/wiki/Q409478","display_name":"Quercetin","level":3,"score":0.690613865852356},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.5299115180969238},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.5216087102890015},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4862869679927826},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3543868064880371},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3351319432258606},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33419615030288696},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2870389223098755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17411068081855774},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.148135244846344},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12642991542816162},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.07006800174713135}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:doaj.org/article:399d215b5d0d4bfeae486eeb32a853ed","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/399d215b5d0d4bfeae486eeb32a853ed","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 1, Iss 1, Pp 3-6 (2009)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4d7f1978e0094c8bbd4ed728e4514cef","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4d7f1978e0094c8bbd4ed728e4514cef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 1, Iss 1, Pp 3-6 (2009)","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:doaj.org/article:4d7f1978e0094c8bbd4ed728e4514cef","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4d7f1978e0094c8bbd4ed728e4514cef","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Basic and Clinical Neuroscience, Vol 1, Iss 1, Pp 3-6 (2009)","raw_type":"article"},"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":12,"referenced_works":["https://openalex.org/W62603772","https://openalex.org/W1966259921","https://openalex.org/W1968847638","https://openalex.org/W1973101427","https://openalex.org/W1977633602","https://openalex.org/W2008834460","https://openalex.org/W2016619600","https://openalex.org/W2027274005","https://openalex.org/W2047357186","https://openalex.org/W2065000444","https://openalex.org/W2163815564","https://openalex.org/W2163960849"],"related_works":["https://openalex.org/W2035008654","https://openalex.org/W1972092229","https://openalex.org/W2259477628","https://openalex.org/W2116952515","https://openalex.org/W1976219141","https://openalex.org/W2052168648","https://openalex.org/W3000145627","https://openalex.org/W2172483615","https://openalex.org/W2767185817","https://openalex.org/W3207569231"],"abstract_inverted_index":{"AbstractIntroduction:":[0],"Parkinson's":[1],"disease":[2,48],"(PD)":[3],"is":[4,32],"a":[5,29,33,44,75],"neuropathological":[6],"disorder":[7],"involving":[8],"the":[9,15,19,26,133],"degeneration":[10],"of":[11,22,46,82,92,98,100,135],"dopaminergic":[12],"neurons":[13,81,94,134],"in":[14,25,43,49,95,114],"substantia":[16,83],"nigra,":[17],"with":[18,63],"subsequent":[20],"loss":[21],"their":[23],"terminals":[24],"striatum.":[27],"Quercetin,":[28],"natural":[30],"flavonoid,":[31],"strong":[34],"antioxidant":[35],"and":[36,72,110],"radical":[37],"scavenger.":[38],"Therefore,":[39],"its":[40],"neuroprotective":[41],"effect":[42],"model":[45],"Parkinson\u2019s":[47],"rat":[50],"was":[51,103,112],"evaluated.Methods:":[52],"For":[53],"this":[54],"purpose,":[55],"unilateral":[56],"intrastriatal":[57],"6-hydroxydopamine":[58],"(6-OHDA)-lesioned":[59],"rats":[60],"were":[61,88],"pretreated":[62],"quercetin":[64,126],"(20":[65],"mg/kg":[66],"i.p.)":[67],"1":[68],"hour":[69],"before":[70],"surgery":[71],"treated":[73],"once":[74],"day":[76],"for":[77,128],"one":[78,129],"month.":[79],"Nissl-stained":[80,93],"nigra":[84],"pars":[85],"compacta":[86],"(SNC)":[87],"counted.":[89],"Results:":[90],"Number":[91],"left":[96],"side":[97],"SNC":[99,136],"lesion":[101,116,122],"group":[102,108,117,123],"lower":[104],"relative":[105],"to":[106,120],"sham-operated":[107],"(p<0.005)":[109],"it":[111],"higher":[113],"quercetin-treated":[115],"as":[118],"compared":[119],"untreated":[121],"(p<0.01).Discussion:":[124],"Flavonoid":[125],"administration":[127],"month":[130],"could":[131],"protect":[132],"against":[137],"6-OHDA":[138],"toxicity.":[139]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}
