{"id":"https://openalex.org/W2803333429","doi":"https://doi.org/10.1136/jnnp-2018-anzan.38","title":"039 Rates of lymphopenia in years 1\u20134 in patients with relapsing multiple sclerosis treated annually with cladribine tablets","display_name":"039 Rates of lymphopenia in years 1\u20134 in patients with relapsing multiple sclerosis treated annually with cladribine tablets","publication_year":2018,"publication_date":"2018-05-24","ids":{"openalex":"https://openalex.org/W2803333429","doi":"https://doi.org/10.1136/jnnp-2018-anzan.38","mag":"2803333429"},"language":"en","primary_location":{"id":"doi:10.1136/jnnp-2018-anzan.38","doi":"https://doi.org/10.1136/jnnp-2018-anzan.38","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2018-anzan.38","pdf_url":null,"source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112195496","display_name":"Stuart D. Cook","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]},{"id":"https://openalex.org/I4402554120","display_name":"Rutgers New Jersey Medical School","ror":"https://ror.org/014ye1258","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142","https://openalex.org/I4390039302","https://openalex.org/I4402554120"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stuart Cook","raw_affiliation_strings":["Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA","1Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I102322142","https://openalex.org/I4402554120"]},{"raw_affiliation_string":"1Rutgers, The State University of New Jersey, New Jersey Medical School, Newark, New Jersey, USA","institution_ids":["https://openalex.org/I4402554120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043499649","display_name":"G\u0131ancarlo Com\u0131","orcid":"https://orcid.org/0000-0002-6989-1054","observed_orcids":["https://orcid.org/0000-0002-6989-1054"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I4210133214","display_name":"IRCCS Ospedale San Raffaele","ror":"https://ror.org/039zxt351","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giancarlo Comi","raw_affiliation_strings":["Department of Neurology and Institute of Experimental Neurology, Universit\u00e0 Vita-Salute San Raffaele, Ospedale San Raffaele, Milan, Italy","2Department of Neurology and Institute of Experimental Neurology, Universit\u00e0 Vita-Salute San Raffaele, Ospedale San Raffaele, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology and Institute of Experimental Neurology, Universit\u00e0 Vita-Salute San Raffaele, Ospedale San Raffaele, Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I4210133214"]},{"raw_affiliation_string":"2Department of Neurology and Institute of Experimental Neurology, Universit\u00e0 Vita-Salute San Raffaele, Ospedale San Raffaele, Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I4210133214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015754502","display_name":"Gavin Giovannoni","orcid":"https://orcid.org/0000-0001-9995-1700","observed_orcids":["https://orcid.org/0000-0001-9995-1700"]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]},{"id":"https://openalex.org/I4405263501","display_name":"Blizard Institute","ror":"https://ror.org/01y7pzx08","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079","https://openalex.org/I4405263501"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Gavin Giovannoni","raw_affiliation_strings":["Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK","3Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]},{"raw_affiliation_string":"3Queen Mary University of London, Blizard Institute, Barts and The London School of Medicine and Dentistry, London, UK","institution_ids":["https://openalex.org/I166337079","https://openalex.org/I4405263501"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Peter Rieckmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter Rieckmann","raw_affiliation_strings":["Department of Neurology, Medical Park Loipl and University of Erlangen, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Medical Park Loipl and University of Erlangen, Erlangen, Germany","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066796645","display_name":"Per Soelberg S\u00f8rensen","orcid":"https://orcid.org/0000-0002-2818-3780","observed_orcids":["https://orcid.org/0000-0002-2818-3780"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Per Soelberg Sorensen","raw_affiliation_strings":["Department of Neurology, Danish MS Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark","5Department of Neurology, Danish MS Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Danish MS Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"5Department of Neurology, Danish MS Center, University of Copenhagen, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025462803","display_name":"Patrick Vermersch","orcid":"https://orcid.org/0000-0003-0997-8817","observed_orcids":["https://orcid.org/0000-0003-0997-8817"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I2279609970","display_name":"Universit\u00e9 de Lille","ror":"https://ror.org/02kzqn938","country_code":"FR","type":"education","lineage":["https://openalex.org/I2279609970"]},{"id":"https://openalex.org/I3018718406","display_name":"Centre Hospitalier Universitaire de Lille","ror":"https://ror.org/02ppyfa04","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406"]},{"id":"https://openalex.org/I4210128436","display_name":"Lille Inflammation Research International Center","ror":"https://ror.org/03c3m6m66","country_code":"FR","type":"facility","lineage":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210093160","https://openalex.org/I4210128436","https://openalex.org/I4387152267"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Patrick Vermersch","raw_affiliation_strings":["Universit\u00e9 de Lille, CHU Lille, LIRIC-INSERM U995, FHU Imminent, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Lille, CHU Lille, LIRIC-INSERM U995, FHU Imminent, Lille, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I2279609970","https://openalex.org/I3018718406","https://openalex.org/I4210128436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010771032","display_name":"Fernando Dangond","orcid":"https://orcid.org/0000-0002-6723-4229","observed_orcids":["https://orcid.org/0000-0002-6723-4229"]},"institutions":[{"id":"https://openalex.org/I4210111614","display_name":"EMD Serono, Inc. (United States)","ror":"https://ror.org/027zrs220","country_code":"US","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I4210111614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fernando Dangond","raw_affiliation_strings":["EMD Serono, Inc., Billerica, Massachusetts, USA","#N#7EMD Serono, Inc., Billerica, Massachusetts, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"EMD Serono, Inc., Billerica, Massachusetts, USA","institution_ids":["https://openalex.org/I4210111614"]},{"raw_affiliation_string":"#N#7EMD Serono, Inc., Billerica, Massachusetts, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113651603","display_name":"John O King","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1320473756","display_name":"The Royal Melbourne Hospital","ror":"https://ror.org/005bvs909","country_code":"AU","type":"funder","lineage":["https://openalex.org/I1320473756","https://openalex.org/I4210158168"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"John King","raw_affiliation_strings":["Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia","8Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]},{"raw_affiliation_string":"8Department of Neurology, Royal Melbourne Hospital, Parkville, VIC, Australia","institution_ids":["https://openalex.org/I1320473756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000898624","display_name":"Christine Hicking","orcid":"https://orcid.org/0009-0002-7750-8892","observed_orcids":["https://orcid.org/0009-0002-7750-8892"]},"institutions":[{"id":"https://openalex.org/I164928964","display_name":"Merck KGaA, Darmstadt (Germany)","ror":"https://ror.org/04b2dty93","country_code":"DE","type":"company","lineage":["https://openalex.org/I164928964"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Hicking","raw_affiliation_strings":["Merck KGaA, Darmstadt, Germany","9Merck KGaA, Darmstadt, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]},{"raw_affiliation_string":"9Merck KGaA, Darmstadt, Germany","institution_ids":["https://openalex.org/I164928964"]}]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":16,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.191,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.51900027,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"89","issue":"6","first_page":"A16.2","last_page":"A16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/relapsing-multiple-sclerosis","display_name":"relapsing multiple sclerosis","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cladribine-tablets","display_name":"cladribine tablets","score":0.9779999852180481},{"id":"https://openalex.org/keywords/lymphopenia","display_name":"lymphopenia","score":0.9900000095367432},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6399999856948853},{"id":"https://openalex.org/keywords/lymphodepletion","display_name":"lymphocyte depletion","score":0.48500001430511475},{"id":"https://openalex.org/keywords/relapse-prevention","display_name":"relapse prevention","score":0.453000009059906},{"id":"https://openalex.org/keywords/immunomodulatory-therapy","display_name":"immunomodulatory therapy","score":0.6809999942779541},{"id":"https://openalex.org/keywords/safety-and-tolerability","display_name":"safety and tolerability","score":0.47099998593330383},{"id":"https://openalex.org/keywords/relapse-rate","display_name":"relapse rate","score":0.36000001430511475}],"concepts":[{"id":"https://openalex.org/C2779200787","wikidata":"https://www.wikidata.org/wiki/Q414030","display_name":"Cladribine","level":2,"score":0.9876581430435181},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8384401202201843},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5121443271636963},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5068071484565735},{"id":"https://openalex.org/C2777146004","wikidata":"https://www.wikidata.org/wiki/Q14949826","display_name":"CLARITY","level":2,"score":0.44596683979034424},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.41020888090133667},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36520618200302124},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.18762463331222534},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jnnp-2018-anzan.38","doi":"https://doi.org/10.1136/jnnp-2018-anzan.38","is_oa":false,"landing_page_url":"https://doi.org/10.1136/jnnp-2018-anzan.38","pdf_url":null,"source":{"id":"https://openalex.org/S134773490","display_name":"Journal of Neurology Neurosurgery & Psychiatry","issn_l":"0022-3050","issn":["0022-3050","1468-330X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurology, Neurosurgery &amp; Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:open-archive.highwire.org:jnnp:89/6/A16-b","doi":null,"is_oa":false,"landing_page_url":"http://jnnp.bmj.com/cgi/content/short/89/6/A16-b","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2890583582","https://openalex.org/W2751578374","https://openalex.org/W2805202240","https://openalex.org/W2556353245","https://openalex.org/W4200298634","https://openalex.org/W2782364759","https://openalex.org/W2889659580","https://openalex.org/W2771900644","https://openalex.org/W3145321899","https://openalex.org/W2865333669"],"abstract_inverted_index":{"Introduction":[0],"The":[1,19],"CLARITY":[2,4,64,73,125,133],"and":[3,65,99,111,127,151,155,164,175,186,199,210],"Extension":[5,74,134],"studies":[6],"demonstrated":[7],"the":[8,28,93,116,250,267,281,289],"efficacy":[9],"of":[10,30,32,96,143,188,212,224,228,237,252,269,283,291],"cladribine":[11,33,46,59,68,97,298],"tablets":[12,60,69,98],"in":[13,63,72,107,115,141,148,152,160,170,182,194,206,221,235,259,287],"patients":[14,56,120,144,238,244,257],"with":[15,27,45,86,297],"relapsing":[16],"multiple":[17],"sclerosis.":[18],"most":[20],"common":[21],"adverse":[22],"event":[23],"was":[24,36,139,180,204,218,233,276],"lymphopenia,":[25],"consistent":[26],"mechanism":[29],"action":[31],"tablets.":[34,47,299],"Objective":[35],"to":[37,58,67,105],"evaluate":[38],"whether":[39],"lymphopenia":[40,89,138,179,203,217,232,248,265,275,294],"persists":[41],"following":[42],"annual":[43],"treatment":[44,271,285,296],"Methods":[48],"Lymphopenia":[49],"by":[50],"grade":[51],"(NCI":[52],"CTCAE":[53],"v3.0)":[54],"for":[55],"randomised":[57],"3.5":[61,70],"mg/kg":[62,71,76],"re-randomised":[66],"(7":[75],"cumulative":[77],"dose":[78],"over":[79],"4":[80,112,247,264],"years;":[81],"n=186)":[82],"are":[83],"reported.":[84],"Patients":[85],"Grade":[87,100,122,130,136,177,201,215,230,246,263,273],"0":[88,123],"(\u22651.0\u00d7109":[90],"cells/L)":[91,103],"before":[92],"first":[94],"course":[95],"0/1":[101,131],"(\u22650.8\u00d7109":[102],"prior":[104],"administration":[106],"Years":[108,161,171,195],"2,":[109,162,173,197],"3":[110,137,163,174,178,198,202,216,231,274],"were":[113,121,129],"included":[114,258],"analysis.":[117],"Results":[118],"176":[119],"at":[124,132,145,157,239,249,266],"baseline":[126],"167":[128],"baseline.":[135],"observed":[140,181,205,220],"1%":[142],"Week":[146,158,168,192,222],"13":[147],"Year":[149,225],"1,":[150,172,196],"7%,":[153],"11%":[154],"12%":[156],"12":[159],"4,":[165,176,200],"respectively.":[166,190,214],"By":[167,191],"24":[169],"1%,":[183,207],"4%,":[184],"4%":[185,187],"patients,":[189,213],"36":[193],"2%,":[208],"2%":[209,211],"only":[219],"48":[223],"2":[226],"(1%":[227],"patients).":[229],"reported":[234],"<18%":[236],"any":[240,253,270],"time":[241],"point.":[242],"No":[243,256],"had":[245],"end":[251,268],"years.":[254],"Conclusion":[255],"this":[260],"analysis":[261],"experienced":[262],"year.":[272],"uncommon.":[277],"This":[278],"study":[279],"demonstrates":[280],"effectiveness":[282],"lymphocyte-based":[284],"criteria":[286],"minimising":[288],"incidence":[290],"severe,":[292],"sustained":[293],"during":[295]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2018-06-01T00:00:00"}
