{"id":"https://openalex.org/W2803332475","doi":"https://doi.org/10.1038/s41398-018-0144-4","title":"Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms","display_name":"Polygenic pleiotropy and potential causal relationships between educational attainment, neurobiological profile, and positive psychotic symptoms","publication_year":2018,"publication_date":"2018-05-10","ids":{"openalex":"https://openalex.org/W2803332475","doi":"https://doi.org/10.1038/s41398-018-0144-4","mag":"2803332475","pmid":"https://pubmed.ncbi.nlm.nih.gov/29765027","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5954124"},"language":"en","primary_location":{"id":"doi:10.1038/s41398-018-0144-4","doi":"https://doi.org/10.1038/s41398-018-0144-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0144-4","pdf_url":"https://www.nature.com/articles/s41398-018-0144-4.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41398-018-0144-4.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101550261","display_name":"Kuang Lin","orcid":"https://orcid.org/0000-0003-3017-6026","observed_orcids":["https://orcid.org/0000-0003-3017-6026"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210119487","display_name":"Taipei City Hospital","ror":"https://ror.org/02gzfb532","country_code":"TW","type":"healthcare","lineage":["https://openalex.org/I4210119487"]}],"countries":["TW","US"],"is_corresponding":true,"raw_author_name":"Yen-Feng Lin","raw_affiliation_strings":["Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. linyenfeng@gmail.com","Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan. linyenfeng@gmail.com","Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0000-0003-3017-6026","affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA. linyenfeng@gmail.com","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan. linyenfeng@gmail.com","institution_ids":["https://openalex.org/I4210119487"]},{"raw_affiliation_string":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035223725","display_name":"Chia\u2010Yen Chen","orcid":"https://orcid.org/0000-0001-9548-5597","observed_orcids":["https://orcid.org/0000-0001-9548-5597"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Yen Chen","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":"https://orcid.org/0000-0001-9548-5597","affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018380909","display_name":"D\u00f6st \u00d6ng\u00fcr","orcid":"https://orcid.org/0000-0001-8151-5759","observed_orcids":["https://orcid.org/0000-0001-8151-5759"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dost \u00d6ng\u00fcr","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Psychotic Disorders Division, McLean Hospital, Belmont, MA, USA","institution_ids":["https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018044773","display_name":"Rebecca A. Betensky","orcid":"https://orcid.org/0000-0002-3793-1437","observed_orcids":["https://orcid.org/0000-0002-3793-1437"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca Betensky","raw_affiliation_strings":["Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biostatistics, Harvard T. H. Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044998046","display_name":"Jordan W. Smoller","orcid":"https://orcid.org/0000-0002-0381-6334","observed_orcids":["https://orcid.org/0000-0002-0381-6334"]},"institutions":[{"id":"https://openalex.org/I107606265","display_name":"Broad Institute","ror":"https://ror.org/05a0ya142","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I107606265"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4392738323","display_name":"Stanley Center for Psychiatric Research","ror":"https://ror.org/01tm9b530","country_code":"US","type":"facility","lineage":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jordan W. Smoller","raw_affiliation_strings":["Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA","Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA","Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Psychiatric and Neurodevelopmental Genetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA","institution_ids":["https://openalex.org/I107606265","https://openalex.org/I4392738323"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006645872","display_name":"Deborah Blacker","orcid":"https://orcid.org/0000-0001-6107-7376","observed_orcids":["https://orcid.org/0000-0001-6107-7376"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Deborah Blacker","raw_affiliation_strings":["Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA","Department of Psychiatry, Harvard Medical School, Boston, MA, USA","Gerontology Research Unit, Massachusetts General Hospital, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Gerontology Research Unit, Massachusetts General Hospital, Boston, MA, USA","institution_ids":["https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032958174","display_name":"Mei\u2010Hua Hall","orcid":"https://orcid.org/0000-0002-4558-7023","observed_orcids":["https://orcid.org/0000-0002-4558-7023"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mei-Hua Hall","raw_affiliation_strings":["Department of Psychiatry, Harvard Medical School, Boston, MA, USA. mhall@mclean.harvard.edu","Psychosis Neurobiology Laboratory, McLean Hospital, Belmont, MA, USA. mhall@mclean.harvard.edu","Department of Psychiatry, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA. mhall@mclean.harvard.edu","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Psychosis Neurobiology Laboratory, McLean Hospital, Belmont, MA, USA. mhall@mclean.harvard.edu","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]},{"raw_affiliation_string":"Department of Psychiatry, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5032958174","https://openalex.org/A5101550261"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111","https://openalex.org/I4210119487"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":0.7494,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.70152765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"1","first_page":"97","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":0.9794999957084656,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.017100000753998756,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/event-related-potentials","display_name":"event-related potentials","score":0.871999979019165},{"id":"https://openalex.org/keywords/schizophrenia","display_name":"schizophrenia","score":0.8320000171661377},{"id":"https://openalex.org/keywords/bipolar-disorder","display_name":"bipolar disorder","score":1.0},{"id":"https://openalex.org/keywords/psychotic-symptoms","display_name":"psychotic symptoms","score":0.8100000023841858},{"id":"https://openalex.org/keywords/positive-symptoms","display_name":"positive symptoms","score":0.6470000147819519},{"id":"https://openalex.org/keywords/educational-attainment","display_name":"educational attainment","score":0.8410000205039978},{"id":"https://openalex.org/keywords/college-completion","display_name":"college completion","score":0.7149999737739563},{"id":"https://openalex.org/keywords/children-s-intelligence","display_name":"child intelligence","score":0.8799999952316284},{"id":"https://openalex.org/keywords/polygenic-risk-score","display_name":"polygenic risk score","score":0.9700000286102295},{"id":"https://openalex.org/keywords/mediation-analysis","display_name":"mediation analysis","score":0.7390000224113464},{"id":"https://openalex.org/keywords/cognitive-impairment","display_name":"cognitive impairment","score":0.527999997138977}],"concepts":[{"id":"https://openalex.org/C26207810","wikidata":"https://www.wikidata.org/wiki/Q1134884","display_name":"Pleiotropy","level":4,"score":0.8207577466964722},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.6551910638809204},{"id":"https://openalex.org/C2776412080","wikidata":"https://www.wikidata.org/wiki/Q7431605","display_name":"Schizophrenia (object-oriented programming)","level":2,"score":0.610041081905365},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.5020406246185303},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.49600324034690857},{"id":"https://openalex.org/C187869287","wikidata":"https://www.wikidata.org/wiki/Q2032061","display_name":"Endophenotype","level":3,"score":0.4771173298358917},{"id":"https://openalex.org/C2993137441","wikidata":"https://www.wikidata.org/wiki/Q28135712","display_name":"Polygenic risk score","level":5,"score":0.452169269323349},{"id":"https://openalex.org/C2779297142","wikidata":"https://www.wikidata.org/wiki/Q3276412","display_name":"Educational attainment","level":2,"score":0.4146444499492645},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.3846069276332855},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.37299710512161255},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18894550204277039},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.1744827926158905},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10730883479118347},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.10689389705657959},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.09297600388526917},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C50522688","wikidata":"https://www.wikidata.org/wiki/Q189833","display_name":"Economic growth","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004522","descriptor_name":"Educational Status","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005071","descriptor_name":"Evoked Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009483","descriptor_name":"Neuropsychological Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020412","descriptor_name":"Multifactorial Inheritance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1038/s41398-018-0144-4","doi":"https://doi.org/10.1038/s41398-018-0144-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0144-4","pdf_url":"https://www.nature.com/articles/s41398-018-0144-4.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4873252","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5954124","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5954124","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5954124","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry","raw_type":"Text"},{"id":"pmid:29765027","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29765027","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:dash.harvard.edu:1/37160326","doi":null,"is_oa":true,"landing_page_url":"http://nrs.harvard.edu/urn-3:HUL.InstRepos:37160326","pdf_url":null,"source":{"id":"https://openalex.org/S4306401540","display_name":"Digital Access to Scholarship at Harvard (DASH) (Harvard University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I136199984","host_organization_name":"Harvard University","host_organization_lineage":["https://openalex.org/I136199984"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:ba7ff74caf4046d68512abbcf79a85f5","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/ba7ff74caf4046d68512abbcf79a85f5","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry, Vol 8, Iss 1, Pp 1-11 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1038/s41398-018-0144-4","doi":"https://doi.org/10.1038/s41398-018-0144-4","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0144-4","pdf_url":"https://www.nature.com/articles/s41398-018-0144-4.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2952336907","display_name":"Genetic Basis of Reward Learning and Symptom, Smoking, and Neural Signature Correlates","funder_award_id":"R03MH108850","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"}],"funders":[{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803332475.pdf","grobid_xml":"https://content.openalex.org/works/W2803332475.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W40003836","https://openalex.org/W1200752817","https://openalex.org/W1643478577","https://openalex.org/W1681270005","https://openalex.org/W1771603797","https://openalex.org/W1936043210","https://openalex.org/W1968008611","https://openalex.org/W1970528899","https://openalex.org/W1971440513","https://openalex.org/W1973285887","https://openalex.org/W1977556410","https://openalex.org/W1983939607","https://openalex.org/W1985586328","https://openalex.org/W1993560189","https://openalex.org/W1993588417","https://openalex.org/W1997338841","https://openalex.org/W1998306784","https://openalex.org/W2002245291","https://openalex.org/W2015772384","https://openalex.org/W2020575476","https://openalex.org/W2022042990","https://openalex.org/W2023856002","https://openalex.org/W2025015001","https://openalex.org/W2026884584","https://openalex.org/W2039576727","https://openalex.org/W2045227722","https://openalex.org/W2049081095","https://openalex.org/W2058378999","https://openalex.org/W2061539393","https://openalex.org/W2086213036","https://openalex.org/W2098597355","https://openalex.org/W2101357408","https://openalex.org/W2104640717","https://openalex.org/W2105381419","https://openalex.org/W2107845304","https://openalex.org/W2108263267","https://openalex.org/W2110048796","https://openalex.org/W2115732191","https://openalex.org/W2116031764","https://openalex.org/W2116928980","https://openalex.org/W2127499921","https://openalex.org/W2128306635","https://openalex.org/W2128490229","https://openalex.org/W2135203595","https://openalex.org/W2135961695","https://openalex.org/W2139205784","https://openalex.org/W2139852368","https://openalex.org/W2140606211","https://openalex.org/W2142161268","https://openalex.org/W2146273335","https://openalex.org/W2152471397","https://openalex.org/W2154100681","https://openalex.org/W2154444513","https://openalex.org/W2157752701","https://openalex.org/W2161633633","https://openalex.org/W2163414567","https://openalex.org/W2167659819","https://openalex.org/W2169442707","https://openalex.org/W2170458546","https://openalex.org/W2190536949","https://openalex.org/W2193561325","https://openalex.org/W2195783463","https://openalex.org/W2209451986","https://openalex.org/W2269359293","https://openalex.org/W2293662507","https://openalex.org/W2334248800","https://openalex.org/W2346626662","https://openalex.org/W2470044734","https://openalex.org/W2558182452","https://openalex.org/W2578777427","https://openalex.org/W3195234955"],"related_works":["https://openalex.org/W2609317792","https://openalex.org/W2165807458","https://openalex.org/W2135203595","https://openalex.org/W2173616582","https://openalex.org/W2607608758","https://openalex.org/W2798264663","https://openalex.org/W4402398066","https://openalex.org/W4387501520","https://openalex.org/W4390609037","https://openalex.org/W4385669020"],"abstract_inverted_index":{"Abstract":[0],"Event-related":[1],"potential":[2],"(ERP)":[3],"components":[4],"have":[5],"been":[6],"used":[7,111],"to":[8,58,67,71,129,151],"assess":[9],"cognitive":[10,61],"functions":[11],"in":[12,88,135,169],"patients":[13,21],"with":[14,22,93,143,175,195],"psychotic":[15,162,269],"illness.":[16],"Evidence":[17],"suggests":[18],"that":[19,164,246],"among":[20],"psychosis":[23,59],"there":[24],"is":[25,165],"a":[26,36,89,209],"distinct":[27],"heritable":[28],"neurophysiologic":[29],"phenotypic":[30],"subtype":[31],"captured":[32],"by":[33],"impairments":[34],"across":[35],"range":[37],"of":[38,49,91,155,161,229,256],"ERP":[39,53,69,83,178,198,219,250],"measures.":[40],"In":[41],"this":[42,50],"study,":[43],"we":[44],"investigated":[45],"the":[46,73,80,126,153,170,214,247,260],"genetic":[47,263],"basis":[48],"\u201cglobally":[51],"impaired\u201d":[52],"cluster":[54],"and":[55,60,79,104,122,139,216,268],"its":[56],"relationship":[57],"abilities.":[62],"We":[63,110,147,206],"applied":[64],"K-means":[65],"clustering":[66],"six":[68],"measures":[70],"re-derive":[72],"globally":[74,144,171,176,196,217,240,248],"impaired":[75,82,145,172,177,197,218,241,249],"(n":[76,85,107],"=":[77,86,96,102,108,185,188,201,204,222,225],"60)":[78],"non-globally":[81],"clusters":[84],"323)":[87],"sample":[90,138],"cases":[92],"schizophrenia":[94],"(SCZ":[95],"136)":[97],"or":[98],"bipolar":[99],"disorder":[100],"(BPD":[101],"121)":[103],"healthy":[105],"controls":[106],"126).":[109],"genome-wide":[112],"association":[113,212],"study":[114,137],"(GWAS)":[115],"results":[116,244],"for":[117],"SCZ,":[118],"BPD,":[119],"college":[120],"completion,":[121],"childhood":[123],"intelligence":[124],"as":[125],"discovery":[127],"datasets":[128],"derive":[130],"polygenic":[131],"risk":[132],"scores":[133,183],"(PRS)":[134],"our":[136],"tested":[140],"their":[141],"associations":[142],"ERP.":[146,173,242],"conducted":[148],"mediation":[149],"analyses":[150],"estimate":[152],"proportion":[154],"each":[156],"PRS":[157],"effect":[158,228],"on":[159,231,259,265],"severity":[160],"symptoms":[163],"mediated":[166,238],"through":[167,239],"membership":[168],"Individuals":[174],"had":[179],"significantly":[180],"higher":[181],"PANSS-positive":[182],"(\u03b2":[184],"3.95,":[186],"P":[187,200,221],"0.005).":[189],"The":[190,227],"SCZ-PRS":[191],"was":[192,234],"nominally":[193],"associated":[194],"(unadjusted":[199],"0.01;":[202],"R2":[203,224],"3.07%).":[205],"also":[207],"found":[208],"significant":[210],"positive":[211],"between":[213,262],"college-PRS":[215,230],"(FDR-corrected":[220],"0.004;":[223],"6.15%).":[226],"PANSS":[232],"positivity":[233],"almost":[235],"entirely":[236],"(97.1%)":[237],"These":[243],"suggest":[245],"phenotype":[251],"may":[252],"represent":[253],"some":[254],"aspects":[255],"brain":[257],"physiology":[258],"path":[261],"influences":[264],"educational":[266],"attainment":[267],"symptoms.":[270]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-06-01T00:00:00"}
