{"id":"https://openalex.org/W2803331432","doi":"https://doi.org/10.2147/dddt.s159546","title":"Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-\u03baB/I\u03baB\u03b1 signaling pathway","display_name":"Tanshinol ameliorates CCl4-induced liver fibrosis in rats through the regulation of Nrf2/HO-1 and NF-\u03baB/I\u03baB\u03b1 signaling pathway","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2803331432","doi":"https://doi.org/10.2147/dddt.s159546","mag":"2803331432","pmid":"https://pubmed.ncbi.nlm.nih.gov/29844659","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5961642"},"language":"en","primary_location":{"id":"doi:10.2147/dddt.s159546","doi":"https://doi.org/10.2147/dddt.s159546","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s159546","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2147/dddt.s159546","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005778507","display_name":"Rong Wang","orcid":"https://orcid.org/0000-0001-5706-7650","observed_orcids":["https://orcid.org/0000-0001-5706-7650"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rong Wang","raw_affiliation_strings":["Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Department of Pharmacy, shanghai 9th People's hospital, shanghai Jiao Tong University school of Medicine, 280 Mo he road, shanghai 201999, china"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Pharmacy, shanghai 9th People's hospital, shanghai Jiao Tong University school of Medicine, 280 Mo he road, shanghai 201999, china","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013503893","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-6394-5357","observed_orcids":["https://orcid.org/0000-0002-6394-5357"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Department of Pharmacy, shanghai 9th People's hospital, shanghai Jiao Tong University school of Medicine, 280 Mo he road, shanghai 201999, china"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Pharmacy, shanghai 9th People's hospital, shanghai Jiao Tong University school of Medicine, 280 Mo he road, shanghai 201999, china","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045948738","display_name":"Fuxing Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fuxing Song","raw_affiliation_strings":["Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100359475","display_name":"Shengnan Li","orcid":"https://orcid.org/0000-0003-1111-5981","observed_orcids":["https://orcid.org/0000-0003-1111-5981"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shengnan Li","raw_affiliation_strings":["Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0003-1111-5981","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079847437","display_name":"Yongfang Yuan","orcid":"https://orcid.org/0000-0003-1123-2379","observed_orcids":["https://orcid.org/0000-0003-1123-2379","https://orcid.org/0009-0006-0958-1739"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongfang Yuan","raw_affiliation_strings":["Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","Department of Pharmacy, shanghai 9th People's hospital, shanghai Jiao Tong University school of Medicine, 280 Mo he road, shanghai 201999, china"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Department of Pharmacy, shanghai 9th People's hospital, shanghai Jiao Tong University school of Medicine, 280 Mo he road, shanghai 201999, china","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079847437"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":4.8361,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.96333173,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"Volume 12","issue":null,"first_page":"1281","last_page":"1292"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.9771000146865845,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.010400000028312206,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.006000000052154064,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.6819999814033508},{"id":"https://openalex.org/keywords/tanshinol","display_name":"tanshinol","score":0.7990000247955322},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.9750000238418579},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.8830000162124634},{"id":"https://openalex.org/keywords/nrf2-ho-1-signaling-pathway","display_name":"Nrf2/HO-1 pathway","score":0.9020000100135803},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.949999988079071},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9169999957084656},{"id":"https://openalex.org/keywords/salvia-miltiorrhiza","display_name":"Salvia miltiorrhiza","score":0.9079999923706055},{"id":"https://openalex.org/keywords/antioxidants","display_name":"antioxidants","score":0.37700000405311584},{"id":"https://openalex.org/keywords/anti-inflammatory-agents","display_name":"anti-inflammatory agents","score":0.7820000052452087},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.6819999814033508},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.48899999260902405},{"id":"https://openalex.org/keywords/transforming-growth-factor-beta","display_name":"TGF-beta","score":0.6740000247955322},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.8759999871253967},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7020000219345093}],"concepts":[{"id":"https://openalex.org/C2777529286","wikidata":"https://www.wikidata.org/wiki/Q337231","display_name":"Hyaluronic acid","level":2,"score":0.7185590863227844},{"id":"https://openalex.org/C2776332195","wikidata":"https://www.wikidata.org/wiki/Q1000854","display_name":"Salvia miltiorrhiza","level":4,"score":0.6894591450691223},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.5584920644760132},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5139405131340027},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.45769980549812317},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.45344266295433044},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.44752371311187744},{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.4284919202327728},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.4201638996601105},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4127890467643738},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4092284142971039},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3676987886428833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.21922042965888977},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.1891627311706543},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18073830008506775},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.09357088804244995},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002109","descriptor_name":"Caffeic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002251","descriptor_name":"Carbon Tetrachloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007274","descriptor_name":"Injections, Intraperitoneal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D008103","descriptor_name":"Liver Cirrhosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051547","descriptor_name":"Heme Oxygenase-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.2147/dddt.s159546","doi":"https://doi.org/10.2147/dddt.s159546","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s159546","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4922752","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5961642","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5961642","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5961642","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Des Devel Ther","raw_type":"Text"},{"id":"pmid:29844659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29844659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug design, development and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:3232c54aa366473e850082ae716722cb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3232c54aa366473e850082ae716722cb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Drug Design, Development and Therapy, Vol Volume 12, Pp 1281-1292 (2018)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/38357","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/tanshinol-ameliorates-ccl4-induced-liver-fibrosis-in-rats-through-the--peer-reviewed-article-DDDT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/dddt.s159546","doi":"https://doi.org/10.2147/dddt.s159546","is_oa":true,"landing_page_url":"https://doi.org/10.2147/dddt.s159546","pdf_url":null,"source":{"id":"https://openalex.org/S2496126384","display_name":"Drug Design Development and Therapy","issn_l":"1177-8881","issn":["1177-8881"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Drug Design, Development and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"},{"id":"https://openalex.org/F4320335305","display_name":"School of Medicine, Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W566617908","https://openalex.org/W593042049","https://openalex.org/W1227022651","https://openalex.org/W1487832278","https://openalex.org/W1748034980","https://openalex.org/W1794770698","https://openalex.org/W1976777085","https://openalex.org/W1982927063","https://openalex.org/W2005025375","https://openalex.org/W2006571181","https://openalex.org/W2007728926","https://openalex.org/W2007867750","https://openalex.org/W2010706205","https://openalex.org/W2022418725","https://openalex.org/W2028993208","https://openalex.org/W2037733084","https://openalex.org/W2048792427","https://openalex.org/W2059997493","https://openalex.org/W2062422746","https://openalex.org/W2077234663","https://openalex.org/W2099823649","https://openalex.org/W2124728669","https://openalex.org/W2144310972","https://openalex.org/W2199654259","https://openalex.org/W2253639993","https://openalex.org/W2257640039","https://openalex.org/W2328650856","https://openalex.org/W2404267413","https://openalex.org/W2405123385","https://openalex.org/W2471826260","https://openalex.org/W2500661885","https://openalex.org/W2552083010","https://openalex.org/W2589899902","https://openalex.org/W2595622037","https://openalex.org/W2604649536","https://openalex.org/W2607364559","https://openalex.org/W2610833176","https://openalex.org/W2992650947","https://openalex.org/W6652594400"],"related_works":["https://openalex.org/W2610833176","https://openalex.org/W6996524383","https://openalex.org/W4391078325","https://openalex.org/W2260601180","https://openalex.org/W2394797062","https://openalex.org/W2266572254","https://openalex.org/W4220752936","https://openalex.org/W4206374682","https://openalex.org/W2370777376","https://openalex.org/W2096412176"],"abstract_inverted_index":{"Abstract:":[0],"Tanshinol,":[1],"a":[2,12],"water-soluble":[3],"component":[4],"isolated":[5],"from":[6],"Salvia":[7],"miltiorrhiza":[8],"Bunge":[9],",":[10],"has":[11,251],"variety":[13],"of":[14,42,112,123,135,162,194,207,230,273,284],"biological":[15],"activities":[16,39],"involving":[17],"anti-fibrotic":[18],"effect.":[19],"However,":[20],"the":[21,25,36,79,109,147,157,160,192,205,271],"exact":[22],"role":[23],"and":[24,40,56,73,115,121,140,170,190,198,202,242,264,279],"underlying":[26],"mechanisms":[27,41,122],"remain":[28],"largely":[29],"unclear.":[30],"This":[31],"study":[32],"mainly":[33],"focused":[34],"on":[35,44,125,254],"anti-hepatic":[37],"fibrotic":[38],"tanshinol":[43,70,74,97,124,148,181,184,218,250],"carbon":[45],"tetrachloride":[46],"(CCl":[47],"4":[48,64,83,256],")-induced":[49],"liver":[50,88,126,258,291],"fibrosis":[51,89,127,259],"in":[52,96,128,146,175],"rats":[53,60,95,129],"via":[54,260],"anti-oxidative":[55],"anti-inflammation":[57],"pathways.":[58,289],"The":[59,117,132],"were":[61,99,130,143,177],"divided":[62],"into":[63],"groups":[65,98,150],"as":[66],"follows:":[67],"control,":[68],"model,":[69],"20":[71],"mg/kg,":[72],"40":[75],"mg/kg.":[76],"Except":[77],"for":[78,91],"control":[80],"group,":[81,159],"CCl":[82,255],"was":[84],"used":[85],"to":[86,152,210,227],"induce":[87],"processing":[90],"8":[92],"weeks,":[93],"meanwhile":[94],"intraperitoneally":[100],"injected":[101],"with":[102,156,270],"additional":[103],"tanshinol.":[104],"Control":[105],"group":[106],"simultaneously":[107],"received":[108],"same":[110],"volumes":[111],"olive":[113],"oil":[114],"saline.":[116],"potentially":[118],"protective":[119,252],"effect":[120,253],"evaluated.":[131],"serum":[133,176],"levels":[134,161],"alanine":[136],"aminotransferase,":[137,139],"aspartate":[138],"total":[141],"bilirubin":[142],"obviously":[144],"lower":[145],"treatment":[149],"related":[151],"model":[153,158],"group.":[154],"Compared":[155],"hyaluronic":[163],"acid,":[164],"type":[165],"IV":[166],"collagen,":[167],"Laminin":[168],"(LN),":[169],"procollagen":[171],"III":[172],"peptide":[173],"(PIIIP)":[174],"significantly":[178],"decreased":[179],"after":[180],"treatment.":[182],"Furthermore,":[183],"could":[185,219],"regulate":[186,220],"Nrf2/HO-1":[187],"signaling":[188,225,288],"pathway":[189,226],"increase":[191],"level":[193,206],"superoxide":[195],"dismutase":[196],"(SOD)":[197],"glutathione":[199],"peroxidase":[200],"(GSH-Px),":[201],"also":[203],"decrease":[204],"malondialdehyde":[208],"(MDA)":[209],"against":[211],"damage":[212],"induced":[213],"by":[214],"oxidative":[215,262,294],"stress.":[216],"Simultaneously":[217],"nuclear":[221,274,280],"factor":[222,275,277,281],"kappa":[223,282,285],"B":[224,286],"inhibit":[228],"expression":[229],"inflammation":[231],"factors,":[232],"including":[233],"transforming":[234],"growth":[235],"factor-\u03b2,":[236],"tumor":[237],"necrosis":[238],"factor-\u03b1,":[239],"Cox-2,":[240],"interleukin-1\u03b2,":[241],"interleukin-6.":[243],"In":[244],"summary,":[245],"our":[246],"research":[247],"demonstrated":[248],"that":[249],"-induced":[257],"inhibiting":[261],"stress":[263],"inflammation,":[265,296],"which":[266],"may":[267],"be":[268],"associated":[269],"regulation":[272],"erythroid2-related":[276],"2/hemeoxygenase-a":[278],"B/inhibitor":[283],"alpha":[287],"Keywords:":[290],"fibrosis,":[292],"tanshinol,":[293],"stress,":[295],"Nrf2,":[297],"NF-\u03baB":[298]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":11},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":4}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-06-01T00:00:00"}
