{"id":"https://openalex.org/W2803325246","doi":"https://doi.org/10.2147/ott.s166597","title":"miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R","display_name":"miR-598 acts as a tumor suppressor in human gastric cancer by targeting IGF-1R","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2803325246","doi":"https://doi.org/10.2147/ott.s166597","mag":"2803325246","pmid":"https://pubmed.ncbi.nlm.nih.gov/29844688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5961641"},"language":"en","primary_location":{"id":"doi:10.2147/ott.s166597","doi":"https://doi.org/10.2147/ott.s166597","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s166597","pdf_url":null,"source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.2147/ott.s166597","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100389746","display_name":"Na Liu","orcid":"https://orcid.org/0000-0001-8654-3636","observed_orcids":["https://orcid.org/0000-0001-8654-3636"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Na Liu","raw_affiliation_strings":["Intensive Care Unit, Shandong Provincial Third Hospital, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Shandong Provincial Third Hospital, Shandong, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103908778","display_name":"Hua Yang","orcid":"https://orcid.org/0000-0001-5212-7933","observed_orcids":["https://orcid.org/0000-0001-5212-7933"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":["Intensive Care Unit, Chiping County People's Hospital, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Chiping County People's Hospital, Shandong, China","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Department of General Surgery, Shandong Provincial Third Hospital, Shandong, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shandong Provincial Third Hospital, Shandong, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.991,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.68876081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"Volume 11","issue":null,"first_page":"2911","last_page":"2923"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-1-receptor","display_name":"IGF-1 receptor","score":0.9480000138282776},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.9800000190734863},{"id":"https://openalex.org/keywords/tumor-suppressor-microrna","display_name":"tumor suppressor microRNA","score":0.9300000071525574},{"id":"https://openalex.org/keywords/3-utr-targeting","display_name":"3' UTR targeting","score":0.8140000104904175},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.800000011920929},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.972000002861023},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.8899999856948853},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8130000233650208},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9670000076293945},{"id":"https://openalex.org/keywords/akt-phosphorylation","display_name":"Akt phosphorylation","score":0.984000027179718},{"id":"https://openalex.org/keywords/prognosis","display_name":"prognosis","score":0.5580000281333923},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.8109999895095825},{"id":"https://openalex.org/keywords/vascular-invasion","display_name":"vascular invasion","score":0.8560000061988831}],"concepts":[{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5952423810958862},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5744122266769409},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5517501831054688},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5464502573013306},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5161551237106323},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5117718577384949},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5097758173942566},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4619244933128357},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.44799840450286865},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2841048240661621},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2609785795211792},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.2147/ott.s166597","doi":"https://doi.org/10.2147/ott.s166597","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s166597","pdf_url":null,"source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4922751","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5961641","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5961641","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5961641","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Onco Targets Ther","raw_type":"Text"},{"id":"pmid:29844688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29844688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and therapy","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:139be39434854704a58c06b60e194175","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/139be39434854704a58c06b60e194175","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"OncoTargets and Therapy, Vol Volume 11, Pp 2911-2923 (2018)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/38353","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/mir-598-acts-as-a-tumor-suppressor-in-human-gastric-cancer-by-targetin-peer-reviewed-article-OTT","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/ott.s166597","doi":"https://doi.org/10.2147/ott.s166597","is_oa":true,"landing_page_url":"https://doi.org/10.2147/ott.s166597","pdf_url":null,"source":{"id":"https://openalex.org/S120324992","display_name":"OncoTargets and Therapy","issn_l":"1178-6930","issn":["1178-6930"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"OncoTargets and Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":25,"referenced_works":["https://openalex.org/W1965983806","https://openalex.org/W2124018073","https://openalex.org/W2129049675","https://openalex.org/W2152317098","https://openalex.org/W2524983779","https://openalex.org/W2585026947","https://openalex.org/W2728408249","https://openalex.org/W2741953965","https://openalex.org/W2742895647","https://openalex.org/W2743116197","https://openalex.org/W2743651269","https://openalex.org/W2744405493","https://openalex.org/W2748662256","https://openalex.org/W2751911397","https://openalex.org/W2753042008","https://openalex.org/W2766076173","https://openalex.org/W2767495500","https://openalex.org/W2767784638","https://openalex.org/W2770957382","https://openalex.org/W2778071905","https://openalex.org/W2779610575","https://openalex.org/W2791968111","https://openalex.org/W2912667178","https://openalex.org/W2982679874","https://openalex.org/W6727703212"],"related_works":["https://openalex.org/W2983606872","https://openalex.org/W2570881595","https://openalex.org/W2810367547","https://openalex.org/W2735966241","https://openalex.org/W2904475152","https://openalex.org/W2806446265","https://openalex.org/W3198092004","https://openalex.org/W1971645189","https://openalex.org/W2884482057","https://openalex.org/W3005539210"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1,164],"recent":[2],"years,":[3],"the":[4,17,20,27,40,55,68,89,142,147,168,195],"aberrant":[5],"expression":[6,46,56,98,184,204],"of":[7,29,57,71,92,128,149,154,171,192,198,202],"miR-598":[8,58,72,93,97,129,155,172,180,209,223],"in":[9,26,47,61,75,79,82,102,141],"tumorigenesis":[10],"has":[11],"been":[12],"demonstrated,":[13],"as":[14,16,121,123],"well":[15,122],"fact":[18],"that":[19,179],"IGF-1R":[21,45,60,74,124,182,193,203,220],"pathway":[22],"is":[23],"also":[24,156],"involved":[25],"development":[28],"human":[30,48],"gastric":[31],"cancer":[32],"(GC).":[33],"The":[34,126,152],"present":[35],"study":[36],"aimed":[37],"to":[38,87],"investigate":[39,88],"molecular":[41,90],"mechanisms":[42,91],"underlying":[43],"miR-598-regulated":[44],"GC.":[49],"MATERIALS":[50],"AND":[51],"METHODS:":[52],"We":[53],"analyzed":[54],"and":[59,64,66,73,81,94,105,107,117,136,145,160,215],"GC":[62,76,103,150,211,230],"samples":[63],"cells,":[65,106],"evaluated":[67],"clinical":[69],"significance":[70],"patients.":[77,231],"Furthermore,":[78],"vitro":[80],"vivo":[83,165],"assays":[84],"were":[85],"used":[86],"IGF-1R.":[95],"RESULTS:":[96],"was":[99],"frequently":[100],"downregulated":[101],"tissues":[104],"significantly":[108,157],"correlated":[109],"with":[110],"poor":[111],"prognosis,":[112],"vascular":[113],"invasion,":[114,135],"TNM":[115],"stage,":[116],"lymph":[118],"node":[119],"metastases":[120],"expression.":[125,221],"overexpression":[127,153],"obviously":[130],"inhibited":[131,158,181],"cell":[132,138,212],"proliferation,":[133,213],"migration,":[134],"induced":[137],"cycle":[139],"arrest":[140],"G1/S":[143],"phase,":[144],"increased":[146],"apoptosis":[148],"cells.":[151],"ERK1/2":[159],"Akt":[161],"phosphorylation":[162],"level.":[163],"assay":[166],"validated":[167],"inhibitory":[169,196],"effect":[170],"on":[173],"tumor":[174],"growth.":[175],"Further":[176],"studies":[177],"showed":[178,205],"protein":[183],"by":[185,217],"directly":[186,218],"targeting":[187,219],"its":[188],"3'-UTR.":[189],"Besides,":[190],"over-expression":[191],"reversed":[194],"effects":[197],"miR-598,":[199],"while":[200],"suppression":[201],"inverse":[206],"effects.":[207],"CONCLUSION:":[208],"suppresses":[210],"migration":[214],"invasion":[216],"Thus,":[222],"may":[224],"be":[225],"a":[226],"useful":[227],"target":[228],"for":[229]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-01T00:00:00"}
