{"id":"https://openalex.org/W2803237981","doi":"https://doi.org/10.1021/acsbiomaterials.8b00348","title":"Pulsatile Chemotherapeutic Delivery Profiles Using Magnetically Responsive Hydrogels","display_name":"Pulsatile Chemotherapeutic Delivery Profiles Using Magnetically Responsive Hydrogels","publication_year":2018,"publication_date":"2018-05-15","ids":{"openalex":"https://openalex.org/W2803237981","doi":"https://doi.org/10.1021/acsbiomaterials.8b00348","mag":"2803237981","pmid":"https://pubmed.ncbi.nlm.nih.gov/30019005","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6039960"},"language":"en","primary_location":{"id":"doi:10.1021/acsbiomaterials.8b00348","doi":"https://doi.org/10.1021/acsbiomaterials.8b00348","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b00348","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.8b00348","source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science & Engineering","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.8b00348","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001778434","display_name":"Tania Emi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tania T. Emi","raw_affiliation_strings":["University of Rhode Island , , , ,","Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island , , , ,","institution_ids":["https://openalex.org/I17626003"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021128768","display_name":"Tanner Barnes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tanner Barnes","raw_affiliation_strings":["University of Rhode Island , , , ,","Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island 028881, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island , , , ,","institution_ids":["https://openalex.org/I17626003"]},{"raw_affiliation_string":"Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island 028881, United States","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084468454","display_name":"Emma Orton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emma Orton","raw_affiliation_strings":["University of Rhode Island , , , ,","Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island 028881, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island , , , ,","institution_ids":["https://openalex.org/I17626003"]},{"raw_affiliation_string":"Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island 028881, United States","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092761468","display_name":"Anne Reisch","orcid":"https://orcid.org/0000-0003-2994-7495","observed_orcids":["https://orcid.org/0000-0003-2994-7495"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anne Reisch","raw_affiliation_strings":["University of Rhode Island , , , ,","Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island 028881, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island , , , ,","institution_ids":["https://openalex.org/I17626003"]},{"raw_affiliation_string":"Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island 028881, United States","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013289500","display_name":"Anita E. Tolouei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anita E. Tolouei","raw_affiliation_strings":["University of Rhode Island , , , ,","Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island , , , ,","institution_ids":["https://openalex.org/I17626003"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071980726","display_name":"S. Zahra M. Madani","orcid":"https://orcid.org/0000-0001-5435-4697","observed_orcids":["https://orcid.org/0000-0001-5435-4697"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Zahra M. Madani","raw_affiliation_strings":["University of Rhode Island , , , ,","Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Rhode Island , , , ,","institution_ids":["https://openalex.org/I17626003"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States","institution_ids":["https://openalex.org/I17626003"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035658170","display_name":"Stephen M. Kennedy","orcid":"https://orcid.org/0000-0002-7106-2458","observed_orcids":["https://orcid.org/0000-0002-7106-2458"]},"institutions":[{"id":"https://openalex.org/I17626003","display_name":"University of Rhode Island","ror":"https://ror.org/013ckk937","country_code":"US","type":"education","lineage":["https://openalex.org/I17626003"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Stephen M. Kennedy","raw_affiliation_strings":["University of Rhode Island , , , ,","Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States","Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island 028881, United States"],"raw_orcid":"https://orcid.org/0000-0002-7106-2458","affiliations":[{"raw_affiliation_string":"University of Rhode Island , , , ,","institution_ids":["https://openalex.org/I17626003"]},{"raw_affiliation_string":"Department of Chemical Engineering, University of Rhode Island, Kingston, Rhode Island 02881, United States","institution_ids":["https://openalex.org/I17626003"]},{"raw_affiliation_string":"Department of Electrical, Computer, and Biomedical Engineering, University of Rhode Island, Kingston, Rhode Island 028881, United States","institution_ids":["https://openalex.org/I17626003"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5035658170"],"corresponding_institution_ids":["https://openalex.org/I17626003"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":1.6045,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.80102145,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"4","issue":"7","first_page":"2412","last_page":"2423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulsatile-drug-delivery","display_name":"pulsatile drug delivery","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ferrogels","display_name":"ferrogels","score":0.9639999866485596},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.9330000281333923},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.6240000128746033},{"id":"https://openalex.org/keywords/implantable-drug-delivery-systems","display_name":"implantable drug delivery","score":0.7129999995231628},{"id":"https://openalex.org/keywords/magnetic-stimulation","display_name":"magnetic stimulation","score":0.6299999952316284},{"id":"https://openalex.org/keywords/pulse-duration","display_name":"pulse duration","score":0.46299999952316284},{"id":"https://openalex.org/keywords/pulse-height","display_name":"pulse height","score":0.48500001430511475},{"id":"https://openalex.org/keywords/local-chemotherapy","display_name":"local chemotherapy","score":0.5289999842643738},{"id":"https://openalex.org/keywords/anticancer-drug-delivery","display_name":"anticancer drug delivery","score":0.5929999947547913}],"concepts":[{"id":"https://openalex.org/C79191276","wikidata":"https://www.wikidata.org/wiki/Q7259620","display_name":"Pulsatile flow","level":2,"score":0.9349852800369263},{"id":"https://openalex.org/C2780167933","wikidata":"https://www.wikidata.org/wiki/Q1550652","display_name":"Pulse (music)","level":3,"score":0.6384569406509399},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.6197389960289001},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6151851415634155},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5605002641677856},{"id":"https://openalex.org/C108586683","wikidata":"https://www.wikidata.org/wiki/Q17164826","display_name":"Self-healing hydrogels","level":2,"score":0.5282853245735168},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.5089023113250732},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2592393457889557},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23851609230041504},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.18162301182746887},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1477813422679901},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13677391409873962},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C94915269","wikidata":"https://www.wikidata.org/wiki/Q1834857","display_name":"Detector","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C188027245","wikidata":"https://www.wikidata.org/wiki/Q750446","display_name":"Polymer chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1021/acsbiomaterials.8b00348","doi":"https://doi.org/10.1021/acsbiomaterials.8b00348","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b00348","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.8b00348","source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science & Engineering","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4998164","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6039960","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6039960","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6039960","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomater Sci Eng","raw_type":"Text"},{"id":"pmid:30019005","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30019005","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS biomaterials science & engineering","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1021/acsbiomaterials.8b00348","doi":"https://doi.org/10.1021/acsbiomaterials.8b00348","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsbiomaterials.8b00348","pdf_url":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.8b00348","source":{"id":"https://openalex.org/S2764739176","display_name":"ACS Biomaterials Science & Engineering","issn_l":"2373-9878","issn":["2373-9878"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Biomaterials Science & Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2412513013","display_name":null,"funder_award_id":"32976949","funder_id":"https://openalex.org/F4320307785","funder_display_name":"3M"},{"id":"https://openalex.org/G5011558782","display_name":null,"funder_award_id":"CBET-1603433","funder_id":"https://openalex.org/F4320337390","funder_display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems"},{"id":"https://openalex.org/G7359496464","display_name":null,"funder_award_id":"20144262","funder_id":"https://openalex.org/F4320314596","funder_display_name":"Rhode Island Foundation"},{"id":"https://openalex.org/G8008422926","display_name":null,"funder_award_id":"1539068","funder_id":"https://openalex.org/F4320337378","funder_display_name":"Office of Integrative Activities"},{"id":"https://openalex.org/G9000863388","display_name":"Rhode Island IDeA Network of Biomedical Research Excellence","funder_award_id":"P20GM103430","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320307785","display_name":"3M","ror":"https://ror.org/00mgss748"},{"id":"https://openalex.org/F4320314596","display_name":"Rhode Island Foundation","ror":"https://ror.org/02y6cph55"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337378","display_name":"Office of Integrative Activities","ror":"https://ror.org/04k9mqs78"},{"id":"https://openalex.org/F4320337390","display_name":"Division of Chemical, Bioengineering, Environmental, and Transport Systems","ror":"https://ror.org/0471zv972"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803237981.pdf","grobid_xml":"https://content.openalex.org/works/W2803237981.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1593844282","https://openalex.org/W1821415384","https://openalex.org/W1875996132","https://openalex.org/W1885536305","https://openalex.org/W1965642226","https://openalex.org/W1965805426","https://openalex.org/W1989053944","https://openalex.org/W2001198522","https://openalex.org/W2004334950","https://openalex.org/W2005082473","https://openalex.org/W2010723976","https://openalex.org/W2011546003","https://openalex.org/W2018339166","https://openalex.org/W2020255727","https://openalex.org/W2024306244","https://openalex.org/W2027134043","https://openalex.org/W2031096930","https://openalex.org/W2038610301","https://openalex.org/W2049401592","https://openalex.org/W2049431170","https://openalex.org/W2053672030","https://openalex.org/W2073442004","https://openalex.org/W2081208715","https://openalex.org/W2081820338","https://openalex.org/W2091552691","https://openalex.org/W2098562786","https://openalex.org/W2100567246","https://openalex.org/W2116351792","https://openalex.org/W2120366984","https://openalex.org/W2129297473","https://openalex.org/W2131469764","https://openalex.org/W2139844513","https://openalex.org/W2152486489","https://openalex.org/W2267133977","https://openalex.org/W2268970839","https://openalex.org/W2490097462","https://openalex.org/W2791334979","https://openalex.org/W3145678530","https://openalex.org/W4231516524"],"related_works":["https://openalex.org/W3084318262","https://openalex.org/W3126572620","https://openalex.org/W2312709094","https://openalex.org/W2997083311","https://openalex.org/W1981051452","https://openalex.org/W2791334979","https://openalex.org/W3082623341","https://openalex.org/W4400657934","https://openalex.org/W7202050341","https://openalex.org/W3008607497"],"abstract_inverted_index":{"Pulsatile":[0],"chemotherapeutic":[1,54,249,272],"delivery":[2,55,70,81,107,124,175,192,250,273],"profiles":[3,56,71,82,129,147,176,251],"may":[4,252],"provide":[5,263],"a":[6,142,233],"number":[7],"advantages":[8],"by":[9,214],"maximizing":[10],"the":[11,73,99,115,187,201,236,244],"anticancer":[12],"toxicity":[13],"of":[14,72,101,117,127,140,145,149,171,191,203,209,226,235],"chemotherapeutics,":[15],"reducing":[16],"off-target":[17],"side":[18],"effects,":[19],"and":[20,65,114,155,189,217,256,268],"combating":[21],"adaptive":[22],"resistance.":[23],"While":[24],"these":[25],"temporally":[26],"dynamic":[27],"deliveries":[28,45],"have":[29,34],"shown":[30],"some":[31],"promise,":[32],"they":[33],"yet":[35],"to":[36,67,122,162,178,221,243],"be":[37,120,197,253],"clinically":[38,269],"deployed":[39],"from":[40],"implantable":[41],"hydrogels,":[42],"whose":[43],"localized":[44],"could":[46,119,196,262],"further":[47],"enhance":[48],"therapeutic":[49],"outcomes.":[50],"Here,":[51],"several":[52],"pulsatile":[53,80,128,146,173,248,271],"were":[57,83],"tested":[58,180],"on":[59,161],"melanoma":[60,88],"cell":[61],"survival":[62],"in":[63,133,181],"vitro":[64],"compared":[66],"constant":[68],"(flatline)":[69],"same":[74],"integrated":[75],"dose.":[76],"Results":[77],"indicated":[78],"that":[79,96,164,247,258],"more":[84],"efficient":[85],"at":[86,130],"killing":[87],"cells":[89],"than":[90],"flatline":[91],"deliveries.":[92],"Furthermore,":[93],"results":[94],"suggested":[95],"parameters":[97,184],"like":[98],"duration":[100],"drug":[102],"\"on\"":[103,194,230],"periods":[104,111,195,231],"(pulse":[105,112],"width),":[106],"rates":[108],"during":[109,193,228],"those":[110,179],"heights),":[113],"number/frequency":[116],"pulses":[118,210],"used":[121],"optimize":[123],"profiles.":[125,274],"Optimization":[126],"tumor":[131],"sites":[132],"vivo":[134],"would":[135],"require":[136],"hydrogel":[137],"materials":[138],"capable":[139,170],"producing":[141,172],"wide":[143],"variety":[144],"(e.g.,":[148],"different":[150],"pulse":[151,153,156,229],"heights,":[152],"widths,":[154],"numbers).":[157],"This":[158],"work":[159],"goes":[160],"demonstrate":[163],"magnetically":[165,222,259],"responsive,":[166],"biphasic":[167],"ferrogels":[168],"are":[169],"mitoxantrone":[174],"similar":[177],"vitro.":[182],"Pulse":[183],"such":[185],"as":[186],"timing":[188,208],"rate":[190,225],"remotely":[198],"regulated":[199],"through":[200],"use":[202],"simple,":[204],"hand-held":[205],"magnets.":[206],"The":[207,224],"was":[211,232],"controlled":[212],"simply":[213],"deciding":[215],"when":[216],"for":[218,266],"how":[219],"long":[220],"stimulate.":[223],"release":[227],"function":[234],"magnetic":[237],"stimulation":[238],"frequency.":[239],"These":[240],"findings":[241],"add":[242],"growing":[245],"evidence":[246],"therapeutically":[254],"beneficial":[255],"suggest":[257],"responsive":[260],"hydrogels":[261],"useful":[264],"tools":[265],"optimizing":[267],"deploying":[270]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2018-06-01T00:00:00"}