{"id":"https://openalex.org/W2803186409","doi":"https://doi.org/10.1111/bjh.15386","title":"Difficulty distinguishing essential thrombocythaemia from polycythaemia vera in children with JAK 2 V617F\u2010positive myeloproliferative neoplasms","display_name":"Difficulty distinguishing essential thrombocythaemia from polycythaemia vera in children with JAK 2 V617F\u2010positive myeloproliferative neoplasms","publication_year":2018,"publication_date":"2018-05-16","ids":{"openalex":"https://openalex.org/W2803186409","doi":"https://doi.org/10.1111/bjh.15386","mag":"2803186409","pmid":"https://pubmed.ncbi.nlm.nih.gov/29767848","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6239998"},"language":"en","primary_location":{"id":"doi:10.1111/bjh.15386","doi":"https://doi.org/10.1111/bjh.15386","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.15386","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15386","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15386","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003759796","display_name":"Nicole Kucine","orcid":"https://orcid.org/0000-0002-4865-4033","observed_orcids":["https://orcid.org/0000-0002-4865-4033"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicole Kucine","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":"https://orcid.org/0000-0002-4865-4033","affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061210661","display_name":"Mustafa Al\u2010Kawaaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mustafa Al\u2010Kawaaz","raw_affiliation_strings":["Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048947782","display_name":"Daher Hajje","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daher Hajje","raw_affiliation_strings":["Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062688748","display_name":"James Bruce Bussel","orcid":"https://orcid.org/0000-0002-2884-9247","observed_orcids":["https://orcid.org/0000-0002-2884-9247"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Bussel","raw_affiliation_strings":["Division of Pediatric Hematology/Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Pediatric Hematology/Oncology, Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037453366","display_name":"Attilio Orazi","orcid":"https://orcid.org/0000-0002-1660-7013","observed_orcids":["https://orcid.org/0000-0002-1660-7013"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Attilio Orazi","raw_affiliation_strings":["Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003759796"],"corresponding_institution_ids":["https://openalex.org/I4387153466"],"apc_list":{"value":5190,"currency":"USD","value_usd":5190},"apc_paid":null,"fwci":1.1315,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.75589843,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"185","issue":"1","first_page":"136","last_page":"139"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/essential-thrombocythemia","display_name":"essential thrombocythemia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/polycythemia-vera","display_name":"polycythemia vera","score":1.0},{"id":"https://openalex.org/keywords/jak2-v617f-mutation","display_name":"JAK2 V617F mutation","score":0.9089999794960022},{"id":"https://openalex.org/keywords/myeloproliferative-neoplasms","display_name":"myeloproliferative neoplasms","score":0.9909999966621399},{"id":"https://openalex.org/keywords/differential-diagnosis","display_name":"differential diagnosis","score":0.8140000104904175},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C2778740236","wikidata":"https://www.wikidata.org/wiki/Q933716","display_name":"Polycythaemia","level":2,"score":0.910682201385498},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6797372102737427},{"id":"https://openalex.org/C2779788118","wikidata":"https://www.wikidata.org/wiki/Q1542410","display_name":"Thrombocytosis","level":3,"score":0.6303867697715759},{"id":"https://openalex.org/C2780076729","wikidata":"https://www.wikidata.org/wiki/Q1752571","display_name":"Myelofibrosis","level":3,"score":0.5994356870651245},{"id":"https://openalex.org/C2778837598","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia vera","level":2,"score":0.5669977068901062},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5307811498641968},{"id":"https://openalex.org/C2910079294","wikidata":"https://www.wikidata.org/wiki/Q948318","display_name":"Polycythemia rubra vera","level":3,"score":0.514153778553009},{"id":"https://openalex.org/C2781057849","wikidata":"https://www.wikidata.org/wiki/Q1368780","display_name":"Essential thrombocythemia","level":3,"score":0.49187374114990234},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.469463974237442},{"id":"https://openalex.org/C2780829020","wikidata":"https://www.wikidata.org/wiki/Q408163","display_name":"Anagrelide","level":4,"score":0.45582708716392517},{"id":"https://openalex.org/C2778713057","wikidata":"https://www.wikidata.org/wiki/Q18029261","display_name":"Thrombopoietin receptor","level":5,"score":0.44515544176101685},{"id":"https://openalex.org/C2777863708","wikidata":"https://www.wikidata.org/wiki/Q424519","display_name":"Thrombopoietin","level":4,"score":0.3817159831523895},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3809071481227875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3730376958847046},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.31323468685150146},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.23117852210998535},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18745088577270508},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.18447265028953552},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12015402317047119}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002675","descriptor_name":"Child, Preschool","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003937","descriptor_name":"Diagnosis, Differential","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011087","descriptor_name":"Polycythemia Vera","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D011087","descriptor_name":"Polycythemia Vera","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D011087","descriptor_name":"Polycythemia Vera","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011087","descriptor_name":"Polycythemia Vera","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013920","descriptor_name":"Thrombocythemia, Essential","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D013920","descriptor_name":"Thrombocythemia, Essential","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D013920","descriptor_name":"Thrombocythemia, Essential","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013920","descriptor_name":"Thrombocythemia, Essential","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D017354","descriptor_name":"Point Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020125","descriptor_name":"Mutation, Missense","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/bjh.15386","doi":"https://doi.org/10.1111/bjh.15386","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.15386","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15386","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:29767848","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29767848","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of haematology","raw_type":"Letter"},{"id":"pmh:oai:europepmc.org:6055950","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6239998","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6239998","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6239998","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Br J Haematol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1111/bjh.15386","doi":"https://doi.org/10.1111/bjh.15386","is_oa":true,"landing_page_url":"https://doi.org/10.1111/bjh.15386","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/bjh.15386","source":{"id":"https://openalex.org/S153015021","display_name":"British Journal of Haematology","issn_l":"0007-1048","issn":["0007-1048","1365-2141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G607826091","display_name":"Clinical and Translational Science Center","funder_award_id":"KL2TR000458","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8825362598","display_name":"Pathogenesis and Symptomatology of Pediatric Myeloproliferative Neoplasms","funder_award_id":"K23HL127223","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000867119","display_name":"Clinical and Translational Science Center","funder_award_id":"UL1TR002384","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803186409.pdf","grobid_xml":"https://content.openalex.org/works/W2803186409.grobid-xml"},"referenced_works_count":6,"referenced_works":["https://openalex.org/W2057360098","https://openalex.org/W2090885521","https://openalex.org/W2144664431","https://openalex.org/W2169405856","https://openalex.org/W2333900045","https://openalex.org/W2339658711"],"related_works":["https://openalex.org/W7222821732","https://openalex.org/W2035920850","https://openalex.org/W3031471389","https://openalex.org/W1968748221","https://openalex.org/W2187607819","https://openalex.org/W2552347611","https://openalex.org/W2123811142","https://openalex.org/W1993230940","https://openalex.org/W2007353810","https://openalex.org/W2017957175"],"abstract_inverted_index":{"Classical":[0],"Myeloproliferative":[1],"Neoplasms":[2],"(MPNs)":[3],"include":[4,299],"Essential":[5],"Thrombocythaemia":[6],"(ET)":[7],"and":[8,71,89,116,211,232,243,248,252,272,294,350,516,652,687,774,798,844,879,883,907,925,955,973,1019],"Polycythaemia":[9],"Vera":[10],"(PV)":[11],"(Arber":[12,57],"et":[13,38,42,58,62,124,171,690,782,786],"al,":[14,39,43,59,63,125,691,783,787],"2016).":[15],"These":[16],"diseases":[17],"are":[18,100,117,180,561,626,887],"frequently":[19],"due":[20],"to":[21,75,104,202,206,298,312,395,576,592,640,673,724,755,779,889],"a":[22,95,192,317,398,476,616,635,772,820,914],"mutation":[23,479,641],"in":[24,152,160,168,183,216,379,425,446,470,480,519,563,610,648,669,719,727,752,757,759,765,796,802,819,846,849],"the":[25,29,128,153,290,306,354,369,481,502,577,599,712,762,790,824,838,895,917,927,935,950,953,960,964,971,1017],"pseudokinase":[26],"domain":[27],"of":[28,97,109,175,194,278,320,325,381,400,403,411,435,475,483,556,587,601,619,634,656,792,826,853,862,897,934,938,952,963,967,1029],"Janus":[30],"Kinase":[31],"2":[32],"(JAK2)":[33],"gene,":[34],"JAK2":[35,199,254,388,477,684,746],"V617F":[36,389,478],"(Baxter":[37],"2005;":[40,784],"Levine":[41],"2005).":[44,126],"The":[45,82,106,213,259,473,493,744,851,946,1024],"World":[46],"Health":[47,939],"Organization":[48],"(WHO)":[49],"recently":[50],"revised":[51],"its":[52,1022],"diagnostic":[53,204,559,855],"criteria":[54,84,99,154,495,560,614,856,869],"for":[55,111,132,240,357,372,496,628,870],"MPNs":[56,769],"2016;":[60],"Swerdlow":[61],"2017),":[64],"including":[65],"laboratory":[66,800],"values,":[67],"clonal":[68],"driver":[69],"mutations":[70],"bone":[72,163],"marrow":[73,164,441,660],"morphology":[74,454],"define":[76],"specific":[77,863],"MPN":[78,201,507,558,625,794,818,827,839,864],"types":[79],"(Table":[80,498],"1).":[81,464],"WHO":[83,129,494,546,578],"utilized":[85],"adult":[86,92,121],"reference":[87],"ranges":[88,108],"experience":[90],"with":[91,138,185,198,316,397,431,461,624,650,683,694,702,738,761,1021],"disease,":[93,410],"therefore":[94],"number":[96],"these":[98,188,541,891,898],"not":[101,283,504,544,572,646,957],"generally":[102,118],"applicable":[103],"children.":[105,472],"normal":[107,445,526,568],"haemoglobin":[110,130,139,230,366,535,588],"children":[112,137,169,184,196,215,383,405,429,434,521,529,542,570,623,649,810,871,878],"vary":[113],"by":[114,305,533,666,913,982,988,995,1002,1010],"age":[115,319],"lower":[119,718],"than":[120,458,700],"values":[122],"(Cembrowski":[123],"Applying":[127],"cut-offs":[131],"PV":[133,489,547,579,688,695,720,734,780],"would":[134,901],"miss":[135],"identifying":[136],"levels":[140,179,367,376],"clearly":[141],"above":[142,353,368],"their":[143,657],"age-specific":[144,525,593],"range.":[145],"Increased":[146],"red":[147,225],"cell":[148,222,227],"mass":[149],"is":[150,156,166,595,609,644,834,948],"included":[151],"but":[155,488,581],"virtually":[157],"never":[158],"tested":[159,647],"paediatrics.":[161],"Normal":[162],"cellularity":[165,442],"higher":[167,697],"(Hartsock":[170],"al,1965),":[172],"making":[173],"determination":[174],"\u201chypercellularity\u201d":[176],"difficult.":[177],"Erythropoietin":[178,643],"infrequently":[181],"performed":[182,987],"thrombocytosis.":[186,416,620],"Given":[187,566,604,789,894],"issues,":[189],"we":[190,631],"reviewed":[191,1016],"cohort":[193,218],"eight":[195,214,326],"diagnosed":[197],"V617F-postive":[200],"explore":[203],"considerations":[205],"help":[207],"differentiate":[208],"between":[209,551,877],"ET":[210,462,497,686,706,753,778],"PV.":[212,523,814],"this":[217,269,300,900,977],"had":[219,334,342,360,364,406,414,437,450,530,696],"white":[220],"blood":[221,226],"(WBC)":[223],"counts,":[224,229],"(RBC)":[228],"level":[231,536,715],"platelet":[233],"counts":[234,336,345,352,591,699,739],"assessed.":[235],"Bone":[236,440],"marrows":[237],"were":[238,257,274,327,377],"re-evaluated":[239],"cellularity,":[241],"fibrosis":[242],"megakaryocyte":[244],"morphology.":[245],"Pre-treatment":[246],"erythropoietin":[247,375,515,710,714],"von":[249,408],"Willebrand":[250,409],"levels,":[251,527,711],"peak":[253,335,343,365],"allele":[255,390,748],"burden":[256,391,749],"reviewed.":[258],"Weill":[260],"Cornell":[261],"Medical":[262],"College":[263],"Institutional":[264],"Review":[265],"Board":[266],"(IRB)":[267],"approved":[268],"study.":[270,908],"Consents":[271],"assents":[273],"obtained":[275,285],"from":[276,286,310,393,777,916,926],"7":[277],"8":[279],"families;":[280],"consent":[281],"could":[282],"be":[284,491,511,654,663,831],"one":[287],"family.":[288],"Since":[289],"data":[291],"was":[292,303,420,423,444,468,716,750,911],"pooled":[293],"fully":[295],"de-identified,":[296],"approval":[297],"8th":[301],"subject":[302,503],"given":[304],"IRB.":[307],"Ages":[308],"ranged":[309,392],"3":[311,385],"17":[313],"years":[314],"old,":[315],"median":[318,399,713,745],"10":[321],"years;":[322],"five":[323,380,528],"out":[324],"female.":[328],"Five":[329],"experienced":[330,668],"extreme":[331,415],"thrombocytosis;":[332],"three":[333,433,471],"over":[337,346,740],"2000":[338],"\u00d7":[339,348,742],"109/l.":[340,743],"Seven":[341],"WBC":[344,698],"11":[347],"109/l":[349],"RBC":[351,538,590],"97\u00b75th":[355,370],"percentile":[356,371],"age;":[358],"none":[359],"thalassemia":[361,602],"trait.":[362],"Three":[363,402],"age.":[373],"Serum":[374],"subnormal":[378,709],"six":[382,449],"(median":[384],"iu/l).":[386,731],"Peak":[387],"19%":[394],"54%,":[396],"39%.":[401],"four":[404],"acquired":[407],"which":[412,509],"two":[413,447,552],"No":[417],"severe":[418],"bleeding":[419],"reported.":[421],"Headache":[422],"observed":[424],"all":[426],"subjects.":[427],"Six":[428],"presented":[430],"splenomegaly,":[432],"whom":[436],"Budd-Chiari":[438],"syndrome.":[439],"pre-treatment":[443],"children;":[448],"hypercellular":[451],"marrows.":[452],"Megakaryocyte":[453],"revealed":[455],"more":[456,596,859],"pleiomorphism":[457],"typically":[459],"reported":[460],"(Fig":[463],"Reticulin":[465],"fibrosis,":[466],"MF-1,":[467],"noted":[469],"presence":[474],"setting":[482],"thrombocytosis":[484,608,651,737],"may":[485,571,582,811,829],"imply":[486],"ET,":[487],"cannot":[490],"excluded.":[492],"1)":[499],"requires":[500],"that":[501,725,808,836],"meet":[505,545],"other":[506],"criteria,":[508,548,580],"can":[510,775],"complicated.":[512],"Low":[513],"serum":[514],"pleiomorphic":[517],"megakaryocytes":[518],"some":[520,705,733,809],"favour":[522],"Using":[524],"polycythaemia,":[531],"defined":[532],"elevated":[534],"or":[537],"count.":[539],"However,":[540],"did":[543],"creating":[549],"uncertainty":[550],"diagnoses.":[553],"Proposed":[554],"modifications":[555],"paediatric":[557,671,821],"shown":[562],"Table":[564],"1.":[565],"different":[567],"ranges,":[569],"demonstrate":[573],"polycythaemia":[574],"according":[575],"still":[583],"have":[584,813],"PV;":[585],"comparison":[586],"and/or":[589],"norms":[594],"appropriate":[597],"(in":[598],"absence":[600,633],"trait).":[603],"how":[605],"common":[606],"reactive":[607,636],"children,":[611,847],"our":[612,728,766,803,866],"proposed":[613,867,892],"suggest":[615],"minimum":[617],"duration":[618],"As":[621],"many":[622],"negative":[627],"known":[629],"mutations,":[630],"gave":[632],"cause":[637],"equal":[638],"weight":[639],"status.":[642],"often":[645],"should":[653,662,857],"part":[655],"work-up.":[658],"Furthermore,":[659],"pathology":[661],"carefully":[664],"assessed":[665],"haematopathologists":[667],"reviewing":[670],"specimens":[672],"optimally":[674],"distinguish":[675],"among":[676],"MPNs.":[677],"A":[678],"recent":[679],"study":[680,978],"compared":[681,754],"adults":[682,797],"V617F-mutant":[685],"(Rumi":[689],"2014).":[692,788],"Patients":[693],"those":[701],"ET.":[703],"While":[704],"patients":[707,735],"showed":[708],"significantly":[717],"(2\u00b77":[721],"iu/l),":[722],"close":[723],"found":[726],"group":[729],"(3":[730],"Similarly,":[732],"exhibited":[736],"1000":[741],"mutant":[747],"18%":[751],"42%":[756],"PV,":[758],"line":[760],"39%":[763],"seen":[764],"cohort.":[767],"JAK2-mutated":[768,793],"exist":[770],"on":[771],"continuum":[773],"progress":[776],"(Campbell":[781],"Rumi":[785],"spectrum":[791],"described":[795],"varying":[799],"findings":[801],"cohort,":[804],"it":[805],"seems":[806],"likely":[807,835],"actually":[812],"When":[815],"diagnosing":[816],"an":[817],"patient,":[822],"assigning":[823],"diagnosis":[825],"unclassified":[828],"currently":[830],"best.":[832],"It":[833],"knowing":[837],"type":[840],"will":[841],"affect":[842],"management":[843],"prognosis":[845],"as":[848],"adults.":[850,880],"development":[852],"paediatric-specific":[854],"allow":[858],"accurate":[860],"identification":[861],"type;":[865],"alternative":[868],"take":[872],"into":[873],"account":[874],"key":[875],"differences":[876],"Long-term":[881],"follow-up":[882],"large":[884],"patient":[885],"numbers":[886],"required":[888],"validate":[890],"criteria.":[893],"rarity":[896],"diseases,":[899],"require":[902],"international,":[903],"multi-centre,":[904],"collaborative":[905],"discussion":[906],"This":[909],"work":[910],"supported":[912],"grant":[915],"NIH/NCATS":[918],"(USA),":[919,940],"Grant":[920],"#":[921],"KL2TR000458":[922],"(to":[923,944],"NK)":[924],"National":[928,936,965],"Heart,":[929],"Lung,":[930],"And":[931],"Blood":[932],"Institute":[933],"Institutes":[937,966],"under":[941],"award":[942],"#K23HL127223":[943],"NK).":[945],"content":[947],"solely":[949],"responsibility":[951],"authors":[954,1015,1025],"does":[956],"necessarily":[958],"represent":[959],"official":[961],"views":[962],"Health.":[968],"We":[969],"thank":[970],"families":[972],"colleagues":[974],"who":[975],"made":[976],"possible.":[979],"Study":[980],"designed":[981],"NK,":[983,989,996,1003,1011],"JB,":[984,1006,1012],"AO.":[985,992,999,1007,1013],"Research":[986],"MA,":[990,997,1004],"DH,":[991,998,1005],"Data":[993],"analysed":[994],"Paper":[1000,1008],"written":[1001],"edited":[1009],"All":[1014],"manuscript":[1018],"agreed":[1020],"submission.":[1023],"declare":[1026],"no":[1027],"conflicts":[1028],"interest.":[1030]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2018-06-01T00:00:00"}
