{"id":"https://openalex.org/W2803104635","doi":null,"title":"Anti-inflammatory Activity of Rubus suavissimus S. Lee leaf extract in a C57BL/6J Mouse Model with LPS-induced Low-grade Chronic Inflammation","display_name":"Anti-inflammatory Activity of Rubus suavissimus S. Lee leaf extract in a C57BL/6J Mouse Model with LPS-induced Low-grade Chronic Inflammation","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2803104635","mag":"2803104635"},"language":"en","primary_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/13054","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/13054","pdf_url":"http://hdl.handle.net/10214/13054","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10214/13054","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Ruili Qi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ruili Qi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.46459999680519104,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.46459999680519104,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.20589999854564667,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.1137000024318695,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rubus-suavissimus","display_name":"Rubus suavissimus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/leaf-extract","display_name":"leaf extract","score":0.8949999809265137},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/chronic-low-grade-inflammation","display_name":"low-grade inflammation","score":0.9739999771118164},{"id":"https://openalex.org/keywords/lps-induced-inflammation","display_name":"lipopolysaccharide-induced inflammation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/intestinal-permeability","display_name":"intestinal permeability","score":0.9819999933242798},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.9810000061988831},{"id":"https://openalex.org/keywords/macrophage-infiltration","display_name":"macrophage infiltration","score":0.8870000243186951},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8560000061988831},{"id":"https://openalex.org/keywords/adiponectin","display_name":"adiponectin","score":0.9269999861717224},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9490000009536743},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9869999885559082},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.9929999709129333},{"id":"https://openalex.org/keywords/irs-1","display_name":"IRS-1","score":0.8579999804496765},{"id":"https://openalex.org/keywords/metabolic-disorders","display_name":"metabolic disorders","score":0.7749999761581421},{"id":"https://openalex.org/keywords/c57bl-6j-mice","display_name":"C57BL/6J mice","score":0.8479999899864197}],"concepts":[{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6915880441665649},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4170880615711212},{"id":"https://openalex.org/C2777220221","wikidata":"https://www.wikidata.org/wiki/Q602740","display_name":"Rubus","level":2,"score":0.41579994559288025},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3933979868888855},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36869513988494873},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3605475425720215},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.21101579070091248}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/13054","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/13054","pdf_url":"http://hdl.handle.net/10214/13054","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2803104635","doi":null,"is_oa":false,"landing_page_url":"https://atrium.lib.uoguelph.ca/xmlui/handle/10214/13054","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:atrium.lib.uoguelph.ca:10214/13054","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10214/13054","pdf_url":"http://hdl.handle.net/10214/13054","source":{"id":"https://openalex.org/S4306401043","display_name":"The Atrium (University of Guelph)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79817857","host_organization_name":"University of Guelph","host_organization_lineage":["https://openalex.org/I79817857"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803104635.pdf","grobid_xml":"https://content.openalex.org/works/W2803104635.grobid-xml"},"referenced_works_count":112,"referenced_works":["https://openalex.org/W132029867","https://openalex.org/W1562891630","https://openalex.org/W1592353726","https://openalex.org/W1602718319","https://openalex.org/W1877854700","https://openalex.org/W1882326031","https://openalex.org/W1900164800","https://openalex.org/W1926205250","https://openalex.org/W1938907407","https://openalex.org/W1950704496","https://openalex.org/W1970212606","https://openalex.org/W1970501127","https://openalex.org/W1975024842","https://openalex.org/W1978804425","https://openalex.org/W1980080938","https://openalex.org/W1982279452","https://openalex.org/W1985931135","https://openalex.org/W1990261712","https://openalex.org/W1990857181","https://openalex.org/W1991047945","https://openalex.org/W1992118751","https://openalex.org/W1997432357","https://openalex.org/W1997773716","https://openalex.org/W1998598599","https://openalex.org/W1999863129","https://openalex.org/W2000054651","https://openalex.org/W2002201827","https://openalex.org/W2004919453","https://openalex.org/W2008869160","https://openalex.org/W2009339344","https://openalex.org/W2011210301","https://openalex.org/W2014368597","https://openalex.org/W2023007981","https://openalex.org/W2025154140","https://openalex.org/W2030526970","https://openalex.org/W2031070839","https://openalex.org/W2033489858","https://openalex.org/W2033761996","https://openalex.org/W2033829415","https://openalex.org/W2033874003","https://openalex.org/W2035841380","https://openalex.org/W2040645020","https://openalex.org/W2045441924","https://openalex.org/W2046833545","https://openalex.org/W2051504220","https://openalex.org/W2053456880","https://openalex.org/W2054766392","https://openalex.org/W2062835892","https://openalex.org/W2065280032","https://openalex.org/W2065366241","https://openalex.org/W2067756762","https://openalex.org/W2068494384","https://openalex.org/W2074802791","https://openalex.org/W2085441859","https://openalex.org/W2090209018","https://openalex.org/W2091379601","https://openalex.org/W2093332239","https://openalex.org/W2093705034","https://openalex.org/W2094354621","https://openalex.org/W2094614991","https://openalex.org/W2094941678","https://openalex.org/W2095096262","https://openalex.org/W2099456560","https://openalex.org/W2099484297","https://openalex.org/W2100573896","https://openalex.org/W2102683312","https://openalex.org/W2107277218","https://openalex.org/W2107414352","https://openalex.org/W2110235509","https://openalex.org/W2113788396","https://openalex.org/W2114816137","https://openalex.org/W2114892234","https://openalex.org/W2115734998","https://openalex.org/W2117727476","https://openalex.org/W2118742454","https://openalex.org/W2119812663","https://openalex.org/W2120532705","https://openalex.org/W2123398242","https://openalex.org/W2128009708","https://openalex.org/W2132268950","https://openalex.org/W2135447862","https://openalex.org/W2137256845","https://openalex.org/W2138611522","https://openalex.org/W2138651252","https://openalex.org/W2140380746","https://openalex.org/W2141710693","https://openalex.org/W2143516276","https://openalex.org/W2143708601","https://openalex.org/W2145819863","https://openalex.org/W2150267721","https://openalex.org/W2154105741","https://openalex.org/W2155379427","https://openalex.org/W2156868373","https://openalex.org/W2160675185","https://openalex.org/W2160770872","https://openalex.org/W2163625494","https://openalex.org/W2165356529","https://openalex.org/W2166370133","https://openalex.org/W2167485774","https://openalex.org/W2167495688","https://openalex.org/W2167874330","https://openalex.org/W2168532942","https://openalex.org/W2169817304","https://openalex.org/W2191750629","https://openalex.org/W2215629512","https://openalex.org/W2402125950","https://openalex.org/W2441236547","https://openalex.org/W2466503468","https://openalex.org/W2466845724","https://openalex.org/W2576734117","https://openalex.org/W2590252500","https://openalex.org/W2593219128"],"related_works":["https://openalex.org/W2998081633","https://openalex.org/W2377813691","https://openalex.org/W7017441002","https://openalex.org/W2299584888","https://openalex.org/W4403297766","https://openalex.org/W2982573795","https://openalex.org/W3194309485","https://openalex.org/W2324243517","https://openalex.org/W2981546872","https://openalex.org/W2735793775"],"abstract_inverted_index":{"This":[0,121],"study":[1,122],"aimed":[2],"to":[3,31],"identify":[4],"the":[5,45,61,72,95,107,116],"anti-inflammatory":[6,75,133],"activity":[7],"and":[8,36,68,70,105,114,134,143],"mechanism":[9],"of":[10,48,53,63,74,82,98,119,147],"Rubus":[11,54,84,126],"suavissimus":[12,55,85,127],"S.":[13,56,86,128],"Lee":[14,57,87,129],"leaf":[15,58,88,130],"extract":[16,59,89,131],"in":[17,137],"a":[18,38],"mouse":[19],"model":[20],"with":[21],"LPS-induced":[22],"systemic":[23,39,139],"low-grade":[24,40,140],"chronic":[25,41,141],"inflammation.":[26],"The":[27],"persistent":[28],"LPS":[29],"administration":[30],"mice":[32],"increased":[33],"intestinal":[34,91],"permeability":[35,92],"induced":[37],"inflammation,":[42],"which":[43],"increases":[44],"potential":[46],"risk":[47],"developing":[49],"metabolic":[50,148],"disorders.":[51,149],"Supplementation":[52],"suppressed":[60],"secretion":[62,73],"pro-inflammatory":[64],"mediators,":[65],"TNF-\u03b1,":[66],"IL-6,":[67],"MCP-1,":[69],"promoted":[71],"mediator,":[76],"adiponectin":[77],"by":[78,93,110],"increasing":[79,115],"protein":[80,117],"expression":[81,97,118],"PPAR-\u03b3.":[83],"decreased":[90],"modulating":[94],"gene":[96],"tight":[99],"junction":[100],"proteins,":[101],"prevented":[102,106],"macrophage":[103],"infiltration,":[104],"insulin":[108,112],"resistance":[109],"restoring":[111],"sensitivity":[113],"IRS-1.":[120],"has":[123],"demonstrated":[124],"that":[125],"possessed":[132],"protective":[135],"effects":[136],"preventing":[138],"inflammation":[142],"inflammation-induced":[144],"early":[145],"stage":[146]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2018-06-01T00:00:00"}