{"id":"https://openalex.org/W2803102053","doi":"https://doi.org/10.1158/1538-7445.mousemodels17-a33","title":"Abstract A33: Loss of Id4 initiates PIN-like lesions by maintaining stemness in mice prostate","display_name":"Abstract A33: Loss of Id4 initiates PIN-like lesions by maintaining stemness in mice prostate","publication_year":2018,"publication_date":"2018-05-14","ids":{"openalex":"https://openalex.org/W2803102053","doi":"https://doi.org/10.1158/1538-7445.mousemodels17-a33","mag":"2803102053"},"language":"en","primary_location":{"id":"doi:10.1158/1538-7445.mousemodels17-a33","doi":"https://doi.org/10.1158/1538-7445.mousemodels17-a33","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.mousemodels17-a33","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089960676","display_name":"Dhanushka Hewa Bostanthirige","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dhanushka Hewa Bostanthirige","raw_affiliation_strings":["Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058716819","display_name":"Jugal Joshi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jugal Joshi","raw_affiliation_strings":["Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111284610","display_name":"Shravan Kumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shravan Kumar","raw_affiliation_strings":["Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101623033","display_name":"Divya J. Patel","orcid":"https://orcid.org/0009-0003-3425-2978","observed_orcids":["https://orcid.org/0009-0003-3425-2978"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Divya Patel","raw_affiliation_strings":["Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072992833","display_name":"Jaideep Chaudhary","orcid":"https://orcid.org/0000-0002-8793-4329","observed_orcids":["https://orcid.org/0000-0002-8793-4329"]},"institutions":[{"id":"https://openalex.org/I52064589","display_name":"Clark Atlanta University","ror":"https://ror.org/0397tsa92","country_code":"US","type":"education","lineage":["https://openalex.org/I52064589"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jaideep Chaudhary","raw_affiliation_strings":["Clark Atlanta University, Atlanta, GA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clark Atlanta University, Atlanta, GA","institution_ids":["https://openalex.org/I52064589"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52064589"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"78","issue":"10_Supplement","first_page":"A33","last_page":"A33"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/id4","display_name":"Id4","score":0.972000002861023},{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.7519999742507935},{"id":"https://openalex.org/keywords/prostatic-intraepithelial-neoplasia","display_name":"prostatic intraepithelial neoplasia","score":0.9520000219345093},{"id":"https://openalex.org/keywords/tumor-initiation","display_name":"tumor initiation","score":0.45399999618530273},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.6890000104904175},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.6150000095367432},{"id":"https://openalex.org/keywords/sca-1","display_name":"Sca-1","score":0.796999990940094},{"id":"https://openalex.org/keywords/nkx3-1","display_name":"NKX3.1","score":0.8360000252723694},{"id":"https://openalex.org/keywords/androgen-receptor","display_name":"androgen receptor","score":0.734000027179718},{"id":"https://openalex.org/keywords/helix-loop-helix-transcription-factors","display_name":"helix-loop-helix transcription factors","score":0.7699999809265137},{"id":"https://openalex.org/keywords/prostate-development","display_name":"prostate development","score":0.4620000123977661},{"id":"https://openalex.org/keywords/castration-resistant-prostate-cancer","display_name":"castration-resistant prostate cancer","score":0.7710000276565552},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.5189999938011169}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8890599012374878},{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.8593069314956665},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7757533192634583},{"id":"https://openalex.org/C2779723316","wikidata":"https://www.wikidata.org/wiki/Q6459234","display_name":"LNCaP","level":4,"score":0.6482663154602051},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6012538075447083},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5253899693489075},{"id":"https://openalex.org/C2780940892","wikidata":"https://www.wikidata.org/wiki/Q1965933","display_name":"Tramp","level":4,"score":0.5139407515525818},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4652263820171356},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.42452266812324524},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3722281754016876},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33719396591186523},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3220260739326477},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2660204768180847},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.18842047452926636},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.15692338347434998},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.1363813281059265},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.1196749210357666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09038171172142029},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/1538-7445.mousemodels17-a33","doi":"https://doi.org/10.1158/1538-7445.mousemodels17-a33","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1538-7445.mousemodels17-a33","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3155929859","https://openalex.org/W2953849367","https://openalex.org/W2118321738","https://openalex.org/W2126996873","https://openalex.org/W34574416","https://openalex.org/W1967537767","https://openalex.org/W2164508669","https://openalex.org/W2003541059","https://openalex.org/W2071641998","https://openalex.org/W1979470954"],"abstract_inverted_index":{"Abstract":[0],"Inhibitor":[1],"of":[2,8,12,78,102,110,114,133,141,161,176,197,218,234,260,264,290,341,360,395,409],"differentiation":[3],"4":[4],"(Id4),":[5],"a":[6,18,105,145,212,251,258],"member":[7,259],"the":[9,35,76,91,195,198,216,219,226,231,261,291,310,317,358,410],"helix-loop-helix":[10],"family":[11,263],"transcriptional":[13,204],"regulators,":[14],"has":[15,54,178],"emerged":[16],"as":[17,272],"tumor":[19,165],"suppressor":[20,166],"in":[21,34,40,50,64,67,108,152,168,192,214,230,242,247,253,276,287,328,403,415,418],"prostate":[22,37,41,61,74,111,118,134,157,170,292,323,334,405],"cancer":[23,42,62,281],"(PCa).":[24],"Recent":[25],"studies":[26],"have":[27],"shown":[28,56],"that":[29,88,100,174,209,239,245,339,372],"Id4":[30,48,92,103,115,177,210,342,396],"is":[31,144,257,326],"highly":[32],"expressed":[33,327],"normal":[36],"and":[38,66,126,149,155,163,300,332,364,422],"decreases":[39],"(PCa)":[43],"due":[44,249],"to":[45,57,59,72,180,184,250,280,296,316],"epigenetic":[46],"silencing.":[47],"knockdown":[49],"androgen-sensitive":[51],"LNCaP":[52],"cells":[53,286,299],"been":[55],"lead":[58],"castration-resistant":[60],"(CRPC)":[63],"vitro":[65],"vivo.":[68],"Id4-/-":[69,153,193,329],"mice":[70,95,117,330,404],"leads":[71],"underdeveloped":[73],"without":[75,129],"loss":[77,101,175,340],"androgen":[79],"receptor":[80],"(AR)":[81],"expression.":[82],"In":[83],"this":[84],"study":[85],"we":[86,369],"demonstrate":[87],"prostates":[89],"from":[90],"knockout":[93],"(Id4-/-)":[94],"show":[96],"PIN-like":[97,398],"lesions,":[98],"suggesting":[99,173],"plays":[104,211],"major":[106],"role":[107,213],"initiation":[109],"PCa.":[112,185],"Histology":[113],"-/-":[116],"shows":[119],"more":[120],"PIN":[121,148,243,345],"lesions":[122,244,347,399],"at":[123],"3":[124],"months":[125,128],"6":[127],"showing":[130],"clear":[131],"evidence":[132],"cancer.":[135,324],"Immunohistochemical":[136],"analysis":[137],"demonstrated":[138],"increased":[139],"expression":[140,160,359],"Amacr,":[142],"which":[143,320],"biomarker":[146],"for":[147],"PCa,":[150],"only":[151],"3-month-":[154,331],"6-month-old":[156,333],"tissue.":[158],"The":[159,236],"Nkx3.1":[162],"Pten":[164,254],"genes":[167],"Id4-/-mouse":[169],"was":[171,189],"undetectable,":[172],"potential":[179],"initiate":[181,344],"or":[182],"progress":[183],"Although":[186],"PTEN":[187,200,220],"protein":[188],"not":[190],"present":[191],"mice,":[194],"presence":[196],"corresponding":[199],"mRNA":[201,378],"suggested":[202,208,238],"intact":[203],"program.":[205],"These":[206,336],"results":[207,237,241],"regulating":[215,352],"translation":[217],"mRNA.":[221],"We":[222],"are":[223,246,370],"currently":[224],"investigating":[225,371],"ID4-regulated":[227],"mechanisms":[228],"involved":[229],"translational":[232,354],"control":[233],"PTEN.":[235],"id4-/-":[240],"part":[248],"block":[252],"translation.":[255],"Sca-1":[256,325],"Ly6":[262],"glycosyl":[265],"phostidylinositol":[266],"(GPI)-anchored":[267],"cell":[268,274,283],"surface":[269],"proteins":[270],"used":[271],"stem":[273,282,285],"marker":[275],"murine":[277],"prostate.":[278],"According":[279],"theory,":[284],"basal":[288],"layer":[289],"tubules":[293],"give":[294],"rise":[295,315],"transient":[297],"amplifying":[298],"differentiate":[301],"into":[302],"terminally":[303],"differentiated":[304],"secretory":[305],"luminal":[306],"epithelial":[307],"cells.":[308],"From":[309],"same":[311],"pathway":[312],"it":[313],"gives":[314],"tumor-promoting":[318],"cells,":[319],"ultimately":[321],"form":[322],"glands.":[335],"data":[337],"suggest":[338],"can":[343],"like":[346],"by":[348,400],"maintaining":[349,401],"stemness":[350,402],"through":[351],"transcriptional,":[353],"mechanism":[355],"via":[356],"altering":[357],"PTEN,":[361],"NKX3.1,":[362],"C-MYC":[363],"other":[365],"regulatory":[366,373],"molecules.":[367],"Currently":[368],"mechanism,":[374],"mainly":[375],"focusing":[376],"on":[377],"interference":[379],"mechanisms.":[380],"Citation":[381],"Format:":[382],"Dhanushka":[383],"Hewa":[384],"Bostanthirige,":[385],"Jugal":[386],"Joshi,":[387],"Shravan":[388],"Kumar,":[389],"Divya":[390],"Patel,":[391],"Jaideep":[392],"Chaudhary.":[393],"Loss":[394],"initiates":[397],"[abstract].":[406],"In:":[407],"Proceedings":[408],"AACR":[411],"Special":[412],"Conference:":[413],"Advances":[414],"Modeling":[416],"Cancer":[417,432],"Mice:":[419],"Technology,":[420],"Biology,":[421],"Beyond;":[423],"2017":[424],"Sep":[425],"24-27;":[426],"Orlando,":[427],"Florida.":[428],"Philadelphia":[429],"(PA):":[430],"AACR;":[431],"Res":[433],"2018;78(10":[434],"Suppl):Abstract":[435],"nr":[436],"A33.":[437]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-06-01T00:00:00"}
