{"id":"https://openalex.org/W2803099003","doi":"https://doi.org/10.1530/eje-18-0306","title":"THERAPY OF ENDOCRINE DISEASE: Growth hormone replacement therapy in adults: 30 years of personal clinical experience","display_name":"THERAPY OF ENDOCRINE DISEASE: Growth hormone replacement therapy in adults: 30 years of personal clinical experience","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2803099003","doi":"https://doi.org/10.1530/eje-18-0306","mag":"2803099003","pmid":"https://pubmed.ncbi.nlm.nih.gov/29716978"},"language":"en","primary_location":{"id":"doi:10.1530/eje-18-0306","doi":"https://doi.org/10.1530/eje-18-0306","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje-18-0306","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pure.au.dk/portal/en/publications/738d618e-7595-4a7c-b4ab-bc55fc8b0653","any_repository_has_fulltext":null},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090850055","display_name":"Jens Otto Lunde J\u00f8rgensen","orcid":"https://orcid.org/0000-0001-7408-1526","observed_orcids":["https://orcid.org/0000-0001-7408-1526"]},"institutions":[{"id":"https://openalex.org/I2802335433","display_name":"Aarhus University Hospital","ror":"https://ror.org/040r8fr65","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802335433"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Jens O L J\u00f8rgensen","raw_affiliation_strings":["1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, Denmark","institution_ids":["https://openalex.org/I2802335433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045917807","display_name":"Anders Juul","orcid":"https://orcid.org/0000-0002-0534-4350","observed_orcids":["https://orcid.org/0000-0002-0534-4350"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders Juul","raw_affiliation_strings":["2Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Department of Growth and Reproduction, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5090850055"],"corresponding_institution_ids":["https://openalex.org/I2802335433"],"apc_list":{"value":3798,"currency":"EUR","value_usd":4292},"apc_paid":null,"fwci":0.958,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.70675611,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"179","issue":"1","first_page":"R47","last_page":"R56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11146","display_name":"Hormonal and reproductive studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10832","display_name":"Pituitary Gland Disorders and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/growth-hormone-replacement-therapy","display_name":"growth hormone replacement therapy","score":0.9900000095367432},{"id":"https://openalex.org/keywords/adult-growth-hormone-deficiency","display_name":"adult growth hormone deficiency","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hypopituitarism","display_name":"hypopituitarism","score":0.9340000152587891},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.5540000200271606},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.7509999871253967},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8769999742507935},{"id":"https://openalex.org/keywords/fluid-retention","display_name":"fluid retention","score":0.9829999804496765},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.414000004529953},{"id":"https://openalex.org/keywords/childhood-onset-growth-hormone-deficiency","display_name":"childhood-onset growth hormone deficiency","score":0.7639999985694885},{"id":"https://openalex.org/keywords/frail-elderly","display_name":"frail elderly","score":0.6190000176429749}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8446141481399536},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6728714108467102},{"id":"https://openalex.org/C2780159708","wikidata":"https://www.wikidata.org/wiki/Q17003363","display_name":"Hormone replacement therapy (female-to-male)","level":3,"score":0.5661585927009583},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5640712976455688},{"id":"https://openalex.org/C2777083390","wikidata":"https://www.wikidata.org/wiki/Q1367706","display_name":"Osteopenia","level":4,"score":0.5237048864364624},{"id":"https://openalex.org/C2776869705","wikidata":"https://www.wikidata.org/wiki/Q2661443","display_name":"Endocrine disease","level":4,"score":0.4939907193183899},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.49180272221565247},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4584157168865204},{"id":"https://openalex.org/C2779952775","wikidata":"https://www.wikidata.org/wiki/Q369262","display_name":"Growth hormone deficiency","level":4,"score":0.45271575450897217},{"id":"https://openalex.org/C120863210","wikidata":"https://www.wikidata.org/wiki/Q17064264","display_name":"Lean body mass","level":3,"score":0.4474659562110901},{"id":"https://openalex.org/C2778491484","wikidata":"https://www.wikidata.org/wiki/Q922411","display_name":"Hypopituitarism","level":2,"score":0.4176933467388153},{"id":"https://openalex.org/C46699223","wikidata":"https://www.wikidata.org/wiki/Q11078","display_name":"Endocrine system","level":3,"score":0.41178661584854126},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.3182511031627655},{"id":"https://openalex.org/C2984496839","wikidata":"https://www.wikidata.org/wiki/Q29956617","display_name":"Growth hormone","level":3,"score":0.2970338463783264},{"id":"https://openalex.org/C2779279991","wikidata":"https://www.wikidata.org/wiki/Q6058681","display_name":"Testosterone (patch)","level":2,"score":0.24184754490852356},{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.2246374487876892},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.11388158798217773},{"id":"https://openalex.org/C2776886416","wikidata":"https://www.wikidata.org/wiki/Q4941567","display_name":"Bone mineral","level":3,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001823","descriptor_name":"Body Composition","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001851","descriptor_name":"Bone Diseases, Metabolic","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D007018","descriptor_name":"Hypopituitarism","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D014883","descriptor_name":"Water-Electrolyte Imbalance","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017079","descriptor_name":"Exercise Tolerance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D019382","descriptor_name":"Human Growth Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020249","descriptor_name":"Hormone Replacement Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056128","descriptor_name":"Obesity, Abdominal","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1530/eje-18-0306","doi":"https://doi.org/10.1530/eje-18-0306","is_oa":false,"landing_page_url":"https://doi.org/10.1530/eje-18-0306","pdf_url":null,"source":{"id":"https://openalex.org/S4210218062","display_name":"European Journal of Endocrinology","issn_l":"0804-4643","issn":["0804-4643","1479-683X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Endocrinology","raw_type":"journal-article"},{"id":"pmid:29716978","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29716978","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of endocrinology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/738d618e-7595-4a7c-b4ab-bc55fc8b0653","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/738d618e-7595-4a7c-b4ab-bc55fc8b0653","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J\u00f8rgensen, J O L & Juul, A 2018, 'THERAPY OF ENDOCRINE DISEASE: Growth hormone replacement therapy in adults: 30 years of personal clinical experience', European Journal of Endocrinology, vol. 179, no. 1, pp. R47-R56. https://doi.org/10.1530/EJE-18-0306","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/3162cb5d-244f-4571-887a-965a0a157bcb","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/3162cb5d-244f-4571-887a-965a0a157bcb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J\u00f8rgensen, J O L & Juul, A 2018, 'THERAPY OF ENDOCRINE DISEASE : Growth hormone replacement therapy in adults: 30 years of personal clinical experience', European Journal of Endocrinology, vol. 179, no. 1, pp. R47-R56. https://doi.org/10.1530/EJE-18-0306","raw_type":"info:eu-repo/semantics/review"}],"best_oa_location":{"id":"pmh:oai:pure.atira.dk:openaire/738d618e-7595-4a7c-b4ab-bc55fc8b0653","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/738d618e-7595-4a7c-b4ab-bc55fc8b0653","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J\u00f8rgensen, J O L & Juul, A 2018, 'THERAPY OF ENDOCRINE DISEASE: Growth hormone replacement therapy in adults: 30 years of personal clinical experience', European Journal of Endocrinology, vol. 179, no. 1, pp. R47-R56. https://doi.org/10.1530/EJE-18-0306","raw_type":"info:eu-repo/semantics/review"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W168334045","https://openalex.org/W1908144174","https://openalex.org/W1966537913","https://openalex.org/W1973560472","https://openalex.org/W1974427816","https://openalex.org/W1975979596","https://openalex.org/W1976811955","https://openalex.org/W1977389255","https://openalex.org/W1982675679","https://openalex.org/W1982685226","https://openalex.org/W1988436609","https://openalex.org/W1993933064","https://openalex.org/W1996400421","https://openalex.org/W1999759703","https://openalex.org/W2000607618","https://openalex.org/W2005127269","https://openalex.org/W2006074731","https://openalex.org/W2007272731","https://openalex.org/W2007440709","https://openalex.org/W2009977583","https://openalex.org/W2011526922","https://openalex.org/W2011872150","https://openalex.org/W2012431090","https://openalex.org/W2018332357","https://openalex.org/W2020108509","https://openalex.org/W2022544202","https://openalex.org/W2023173110","https://openalex.org/W2025999464","https://openalex.org/W2026162786","https://openalex.org/W2026229202","https://openalex.org/W2033003653","https://openalex.org/W2034104919","https://openalex.org/W2036286877","https://openalex.org/W2038537588","https://openalex.org/W2040318502","https://openalex.org/W2044351326","https://openalex.org/W2045367910","https://openalex.org/W2052576311","https://openalex.org/W2052654884","https://openalex.org/W2052875048","https://openalex.org/W2053429711","https://openalex.org/W2054229227","https://openalex.org/W2055648105","https://openalex.org/W2056415845","https://openalex.org/W2057186901","https://openalex.org/W2057696296","https://openalex.org/W2058504424","https://openalex.org/W2059476791","https://openalex.org/W2061710273","https://openalex.org/W2063972644","https://openalex.org/W2070283543","https://openalex.org/W2071570471","https://openalex.org/W2071876386","https://openalex.org/W2072866212","https://openalex.org/W2074323061","https://openalex.org/W2082210087","https://openalex.org/W2089262859","https://openalex.org/W2092179662","https://openalex.org/W2093168997","https://openalex.org/W2096935190","https://openalex.org/W2097003895","https://openalex.org/W2097556482","https://openalex.org/W2100488282","https://openalex.org/W2105036599","https://openalex.org/W2111528719","https://openalex.org/W2114943750","https://openalex.org/W2120108803","https://openalex.org/W2126784809","https://openalex.org/W2128944618","https://openalex.org/W2132001222","https://openalex.org/W2132316794","https://openalex.org/W2136435543","https://openalex.org/W2140469927","https://openalex.org/W2140937357","https://openalex.org/W2143752759","https://openalex.org/W2146352480","https://openalex.org/W2149440651","https://openalex.org/W2153909093","https://openalex.org/W2156315381","https://openalex.org/W2158139052","https://openalex.org/W2158192084","https://openalex.org/W2158239446","https://openalex.org/W2161622680","https://openalex.org/W2162653055","https://openalex.org/W2167436746","https://openalex.org/W2170536472","https://openalex.org/W2171188259","https://openalex.org/W2172067681","https://openalex.org/W2181043099","https://openalex.org/W2296419927","https://openalex.org/W2309974931","https://openalex.org/W2331609610","https://openalex.org/W2341412594","https://openalex.org/W2396980688","https://openalex.org/W2439101359","https://openalex.org/W2536625775","https://openalex.org/W2606513528","https://openalex.org/W2772334255","https://openalex.org/W2789906464","https://openalex.org/W2791721504","https://openalex.org/W4236757670","https://openalex.org/W4238320690","https://openalex.org/W4251027187"],"related_works":["https://openalex.org/W2996744401","https://openalex.org/W2323034286","https://openalex.org/W4210711263","https://openalex.org/W2163029986","https://openalex.org/W1989926192","https://openalex.org/W2787612994","https://openalex.org/W1964620287","https://openalex.org/W2223436288","https://openalex.org/W1985023326","https://openalex.org/W2144248422"],"abstract_inverted_index":{"The":[0,97,113],"acute":[1],"metabolic":[2],"actions":[3],"of":[4,37,72,77,91,126,145],"purified":[5],"human":[6,39],"growth":[7],"hormone":[8],"(GH)":[9],"were":[10],"first":[11],"documented":[12,150],"in":[13,27,32,123,131,160,182],"adult":[14],"hypopituitary":[15],"patients":[16,132,162],"more":[17],"than":[18],"50":[19],"years":[20],"ago,":[21],"and":[22,48,53,69,81,104,110,120,187],"placebo-controlled":[23],"long-term":[24],"GH":[25,84,127,143,180],"trials":[26],"GH-deficient":[28],"adults":[29],"(GHDA)":[30],"surfaced":[31],"1989":[33],"with":[34,45,83,118,133],"the":[35,54,139],"availability":[36],"biosynthetic":[38],"GH.":[40],"Untreated":[41],"GHDA":[42,183],"is":[43,121,136,141,163],"associated":[44],"excess":[46],"morbidity":[47],"mortality":[49,159,173],"from":[50],"cardiovascular":[51,74],"disease":[52,135,152],"phenotype":[55],"includes":[56],"fatigue,":[57],"reduced":[58,64,164,172],"aerobic":[59],"exercise":[60],"capacity,":[61],"abdominal":[62],"obesity,":[63],"lean":[65],"body":[66],"mass,":[67],"osteopenia":[68],"elevated":[70],"levels":[71],"circulating":[73],"biomarkers.":[75],"Several":[76],"these":[78],"features":[79],"reverse":[80],"normalize":[82],"replacement.":[85],"It":[86],"remains":[87,153],"controversial":[88],"whether":[89],"quality":[90],"life,":[92],"assessed":[93],"by":[94],"questionnaires,":[95],"improves.":[96],"known":[98],"side":[99],"effects":[100],"are":[101,108],"fluid":[102],"retention":[103],"insulin":[105],"resistance,":[106],"which":[107],"reversible":[109],"dose":[111,114],"dependent.":[112],"requirement":[115],"declines":[116],"markedly":[117],"age":[119],"higher":[122],"women.":[124],"Continuation":[125],"replacement":[128,181],"into":[129],"adulthood":[130],"childhood-onset":[134],"indicated,":[137],"if":[138],"diagnosis":[140],"reconfirmed.":[142],"treatment":[144],"frail":[146],"elderly":[147],"subjects":[148],"without":[149],"pituitary":[151],"unwarranted.":[154],"Observational":[155],"data":[156],"show":[157],"that":[158],"GH-replaced":[161],"compared":[165],"to":[166,177],"untreated":[167],"patients.":[168],"Even":[169],"though":[170],"this":[171],"could":[174],"be":[175],"due":[176],"selection":[178],"bias,":[179],"has":[184],"proven":[185],"beneficial":[186],"safe.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}