{"id":"https://openalex.org/W2803085691","doi":"https://doi.org/10.1111/bcp.13585","title":"Model\u2010based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management","display_name":"Model\u2010based dosing with concentration feedback as an integral part of personalized hydroxycarbamide management","publication_year":2018,"publication_date":"2018-04-17","ids":{"openalex":"https://openalex.org/W2803085691","doi":"https://doi.org/10.1111/bcp.13585","mag":"2803085691","pmid":"https://pubmed.ncbi.nlm.nih.gov/29667224","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6005594"},"language":"en","primary_location":{"id":"doi:10.1111/bcp.13585","doi":"https://doi.org/10.1111/bcp.13585","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bcp.13585","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"letter","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6005594","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090500677","display_name":"Min Dong","orcid":"https://orcid.org/0000-0002-8552-8298","observed_orcids":["https://orcid.org/0000-0002-8552-8298"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Min Dong","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0002-8552-8298","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017286562","display_name":"Patrick T. McGann","orcid":"https://orcid.org/0000-0001-6198-4785","observed_orcids":["https://orcid.org/0000-0001-6198-4785"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrick T. McGann","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016058238","display_name":"Tomoyuki Mizuno","orcid":"https://orcid.org/0000-0002-8471-9826","observed_orcids":["https://orcid.org/0000-0002-8471-9826"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tomoyuki Mizuno","raw_affiliation_strings":["Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040752648","display_name":"Russell E. Ware","orcid":"https://orcid.org/0000-0001-9582-0594","observed_orcids":["https://orcid.org/0000-0001-9582-0594"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell E. Ware","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040060343","display_name":"Alexander A. T. M. M. Vinks","orcid":"https://orcid.org/0000-0003-4224-2967","observed_orcids":["https://orcid.org/0000-0003-4224-2967"]},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexander A. Vinks","raw_affiliation_strings":["Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Clinical Pharmacology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA","institution_ids":["https://openalex.org/I1285204247"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5090500677"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":{"value":4780,"currency":"USD","value_usd":4780},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"84","issue":"7","first_page":"1410","last_page":"1412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.9688000082969666,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.006599999964237213,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hydroxyurea","display_name":"hydroxyurea","score":0.949999988079071},{"id":"https://openalex.org/keywords/sickle-cell-disease","display_name":"sickle cell disease","score":0.9649999737739563},{"id":"https://openalex.org/keywords/bayesian-dosing","display_name":"Bayesian dosing","score":0.6980000138282776},{"id":"https://openalex.org/keywords/inter-individual-variability","display_name":"interindividual variability","score":0.7549999952316284},{"id":"https://openalex.org/keywords/shrinkage","display_name":"shrinkage","score":0.3100000023841858},{"id":"https://openalex.org/keywords/sparse-sampling","display_name":"sparse sampling","score":0.6340000033378601},{"id":"https://openalex.org/keywords/individualized-dosing","display_name":"individualized dosing","score":0.45899999141693115},{"id":"https://openalex.org/keywords/pharmacokinetic-prediction","display_name":"pharmacokinetic prediction","score":0.5299999713897705},{"id":"https://openalex.org/keywords/external-validation","display_name":"external validation","score":0.5860000252723694},{"id":"https://openalex.org/keywords/children","display_name":"children","score":0.34700000286102295},{"id":"https://openalex.org/keywords/drug-exposure-prediction","display_name":"drug exposure prediction","score":0.5070000290870667},{"id":"https://openalex.org/keywords/body-weight-covariate","display_name":"body weight covariate","score":0.45399999618530273}],"concepts":[{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.8942698836326599},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.7747317552566528},{"id":"https://openalex.org/C119043178","wikidata":"https://www.wikidata.org/wiki/Q320723","display_name":"Covariate","level":2,"score":0.7587629556655884},{"id":"https://openalex.org/C2779316324","wikidata":"https://www.wikidata.org/wiki/Q212272","display_name":"Hydroxycarbamide","level":3,"score":0.553903341293335},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5145996809005737},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.46914830803871155},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44181740283966064},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4164290428161621},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.3270089626312256},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2807960510253906},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20434391498565674},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000755","descriptor_name":"Anemia, Sickle Cell","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005246","descriptor_name":"Feedback","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006918","descriptor_name":"Hydroxyurea","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/bcp.13585","doi":"https://doi.org/10.1111/bcp.13585","is_oa":false,"landing_page_url":"https://doi.org/10.1111/bcp.13585","pdf_url":null,"source":{"id":"https://openalex.org/S13842274","display_name":"British Journal of Clinical Pharmacology","issn_l":"0306-5251","issn":["0306-5251","1365-2125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5566867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6005594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6005594","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6005594","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Br J Clin Pharmacol","raw_type":"Text"},{"id":"pmid:29667224","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29667224","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"British journal of clinical pharmacology","raw_type":"Letter"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5566867","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6005594","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G674879958","display_name":null,"funder_award_id":"R01-HL090941","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":13,"referenced_works":["https://openalex.org/W2034832239","https://openalex.org/W2065039877","https://openalex.org/W2083668821","https://openalex.org/W2113613653","https://openalex.org/W2122176876","https://openalex.org/W2157298598","https://openalex.org/W2172684893","https://openalex.org/W2587355458","https://openalex.org/W2735618937","https://openalex.org/W2742410006","https://openalex.org/W2752272969","https://openalex.org/W2771328536","https://openalex.org/W4321429438"],"related_works":["https://openalex.org/W2092068901","https://openalex.org/W2533000830","https://openalex.org/W2735618937","https://openalex.org/W2742410006","https://openalex.org/W2752272969","https://openalex.org/W2172684893","https://openalex.org/W3082058144","https://openalex.org/W4389147140","https://openalex.org/W2997802891","https://openalex.org/W2944852231"],"abstract_inverted_index":{"We":[0,927],"read":[1],"with":[2,24,79,127,287,417,555,653,735,746,750,759,929,960,976,1056],"great":[3],"interest":[4,1063],"the":[5,12,52,69,99,118,178,201,208,215,227,244,248,301,304,308,315,328,341,355,360,372,379,398,434,450,457,470,474,482,500,507,546,584,588,591,607,618,631,669,675,682,720,729,736,747,751,771,777,795,802,862,866,892,898,919,935,1001,1007,1018,1028,1039,1050,1065,1069,1084],"manuscript":[6,778],"by":[7,43,88,207,257,314,401,438,779,1092],"Estepp":[8,89,93,258,402,483,569,683,724,780,930],"and":[9,150,191,211,277,284,426,432,561,586,593,611,630,704,739,749,757,900,978,989,1013,1042],"colleagues":[10],"where":[11],"authors":[13,31,305,1025],"evaluated":[14,983],"model-based":[15,958],"strategies":[16],"for":[17,83,185,223,254,273,384,423,449,865,903,968,1004,1049],"predicting":[18],"hydroxycarbamide":[19,311,331,893,972],"(hydroxyurea)":[20],"exposure":[21,184,901],"in":[22,68,111,198,296,322,333,340,352,354,473,481,548,574,604,621,627,646,651,681,715,723,732,776,874,950,973,991,999,1017,1064,1068],"children":[23],"sickle":[25],"cell":[26],"anaemia":[27],"(SCA)":[28],"1.":[29],"The":[30,695,830,1087],"conclude":[32],"that":[33,98,137,220,307,506,688,787,805,847,934,956,1059,1078],"a":[34,75,146,410,418,513,521,529,556,716,806,822,848,854,870,957],"Bayesian":[35,81,100,166,168,237,255,361,382,654,788,885,916],"dosing":[36,59,139,162,849,939,970],"approach":[37,101,959],"using":[38,141,499,674,810,883,915],"sparse":[39,807,961],"sampling":[40,665,808,962],"as":[41,86,123,145,158,160,195,197,265,479,532,551,668,680,708,719,861],"proposed":[42],"our":[44,389,658],"group":[45],"2":[46,504,703],"\u2018did":[47],"not":[48,63,466,511],"measurably":[49],"add":[50],"to":[51,56,65,129,176,214,243,292,413,469,567,639,818,838,887,895,947,996,1010,1021,1081],"prediction":[53,107,647,730],"accuracy":[54,108,936],"compared":[55,392,817],"various":[57],"population-based":[58,938],"algorithms\u2019,":[60],"which":[61],"is":[62,157,553,650,945,979],"consistent":[64],"findings":[66],"reported":[67,267,306,339,722],"literature":[70],"3-5.":[71],"Therefore,":[72],"we":[73,391,452,464,519,541,686,908],"conducted":[74],"predictive":[76,159,772,913],"performance":[77,773,914],"analysis":[78,217,317,803,954],"similar":[80,412,717],"scenarios":[82,478],"external":[84,446],"validation":[85,659],"described":[87,400,480],"et":[90,94,259,403,440,570,725,781,931],"al.":[91,95,260,404,441,571,726,782,932],"1":[92,96,415,485,490,572,727,783,933],"suggested":[97,573],"(Scenarios":[102,564],"3\u20135)":[103],"only":[104,142,863],"slightly":[105],"improved":[106,815,835],"(as":[109,294,320],"shown":[110,295,321,603],"their":[112,138,575],"Figure":[113,539,576,605],"3),":[114],"even":[115,693],"when":[116,226,596,701,821,918],"all":[117,597],"concentration":[119,174,525,580,755,762,792,899],"measurements":[120,131,175,793],"were":[121,221,262,282,486,497],"used":[122,194,222,253,453,520,707],"feedback":[124,169,196,578,763,963],"(Scenario":[125,148,526,536,559],"5":[126,623],"up":[128],"12":[130,676],"from":[132,456,637,770,836,1006,1038,1046,1094],"each":[133,760,904],"subject).":[134],"They":[135],"concluded":[136],"model":[140,229,358,399,411,437,503,522,753,857,922],"body":[143,859],"weight":[144,860],"covariate":[147,864],"1)":[149,397,406,560],"without":[151,754,940],"inclusion":[152],"of":[153,182,235,250,270,279,310,330,343,368,381,421,428,545,579,590,633,697,825,832,891,912,937,971],"patient-specific":[154,192,791],"PK":[155,228,357,395,436,454,471,502,664,856,921,943],"data":[156,210,447,455,472,581,598,660,721,1005],"individualized":[161],"based":[163,852],"on":[164,853,1036],"posterior":[165,884],"estimation.":[167],"utilizes":[170],"patient":[171],"specific":[172],"real-time":[173],"obtain":[177],"most":[179,594,875],"accurate":[180,385],"estimate":[181],"drug":[183],"dose":[186,873,881,894],"individualization":[187,882],"6.":[188],"With":[189],"detailed":[190],"information":[193],"Scenario":[199,517,622,628],"5,":[200],"predictions":[202,610,689,816,820],"should":[203],"be":[204,212],"largely":[205],"informed":[206],"individual":[209,369,386,951],"close":[213,242],"noncompartmental":[216,316],"(NCA)":[218],"estimates":[219,239,252,370,734],"comparison.":[224],"However,":[225],"assumes":[230,923],"small":[231,264],"inter-individual":[232],"variability":[233,329,351,547,585,925],"(IIV)":[234],"parameters,":[236],"parameter":[238,251],"will":[240],"remain":[241],"population":[245,356,373,394,435,501,752,819,855,920],"mean.":[246],"Indeed,":[247],"IIV":[249,289,826],"estimation":[256,383,886,917],"7":[261,297,323],"unusually":[263],"they":[266,625],"\u2013":[268],"coefficients":[269,696],"variation":[271],"(CVs)":[272],"oral":[274],"clearance":[275,312,332,353,425],"(CL/F)":[276],"volume":[278,427],"distribution":[280,429],"(V/F)":[281],"6.9%":[283],"9.4%":[285],"respectively,":[286],"other":[288,334,1074],"values":[290],"fixed":[291],"zero":[293],"Table":[298,324],"S3).":[299],"In":[300,326,388,538,800,906],"same":[302],"manuscript,":[303],"CV":[309,420],"analysed":[313],"was":[318,828,1090],"15%":[319,422],"2).":[325],"addition,":[327,801],"studies":[335],"has":[336],"been":[337,692],"consistently":[338],"range":[342],"15%\u201330%":[344],"1,":[345,407,629,685],"2,":[346],"8,":[347],"9.":[348],"A":[349],"low":[350],"(i.e.":[359],"prior)":[362],"would":[363,690,878],"have":[364,467,691,1026,1061,1082],"caused":[365],"significant":[366,910],"shrinkage":[367],"towards":[371],"mean":[374],"10,":[375],"11":[376],"thus":[377],"defeating":[378],"value":[380],"predictions.":[387],"evaluation,":[390],"three":[393],"models:":[396],"(Model":[405,430,442],"7;":[408],"2)":[409],"Model":[414],"but":[416,877],"higher":[419],"both":[424],"2);":[431],"3)":[433,443],"Dong":[439],"2.":[444],"As":[445,602],"source":[448],"validation,":[451],"HUSTLE":[458,508,1088],"trial":[459,1089],"(ClinicalTrials.gov":[460],"NCT00305175)":[461],"9":[462],"since":[463],"did":[465,510],"access":[468],"current":[475],"study.":[476],"Similar":[477],"study":[484,509,684],"tested.":[487],"For":[488,516],"Scenarios":[489],"&":[491],"3,":[492,577],"concentrations":[493,531,677],"at":[494,1033],"1.5":[495],"h":[496],"simulated":[498],"given":[505],"collect":[512],"1.5-h":[514],"sample.":[515],"4,":[518],"predicted":[523],"3-h":[524],"4.1),":[527],"or":[528,840,1076],"4-h":[530],"an":[533,642,965,1062],"alternative":[534],"scenario":[535],"4.2).":[537],"1A\u2013C,":[540],"summarize":[542],"how":[543],"much":[544],"AUC":[549,733],"(reported":[550],"R2)":[552],"explained":[554],"regression":[557,737,798],"equation":[558,738,748],"Models":[562,702,740],"1\u20133":[563],"2\u20135).":[565],"Contrary":[566],"what":[568],"does":[582],"lower":[583],"improve":[587,700],"precision":[589,969],"predictions,":[592],"significantly":[595],"points":[599,667],"are":[600,613,626,706,744,767,994,1014],"used.":[601],"1A,":[606],"correlations":[608],"between":[609],"observations":[612],"more":[614],"tightly":[615],"clustered":[616],"around":[617],"identity":[619],"line":[620,652],"than":[624],"coefficient":[632,831],"determination":[634,698,833],"(R2)":[635,834],"increased":[636],"0.43":[638,837],"0.83,":[640],"indicating":[641],"overall":[643],"93%":[644],"increase":[645],"accuracy.":[648],"This":[649],"theory.":[655],"Of":[656],"note,":[657],"set":[661],"had":[662],"seven":[663],"time":[666],"maximum":[670],"per":[671,678],"subject.":[672],"When":[673],"subject":[679],"expect":[687],"better.":[694],"further":[699,889],"3":[705,811,1071],"priors.":[709],"Panel":[710],"D":[711],"shows":[712,786],"box-and-whisker":[713],"plots":[714],"fashion":[718],"summarizing":[728],"errors":[731,743],"1\u20133.":[741],"Prediction":[742],"largest":[745],"feedback,":[756],"decrease":[758],"additional":[761],"scenario.":[764],"These":[765,844],"results":[766,774,845],"very":[768],"different":[769],"presented":[775],"Our":[784,953],"evaluation":[785],"estimations":[789],"incorporating":[790],"outperform":[794],"one":[796],"sample":[797],"equation.":[799],"indicates":[804],"strategy":[809,967],"timed":[812],"samples":[813,944],"provides":[814],"moderate":[823],"level":[824],"(15%)":[827],"applied.":[829],"0.63":[839],"0.82":[841],"(Figure":[842],"1B).":[843],"suggest":[846],"algorithm":[850],"developed":[851],"(with":[858],"parameters)":[867],"can":[868],"generate":[869],"reasonable":[871],"starting":[872],"patients,":[876],"require":[879],"subsequent":[880],"facilitate":[888],"tailoring":[890],"precisely":[896],"reach":[897],"targets":[902,988],"patient.":[905],"summary,":[907],"found":[909],"improvements":[911],"realistic":[924],"estimates.":[926],"disagree":[928],"any":[941,1047,1057],"patient-derived":[942],"sufficient":[946],"target":[948],"AUCs":[949],"patients.":[952],"confirms":[955],"remains":[964],"attractive":[966],"paediatric":[974],"patients":[975],"SCA":[977],"currently":[980],"being":[981],"prospectively":[982],"12,":[984],"13.":[985],"Key":[986],"protein":[987],"ligands":[990],"this":[992],"article":[993],"hyperlinked":[995],"corresponding":[997,1040],"entries":[998],"http://www.guidetopharmacology.org,":[1000],"common":[1002],"portal":[1003],"IUPHAR/BPS":[1008],"Guide":[1009,1020],"PHARMACOLOGY":[1011,1022],"14,":[1012],"permanently":[1015],"archived":[1016],"Concise":[1019],"2017/18.":[1023],"All":[1024],"completed":[1027],"Unified":[1029],"Competing":[1030],"Interest":[1031],"form":[1032],"www.icmje.org/coi_disclosure.pdf":[1034],"(available":[1035],"request":[1037],"author)":[1041],"declare:":[1043],"no":[1044,1053,1073],"support":[1045],"organization":[1048],"submitted":[1051,1066,1085],"work;":[1052],"financial":[1054],"relationships":[1055,1075],"organizations":[1058],"might":[1060],"work":[1067],"previous":[1070],"years;":[1072],"activities":[1077],"could":[1079],"appear":[1080],"influenced":[1083],"work.":[1086],"supported":[1091],"R01-HL090941":[1093],"NHLBI":[1095],"(REW).":[1096]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}