{"id":"https://openalex.org/W2803080671","doi":"https://doi.org/10.1021/acs.nanolett.8b00660","title":"Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape","display_name":"Modulation of the Cellular Uptake of DNA Origami through Control over Mass and Shape","publication_year":2018,"publication_date":"2018-05-14","ids":{"openalex":"https://openalex.org/W2803080671","doi":"https://doi.org/10.1021/acs.nanolett.8b00660","mag":"2803080671","pmid":"https://pubmed.ncbi.nlm.nih.gov/29756442"},"language":"en","primary_location":{"id":"doi:10.1021/acs.nanolett.8b00660","doi":"https://doi.org/10.1021/acs.nanolett.8b00660","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.8b00660","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://infoscience.epfl.ch/record/259411","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017066424","display_name":"Maartje M. C. Bastings","orcid":"https://orcid.org/0000-0002-7603-4018","observed_orcids":["https://orcid.org/0000-0002-7603-4018"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maartje M. C. Bastings","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054880031","display_name":"Frances M. Anastassacos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Frances M. Anastassacos","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073684017","display_name":"Nandhini Ponnuswamy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nandhini Ponnuswamy","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016672833","display_name":"Franziska Leifer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Franziska G. Leifer","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015530329","display_name":"Garry J. Cuneo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Garry Cuneo","raw_affiliation_strings":["Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036289724","display_name":"Chenxiang Lin","orcid":"https://orcid.org/0000-0001-7041-1946","observed_orcids":["https://orcid.org/0000-0001-7041-1946"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenxiang Lin","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":"https://orcid.org/0000-0001-7041-1946","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005669988","display_name":"Donald E. Ingber","orcid":"https://orcid.org/0000-0002-4319-6520","observed_orcids":["https://orcid.org/0000-0002-4319-6520"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald E. Ingber","raw_affiliation_strings":["School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States","Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":"https://orcid.org/0000-0002-4319-6520","affiliations":[{"raw_affiliation_string":"School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073676165","display_name":"Ju Hee Ryu","orcid":"https://orcid.org/0000-0003-3422-3272","observed_orcids":["https://orcid.org/0000-0003-3422-3272"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]},{"id":"https://openalex.org/I58716616","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883","country_code":"KR","type":"facility","lineage":["https://openalex.org/I27494661","https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I58716616"]}],"countries":["KR","US"],"is_corresponding":true,"raw_author_name":"Ju Hee Ryu","raw_affiliation_strings":["Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea","Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science and Technology, Seoul 02792, Republic of Korea","institution_ids":["https://openalex.org/I58716616"]},{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015398607","display_name":"William M. Shih","orcid":"https://orcid.org/0000-0002-1395-9267","observed_orcids":["https://orcid.org/0000-0002-1395-9267"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]},{"id":"https://openalex.org/I44142251","display_name":"Wyss Institute for Biologically Inspired Engineering","ror":"https://ror.org/008cfmj78","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William M. Shih","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States"],"raw_orcid":"https://orcid.org/0000-0002-1395-9267","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Cancer Biology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, Massachusetts 02215, United States","institution_ids":["https://openalex.org/I4210117453"]},{"raw_affiliation_string":"Wyss Institute for Biologically Inspired Engineering at Harvard, Boston, Massachusetts 02115, United States","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I44142251"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5015398607","https://openalex.org/A5073676165"],"corresponding_institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210117453","https://openalex.org/I44142251","https://openalex.org/I58716616"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":9.7783,"has_fulltext":false,"cited_by_count":251,"citation_normalized_percentile":{"value":0.99057374,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"18","issue":"6","first_page":"3557","last_page":"3564"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10207","display_name":"Advanced biosensing and bioanalysis techniques","score":0.5727999806404114,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.2168000042438507,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.17399999499320984,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-origami","display_name":"DNA origami","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.9110000133514404},{"id":"https://openalex.org/keywords/nanoparticle-morphology","display_name":"nanoparticle morphology","score":0.9319999814033508},{"id":"https://openalex.org/keywords/nanoparticle-size","display_name":"nanoparticle size","score":0.8100000023841858},{"id":"https://openalex.org/keywords/uptake-kinetics","display_name":"uptake kinetics","score":0.8090000152587891},{"id":"https://openalex.org/keywords/dendritic-cells","display_name":"dendritic cells","score":0.8659999966621399},{"id":"https://openalex.org/keywords/dna-nanotechnology","display_name":"DNA nanotechnology","score":0.6620000004768372},{"id":"https://openalex.org/keywords/cell-delivery-vehicle","display_name":"cell delivery vehicle","score":0.6119999885559082},{"id":"https://openalex.org/keywords/self-assembled-nanostructures","display_name":"self-assembled nanostructures","score":0.6690000295639038}],"concepts":[{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.7328665852546692},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.6889654397964478},{"id":"https://openalex.org/C118630614","wikidata":"https://www.wikidata.org/wiki/Q1154606","display_name":"DNA origami","level":3,"score":0.6477253437042236},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.6195688247680664},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5689067840576172},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.5066143274307251},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4808995723724365},{"id":"https://openalex.org/C186187911","wikidata":"https://www.wikidata.org/wiki/Q1093894","display_name":"Nanostructure","level":2,"score":0.43457847833633423},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.4273439645767212},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.38347309827804565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17870381474494934},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09277185797691345},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D057809","descriptor_name":"HEK293 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061307","descriptor_name":"Human Umbilical Vein Endothelial Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1021/acs.nanolett.8b00660","doi":"https://doi.org/10.1021/acs.nanolett.8b00660","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.nanolett.8b00660","pdf_url":null,"source":{"id":"https://openalex.org/S143846845","display_name":"Nano Letters","issn_l":"1530-6984","issn":["1530-6984","1530-6992"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano Letters","raw_type":"journal-article"},{"id":"pmid:29756442","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29756442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nano letters","raw_type":"Journal Article"},{"id":"pmh:oai:infoscience.epfl.ch:259411","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/259411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WoS","raw_type":"research article"}],"best_oa_location":{"id":"pmh:oai:infoscience.epfl.ch:259411","doi":null,"is_oa":true,"landing_page_url":"http://infoscience.epfl.ch/record/259411","pdf_url":null,"source":{"id":"https://openalex.org/S4306400487","display_name":"Infoscience (Ecole Polytechnique F\u00e9d\u00e9rale de Lausanne)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I5124864","host_organization_name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","host_organization_lineage":["https://openalex.org/I5124864"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"WoS","raw_type":"research article"},"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1142246197","display_name":null,"funder_award_id":"CCF 1317291","funder_id":"https://openalex.org/F4320337387","funder_display_name":"Division of Computing and Communication Foundations"},{"id":"https://openalex.org/G1443097487","display_name":null,"funder_award_id":"2E27960","funder_id":"https://openalex.org/F4320322091","funder_display_name":"Korea Institute of Science and Technology"},{"id":"https://openalex.org/G6492295158","display_name":"NMR Structure Determination of Membrane Proteins Enabled by DNA Nanotubes","funder_award_id":"1dp2od004641-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8144947074","display_name":null,"funder_award_id":"1DP2OD004641-01","funder_id":"https://openalex.org/F4320337349","funder_display_name":"NIH Office of the Director"}],"funders":[{"id":"https://openalex.org/F4320307065","display_name":"Schlumberger Foundation","ror":"https://ror.org/03daw3m97"},{"id":"https://openalex.org/F4320320338","display_name":"Human Frontier Science Program","ror":"https://ror.org/02ebx7v45"},{"id":"https://openalex.org/F4320322091","display_name":"Korea Institute of Science and Technology","ror":"https://ror.org/05kzfa883"},{"id":"https://openalex.org/F4320323220","display_name":"Alexander S. Onassis Public Benefit Foundation","ror":"https://ror.org/017nq0d63"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333979","display_name":"Hansj\u00f6rg Wyss Institute for Biologically Inspired Engineering, Harvard University","ror":"https://ror.org/008cfmj78"},{"id":"https://openalex.org/F4320337349","display_name":"NIH Office of the Director","ror":"https://ror.org/00fj8a872"},{"id":"https://openalex.org/F4320337387","display_name":"Division of Computing and Communication Foundations","ror":"https://ror.org/01mng8331"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W1664986234","https://openalex.org/W1763950462","https://openalex.org/W1964535590","https://openalex.org/W1975679096","https://openalex.org/W1996139192","https://openalex.org/W2002749442","https://openalex.org/W2003336829","https://openalex.org/W2004899704","https://openalex.org/W2013470095","https://openalex.org/W2015497529","https://openalex.org/W2023594077","https://openalex.org/W2030699288","https://openalex.org/W2038125628","https://openalex.org/W2091691458","https://openalex.org/W2095914211","https://openalex.org/W2104558356","https://openalex.org/W2108727062","https://openalex.org/W2113972541","https://openalex.org/W2116218627","https://openalex.org/W2117630026","https://openalex.org/W2124869438","https://openalex.org/W2126961173","https://openalex.org/W2129096474","https://openalex.org/W2143439997","https://openalex.org/W2143463421","https://openalex.org/W2161214119","https://openalex.org/W2165031969","https://openalex.org/W2332489732","https://openalex.org/W2601435761","https://openalex.org/W2618072306","https://openalex.org/W2786092482"],"related_works":["https://openalex.org/W2134837651","https://openalex.org/W2786092482","https://openalex.org/W3205333505","https://openalex.org/W4283071310","https://openalex.org/W2046311378","https://openalex.org/W2203174453","https://openalex.org/W2533403374","https://openalex.org/W4311964451","https://openalex.org/W2512399037","https://openalex.org/W3154165597"],"abstract_inverted_index":{"Designer":[0],"nanoparticles":[1,25],"with":[2,45,87,105,113,128],"controlled":[3],"shapes":[4],"and":[5,49,158],"sizes":[6],"are":[7],"increasingly":[8],"popular":[9],"vehicles":[10],"for":[11,56],"therapeutic":[12],"delivery":[13],"due":[14],"to":[15,23,41,65,122,134],"their":[16],"enhanced":[17],"cell-delivery":[18,171],"performance.":[19],"However,":[20],"our":[21,149],"ability":[22,40],"fashion":[24],"has":[26,37],"offered":[27],"only":[28],"limited":[29],"control":[30],"over":[31,136],"these":[32],"parameters.":[33],"Structural":[34],"DNA":[35,163],"nanotechnology":[36],"an":[38,53],"unparalleled":[39],"self-assemble":[42],"three-dimensional":[43],"nanostructures":[44],"near-atomic":[46],"resolution":[47],"features,":[48],"thus,":[50],"it":[51],"offers":[52],"attractive":[54],"platform":[55],"the":[57,61,76,88,145,160,166],"systematic":[58],"exploration":[59],"of":[60,79,82,139,151,162,168],"parameter":[62],"space":[63],"relevant":[64],"nanoparticle":[66],"uptake":[67,78,157],"by":[68],"living":[69],"cells.":[70],"In":[71],"this":[72],"study,":[73],"we":[74],"examined":[75],"cell":[77,98],"a":[80,106],"panel":[81],"11":[83],"distinct":[84],"DNA-origami":[85],"shapes,":[86],"largest":[89],"dimension":[90],"ranging":[91],"from":[92],"50-400":[93],"nm,":[94],"in":[95,144],"3":[96],"different":[97],"lines.":[99],"We":[100],"found":[101,121],"that":[102],"larger":[103],"particles":[104],"greater":[107],"compactness":[108],"were":[109,119],"preferentially":[110],"internalized":[111],"compared":[112],"elongated,":[114],"high-aspect-ratio":[115],"particles.":[116],"Uptake":[117],"kinetics":[118],"also":[120],"be":[123],"more":[124],"cell-type-dependent":[125],"than":[126],"shape-dependent,":[127],"specialized":[129],"endocytosing":[130],"dendritic":[131],"cells":[132],"failing":[133],"saturate":[135],"12":[137],"h":[138],"study.":[140],"The":[141],"knowledge":[142],"gained":[143],"current":[146,169],"study":[147],"furthers":[148],"understanding":[150],"how":[152],"particle":[153],"shape":[154],"affects":[155],"cellular":[156],"heralds":[159],"development":[161],"nanotechnologies":[164],"toward":[165],"improvement":[167],"state-of-the-art":[170],"vehicles.":[172]},"counts_by_year":[{"year":2026,"cited_by_count":21},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":28},{"year":2023,"cited_by_count":32},{"year":2022,"cited_by_count":30},{"year":2021,"cited_by_count":37},{"year":2020,"cited_by_count":35},{"year":2019,"cited_by_count":28},{"year":2018,"cited_by_count":10}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}
