{"id":"https://openalex.org/W2803072064","doi":"https://doi.org/10.1038/s41467-018-03537-w","title":"A serum microRNA signature predicts trastuzumab benefit in HER2-positive metastatic breast cancer patients","display_name":"A serum microRNA signature predicts trastuzumab benefit in HER2-positive metastatic breast cancer patients","publication_year":2018,"publication_date":"2018-04-18","ids":{"openalex":"https://openalex.org/W2803072064","doi":"https://doi.org/10.1038/s41467-018-03537-w","mag":"2803072064","pmid":"https://pubmed.ncbi.nlm.nih.gov/29691399","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5915573"},"language":"en","primary_location":{"id":"doi:10.1038/s41467-018-03537-w","doi":"https://doi.org/10.1038/s41467-018-03537-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-03537-w","pdf_url":"https://www.nature.com/articles/s41467-018-03537-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41467-018-03537-w.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100605683","display_name":"Huiping Li","orcid":"https://orcid.org/0000-0002-3331-647X","observed_orcids":["https://orcid.org/0000-0002-3331-647X"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiping Li","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325218","display_name":"Jiang Liu","orcid":"https://orcid.org/0000-0001-9845-2619","observed_orcids":["https://orcid.org/0000-0001-9845-2619"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiang Liu","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100613501","display_name":"Jianing Chen","orcid":"https://orcid.org/0000-0002-2938-4402","observed_orcids":["https://orcid.org/0000-0002-2938-4402"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianing Chen","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071211512","display_name":"Hui\u2010Yun Wang","orcid":"https://orcid.org/0000-0001-6728-4376","observed_orcids":["https://orcid.org/0000-0001-6728-4376"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiyun Wang","raw_affiliation_strings":["State Key Laboratory of Oncology in Southern China, Tumor Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in Southern China, Tumor Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024382453","display_name":"Linbin Yang","orcid":"https://orcid.org/0000-0002-1651-2516","observed_orcids":["https://orcid.org/0000-0002-1651-2516","https://orcid.org/0009-0000-6326-5231"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linbin Yang","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100405376","display_name":"Fei Chen","orcid":"https://orcid.org/0000-0002-1948-2711","observed_orcids":["https://orcid.org/0000-0002-1948-2711"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Chen","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112338877","display_name":"Siting Fan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siting Fan","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100378487","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-3224-3993","observed_orcids":["https://orcid.org/0000-0002-3224-3993"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101518421","display_name":"Bin Shao","orcid":"https://orcid.org/0000-0001-9195-8043","observed_orcids":["https://orcid.org/0000-0001-9195-8043"]},"institutions":[{"id":"https://openalex.org/I4210093964","display_name":"Peking University Cancer Hospital","ror":"https://ror.org/00nyxxr91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210093964"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Shao","raw_affiliation_strings":["Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Breast Oncology, Peking University Cancer Hospital and Institute, 52 Fucheng Road, Beijing, 100142, China","institution_ids":["https://openalex.org/I4210093964"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004073477","display_name":"Dong Yin","orcid":"https://orcid.org/0000-0002-1878-4849","observed_orcids":["https://orcid.org/0000-0002-1878-4849"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dong Yin","raw_affiliation_strings":["Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","State Key Laboratory of Oncology in Southern China, Tumor Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in Southern China, Tumor Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072945901","display_name":"Mu\u2010Sheng Zeng","orcid":"https://orcid.org/0000-0003-3509-5591","observed_orcids":["https://orcid.org/0000-0003-3509-5591","https://orcid.org/0000-0002-5410-2366"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Musheng Zeng","raw_affiliation_strings":["State Key Laboratory of Oncology in Southern China, Tumor Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou, 510060, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Oncology in Southern China, Tumor Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou, 510060, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054499936","display_name":"Mengfeng Li","orcid":"https://orcid.org/0000-0002-5103-6367","observed_orcids":["https://orcid.org/0000-0002-5103-6367","https://orcid.org/0000-0001-6497-4232"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengfeng Li","raw_affiliation_strings":["Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II,, 510080, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II,, 510080, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362017","display_name":"Jun Li","orcid":"https://orcid.org/0000-0003-0572-1344","observed_orcids":["https://orcid.org/0000-0003-0572-1344","https://orcid.org/0000-0001-5247-576X"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":["Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II,, 510080, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II,, 510080, Guangzhou, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101481719","display_name":"Fengxi Su","orcid":"https://orcid.org/0000-0003-1899-9337","observed_orcids":["https://orcid.org/0000-0003-1899-9337"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengxi Su","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100409479","display_name":"Qiang Liu","orcid":"https://orcid.org/0000-0002-5451-4862","observed_orcids":["https://orcid.org/0000-0002-5451-4862"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiang Liu","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087722578","display_name":"Herui Yao","orcid":"https://orcid.org/0000-0001-5520-6469","observed_orcids":["https://orcid.org/0000-0001-5520-6469"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Herui Yao","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046795810","display_name":"Shicheng Su","orcid":"https://orcid.org/0000-0003-2280-3587","observed_orcids":["https://orcid.org/0000-0003-2280-3587"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shicheng Su","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. sushch@mail.sysu.edu.cn","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. sushch@mail.sysu.edu.cn","Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. sushch@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. sushch@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021387235","display_name":"Erwei Song","orcid":"https://orcid.org/0000-0002-5400-9049","observed_orcids":["https://orcid.org/0000-0002-5400-9049"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Erwei Song","raw_affiliation_strings":["Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. songew@mail.sysu.edu.cn","Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. songew@mail.sysu.edu.cn","State Key Laboratory of Oncology in Southern China, Tumor Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou, 510060, China. songew@mail.sysu.edu.cn","Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II,, 510080, Guangzhou, China. songew@mail.sysu.edu.cn","Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. songew@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China. songew@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]},{"raw_affiliation_string":"State Key Laboratory of Oncology in Southern China, Tumor Center, Sun Yat-sen University, 651 Dongfeng East Road, Guangzhou, 510060, China. songew@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Zhongshan School of Medicine, Sun Yat-sen University, 74 Zhongshan Road II,, 510080, Guangzhou, China. songew@mail.sysu.edu.cn","institution_ids":["https://openalex.org/I157773358"]},{"raw_affiliation_string":"Breast Tumor Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Road, Guangzhou, 510120, China","institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5021387235","https://openalex.org/A5046795810"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210097354","https://openalex.org/I4391768007"],"apc_list":{"value":6990,"currency":"USD","value_usd":6990},"apc_paid":{"value":6990,"currency":"USD","value_usd":6990},"fwci":4.6081,"has_fulltext":true,"cited_by_count":111,"citation_normalized_percentile":{"value":0.97047596,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"9","issue":"1","first_page":"1614","last_page":"1614"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.8237000107765198,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10755","display_name":"HER2/EGFR in Cancer Research","score":0.16850000619888306,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trastuzumab","display_name":"trastuzumab","score":0.8330000042915344},{"id":"https://openalex.org/keywords/her2-positive-breast-cancer","display_name":"HER2-positive breast cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/metastatic-breast-cancer","display_name":"metastatic breast cancer","score":0.996999979019165},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.7480000257492065},{"id":"https://openalex.org/keywords/trastuzumab-resistance","display_name":"trastuzumab resistance","score":0.8140000104904175},{"id":"https://openalex.org/keywords/mir-940","display_name":"miR-940","score":0.9409999847412109},{"id":"https://openalex.org/keywords/mir-451a","display_name":"miR-451a","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mir-16-5p","display_name":"miR-16-5p","score":1.0},{"id":"https://openalex.org/keywords/mir-17-3p","display_name":"miR-17-3p","score":1.0},{"id":"https://openalex.org/keywords/survival-prediction","display_name":"survival prediction","score":0.6439999938011169},{"id":"https://openalex.org/keywords/lasso-model","display_name":"LASSO model","score":0.8529999852180481}],"concepts":[{"id":"https://openalex.org/C2779786085","wikidata":"https://www.wikidata.org/wiki/Q412616","display_name":"Trastuzumab","level":4,"score":0.9565790891647339},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.7666922211647034},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.7250210642814636},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6546918749809265},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6298057436943054},{"id":"https://openalex.org/C2775930923","wikidata":"https://www.wikidata.org/wiki/Q12859063","display_name":"Metastatic breast cancer","level":4,"score":0.5605468153953552},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5042425394058228},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46716153621673584},{"id":"https://openalex.org/C186836561","wikidata":"https://www.wikidata.org/wiki/Q1931516","display_name":"Microarray","level":4,"score":0.4587472081184387},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3950897455215454},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19303488731384277},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.17790719866752625},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17600396275520325},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000068878","descriptor_name":"Trastuzumab","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009362","descriptor_name":"Neoplasm Metastasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016903","descriptor_name":"Drug Monitoring","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1038/s41467-018-03537-w","doi":"https://doi.org/10.1038/s41467-018-03537-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-03537-w","pdf_url":"https://www.nature.com/articles/s41467-018-03537-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4842003","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5915573","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:29691399","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29691399","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature communications","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5915573","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5915573/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nat Commun","raw_type":"Text"},{"id":"pmh:oai:RePEc:nat:natcom:v:9:y:2018:i:1:d:10.1038_s41467-018-03537-w","doi":null,"is_oa":false,"landing_page_url":"https://www.nature.com/articles/s41467-018-03537-w","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:3dad2bae89b54a468c806a881fe5461a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3dad2bae89b54a468c806a881fe5461a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c003d6a25688433dbb79579e8b8f7ab4","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c003d6a25688433dbb79579e8b8f7ab4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)","raw_type":"article"},{"id":"doi:10.60692/0h1mg-r5e44","doi":"https://doi.org/10.60692/0h1mg-r5e44","is_oa":true,"landing_page_url":"https://doi.org/10.60692/0h1mg-r5e44","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"doi:10.60692/t2yy0-enr19","doi":"https://doi.org/10.60692/t2yy0-enr19","is_oa":true,"landing_page_url":"https://doi.org/10.60692/t2yy0-enr19","pdf_url":null,"source":{"id":"https://openalex.org/S7407051682","display_name":"Greater South Information System","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.1038/s41467-018-03537-w","doi":"https://doi.org/10.1038/s41467-018-03537-w","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41467-018-03537-w","pdf_url":"https://www.nature.com/articles/s41467-018-03537-w.pdf","source":{"id":"https://openalex.org/S64187185","display_name":"Nature Communications","issn_l":"2041-1723","issn":["2041-1723"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nature Communications","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G170938748","display_name":null,"funder_award_id":"2016TQ03R553","funder_id":"https://openalex.org/F4320327806","funder_display_name":"Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program"},{"id":"https://openalex.org/G295575827","display_name":"\u80bf\u7624\u76f8\u5173\u5de8\u566c\u7ec6\u80de\u5206\u6cccCCL18\u52df\u96c6Tregs\u8bf1\u5bfc\u4e73\u817a\u764c\u8d6b\u8d5b\u6c40\u8010\u836f\u7684\u673a\u5236\u7814\u7a76","funder_award_id":"81472468","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3362289701","display_name":null,"funder_award_id":"81490750","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5097132270","display_name":null,"funder_award_id":"81622036","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5561890285","display_name":null,"funder_award_id":"2016YFC1302300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6128840442","display_name":null,"funder_award_id":"81672614","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6707749777","display_name":null,"funder_award_id":"81720108029","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6960264021","display_name":null,"funder_award_id":"2017YFA0106300","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G7914012518","display_name":null,"funder_award_id":"81621004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327806","display_name":"Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2803072064.pdf","grobid_xml":"https://content.openalex.org/works/W2803072064.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1531524380","https://openalex.org/W1966566182","https://openalex.org/W1971425687","https://openalex.org/W1985844219","https://openalex.org/W1994717746","https://openalex.org/W2000982792","https://openalex.org/W2012511861","https://openalex.org/W2029166421","https://openalex.org/W2059411043","https://openalex.org/W2059433308","https://openalex.org/W2062074784","https://openalex.org/W2063464619","https://openalex.org/W2068326740","https://openalex.org/W2071813506","https://openalex.org/W2073341747","https://openalex.org/W2073604089","https://openalex.org/W2076304345","https://openalex.org/W2091665689","https://openalex.org/W2096066755","https://openalex.org/W2096724429","https://openalex.org/W2096910745","https://openalex.org/W2098970540","https://openalex.org/W2102540036","https://openalex.org/W2103678314","https://openalex.org/W2106777108","https://openalex.org/W2112434826","https://openalex.org/W2114101532","https://openalex.org/W2114687472","https://openalex.org/W2127457632","https://openalex.org/W2131482305","https://openalex.org/W2131596261","https://openalex.org/W2137673157","https://openalex.org/W2140775205","https://openalex.org/W2141546964","https://openalex.org/W2145848169","https://openalex.org/W2148811436","https://openalex.org/W2149966907","https://openalex.org/W2152032358","https://openalex.org/W2158927987","https://openalex.org/W2160705803","https://openalex.org/W2162759745","https://openalex.org/W2162982444","https://openalex.org/W2165651085","https://openalex.org/W2166199281","https://openalex.org/W2183645018","https://openalex.org/W2195297470","https://openalex.org/W2255744727","https://openalex.org/W2318605753","https://openalex.org/W2332147333","https://openalex.org/W2340698646","https://openalex.org/W2373606074","https://openalex.org/W2469269100","https://openalex.org/W2505568939","https://openalex.org/W2521963431","https://openalex.org/W2559858344","https://openalex.org/W2560367415","https://openalex.org/W2560406314","https://openalex.org/W2594599876","https://openalex.org/W2604419819","https://openalex.org/W2605164590","https://openalex.org/W3150339341"],"related_works":["https://openalex.org/W4385621573","https://openalex.org/W2530236935","https://openalex.org/W2914624858","https://openalex.org/W4282971285","https://openalex.org/W2911682418","https://openalex.org/W3093338627","https://openalex.org/W3000239990","https://openalex.org/W2330737071","https://openalex.org/W6945067656","https://openalex.org/W2743397905"],"abstract_inverted_index":{"Abstract":[0],"Trastuzumab":[1],"is":[2,89],"a":[3,75,127],"standard":[4],"treatment":[5],"for":[6,28,38,139],"HER2-positive":[7],"(HER2+)":[8],"breast":[9,41],"cancer,":[10],"but":[11,31],"some":[12],"patients":[13,44,62,142],"are":[14,71,101],"refractory":[15],"to":[16,24,66,73,77],"the":[17,57,93,104,134],"therapy.":[18],"MicroRNAs":[19],"(miRNAs)":[20],"have":[21],"been":[22],"used":[23],"predict":[25,78],"therapeutic":[26,135],"effects":[27],"various":[29],"cancers,":[30],"whether":[32],"miRNAs":[33,55,70,110],"can":[34],"serve":[35],"as":[36],"biomarkers":[37],"HER2+":[39,60,140],"metastatic":[40],"cancer":[42],"(MBC)":[43],"remains":[45],"unclear.":[46],"Using":[47],"miRNA":[48,129],"microarray,":[49],"we":[50,125],"identify":[51],"13":[52],"differentially":[53],"expressed":[54],"in":[56,119,147],"serum":[58],"of":[59,137],"MBC":[61,141],"with":[63],"distinct":[64],"response":[65],"trastuzumab,":[67],"and":[68,96,99,143],"four":[69,109],"selected":[72],"construct":[74],"signature":[76,130],"survival":[79],"using":[80],"LASSO":[81],"model.":[82],"Further,":[83],"our":[84],"data":[85],"show":[86],"that":[87,115,131],"miR-940":[88],"mainly":[90,102],"released":[91],"from":[92,103],"tumor":[94],"cells":[95],"miR-451a,":[97],"miR-16-5p":[98],"miR-17-3p":[100],"immune":[105],"cells.":[106],"All":[107],"these":[108],"directly":[111],"target":[112],"signaling":[113],"molecules":[114],"play":[116],"crucial":[117],"roles":[118],"regulating":[120],"trastuzumab":[121,138],"resistance.":[122],"In":[123],"summary,":[124],"develop":[126],"serum-based":[128],"potentially":[132],"predicts":[133],"benefit":[136],"warrants":[144],"future":[145],"validation":[146],"prospective":[148],"clinical":[149],"trials.":[150]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":21},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":5}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-05-17T00:00:00"}
