{"id":"https://openalex.org/W2803021714","doi":"https://doi.org/10.1097/crd.0000000000000211","title":"Novel Pharmacotherapy in Hypertrophic Cardiomyopathy","display_name":"Novel Pharmacotherapy in Hypertrophic Cardiomyopathy","publication_year":2018,"publication_date":"2018-05-10","ids":{"openalex":"https://openalex.org/W2803021714","doi":"https://doi.org/10.1097/crd.0000000000000211","mag":"2803021714","pmid":"https://pubmed.ncbi.nlm.nih.gov/29746257"},"language":"en","primary_location":{"id":"doi:10.1097/crd.0000000000000211","doi":"https://doi.org/10.1097/crd.0000000000000211","is_oa":false,"landing_page_url":"https://doi.org/10.1097/crd.0000000000000211","pdf_url":null,"source":{"id":"https://openalex.org/S173369630","display_name":"Cardiology in Review","issn_l":"1061-5377","issn":["1061-5377","1538-4683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology in Review","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014064578","display_name":"Gabriela Andries","orcid":"https://orcid.org/0000-0002-9197-9968","observed_orcids":["https://orcid.org/0000-0002-9197-9968"]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gabriela Andries","raw_affiliation_strings":["Department of Medicine, New York Medical College at Westchester Medical Center, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York Medical College at Westchester Medical Center, Valhalla, NY","institution_ids":["https://openalex.org/I1321686444","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064962663","display_name":"Srikanth Yandrapalli","orcid":"https://orcid.org/0000-0001-6225-1137","observed_orcids":["https://orcid.org/0000-0001-6225-1137"]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Srikanth Yandrapalli","raw_affiliation_strings":["Department of Medicine, New York Medical College at Westchester Medical Center, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, New York Medical College at Westchester Medical Center, Valhalla, NY","institution_ids":["https://openalex.org/I1321686444","https://openalex.org/I181190671"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062298567","display_name":"Srihari S. Naidu","orcid":"https://orcid.org/0000-0003-4073-5143","observed_orcids":["https://orcid.org/0000-0003-4073-5143"]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Srihari S. Naidu","raw_affiliation_strings":["Division of Cardiology, New York Medical College at Westchester Medical Center, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, New York Medical College at Westchester Medical Center, Valhalla, NY","institution_ids":["https://openalex.org/I1321686444","https://openalex.org/I181190671"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043669959","display_name":"Julio A. Panza","orcid":"https://orcid.org/0000-0001-8652-8110","observed_orcids":["https://orcid.org/0000-0001-8652-8110"]},"institutions":[{"id":"https://openalex.org/I1321686444","display_name":"Westchester Medical Center","ror":"https://ror.org/03fcgva33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1321686444"]},{"id":"https://openalex.org/I181190671","display_name":"New York Medical College","ror":"https://ror.org/03dkvy735","country_code":"US","type":"education","lineage":["https://openalex.org/I181190671"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julio A. Panza","raw_affiliation_strings":["Division of Cardiology, New York Medical College at Westchester Medical Center, Valhalla, NY"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Cardiology, New York Medical College at Westchester Medical Center, Valhalla, NY","institution_ids":["https://openalex.org/I1321686444","https://openalex.org/I181190671"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5014064578","https://openalex.org/A5064962663"],"corresponding_institution_ids":["https://openalex.org/I1321686444","https://openalex.org/I181190671"],"apc_list":null,"apc_paid":null,"fwci":0.3271,"has_fulltext":false,"cited_by_count":16,"citation_normalized_percentile":{"value":0.37179117,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"26","issue":"5","first_page":"239","last_page":"244"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11922","display_name":"Cardiovascular Effects of Exercise","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertrophic-cardiomyopathy","display_name":"hypertrophic cardiomyopathy","score":1.0},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.9129999876022339},{"id":"https://openalex.org/keywords/beta-blockers","display_name":"beta-blockers","score":0.9580000042915344},{"id":"https://openalex.org/keywords/non-dihydropyridine-calcium-channel-blockers","display_name":"non-dihydropyridine calcium channel blockers","score":0.9710000157356262},{"id":"https://openalex.org/keywords/disopyramide","display_name":"disopyramide","score":0.9980000257492065},{"id":"https://openalex.org/keywords/left-ventricular-hypertrophy","display_name":"left ventricular hypertrophy","score":0.8429999947547913},{"id":"https://openalex.org/keywords/sudden-cardiac-death","display_name":"sudden cardiac death","score":0.9850000143051147},{"id":"https://openalex.org/keywords/heart-failure","display_name":"heart failure","score":0.7269999980926514},{"id":"https://openalex.org/keywords/disease-modifying-therapy","display_name":"disease-modifying therapy","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9520323276519775},{"id":"https://openalex.org/C2780185194","wikidata":"https://www.wikidata.org/wiki/Q1364270","display_name":"Hypertrophic cardiomyopathy","level":2,"score":0.8989681005477905},{"id":"https://openalex.org/C2775935837","wikidata":"https://www.wikidata.org/wiki/Q202837","display_name":"Sudden cardiac death","level":2,"score":0.6248878836631775},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5968561172485352},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5273419618606567},{"id":"https://openalex.org/C2993353509","wikidata":"https://www.wikidata.org/wiki/Q411867","display_name":"Sudden death","level":2,"score":0.5258577466011047},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.5092111825942993},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5004279613494873},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.48184144496917725},{"id":"https://openalex.org/C2778797674","wikidata":"https://www.wikidata.org/wiki/Q847583","display_name":"Cardiomyopathy","level":3,"score":0.47099441289901733},{"id":"https://openalex.org/C133925201","wikidata":"https://www.wikidata.org/wiki/Q188419","display_name":"Life expectancy","level":3,"score":0.47011247277259827},{"id":"https://openalex.org/C163276114","wikidata":"https://www.wikidata.org/wiki/Q484591","display_name":"Natural history","level":2,"score":0.4101274609565735},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.39938080310821533},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.1292639672756195},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000319","descriptor_name":"Adrenergic beta-Antagonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002121","descriptor_name":"Calcium Channel Blockers","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002312","descriptor_name":"Cardiomyopathy, Hypertrophic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/crd.0000000000000211","doi":"https://doi.org/10.1097/crd.0000000000000211","is_oa":false,"landing_page_url":"https://doi.org/10.1097/crd.0000000000000211","pdf_url":null,"source":{"id":"https://openalex.org/S173369630","display_name":"Cardiology in Review","issn_l":"1061-5377","issn":["1061-5377","1538-4683"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology in Review","raw_type":"journal-article"},{"id":"pmid:29746257","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29746257","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiology in review","raw_type":"Journal Article"},{"id":"pmh:oai:touroscholar.touro.edu:nymc_fac_pubs-2098","doi":null,"is_oa":false,"landing_page_url":"https://touroscholar.touro.edu/nymc_fac_pubs/1216","pdf_url":null,"source":{"id":"https://openalex.org/S4377196437","display_name":"Touro Scholar (Touro College)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I200437953","host_organization_name":"Touro College","host_organization_lineage":["https://openalex.org/I200437953"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NYMC Faculty Publications","raw_type":"article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W74597864","https://openalex.org/W1826116083","https://openalex.org/W1966187802","https://openalex.org/W1966978470","https://openalex.org/W1980026492","https://openalex.org/W1987736934","https://openalex.org/W1988984855","https://openalex.org/W1992100033","https://openalex.org/W1995538993","https://openalex.org/W2012099061","https://openalex.org/W2014371939","https://openalex.org/W2019476174","https://openalex.org/W2023743634","https://openalex.org/W2025666521","https://openalex.org/W2026867257","https://openalex.org/W2036779262","https://openalex.org/W2037615332","https://openalex.org/W2038117952","https://openalex.org/W2047697804","https://openalex.org/W2059043314","https://openalex.org/W2089369921","https://openalex.org/W2091736982","https://openalex.org/W2095275131","https://openalex.org/W2096579994","https://openalex.org/W2097618980","https://openalex.org/W2102041759","https://openalex.org/W2122819292","https://openalex.org/W2123322173","https://openalex.org/W2140116078","https://openalex.org/W2142387793","https://openalex.org/W2158480686","https://openalex.org/W2170350762","https://openalex.org/W2202088711","https://openalex.org/W2219899519","https://openalex.org/W2267786650","https://openalex.org/W2277697424","https://openalex.org/W2469018802","https://openalex.org/W2530243005","https://openalex.org/W2547439053","https://openalex.org/W2566825093","https://openalex.org/W2588396622","https://openalex.org/W2593814574","https://openalex.org/W2594034827","https://openalex.org/W2612440973","https://openalex.org/W2738738939","https://openalex.org/W2782604484","https://openalex.org/W2792619404","https://openalex.org/W4246681983"],"related_works":["https://openalex.org/W2152272372","https://openalex.org/W2587204887","https://openalex.org/W4282588425","https://openalex.org/W2899229757","https://openalex.org/W3014391845","https://openalex.org/W4405082390","https://openalex.org/W7162451218","https://openalex.org/W4306294656","https://openalex.org/W4391303865","https://openalex.org/W4411219426"],"abstract_inverted_index":{"Hypertrophic":[0],"cardiomyopathy":[1],"(HCM)":[2],"is":[3,15,29],"an":[4],"inherited":[5],"disease":[6],"characterized":[7],"by":[8],"unexplained":[9],"left":[10],"ventricular":[11],"hypertrophy.":[12],"Although":[13],"it":[14],"estimated":[16],"to":[17,106,126,133],"affect":[18],"1":[19,37],"out":[20],"of":[21,67,78,89,91,113,139,167,171,177],"500":[22],"people,":[23],"the":[24,65,75,86,111,128,135,145,165,178],"HCM":[25,68,123],"gene":[26],"carrier":[27],"prevalence":[28],"much":[30],"more":[31],"common,":[32],"probably":[33],"as":[34,36],"high":[35],"in":[38,64,95,122,164,183],"200":[39],"people.":[40],"Most":[41],"affected":[42],"individuals":[43],"have":[44],"a":[45],"normal":[46],"life":[47],"expectancy,":[48],"whereas":[49],"some":[50],"patients":[51],"may":[52],"develop":[53],"sudden":[54,114],"cardiac":[55,115],"death":[56],"or":[57,109],"end-stage":[58],"heart":[59],"failure.":[60],"Despite":[61],"significant":[62],"developments":[63],"treatment":[66,102,162],"with":[69],"surgical,":[70],"interventional,":[71],"and":[72,93,148,157,159,173],"device-based":[73],"procedures,":[74],"main":[76],"focus":[77,121],"current":[79],"pharmacological":[80,161],"therapy":[81],"has":[82,103,124],"not":[83],"evolved":[84],"from":[85],"basic":[87],"objectives":[88],"relief":[90],"symptoms":[92],"improvement":[94],"functional":[96],"capacity.":[97],"To":[98],"date,":[99],"no":[100],"medical":[101],"been":[104],"shown":[105],"prolong":[107],"survival":[108],"reduce":[110],"risk":[112],"death.":[116],"In":[117],"recent":[118],"decades,":[119],"research":[120],"shifted":[125],"identify":[127],"treatments":[129],"which":[130],"are":[131,181],"able":[132],"alter":[134],"natural":[136],"pathophysiological":[137],"process":[138],"this":[140],"disease.":[141],"This":[142],"article":[143],"reviews":[144],"currently":[146],"recommended":[147],"frequently":[149],"used":[150],"medications":[151],"(beta-blockers,":[152],"nondihydropyridine":[153],"calcium":[154],"channel":[155],"blockers,":[156],"disopyramide)":[158],"emerging":[160],"options":[163],"management":[166],"HCM.":[168],"The":[169],"mechanism":[170],"action":[172],"latest":[174],"clinical":[175],"trials":[176],"novel":[179],"agents":[180],"discussed":[182],"greater":[184],"detail.":[185]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}
