{"id":"https://openalex.org/W2803000933","doi":"https://doi.org/10.3389/fcimb.2018.00119","title":"PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection","display_name":"PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection","publication_year":2018,"publication_date":"2018-04-26","ids":{"openalex":"https://openalex.org/W2803000933","doi":"https://doi.org/10.3389/fcimb.2018.00119","mag":"2803000933","pmid":"https://pubmed.ncbi.nlm.nih.gov/29755959","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5932173"},"language":"en","primary_location":{"id":"doi:10.3389/fcimb.2018.00119","doi":"https://doi.org/10.3389/fcimb.2018.00119","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2018.00119","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fcimb.2018.00119","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072423794","display_name":"Putri Dwi Utari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Putri D. Utari","raw_affiliation_strings":["Department of Chemical and Pharmaceutical Biology, University of Groningen, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Pharmaceutical Biology, University of Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084961817","display_name":"Rita Setroikromo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rita Setroikromo","raw_affiliation_strings":["Department of Chemical and Pharmaceutical Biology, University of Groningen, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Pharmaceutical Biology, University of Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090741922","display_name":"Barbro N. Melgert","orcid":"https://orcid.org/0000-0001-7091-907X","observed_orcids":["https://orcid.org/0000-0001-7091-907X"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Barbro N. Melgert","raw_affiliation_strings":["Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacokinetics, Toxicology and Targeting, University of Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I169381384"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006246608","display_name":"Wim J. Quax","orcid":"https://orcid.org/0000-0002-5162-9947","observed_orcids":["https://orcid.org/0000-0002-5162-9947"]},"institutions":[{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Wim J. Quax","raw_affiliation_strings":["Department of Chemical and Pharmaceutical Biology, University of Groningen, Groningen, Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemical and Pharmaceutical Biology, University of Groningen, Groningen, Netherlands","institution_ids":["https://openalex.org/I169381384"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006246608"],"corresponding_institution_ids":["https://openalex.org/I169381384"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":1.5868,"has_fulltext":true,"cited_by_count":76,"citation_normalized_percentile":{"value":0.83458544,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"8","issue":null,"first_page":"119","last_page":"119"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10873","display_name":"Bacterial Infections and Vaccines","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/quorum-quenching","display_name":"quorum sensing inhibition","score":0.9909999966621399},{"id":"https://openalex.org/keywords/pseudomonas-aeruginosa","display_name":"Pseudomonas aeruginosa","score":0.9869999885559082},{"id":"https://openalex.org/keywords/n-acyl-homoserine-lactones","display_name":"N-acyl homoserine lactones","score":0.9300000071525574},{"id":"https://openalex.org/keywords/cystic-fibrosis","display_name":"cystic fibrosis","score":0.7699999809265137},{"id":"https://openalex.org/keywords/pulmonary-infection","display_name":"pulmonary infection","score":0.9430000185966492},{"id":"https://openalex.org/keywords/intranasal-drug-delivery","display_name":"intranasal drug delivery","score":0.8349999785423279},{"id":"https://openalex.org/keywords/lung-bacterial-load","display_name":"lung bacterial load","score":0.7369999885559082},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/mip-2","display_name":"CXCL2","score":0.9610000252723694},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9739999771118164},{"id":"https://openalex.org/keywords/in-vivo-imaging","display_name":"in vivo imaging","score":0.5149999856948853},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.9177044034004211},{"id":"https://openalex.org/C2908737351","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum Quenching","level":5,"score":0.8881141543388367},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8145554065704346},{"id":"https://openalex.org/C118687296","wikidata":"https://www.wikidata.org/wiki/Q905754","display_name":"Quorum sensing","level":4,"score":0.7950991988182068},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.707809567451477},{"id":"https://openalex.org/C85663871","wikidata":"https://www.wikidata.org/wiki/Q6966562","display_name":"Nasal administration","level":2,"score":0.6270869970321655},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.579623281955719},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5272613763809204},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.4872645139694214},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4559285640716553},{"id":"https://openalex.org/C2776938444","wikidata":"https://www.wikidata.org/wiki/Q178194","display_name":"Cystic fibrosis","level":2,"score":0.42011114954948425},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.245906263589859},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10541859269142151},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000581","descriptor_name":"Amidohydrolases","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011550","descriptor_name":"Pseudomonas aeruginosa","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":true},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D011552","descriptor_name":"Pseudomonas Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D012141","descriptor_name":"Respiratory Tract Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053038","descriptor_name":"Quorum Sensing","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D054426","descriptor_name":"Chemokine CXCL2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054742","descriptor_name":"Acyl-Butyrolactones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058491","descriptor_name":"Bacterial Load","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.3389/fcimb.2018.00119","doi":"https://doi.org/10.3389/fcimb.2018.00119","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2018.00119","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4865804","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5932173","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5932173","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5932173","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Cell Infect Microbiol","raw_type":"Text"},{"id":"pmid:29755959","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29755959","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cellular and infection microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.rug.nl:openaire/3dcd13d7-f3c3-49f1-a43f-3fb3816c8111","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/3dcd13d7-f3c3-49f1-a43f-3fb3816c8111","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Utari, P D, Setroikromo, R, Melgert, B N & Quax, W J 2018, 'PvdQ Quorum Quenching Acylase Attenuates Pseudomonas aeruginosa Virulence in a Mouse Model of Pulmonary Infection', Frontiers in Cellular and Infection Microbiology, vol. 8, 119. https://doi.org/10.3389/fcimb.2018.00119","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:3fdfda6a47bb4b6997645c5d37b9a7f7","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/3fdfda6a47bb4b6997645c5d37b9a7f7","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, Vol 8 (2018)","raw_type":"article"},{"id":"pmh:rug:oai:pure.rug.nl:publications/3dcd13d7-f3c3-49f1-a43f-3fb3816c8111","doi":null,"is_oa":true,"landing_page_url":"https://research.rug.nl/en/publications/3dcd13d7-f3c3-49f1-a43f-3fb3816c8111","pdf_url":null,"source":{"id":"https://openalex.org/S4306400420","display_name":"University of Groningen research database (University of Groningen / Centre for Information Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I169381384","host_organization_name":"University of Groningen","host_organization_lineage":["https://openalex.org/I169381384"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cellular and Infection Microbiology, 8:119. Frontiers Media SA","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3389/fcimb.2018.00119","doi":"https://doi.org/10.3389/fcimb.2018.00119","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcimb.2018.00119","pdf_url":null,"source":{"id":"https://openalex.org/S2506667490","display_name":"Frontiers in Cellular and Infection Microbiology","issn_l":"2235-2988","issn":["2235-2988"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cellular and Infection Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7314052423","display_name":"Local Training Network on Novel Tailor-Made Antimicrobials and Delivery Strategies  From Synthesis towards Clinical Applications","funder_award_id":"713482","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335079","display_name":"Direktorat Jenderal Pendidikan Tinggi","ror":"https://ror.org/03sxt1c89"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1502461125","https://openalex.org/W1567514429","https://openalex.org/W1964029112","https://openalex.org/W1965088110","https://openalex.org/W1966829335","https://openalex.org/W1968252808","https://openalex.org/W1971067296","https://openalex.org/W1984693521","https://openalex.org/W1989318771","https://openalex.org/W1992145969","https://openalex.org/W1998002492","https://openalex.org/W2001587323","https://openalex.org/W2001661651","https://openalex.org/W2008119892","https://openalex.org/W2011681082","https://openalex.org/W2012945509","https://openalex.org/W2038461753","https://openalex.org/W2050904158","https://openalex.org/W2052037332","https://openalex.org/W2055907915","https://openalex.org/W2061520106","https://openalex.org/W2068217903","https://openalex.org/W2070596988","https://openalex.org/W2070717977","https://openalex.org/W2075003434","https://openalex.org/W2081202846","https://openalex.org/W2083761792","https://openalex.org/W2085360512","https://openalex.org/W2090807021","https://openalex.org/W2092550686","https://openalex.org/W2099944423","https://openalex.org/W2104462602","https://openalex.org/W2108808146","https://openalex.org/W2113061812","https://openalex.org/W2113509617","https://openalex.org/W2114671816","https://openalex.org/W2118023881","https://openalex.org/W2119410664","https://openalex.org/W2130980780","https://openalex.org/W2134033963","https://openalex.org/W2134277349","https://openalex.org/W2134596993","https://openalex.org/W2135782606","https://openalex.org/W2142963330","https://openalex.org/W2143907723","https://openalex.org/W2150417163","https://openalex.org/W2150691479","https://openalex.org/W2150741646","https://openalex.org/W2151674541","https://openalex.org/W2159472714","https://openalex.org/W2162427999","https://openalex.org/W2162986002","https://openalex.org/W2168755417","https://openalex.org/W2169124488","https://openalex.org/W2171941826","https://openalex.org/W2404663361","https://openalex.org/W2420333453","https://openalex.org/W2511941815","https://openalex.org/W2547278095","https://openalex.org/W2916279557"],"related_works":["https://openalex.org/W2169124488","https://openalex.org/W2740259723","https://openalex.org/W7223303222","https://openalex.org/W7100600800","https://openalex.org/W7099840542","https://openalex.org/W7164153398","https://openalex.org/W2332923331","https://openalex.org/W2901109605","https://openalex.org/W7221191947","https://openalex.org/W2071959590"],"abstract_inverted_index":{"Pseudomonas":[0],"aeruginosa":[1,34,102,113,139,212,238,275],"is":[2,121],"the":[3,18,29,38,45,55,71,118,124,144,183,231],"predominant":[4],"pathogen":[5],"in":[6,28,54,62,100,103,106,132,153,162,173,218,244],"pulmonary":[7,137,159,213,239],"infections":[8],"associated":[9],"with":[10,177,207],"cystic":[11],"fibrosis.":[12],"Quorum":[13,60],"sensing":[14],"(QS)":[15],"systems":[16],"regulate":[17],"production":[19],"of":[20,31,37,57,73,111,117,127,136,147,158,182,222,230,253,265],"virulence":[21],"factors":[22],"and":[23,105,193,215,226,255],"play":[24],"an":[25,51],"important":[26],"role":[27],"establishment":[30],"successful":[32],"P.":[33,101,112,138,211,237,274],"infections.":[35],"Inhibition":[36],"QS":[39,99],"system":[40],"(termed":[41],"quorum":[42,270],"quenching)":[43],"renders":[44],"bacteria":[46,65],"avirulent":[47],"thus":[48],"serving":[49],"as":[50,248,250,268],"alternative":[52],"approach":[53],"development":[56],"novel":[58],"antibiotics.":[59],"quenching":[61,271],"Gram":[63],"negative":[64],"can":[66],"be":[67,171],"achieved":[68],"by":[69,85,161],"preventing":[70],"accumulation":[72],"N-acyl":[74],"homoserine":[75],"lactone":[76],"(AHL)":[77],"signaling":[78,94],"molecule":[79],"via":[80],"enzymatic":[81],"degradation.":[82],"Previous":[83],"work":[84],"us":[86],"has":[87,261],"shown":[88,262],"that":[89,216],"PvdQ":[90,130,151,208,241,266],"acylase":[91,131,267],"hydrolyzes":[92],"AHL":[93],"molecules":[95],"irreversibly,":[96],"thereby":[97],"inhibiting":[98],"vitro":[104],"a":[107,133,219,227,235,269],"Caenorhabditis":[108],"elegans":[109],"model":[110,135],"infection.":[114,140,276],"The":[115],"aim":[116],"present":[119],"study":[120,260],"to":[122],"assess":[123],"therapeutic":[125,263],"efficacy":[126,264],"intranasally":[128,148],"instilled":[129],"mouse":[134],"First":[141],"we":[142],"evaluated":[143],"deposition":[145],"pattern":[146],"administered":[149],"fluorochrome-tagged":[150],"(PvdQ-VT)":[152],"mice":[154,206],"at":[155,188,198],"different":[156],"stages":[157],"infection":[160,214],"vivo":[163],"imaging":[164],"studies.":[165],"Following":[166],"intranasal":[167],"instillation,":[168],"PvdQ-VT":[169],"could":[170],"traced":[172],"all":[174],"lung":[175,223,246],"lobes":[176],"42":[178],"\u00b1":[179,195],"7.5":[180],"%":[181,197],"delivered":[184],"dose":[185],"being":[186],"deposited":[187],"0":[189],"hour":[190],"post":[191,201],"bacterial-infection,":[192],"34":[194],"5.2":[196],"72":[199],"hours":[200],"bacterial-infection.":[202],"We":[203],"then":[204],"treated":[205],"during":[209,273],"lethal":[210],"resulted":[217,243],"five-fold":[220],"reduction":[221],"bacterial":[224],"load":[225],"prolonged":[228],"survival":[229],"infected":[232],"animals.":[233],"In":[234,257],"sublethal":[236],"infection,":[240],"treatment":[242],"less":[245],"inflammation":[247],"well":[249],"lower":[251],"levels":[252],"CXCL2":[254],"TNF-\u03b1.":[256],"conclusion,":[258],"our":[259],"agent":[272]},"counts_by_year":[{"year":2026,"cited_by_count":13},{"year":2025,"cited_by_count":13},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}