{"id":"https://openalex.org/W2802995684","doi":"https://doi.org/10.1093/annonc/mdy136","title":"ARTE and craft of bevacizumab in elderly patients with glioblastoma","display_name":"ARTE and craft of bevacizumab in elderly patients with glioblastoma","publication_year":2018,"publication_date":"2018-04-19","ids":{"openalex":"https://openalex.org/W2802995684","doi":"https://doi.org/10.1093/annonc/mdy136","mag":"2802995684","pmid":"https://pubmed.ncbi.nlm.nih.gov/29897386"},"language":"en","primary_location":{"id":"doi:10.1093/annonc/mdy136","doi":"https://doi.org/10.1093/annonc/mdy136","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy136","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"volume":null,"type":"editorial","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/annonc/mdy136","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023905352","display_name":"David Schiff","orcid":"https://orcid.org/0000-0002-1896-2502","observed_orcids":["https://orcid.org/0000-0002-1896-2502","https://orcid.org/0000-0003-1561-9220"]},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"D. Schiff","raw_affiliation_strings":["Department of Neurology, University of Virginia Neuro-Oncology Center, Charlottesville, USA. Electronic address: davidschiff@virginia.edu","Department of Neurology, University of Virginia Neuro-Oncology Center, Charlottesville, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Virginia Neuro-Oncology Center, Charlottesville, USA. Electronic address: davidschiff@virginia.edu","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Neurology, University of Virginia Neuro-Oncology Center, Charlottesville, USA","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5023905352"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":5080,"currency":"USD","value_usd":5080},"apc_paid":{"value":5080,"currency":"USD","value_usd":5080},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"6","first_page":"1346","last_page":"1347"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9359999895095825},{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":0.9779999852180481},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.9980000257492065},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.5559999942779541},{"id":"https://openalex.org/keywords/temozolomide","display_name":"temozolomide","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mgmt-promoter-methylation","display_name":"MGMT promoter methylation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6620000004768372},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7760000228881836},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9648343324661255},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.9050253629684448},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.7982797026634216},{"id":"https://openalex.org/C2779732396","wikidata":"https://www.wikidata.org/wiki/Q2207288","display_name":"Craft","level":2,"score":0.7721652984619141},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4268835783004761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.36461716890335083},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1680339276790619},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.12356624007225037},{"id":"https://openalex.org/C153349607","wikidata":"https://www.wikidata.org/wiki/Q36649","display_name":"Visual arts","level":1,"score":0.048693329095840454},{"id":"https://openalex.org/C142362112","wikidata":"https://www.wikidata.org/wiki/Q735","display_name":"Art","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/annonc/mdy136","doi":"https://doi.org/10.1093/annonc/mdy136","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy136","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},{"id":"pmid:29897386","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29897386","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of oncology : official journal of the European Society for Medical Oncology","raw_type":"Editorial"}],"best_oa_location":{"id":"doi:10.1093/annonc/mdy136","doi":"https://doi.org/10.1093/annonc/mdy136","is_oa":true,"landing_page_url":"https://doi.org/10.1093/annonc/mdy136","pdf_url":null,"source":{"id":"https://openalex.org/S41454044","display_name":"Annals of Oncology","issn_l":"0923-7534","issn":["0923-7534","1569-8041"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.979200005531311}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2096287682","https://openalex.org/W2105100844","https://openalex.org/W2107731988","https://openalex.org/W2124736921","https://openalex.org/W2132697290","https://openalex.org/W2133616597","https://openalex.org/W2154526619","https://openalex.org/W2156330848","https://openalex.org/W2162605078","https://openalex.org/W2167923186","https://openalex.org/W2307494918","https://openalex.org/W2599750069","https://openalex.org/W2768388636","https://openalex.org/W2789544556","https://openalex.org/W2792450213","https://openalex.org/W2797840381"],"related_works":["https://openalex.org/W2418309668","https://openalex.org/W2092378102","https://openalex.org/W2109868410","https://openalex.org/W2064135779","https://openalex.org/W2766677970","https://openalex.org/W2620195645","https://openalex.org/W2118049264","https://openalex.org/W2039840451","https://openalex.org/W3029609210","https://openalex.org/W4389262045"],"abstract_inverted_index":{"Glioblastoma":[0],"is":[1,13,29],"a":[2,30],"disease":[3],"strongly":[4],"associated":[5],"with":[6,16],"aging;":[7],"the":[8,36,42],"median":[9],"age":[10,28],"at":[11],"diagnosis":[12],"64":[14],"years,":[15],"peak":[17],"incidence":[18],"between":[19],"75":[20],"and":[21,85],"84":[22],"years":[23,84],"(CBTRUS":[24],"2013).":[25],"Moreover,":[26,71],"advancing":[27],"powerful":[31],"adverse":[32],"prognostic":[33],"factor.":[34],"While":[35],"\u2018Stupp\u2019":[37],"EORTC-NCIC":[38],"study":[39,64],"found":[40],"that":[41],"addition":[43],"of":[44],"temozolomide":[45,78],"to":[46],"radiation":[47],"improved":[48],"overall":[49],"survival":[50],"(OS)":[51],"[1],":[52],"particularly":[53],"in":[54,79],"patients":[55,66,80],"whose":[56],"tumors":[57],"had":[58],"MGMT":[59],"promoter":[60],"methylation":[61],"[2],":[62],"this":[63],"excluded":[65],"older":[67,81],"than":[68,82],"70":[69],"years.":[70,88],"subgroup":[72],"analysis":[73],"showed":[74],"marginal":[75],"benefit":[76],"from":[77],"60":[83],"especially":[86],"65":[87]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}
