{"id":"https://openalex.org/W2802854435","doi":"https://doi.org/10.1186/s40170-018-0176-5","title":"Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state","display_name":"Elevated circulatory levels of leptin and resistin impair therapeutic efficacy of dacarbazine in melanoma under obese state","publication_year":2018,"publication_date":"2018-03-08","ids":{"openalex":"https://openalex.org/W2802854435","doi":"https://doi.org/10.1186/s40170-018-0176-5","mag":"2802854435","pmid":"https://pubmed.ncbi.nlm.nih.gov/29568521","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5859707"},"language":"en","primary_location":{"id":"doi:10.1186/s40170-018-0176-5","doi":"https://doi.org/10.1186/s40170-018-0176-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40170-018-0176-5","pdf_url":"https://cancerandmetabolism.biomedcentral.com/counter/pdf/10.1186/s40170-018-0176-5","source":{"id":"https://openalex.org/S2764743094","display_name":"Cancer & Metabolism","issn_l":"2049-3002","issn":["2049-3002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer & Metabolism","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cancerandmetabolism.biomedcentral.com/counter/pdf/10.1186/s40170-018-0176-5","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034724363","display_name":"Parmanand Malvi","orcid":"https://orcid.org/0000-0003-4101-5025","observed_orcids":["https://orcid.org/0000-0003-4101-5025"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Parmanand Malvi","raw_affiliation_strings":["National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India","institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039492061","display_name":"Balkrishna Chaube","orcid":"https://orcid.org/0000-0003-4378-7416","observed_orcids":["https://orcid.org/0000-0003-4378-7416"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Balkrishna Chaube","raw_affiliation_strings":["National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India","institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029866856","display_name":"Shivendra Vikram Singh","orcid":"https://orcid.org/0000-0002-4153-8056","observed_orcids":["https://orcid.org/0000-0002-4153-8056"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shivendra Vikram Singh","raw_affiliation_strings":["National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India","institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109235969","display_name":"Naoshad Mohammad","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Naoshad Mohammad","raw_affiliation_strings":["National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India","institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045643967","display_name":"Maleppillil Vavachan Vijayakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Maleppillil Vavachan Vijayakumar","raw_affiliation_strings":["National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India","institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103208824","display_name":"Snahlata Singh","orcid":"https://orcid.org/0000-0002-9998-274X","observed_orcids":["https://orcid.org/0000-0002-9998-274X"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Snahlata Singh","raw_affiliation_strings":["National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India","institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045009507","display_name":"Surbhi Chouhan","orcid":"https://orcid.org/0000-0001-6055-525X","observed_orcids":["https://orcid.org/0000-0001-6055-525X"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Surbhi Chouhan","raw_affiliation_strings":["National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India","institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063424506","display_name":"Manoj Kumar Bhat","orcid":"https://orcid.org/0000-0002-0397-5028","observed_orcids":["https://orcid.org/0000-0002-0397-5028"]},"institutions":[{"id":"https://openalex.org/I4210104670","display_name":"National Centre for Cell Science","ror":"https://ror.org/01bp81r18","country_code":"IN","type":"facility","lineage":["https://openalex.org/I2799351866","https://openalex.org/I4210104670","https://openalex.org/I4210134808"]},{"id":"https://openalex.org/I878213199","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731","country_code":"IN","type":"education","lineage":["https://openalex.org/I878213199"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manoj Kumar Bhat","raw_affiliation_strings":["National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Cell Science, Savitribai Phule Pune University Campus, Ganeshkhind, Pune, 411 007, India","institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5063424506"],"corresponding_institution_ids":["https://openalex.org/I4210104670","https://openalex.org/I878213199"],"apc_list":{"value":3190,"currency":"USD","value_usd":3190},"apc_paid":{"value":3190,"currency":"USD","value_usd":3190},"fwci":6.3808,"has_fulltext":true,"cited_by_count":65,"citation_normalized_percentile":{"value":0.97676994,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"6","issue":"1","first_page":"2","last_page":"2"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.48539999127388,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12465","display_name":"Cancer, Lipids, and Metabolism","score":0.3716000020503998,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.011500000022351742,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leptin","display_name":"leptin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/resistin","display_name":"resistin","score":1.0},{"id":"https://openalex.org/keywords/adipokines","display_name":"adipokines","score":0.9229999780654907},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.8560000061988831},{"id":"https://openalex.org/keywords/dacarbazine","display_name":"dacarbazine","score":0.921999990940094},{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.8500000238418579},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7329999804496765},{"id":"https://openalex.org/keywords/fatty-acid-synthase","display_name":"fatty acid synthase","score":0.9330000281333923},{"id":"https://openalex.org/keywords/caveolin-1","display_name":"caveolin-1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.859000027179718},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/melanoma-cell-proliferation","display_name":"melanoma cell proliferation","score":0.7599999904632568},{"id":"https://openalex.org/keywords/ob-ob-mice","display_name":"ob/ob mice","score":0.6930000185966492},{"id":"https://openalex.org/keywords/db-db-mice","display_name":"db/db mice","score":0.996999979019165}],"concepts":[{"id":"https://openalex.org/C2779760629","wikidata":"https://www.wikidata.org/wiki/Q419499","display_name":"Resistin","level":5,"score":0.9500384330749512},{"id":"https://openalex.org/C194832188","wikidata":"https://www.wikidata.org/wiki/Q2638593","display_name":"Adipokine","level":4,"score":0.8805242776870728},{"id":"https://openalex.org/C2780613262","wikidata":"https://www.wikidata.org/wiki/Q223739","display_name":"Leptin","level":3,"score":0.8805065155029297},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.775483250617981},{"id":"https://openalex.org/C2780964509","wikidata":"https://www.wikidata.org/wiki/Q416975","display_name":"Dacarbazine","level":3,"score":0.7638042569160461},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7409545183181763},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5690721869468689},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5174204111099243},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4735005497932434},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.348981112241745},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.2582295536994934}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s40170-018-0176-5","doi":"https://doi.org/10.1186/s40170-018-0176-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40170-018-0176-5","pdf_url":"https://cancerandmetabolism.biomedcentral.com/counter/pdf/10.1186/s40170-018-0176-5","source":{"id":"https://openalex.org/S2764743094","display_name":"Cancer & Metabolism","issn_l":"2049-3002","issn":["2049-3002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer & Metabolism","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5859707","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5859707","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Metab","raw_type":"Text"},{"id":"pmid:29568521","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29568521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer & metabolism","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:74b9d291729a4a0b805903865eb5c703","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/74b9d291729a4a0b805903865eb5c703","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer & Metabolism, Vol 6, Iss 1, Pp 1-14 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s40170-018-0176-5","doi":"https://doi.org/10.1186/s40170-018-0176-5","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s40170-018-0176-5","pdf_url":"https://cancerandmetabolism.biomedcentral.com/counter/pdf/10.1186/s40170-018-0176-5","source":{"id":"https://openalex.org/S2764743094","display_name":"Cancer & Metabolism","issn_l":"2049-3002","issn":["2049-3002"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer & Metabolism","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G138090644","display_name":null,"funder_award_id":"/2012","funder_id":"https://openalex.org/F4320320767","funder_display_name":"University Grants Commission"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320721","display_name":"Council of Scientific and Industrial Research, India","ror":"https://ror.org/021wm7p51"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"},{"id":"https://openalex.org/F4320326590","display_name":"Savitribai Phule Pune University","ror":"https://ror.org/044g6d731"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2802854435.pdf","grobid_xml":"https://content.openalex.org/works/W2802854435.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1501481238","https://openalex.org/W1511552490","https://openalex.org/W1549121304","https://openalex.org/W1970142642","https://openalex.org/W1971548442","https://openalex.org/W1986234170","https://openalex.org/W1986986419","https://openalex.org/W1988675578","https://openalex.org/W1995744351","https://openalex.org/W2007459290","https://openalex.org/W2007518082","https://openalex.org/W2007626857","https://openalex.org/W2011062870","https://openalex.org/W2016897496","https://openalex.org/W2024717992","https://openalex.org/W2030206404","https://openalex.org/W2030778616","https://openalex.org/W2034825007","https://openalex.org/W2043741624","https://openalex.org/W2047487133","https://openalex.org/W2050769549","https://openalex.org/W2050939102","https://openalex.org/W2060902443","https://openalex.org/W2061836474","https://openalex.org/W2064464068","https://openalex.org/W2069570377","https://openalex.org/W2077140502","https://openalex.org/W2082151578","https://openalex.org/W2088120315","https://openalex.org/W2088823185","https://openalex.org/W2102150058","https://openalex.org/W2129845763","https://openalex.org/W2130156594","https://openalex.org/W2130495917","https://openalex.org/W2133439754","https://openalex.org/W2135135919","https://openalex.org/W2138623655","https://openalex.org/W2144219438","https://openalex.org/W2148734345","https://openalex.org/W2152913697","https://openalex.org/W2157060294","https://openalex.org/W2157241733","https://openalex.org/W2162423163","https://openalex.org/W2165087937","https://openalex.org/W2165604976","https://openalex.org/W2223576924","https://openalex.org/W2264691042","https://openalex.org/W2267744930","https://openalex.org/W2508925283","https://openalex.org/W2560546601","https://openalex.org/W2573612572","https://openalex.org/W2596721541","https://openalex.org/W2601031765","https://openalex.org/W3148261934"],"related_works":["https://openalex.org/W6977479239","https://openalex.org/W2560546601","https://openalex.org/W2061836474","https://openalex.org/W1996489505","https://openalex.org/W2792284123","https://openalex.org/W6921107979","https://openalex.org/W2157241733","https://openalex.org/W3032765754","https://openalex.org/W1546431946","https://openalex.org/W7137098702"],"abstract_inverted_index":{"BACKGROUND:":[0],"Obesity":[1],"is":[2,48],"associated":[3],"with":[4],"increased":[5],"risk,":[6],"poor":[7],"prognosis":[8],"and":[9,22,31,43,54,69,114,118,128,149,164,181,199,212,217],"outcome":[10,73,120,222],"of":[11,33,67,74,110,121,134,146,159,186,193,209,223],"therapy,":[12],"in":[13,46,60,78,81,88,95,116,124,141,155,172,214,220],"various":[14],"cancers.":[15],"Obesity-associated":[16],"factors":[17],"or":[18],"adipokines,":[19],"especially":[20],"leptin":[21,68,113,127,180],"resistin,":[23],"are":[24,139],"purported":[25],"to":[26,63,86,189],"promote":[27],"growth,":[28],"survival,":[29],"proliferation,":[30],"invasiveness":[32],"cancer":[34],"cells.":[35,174],"However,":[36],"the":[37,65,72,96,100,108,119,143,156,184,207,221],"mechanistic":[38],"link":[39],"between":[40],"these":[41],"adipokines":[42,112,210],"therapeutic":[44,144],"response":[45,185],"malignancies":[47],"not":[49,130],"clearly":[50],"understood.":[51],"METHODS:":[52],"ob/ob":[53],"db/db":[55],"mouse":[56],"models":[57],"were":[58,84],"used":[59],"this":[61],"study":[62],"evaluate":[64],"role":[66,109],"resistin":[70,115,129,150,182],"towards":[71],"dacarbazine":[75],"(DTIC)":[76],"therapy":[77,123],"melanoma.":[79,125],"Unique":[80],"vitro":[82],"approaches":[83],"employed":[85],"complement":[87],"vivo":[89],"findings":[90,205],"by":[91],"culturing":[92],"melanoma":[93,135,187,215],"cells":[94,136,188],"serum":[97],"collected":[98],"from":[99],"experimental":[101],"mice.":[102],"RESULTS:":[103],"Here,":[104],"we":[105],"have":[106],"shown":[107],"important":[111],"growth":[117],"DTIC":[122,190,224],"Both":[126],"only":[131],"enhance":[132],"proliferation":[133],"but":[137],"also":[138],"involved":[140],"impairing":[142],"efficacy":[145],"DTIC.":[147],"Leptin":[148],"treatment":[151],"caused":[152],"an":[153],"increase":[154],"protein":[157,196],"levels":[158],"fatty":[160],"acid":[161],"synthase":[162],"(FASN)":[163],"caveolin":[165],"1":[166],"(Cav-1)":[167],"respectively,":[168],"through":[169],"their":[170],"stabilization":[171],"A375":[173],"Further,":[175],"it":[176],"was":[177],"observed":[178],"that":[179],"impaired":[183],"via":[191],"upregulation":[192],"heat":[194],"shock":[195],"90":[197],"(Hsp90)":[198],"P-glycoprotein":[200],"(P-gp)":[201],"respectively.":[202],"CONCLUSION:":[203],"These":[204],"unraveled":[206],"involvement":[208],"(leptin":[211],"resistin)":[213],"progression,":[216],"more":[218],"importantly,":[219],"therapy.":[225]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":20},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-05-17T00:00:00"}