{"id":"https://openalex.org/W2802739878","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.512","title":"Analyzing the efficacy and safety of immunotherapy in pancreatic ductal adenocarcinoma (PDA): A systematic review and meta-analysis.","display_name":"Analyzing the efficacy and safety of immunotherapy in pancreatic ductal adenocarcinoma (PDA): A systematic review and meta-analysis.","publication_year":2018,"publication_date":"2018-02-01","ids":{"openalex":"https://openalex.org/W2802739878","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.512","mag":"2802739878"},"language":"en","primary_location":{"id":"doi:10.1200/jco.2018.36.4_suppl.512","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.512","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.4_suppl.512","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059022515","display_name":"Hani M. Babiker","orcid":"https://orcid.org/0000-0002-9368-6296","observed_orcids":["https://orcid.org/0000-0002-9368-6296"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hani M. Babiker","raw_affiliation_strings":["University of Arizona Cancer Center, Tucson, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Cancer Center, Tucson, AZ;","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111749861","display_name":"Umar Zahid","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Umar Zahid","raw_affiliation_strings":["University of Arizona College of Medicine, Tucson, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona College of Medicine, Tucson, AZ;","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087838202","display_name":"Carol L. Howe","orcid":"https://orcid.org/0000-0002-7911-4160","observed_orcids":["https://orcid.org/0000-0002-7911-4160"]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol L. Howe","raw_affiliation_strings":["University of Arizona College of Medicine/ Arizona Health Science Center Library, Tucson, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona College of Medicine/ Arizona Health Science Center Library, Tucson, AZ;","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025510544","display_name":"Aaron James Scott","orcid":"https://orcid.org/0000-0002-0301-3072","observed_orcids":["https://orcid.org/0000-0002-0301-3072"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron James Scott","raw_affiliation_strings":["University of Arizona Cancer Center, Tucson, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Cancer Center, Tucson, AZ;","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018306647","display_name":"Irbaz Bin Riaz","orcid":"https://orcid.org/0000-0003-4249-0311","observed_orcids":["https://orcid.org/0000-0003-4249-0311"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irbaz Bin Riaz","raw_affiliation_strings":["Mayo Clinic, Rochester, MN;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Mayo Clinic, Rochester, MN;","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079703497","display_name":"Cynthia M Elliott","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I138006243","display_name":"University of Arizona","ror":"https://ror.org/03m2x1q45","country_code":"US","type":"education","lineage":["https://openalex.org/I138006243"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia M Elliott","raw_affiliation_strings":["University of Arizona College of Medicine, Tucson, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona College of Medicine, Tucson, AZ;","institution_ids":["https://openalex.org/I138006243"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050428325","display_name":"Utkarsh H. Acharya","orcid":"https://orcid.org/0000-0002-5920-2796","observed_orcids":["https://orcid.org/0000-0002-5920-2796"]},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Utkarsh H Acharya","raw_affiliation_strings":["Fred Hutchinson Cancer Research Center/ University of Washington, Seattle, WA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fred Hutchinson Cancer Research Center/ University of Washington, Seattle, WA;","institution_ids":["https://openalex.org/I201448701","https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027681156","display_name":"Alejandro Recio Boiles","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alejandro Recio Boiles","raw_affiliation_strings":["University of Arizona Cancer Center, Tucson, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Cancer Center, Tucson, AZ;","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074705508","display_name":"Emad Elquza","orcid":"https://orcid.org/0000-0003-3383-7950","observed_orcids":["https://orcid.org/0000-0003-3383-7950"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emad Elquza","raw_affiliation_strings":["University of Arizona Cancer Center, Tucson, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Cancer Center, Tucson, AZ;","institution_ids":["https://openalex.org/I4390039223"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101638085","display_name":"Daruka Mahadevan","orcid":"https://orcid.org/0000-0002-7129-5593","observed_orcids":["https://orcid.org/0000-0002-7129-5593"]},"institutions":[{"id":"https://openalex.org/I4390039223","display_name":"University of Arizona Cancer Center","ror":"https://ror.org/04tvx8690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039223"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daruka Mahadevan","raw_affiliation_strings":["University of Arizona Cancer Center, Tucson, AZ;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arizona Cancer Center, Tucson, AZ;","institution_ids":["https://openalex.org/I4390039223"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"36","issue":"4_suppl","first_page":"512","last_page":"512"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"immunotherapy","score":0.7990000247955322},{"id":"https://openalex.org/keywords/cytokine-therapy","display_name":"cytokine therapy","score":0.6420000195503235},{"id":"https://openalex.org/keywords/peptide-vaccine","display_name":"peptide vaccine","score":0.9559999704360962},{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.8769999742507935},{"id":"https://openalex.org/keywords/oncolytic-viruses","display_name":"oncolytic viruses","score":0.9919999837875366},{"id":"https://openalex.org/keywords/ctla-4-inhibitors","display_name":"CTLA-4 inhibitors","score":0.9919999837875366},{"id":"https://openalex.org/keywords/adjuvant-immunotherapy","display_name":"adjuvant immunotherapy","score":0.6850000023841858},{"id":"https://openalex.org/keywords/neoadjuvant-immunotherapy","display_name":"neoadjuvant immunotherapy","score":0.9980000257492065},{"id":"https://openalex.org/keywords/metastatic-pancreatic-cancer","display_name":"metastatic pancreatic cancer","score":0.8579999804496765},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.7360000014305115},{"id":"https://openalex.org/keywords/disease-control-rate","display_name":"disease control rate","score":0.8740000128746033},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.8709999918937683},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.5299999713897705},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7620000243186951},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.7799999713897705},{"id":"https://openalex.org/keywords/exhausted-t-cells","display_name":"exhausted T cells","score":0.7870000004768372}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8741682767868042},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5996158719062805},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5970371961593628},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5519030094146729},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.47304123640060425},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.44821256399154663},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.44546735286712646},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.44405925273895264},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2042963206768036}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1200/jco.2018.36.4_suppl.512","doi":"https://doi.org/10.1200/jco.2018.36.4_suppl.512","is_oa":false,"landing_page_url":"https://doi.org/10.1200/jco.2018.36.4_suppl.512","pdf_url":null,"source":{"id":"https://openalex.org/S15137598","display_name":"Journal of Clinical Oncology","issn_l":"0732-183X","issn":["0732-183X","1527-7755"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Oncology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7009239436","https://openalex.org/W7148718719","https://openalex.org/W3033066628","https://openalex.org/W2193001619","https://openalex.org/W7162682462","https://openalex.org/W4311994955","https://openalex.org/W4385577611","https://openalex.org/W3193597618","https://openalex.org/W2923685537","https://openalex.org/W2207015643"],"abstract_inverted_index":{"512":[0],"Background:":[1],"The":[2,159,259,279],"tumor":[3,33],"microenvironment":[4],"in":[5,31,37,47,81,221,249,309,326],"PDA":[6,38],"is":[7],"heterogeneous":[8],"and":[9,18,59,86,104,118,140,169,181,196,218,233,274,288,290,295,329],"immunosuppressive":[10],"given":[11],"the":[12,24,35,65,82,132,153,310],"presence":[13],"of":[14,26,45,74,156,229,239,261,312],"regulatory":[15],"T":[16,21],"cells":[17],"exhausted":[19],"effector":[20],"cells.":[22],"Despite":[23],"upsurge":[25],"effective":[27],"immunotherapeutic":[28],"agents":[29],"(IA)":[30],"other":[32],"types,":[34],"role":[36],"remains":[39],"unknown.":[40],"We":[41,127],"conducted":[42],"a":[43,72,100,224,234,316],"meta-analysis":[44],"IA":[46,78,200,220,252,305],"PDA.":[48],"Methods:":[49],"Following":[50],"PRISMA":[51],"guidelines,":[52],"we":[53],"searched":[54],"PubMed/MEDLINE,":[55],"Elsevier/Embase,":[56],"Wiley/Cochrane":[57],"Library":[58],"ClinicalTrials.gov.":[60],"Articles":[61],"were":[62,90,97,106,121,138,142,150,165,198,284,292],"selected":[63],"per":[64],"following":[66],"criteria:":[67],"(1)":[68],"Study":[69],"participants":[70],"had":[71,223],"diagnosis":[73],"PDA;":[75],"(2)":[76],"An":[77],"was":[79,192,245,264],"used":[80,122],"trial.":[83],"Titles,":[84],"abstracts":[85,167],"full":[87,154],"text":[88,155],"articles":[89],"reviewed":[91],"by":[92,99,108],"2":[93],"independent":[94,110],"reviewers;":[95],"disagreements":[96],"resolved":[98],"third.":[101],"Data":[102],"extraction":[103],"analysis":[105],"performed":[107],"3":[109,182],"reviewers.":[111],"Descriptive":[112],"analysis,":[113],"mean,":[114],"median,":[115],"confidence":[116],"interval":[117],"forest":[119],"plots":[120],"for":[123,163,187,277],"statistical":[124,247],"analysis.":[125,189],"Results:":[126],"found":[128],"20,792":[129],"studies":[130],"through":[131],"database,":[133],"16,105":[134],"remained":[135],"after":[136],"duplicates":[137],"removed":[139],"15,889":[141],"excluded":[143],"due":[144,300],"to":[145,152,269,301],"irrelevance.":[146],"Strict":[147],"inclusion":[148],"criteria":[149,186],"applied":[151],"216":[157],"articles.":[158],"most":[160,280],"common":[161,281],"reason":[162],"exclusion":[164],"conference":[166],"(44%)":[168],"ongoing":[170],"trials":[171,174,263],"(16%).":[172],"Fifty-four":[173],"(39":[175],"metastatic":[176],"(met),":[177],"12":[178],"adjuvant":[179],"(Ad)":[180],"neoadjuvant":[183],"(nAd)":[184],"met":[185],"further":[188],"Age":[190],"range":[191],"27-86":[193],"(median":[194],"61)":[195],"52.3%":[197],"males.":[199],"included":[201],"cytokine":[202],"therapy":[203],"(33%),":[204],"peptide":[205],"vaccines":[206],"(22%),":[207],"dendritic":[208],"cell":[209],"vaccine":[210],"(13%),":[211],"oncolytic":[212],"viruses":[213],"(9%),":[214],"CTLA-4":[215],"inhibitors":[216],"(2%)":[217],"others.":[219],"met-PDA":[222,313],"median":[225],"overall":[226],"survival":[227],"(mOS)":[228],"8.1":[230],"months":[231],"(ms)":[232],"disease":[235],"control":[236],"rate":[237],"(DCR)":[238],"55.4%":[240],"(95%":[241],"CI,":[242],"51.85-58.95).":[243],"There":[244],"no":[246],"difference":[248],"DCR":[250],"among":[251],"subtypes":[253],"(range":[254],"49-60%)":[255],"(p":[256],"=":[257,272],"0.22).":[258],"mOS":[260],"Ad-PDA":[262],"25":[265],"ms":[266,276],"(historically":[267],"comparable":[268],"gemcitabine,":[270],"p":[271],"0.75)":[273],"18":[275],"nAd-PDA.":[278],"Gr1/2":[282],"toxicities":[283],"skin":[285],"reactions,":[286],"fever,":[287],"chills":[289],"Gr3/4":[291],"cytopenias,":[293],"diarrhea,":[294],"mucositis.":[296],"One":[297],"death":[298],"occurred":[299],"neutropenic":[302],"sepsis.":[303],"Conclusions:":[304],"demonstrates":[306],"modest":[307],"efficacy":[308],"treatment":[311],"albeit":[314],"exhibits":[315],"favorable":[317],"toxicity":[318],"profile.":[319],"Many":[320],"trial":[321],"results":[322],"are":[323,331],"available":[324],"only":[325],"abstract":[327],"format":[328],"some":[330],"ongoing.":[332]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2018-05-17T00:00:00"}
