{"id":"https://openalex.org/W2802729619","doi":"https://doi.org/10.1111/1756-185x.13311","title":"Systemic sclerosis and malignancy","display_name":"Systemic sclerosis and malignancy","publication_year":2018,"publication_date":"2018-04-19","ids":{"openalex":"https://openalex.org/W2802729619","doi":"https://doi.org/10.1111/1756-185x.13311","mag":"2802729619","pmid":"https://pubmed.ncbi.nlm.nih.gov/29673080"},"language":"en","primary_location":{"id":"doi:10.1111/1756-185x.13311","doi":"https://doi.org/10.1111/1756-185x.13311","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1756-185x.13311","pdf_url":null,"source":{"id":"https://openalex.org/S169069398","display_name":"International Journal of Rheumatic Diseases","issn_l":"1756-1841","issn":["1756-1841","1756-185X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Rheumatic Diseases","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026338539","display_name":"G\u00f6khan Sarg\u0131n","orcid":"https://orcid.org/0000-0002-3778-8351","observed_orcids":["https://orcid.org/0000-0002-3778-8351"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Gokhan Sargin","raw_affiliation_strings":["Department of Rheumatology, Adnan Menderes University, Aydin, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3778-8351","affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Adnan Menderes University, Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020945020","display_name":"Ta\u015fk\u0131n \u015eent\u00fcrk","orcid":"https://orcid.org/0000-0002-1560-6764","observed_orcids":["https://orcid.org/0000-0002-1560-6764"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Taskin Senturk","raw_affiliation_strings":["Department of Rheumatology, Adnan Menderes University, Aydin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Adnan Menderes University, Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074577676","display_name":"Song\u00fcl \u015eahin \u00c7ilda\u011f","orcid":"https://orcid.org/0000-0001-9617-0925","observed_orcids":["https://orcid.org/0000-0001-9617-0925"]},"institutions":[{"id":"https://openalex.org/I76806599","display_name":"Adnan Menderes University","ror":"https://ror.org/03n7yzv56","country_code":"TR","type":"education","lineage":["https://openalex.org/I76806599"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Songul Cildag","raw_affiliation_strings":["Department of Rheumatology, Adnan Menderes University, Aydin, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology, Adnan Menderes University, Aydin, Turkey","institution_ids":["https://openalex.org/I76806599"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5026338539"],"corresponding_institution_ids":["https://openalex.org/I76806599"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":2.6602,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.89273052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"21","issue":"5","first_page":"1093","last_page":"1097"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":1.0},{"id":"https://openalex.org/keywords/cancer","display_name":"cancer","score":0.7680000066757202},{"id":"https://openalex.org/keywords/cancer-risk-factors","display_name":"cancer risk factors","score":0.8489999771118164},{"id":"https://openalex.org/keywords/diffuse-cutaneous-systemic-sclerosis","display_name":"diffuse cutaneous systemic sclerosis","score":0.9620000123977661},{"id":"https://openalex.org/keywords/anti-scl-70-antibodies","display_name":"anti-Scl-70 antibodies","score":0.9660000205039978},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.703000009059906},{"id":"https://openalex.org/keywords/gastric-adenocarcinoma","display_name":"gastric adenocarcinoma","score":0.8759999871253967},{"id":"https://openalex.org/keywords/gastric-neuroendocrine-tumor","display_name":"gastric neuroendocrine tumor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":0.9959999918937683},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mortality","display_name":"mortality","score":0.8100000023841858},{"id":"https://openalex.org/keywords/renal-crisis","display_name":"renal crisis","score":0.5180000066757202},{"id":"https://openalex.org/keywords/pulmonary-involvement","display_name":"pulmonary involvement","score":0.4560000002384186},{"id":"https://openalex.org/keywords/cardiac-involvement","display_name":"cardiac involvement","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.967719554901123},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7261886596679688},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.680519163608551},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5765037536621094},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5351142883300781},{"id":"https://openalex.org/C2777489490","wikidata":"https://www.wikidata.org/wiki/Q684924","display_name":"Rheumatism","level":2,"score":0.5067020058631897},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4724312722682953}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002423","descriptor_name":"Cause of Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012595","descriptor_name":"Scleroderma, Systemic","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014421","descriptor_name":"Turkey","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016009","descriptor_name":"Chi-Square Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/1756-185x.13311","doi":"https://doi.org/10.1111/1756-185x.13311","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1756-185x.13311","pdf_url":null,"source":{"id":"https://openalex.org/S169069398","display_name":"International Journal of Rheumatic Diseases","issn_l":"1756-1841","issn":["1756-1841","1756-185X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Rheumatic Diseases","raw_type":"journal-article"},{"id":"pmid:29673080","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29673080","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of rheumatic diseases","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8899999856948853,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W4069880","https://openalex.org/W1505701939","https://openalex.org/W1546712514","https://openalex.org/W1951167293","https://openalex.org/W2023382606","https://openalex.org/W2027151698","https://openalex.org/W2028921539","https://openalex.org/W2034183165","https://openalex.org/W2038597635","https://openalex.org/W2041691065","https://openalex.org/W2071133042","https://openalex.org/W2071216920","https://openalex.org/W2076796605","https://openalex.org/W2084554507","https://openalex.org/W2091579544","https://openalex.org/W2104120280","https://openalex.org/W2113150329","https://openalex.org/W2119560279","https://openalex.org/W2121870391","https://openalex.org/W2138899183","https://openalex.org/W2140816451","https://openalex.org/W2164096595","https://openalex.org/W2165416097","https://openalex.org/W2344242273","https://openalex.org/W2412855972","https://openalex.org/W2591609747","https://openalex.org/W4242284829","https://openalex.org/W4296248207"],"related_works":["https://openalex.org/W2329695269","https://openalex.org/W2344242273","https://openalex.org/W2500794955","https://openalex.org/W4408646825","https://openalex.org/W2140816451","https://openalex.org/W2041436636","https://openalex.org/W4409608534","https://openalex.org/W3139365811","https://openalex.org/W2039908361","https://openalex.org/W2982104116"],"abstract_inverted_index":{"BACKGROUND:":[0],"Systemic":[1],"sclerosis":[2],"(SSc)":[3],"has":[4],"increased":[5,229],"risk":[6,32,44,244,256],"of":[7,68,78,98,126,135,177,222,225,250],"morbidity":[8,230],"and":[9,21,26,46,56,95,115,153,159,163,173,186,203,208,231,241,258],"mortality":[10,47,232],"due":[11,168],"to":[12,40,74,111,169,263],"pulmonary":[13,15,202],"fibrosis,":[14],"arterial":[16],"hypertension,":[17],"renal":[18,174],"crisis,":[19],"infections":[20],"malignancies.":[22,52],"Chemical":[23],"exposure,":[24],"smoking":[25],"cytotoxic":[27],"drugs":[28],"increase":[29],"the":[30,99,187,220,235,243,248,253],"malignancy":[31],"in":[33,48,89],"rheumatic":[34],"diseases":[35],"including":[36],"SSc.":[37,223],"We":[38],"aim":[39],"evaluate":[41],"characteristics,":[42],"identify":[43],"factors":[45,245,257],"SSc":[49,60,86,183],"patients":[50,58,100],"with":[51,59,65,132,234],"METHODS:":[53],"One":[54],"hundred":[55],"fifty-three":[57],"(24":[61],"male,":[62,129],"129":[63],"female,":[64,131],"mean":[66,133],"age":[67,134],"56.4":[69],"\u00b1":[70,137],"12.9":[71],"years)":[72,139],"according":[73],"2013":[75],"American":[76],"College":[77],"Rheumatology/European":[79],"League":[80],"Against":[81],"Rheumatism":[82],"classification":[83],"criteria":[84],"for":[85,189],"were":[87,101,140],"enrolled":[88],"this":[90],"study.":[91],"Clinical,":[92],"demographic,":[93],"laboratory":[94],"radiological":[96],"characteristics":[97],"evaluated":[102],"by":[103,266],"using":[104],"SPSS":[105],"17.0.":[106],"Chi-square":[107],"test":[108],"was":[109,191,194],"used":[110],"compare":[112],"qualitative":[113],"data":[114],"descriptive":[116],"statistics":[117],"are":[118,261],"shown":[119],"as":[120],"n":[121],"(%).":[122],"RESULTS:":[123],"Seven":[124],"cases":[125],"cancer":[127,150,207],"(three":[128],"four":[130],"51.2":[136],"7.0":[138],"identified.":[141],"The":[142,212],"tumor":[143],"types":[144],"included":[145],"lung":[146],"cancer,":[147],"gastrointestinal":[148],"tract":[149],"(gastric":[151],"adenocarcinoma":[152],"gastric":[154],"neuroendocrine":[155],"tumor),":[156],"myelodysplastic":[157],"syndrome":[158],"malignant":[160],"melanoma":[161],"(eye":[162],"skin).":[164],"Five":[165],"(3.4%)":[166],"died":[167],"infection,":[170],"cardiopulmonary":[171],"involvement":[172,205],"crisis.":[175],"Six":[176],"them":[178],"had":[179],"a":[180],"diffuse":[181],"cutaneous":[182],"clinical":[184,254],"subtype,":[185],"ratio":[188],"anti-Scl-70":[190],"71.4%.":[192],"There":[193],"no":[195],"significant":[196],"relationship":[197],"between":[198,206],"age,":[199],"sex,":[200],"anti-Scl-70,":[201],"cardiac":[204],"non-cancer":[209],"patients.":[210],"CONCLUSIONS:":[211],"malignancies":[213],"may":[214,246],"occur":[215],"before,":[216],"together":[217],"or":[218],"after":[219],"diagnosis":[221],"Both":[224],"these":[226],"disorders":[227],"have":[228],"compared":[233],"general":[236],"population.":[237],"Rational":[238],"treatment,":[239],"monitoring":[240],"reducing":[242],"prevent":[247],"development":[249],"malignancy.":[251],"Also,":[252],"features,":[255],"prevalence":[259],"ratios":[260],"similar":[262],"that":[264],"reported":[265],"large":[267],"cohorts.":[268]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}