{"id":"https://openalex.org/W2802665732","doi":"https://doi.org/10.1111/exd.13670","title":"Progress in melanoma modelling in vitro","display_name":"Progress in melanoma modelling in vitro","publication_year":2018,"publication_date":"2018-04-26","ids":{"openalex":"https://openalex.org/W2802665732","doi":"https://doi.org/10.1111/exd.13670","mag":"2802665732","pmid":"https://pubmed.ncbi.nlm.nih.gov/29697862"},"language":"en","primary_location":{"id":"doi:10.1111/exd.13670","doi":"https://doi.org/10.1111/exd.13670","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.13670","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.13670","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.13670","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087627289","display_name":"Alessandra Marconi","orcid":"https://orcid.org/0000-0002-5667-5766","observed_orcids":["https://orcid.org/0000-0002-5667-5766"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandra Marconi","raw_affiliation_strings":["Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":"https://orcid.org/0000-0002-5667-5766","affiliations":[{"raw_affiliation_string":"Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063263652","display_name":"Marika Quadri","orcid":"https://orcid.org/0000-0001-7619-660X","observed_orcids":["https://orcid.org/0000-0001-7619-660X"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marika Quadri","raw_affiliation_strings":["Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006920216","display_name":"Annalisa Saltari","orcid":"https://orcid.org/0000-0002-8621-4039","observed_orcids":["https://orcid.org/0000-0002-8621-4039"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annalisa Saltari","raw_affiliation_strings":["Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021374018","display_name":"Carlo Pincelli","orcid":"https://orcid.org/0000-0003-4416-2637","observed_orcids":["https://orcid.org/0000-0003-4416-2637"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Pincelli","raw_affiliation_strings":["Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Cutaneous Biology, Department of Surgical, Medical, Dental and Morphological Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5087627289"],"corresponding_institution_ids":["https://openalex.org/I122346577"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.3417,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.33407243,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"27","issue":"5","first_page":"578","last_page":"586"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.8256999850273132,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.04879999905824661,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.04170000180602074,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/in-vitro-model","display_name":"in vitro model","score":0.6330000162124634},{"id":"https://openalex.org/keywords/three-dimensional-tumor-models","display_name":"3D tumor models","score":0.8849999904632568},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"organ-on-a-chip","score":0.9419999718666077},{"id":"https://openalex.org/keywords/microfluidics","display_name":"microfluidics","score":0.8790000081062317},{"id":"https://openalex.org/keywords/3rs","display_name":"3Rs","score":0.7889999747276306},{"id":"https://openalex.org/keywords/limitations-of-animal-models","display_name":"animal model limitations","score":0.5180000066757202},{"id":"https://openalex.org/keywords/cell-matrix-interactions","display_name":"cell-matrix interactions","score":0.824999988079071},{"id":"https://openalex.org/keywords/cell-cell-interactions","display_name":"cell-cell interactions","score":0.6449999809265137},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7329999804496765}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.8970943689346313},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.7282227873802185},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5248658657073975},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5039805769920349},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.45951902866363525},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4562978744506836},{"id":"https://openalex.org/C2778117688","wikidata":"https://www.wikidata.org/wiki/Q264024","display_name":"Animal model","level":2,"score":0.4202461540699005},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4135560393333435},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34711945056915283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3435443043708801},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34304916858673096},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31166577339172363},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.19132059812545776},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.1189732551574707},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10358574986457825},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008545","descriptor_name":"Melanoma","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/exd.13670","doi":"https://doi.org/10.1111/exd.13670","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.13670","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.13670","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:29697862","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29697862","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/1169221","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1169221","pdf_url":"https://iris.unimore.it/bitstream/11380/1169221/1/_system_appendPDF_proof_hi%20R1.pdf","source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/exd.13670","doi":"https://doi.org/10.1111/exd.13670","is_oa":true,"landing_page_url":"https://doi.org/10.1111/exd.13670","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/exd.13670","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2802665732.pdf","grobid_xml":"https://content.openalex.org/works/W2802665732.grobid-xml"},"referenced_works_count":100,"referenced_works":["https://openalex.org/W71660379","https://openalex.org/W161377529","https://openalex.org/W366325714","https://openalex.org/W1556583010","https://openalex.org/W1560370693","https://openalex.org/W1855028888","https://openalex.org/W1951808778","https://openalex.org/W1963535145","https://openalex.org/W1968583844","https://openalex.org/W1973373814","https://openalex.org/W1977282346","https://openalex.org/W1981684516","https://openalex.org/W1988019417","https://openalex.org/W1990757263","https://openalex.org/W1992514491","https://openalex.org/W1994599132","https://openalex.org/W1997418758","https://openalex.org/W2004643805","https://openalex.org/W2012124753","https://openalex.org/W2012150851","https://openalex.org/W2013520568","https://openalex.org/W2016081742","https://openalex.org/W2017452459","https://openalex.org/W2020203470","https://openalex.org/W2022479474","https://openalex.org/W2023402563","https://openalex.org/W2025858549","https://openalex.org/W2030628519","https://openalex.org/W2036952999","https://openalex.org/W2039252207","https://openalex.org/W2040465662","https://openalex.org/W2041585886","https://openalex.org/W2042222655","https://openalex.org/W2043584813","https://openalex.org/W2043746859","https://openalex.org/W2047209914","https://openalex.org/W2050300062","https://openalex.org/W2051667964","https://openalex.org/W2052069700","https://openalex.org/W2056216570","https://openalex.org/W2056876853","https://openalex.org/W2057818550","https://openalex.org/W2059533688","https://openalex.org/W2059964587","https://openalex.org/W2060834886","https://openalex.org/W2068289276","https://openalex.org/W2072569544","https://openalex.org/W2072830086","https://openalex.org/W2075889966","https://openalex.org/W2078354424","https://openalex.org/W2079356804","https://openalex.org/W2085367227","https://openalex.org/W2087204483","https://openalex.org/W2088716692","https://openalex.org/W2090221057","https://openalex.org/W2094454542","https://openalex.org/W2094970392","https://openalex.org/W2099760403","https://openalex.org/W2102085111","https://openalex.org/W2104604857","https://openalex.org/W2105986003","https://openalex.org/W2107860744","https://openalex.org/W2108333200","https://openalex.org/W2108973415","https://openalex.org/W2111863560","https://openalex.org/W2123232388","https://openalex.org/W2124073148","https://openalex.org/W2136043430","https://openalex.org/W2136445803","https://openalex.org/W2137091935","https://openalex.org/W2138784667","https://openalex.org/W2140723257","https://openalex.org/W2152160280","https://openalex.org/W2153382986","https://openalex.org/W2154196978","https://openalex.org/W2161771297","https://openalex.org/W2164114377","https://openalex.org/W2166753481","https://openalex.org/W2168759510","https://openalex.org/W2170862003","https://openalex.org/W2172183744","https://openalex.org/W2182596905","https://openalex.org/W2221584143","https://openalex.org/W2340470410","https://openalex.org/W2407836966","https://openalex.org/W2441687278","https://openalex.org/W2510540705","https://openalex.org/W2556373707","https://openalex.org/W2560213782","https://openalex.org/W2561750927","https://openalex.org/W2590614416","https://openalex.org/W2593850356","https://openalex.org/W2601867145","https://openalex.org/W2615276742","https://openalex.org/W2615677530","https://openalex.org/W2622369378","https://openalex.org/W2627051037","https://openalex.org/W2751844984","https://openalex.org/W2755543132","https://openalex.org/W2794510804"],"related_works":["https://openalex.org/W2039252207","https://openalex.org/W4295681666","https://openalex.org/W7099733583","https://openalex.org/W4206076315","https://openalex.org/W4416528733","https://openalex.org/W7223454929","https://openalex.org/W4409253682","https://openalex.org/W7131102499","https://openalex.org/W7098415363","https://openalex.org/W2101853195"],"abstract_inverted_index":{"Melanoma":[0,94],"is":[1,166,242],"one":[2],"of":[3,52,67,126,235],"the":[4,25,47,65,83,90,124,127,133,170,188,211,223,227],"most":[5],"studied":[6],"neoplasia,":[7],"although":[8],"laboratory":[9],"techniques":[10],"used":[11,63],"for":[12,54,64],"investigating":[13],"this":[14],"tumor":[15,128],"are":[16,103,175,214],"not":[17,23],"fully":[18],"reliable.":[19],"Animal":[20],"models":[21,157],"may":[22],"predict":[24],"human":[26],"response":[27,134],"due":[28],"to":[29,41,46,69,105,109,135,159,169,192,238],"differences":[30],"in":[31,80,92,96,123,132,162,171,206,224],"skin":[32,150,193,200],"physiology":[33],"and":[34,50,111,116,148,174,178],"immunity.":[35],"In":[36,113],"addition,":[37,114],"international":[38],"guidelines":[39],"recommend":[40],"develop":[42],"processes":[43],"that":[44,165,198,230],"contribute":[45],"reduction,":[48],"refinement":[49],"replacement":[51],"animals":[53,236],"experiments":[55],"(3Rs).":[56],"Adherent":[57],"cell":[58],"culture":[59,84],"has":[60],"been":[61,153],"widely":[62],"study":[66,160],"melanoma":[68,74,141,149],"obtain":[70],"important":[71],"information":[72],"regarding":[73],"biology.":[75],"Nonetheless,":[76],"these":[77],"cells":[78,102],"grow":[79],"adhesion":[81],"on":[82,210],"substrate":[85],"which":[86],"differs":[87],"considerably":[88],"from":[89,245],"situation":[91,173],"vivo.":[93],"grows":[95],"a":[97,106,120,163,220],"3D":[98,156,205],"spatial":[99],"conformation":[100],"where":[101],"subjected":[104],"heterogeneous":[107],"exposure":[108],"oxygen":[110],"nutrient.":[112],"cell-cell":[115],"cell-matrix":[117],"interaction":[118],"play":[119],"crucial":[121],"role":[122],"pathobiology":[125],"as":[129,131,196],"well":[130],"therapeutic":[136],"agents.":[137],"To":[138],"better":[139],"study,":[140],"new":[142,189,212],"techniques,":[143],"including":[144],"spherical":[145],"models,":[146,208],"tumorospheres":[147],"equivalents,":[151],"have":[152],"developed.":[154],"These":[155],"allow":[158,232],"tumors":[161],"microenvironment":[164],"more":[167,216],"close":[168],"vivo":[172,225],"less":[176,233],"expensive":[177],"time-consuming":[179],"than":[180],"animal":[181],"studies.":[182],"This":[183],"review":[184],"will":[185,231],"also":[186],"describe":[187],"technologies":[190],"applied":[191],"reconstructs":[194],"such":[195],"organ-on-a-chip":[197],"allows":[199],"perfusion":[201],"through":[202],"microfluidic":[203],"platforms.":[204],"vitro":[207],"based":[209],"technologies,":[213],"becoming":[215],"sophisticated,":[217],"representing":[218],"at":[219],"great":[221],"extent":[222],"situation,":[226],"\"perfect\"":[228],"model":[229],"involvement":[234],"up":[237],"their":[239],"complete":[240],"replacement,":[241],"still":[243],"far":[244],"being":[246],"achieved.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-05-17T00:00:00"}
