{"id":"https://openalex.org/W2802665025","doi":"https://doi.org/10.1093/sleep/zsy061.039","title":"0040 Elevated 24-hour Free Fatty Acids During Circadian Misalignment","display_name":"0040 Elevated 24-hour Free Fatty Acids During Circadian Misalignment","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2802665025","doi":"https://doi.org/10.1093/sleep/zsy061.039","mag":"2802665025"},"language":"en","primary_location":{"id":"doi:10.1093/sleep/zsy061.039","doi":"https://doi.org/10.1093/sleep/zsy061.039","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleep/zsy061.039","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5058721392","display_name":"Josiane L. Broussard","orcid":"https://orcid.org/0000-0002-6824-8294","observed_orcids":["https://orcid.org/0000-0002-6824-8294"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J L Broussard","raw_affiliation_strings":["University of Colorado Boulder, Boulder, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Boulder, Boulder, CO","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110556034","display_name":"S J Morton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S J Morton","raw_affiliation_strings":["University of Colorado Boulder, Boulder, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Boulder, Boulder, CO","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086778923","display_name":"Andrew W. McHill","orcid":"https://orcid.org/0000-0002-9428-6884","observed_orcids":["https://orcid.org/0000-0002-9428-6884"]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A W McHill","raw_affiliation_strings":["University of Colorado Boulder, Boulder, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Colorado Boulder, Boulder, CO","institution_ids":["https://openalex.org/I188538660"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090956937","display_name":"JANINE A. HIGGINS","orcid":"https://orcid.org/0000-0002-4273-194X","observed_orcids":["https://orcid.org/0000-0002-4273-194X"]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J Higgins","raw_affiliation_strings":["Department of Pediatrics, Endocrinology Section, University of Colorado Denver Anschutz Medical Campus, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Endocrinology Section, University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047490390","display_name":"EL Melanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E K Melanson","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver Anschutz Medical Campus, Aurora, CO","Division of Geriatric Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"Division of Geriatric Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002280977","display_name":"KP Wright","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188538660","display_name":"University of Colorado Boulder","ror":"https://ror.org/02ttsq026","country_code":"US","type":"education","lineage":["https://openalex.org/I188538660"]},{"id":"https://openalex.org/I51713134","display_name":"University of Colorado Anschutz","ror":"https://ror.org/03wmf1y16","country_code":"US","type":"education","lineage":["https://openalex.org/I51713134"]},{"id":"https://openalex.org/I921990950","display_name":"University of Colorado Denver","ror":"https://ror.org/02hh7en24","country_code":"US","type":"education","lineage":["https://openalex.org/I921990950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K P Wright","raw_affiliation_strings":["Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver Anschutz Medical Campus, Aurora, CO","University of Colorado Boulder, Boulder, CO"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Endocrinology, Diabetes, and Metabolism, University of Colorado Denver Anschutz Medical Campus, Aurora, CO","institution_ids":["https://openalex.org/I51713134","https://openalex.org/I921990950"]},{"raw_affiliation_string":"University of Colorado Boulder, Boulder, CO","institution_ids":["https://openalex.org/I188538660"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4388,"currency":"USD","value_usd":4388},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.04023508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"suppl_1","first_page":"A16","last_page":"A17"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.7631999850273132,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11373","display_name":"Sleep and Work-Related Fatigue","score":0.2290000021457672,"subfield":{"id":"https://openalex.org/subfields/3205","display_name":"Experimental and Cognitive Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T12745","display_name":"Dietary Effects on Health","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circadian-misalignment","display_name":"circadian misalignment","score":0.9990000128746033},{"id":"https://openalex.org/keywords/free-fatty-acids","display_name":"free fatty acids","score":0.9610000252723694},{"id":"https://openalex.org/keywords/night-shift-work","display_name":"night shift work","score":0.7170000076293945},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.5540000200271606},{"id":"https://openalex.org/keywords/insulin","display_name":"insulin","score":0.949999988079071},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.5559999942779541},{"id":"https://openalex.org/keywords/melatonin-rhythm","display_name":"melatonin rhythm","score":0.6389999985694885},{"id":"https://openalex.org/keywords/type-2-diabetes-risk","display_name":"type 2 diabetes risk","score":0.7820000052452087},{"id":"https://openalex.org/keywords/metabolic-dysfunction","display_name":"metabolic dysfunction","score":0.7770000100135803},{"id":"https://openalex.org/keywords/sleep-timing","display_name":"sleep timing","score":0.4259999990463257}],"concepts":[{"id":"https://openalex.org/C121446783","wikidata":"https://www.wikidata.org/wiki/Q208353","display_name":"Circadian rhythm","level":2,"score":0.9344311356544495},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6874136328697205},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.661943793296814},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5811963081359863},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.5638231635093689},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.5429711937904358},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.5003666877746582},{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.47979480028152466},{"id":"https://openalex.org/C2776176791","wikidata":"https://www.wikidata.org/wiki/Q1068683","display_name":"Shift work","level":2,"score":0.4638538360595703},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.43553948402404785},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1093/sleep/zsy061.039","doi":"https://doi.org/10.1093/sleep/zsy061.039","is_oa":false,"landing_page_url":"https://doi.org/10.1093/sleep/zsy061.039","pdf_url":null,"source":{"id":"https://openalex.org/S42921845","display_name":"SLEEP","issn_l":"0161-8105","issn":["0161-8105","1550-9109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Sleep","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2948136902","https://openalex.org/W2840330380","https://openalex.org/W2766987916","https://openalex.org/W2608811972","https://openalex.org/W4385564734","https://openalex.org/W2091912666","https://openalex.org/W4297812451","https://openalex.org/W2149420917","https://openalex.org/W4392170118","https://openalex.org/W2113136381"],"abstract_inverted_index":{"Circadian":[0,163],"misalignment\u2014":[1],"sleeping":[2],"during":[3,54,77,111,193,214,240],"the":[4,13,58,100,149,158,176,184,273,277,285,314],"biological":[5],"day":[6],"and":[7,24,51,75,114,117,133,148,207,229,261,304],"eating":[8],"at":[9],"a":[10,19,139,248],"time":[11],"when":[12],"internal":[14],"circadian":[15,34,61,112,115,215,241,254],"clock":[16],"promotes":[17],"sleep\u2014is":[18],"risk":[20,286],"factor":[21],"for":[22,108,124,130,287],"obesity":[23],"diabetes.":[25,291],"However,":[26,57],"little":[27],"is":[28],"known":[29],"about":[30],"mechanisms":[31],"by":[32,167,175,296,313],"which":[33,179],"misalignment":[35,62,116,164,242,255],"leads":[36],"to":[37,145,183,234,245,272],"metabolic":[38],"dysregulation":[39],"in":[40,99,221,232,251,257,270,306],"humans.":[41],"Increased":[42],"free":[43],"fatty":[44],"acids":[45],"(FFA)":[46],"can":[47],"induce":[48],"insulin":[49,76,132],"resistance":[50],"are":[52,200],"elevated":[53,192,258],"insufficient":[55],"sleep.":[56],"impact":[59],"of":[60,276],"on":[63],"FFA":[64,188,260],"has":[65],"not":[66,181],"been":[67],"elucidated.":[68],"We":[69],"therefore":[70],"examined":[71],"circulating":[72],"FFA,":[73,131],"glucose":[74,224,231,262,269],"an":[78,267,297],"inpatient":[79],"simulated":[80,169],"night":[81],"shiftwork":[82],"protocol.":[83],"14":[84],"healthy":[85],"adults":[86],"(6M;":[87],"aged":[88],"26.4":[89],"\u00b1":[90,94,196,204,211,226,237],"1.2y,":[91],"BMI":[92],"22.7":[93],"0.5":[95],"kg/m2;":[96],"mean\u00b1SD)":[97],"participated":[98],"study.":[101],"Blood":[102,127],"was":[103,128,151,155,165,294],"sampled":[104],"every":[105,118],"2":[106,125,290],"hours":[107,110],"24":[109],"alignment":[113],"30":[119],"minutes":[120],"after":[121],"each":[122,161],"meal":[123,275],"hours.":[126],"assayed":[129],"glucose.":[134],"Participants":[135],"were":[136,190],"provided":[137],"with":[138,157],"3-day":[140],"energy":[141],"balance":[142],"diet":[143,150],"prior":[144],"study":[146],"admission":[147],"continued":[152],"inpatient.":[153],"Diet":[154],"designed":[156],"same":[159],"meals":[160],"day.":[162,278],"induced":[166],"our":[168],"nightshift":[170,185],"work":[171,293],"protocol,":[172],"as":[173,243,264,266],"evidenced":[174],"melatonin":[177],"rhythm":[178],"did":[180],"adapt":[182],"schedule.":[186],"Mean":[187],"levels":[189],"significantly":[191],"wake":[194],"(+41":[195],"18%,":[197],"p<0.05;":[198],"results":[199,256],"mean\u00b1SEM),":[201],"sleep":[202],"(+35":[203,210],"10%,":[205],"p<0.01)":[206,213,239],"across":[208],"24h":[209,222,259],"15%,":[212],"misalignment.":[216],"Furthermore,":[217],"we":[218],"found":[219],"elevations":[220],"mean":[223,230],"(+7":[225],"3%,":[227],"p<0.05)":[228],"response":[233,271],"breakfast":[235],"(+24":[236],"6%,":[238],"compared":[244],"baseline,":[246],"without":[247],"compensatory":[249],"increase":[250,284],"insulin.":[252],"Acute":[253],"concentrations,":[263],"well":[265],"increased":[268],"first":[274],"Sustained":[279],"chronically,":[280],"these":[281],"disturbances":[282],"may":[283],"developing":[288],"type":[289],"This":[292],"supported":[295],"SRS":[298],"CDA,":[299],"K01DK110138,":[300],"F32DK111161,":[301],"R01HL132150,":[302],"R21DK092624,":[303],"Society":[305],"Science,":[307],"The":[308],"Branco":[309],"Weiss":[310],"Fellowship,":[311],"administered":[312],"ETH":[315],"Z\u00fcrich.":[316]},"counts_by_year":[],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2018-05-17T00:00:00"}
