{"id":"https://openalex.org/W2802604307","doi":"https://doi.org/10.1016/j.biopha.2018.04.079","title":"In vivo evaluation of antitumoral and antiangiogenic effect of imiquimod-loaded polymeric nanoparticles","display_name":"In vivo evaluation of antitumoral and antiangiogenic effect of imiquimod-loaded polymeric nanoparticles","publication_year":2018,"publication_date":"2018-04-27","ids":{"openalex":"https://openalex.org/W2802604307","doi":"https://doi.org/10.1016/j.biopha.2018.04.079","mag":"2802604307","pmid":"https://pubmed.ncbi.nlm.nih.gov/29715754"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2018.04.079","doi":"https://doi.org/10.1016/j.biopha.2018.04.079","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopha.2018.04.079","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5030845308","display_name":"Marina Fran\u00e7a Dias","orcid":"https://orcid.org/0000-0003-3878-5192","observed_orcids":["https://orcid.org/0000-0003-3878-5192"]},"institutions":[{"id":"https://openalex.org/I68106152","display_name":"Universidade Federal de Goi\u00e1s","ror":"https://ror.org/0039d5757","country_code":"BR","type":"education","lineage":["https://openalex.org/I68106152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Marina Fran\u00e7a Dias","raw_affiliation_strings":["Faculty of Pharmacy, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil","institution_ids":["https://openalex.org/I68106152"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027918413","display_name":"Bruna Caroline Pinheiro de Figueiredo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Bruna Caroline Pinheiro de Figueiredo","raw_affiliation_strings":["Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003220508","display_name":"Julia Teixeira Neto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"J\u00falia Teixeira-Neto","raw_affiliation_strings":["Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084786845","display_name":"Maria Carolina Andrade Guerra","orcid":"https://orcid.org/0000-0003-0847-3737","observed_orcids":["https://orcid.org/0000-0003-0847-3737"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]},{"id":"https://openalex.org/I68106152","display_name":"Universidade Federal de Goi\u00e1s","ror":"https://ror.org/0039d5757","country_code":"BR","type":"education","lineage":["https://openalex.org/I68106152"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maria Carolina Andrade Guerra","raw_affiliation_strings":["Faculty of Pharmacy, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil; Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil","Faculty of Pharmacy, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil","Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil; Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210098174","https://openalex.org/I68106152"]},{"raw_affiliation_string":"Faculty of Pharmacy, Federal University of Goi\u00e1s, Goi\u00e2nia, Brazil","institution_ids":["https://openalex.org/I68106152"]},{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060599674","display_name":"S\u00edlvia Lig\u00f3rio Fialho","orcid":"https://orcid.org/0000-0001-8068-5211","observed_orcids":["https://orcid.org/0000-0001-8068-5211"]},"institutions":[{"id":"https://openalex.org/I4210098174","display_name":"Ezequiel Dias Foundation","ror":"https://ror.org/01qgvp179","country_code":"BR","type":"facility","lineage":["https://openalex.org/I4210098174"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Silvia Lig\u00f3rio Fialho","raw_affiliation_strings":["Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil. Electronic address: silvia.fialho@funed.mg.gov.br","Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil. Electronic address: silvia.fialho@funed.mg.gov.br","institution_ids":["https://openalex.org/I4210098174"]},{"raw_affiliation_string":"Pharmaceutical Research and Development, Ezequiel Dias Foundation, Belo Horizonte, Minas Gerais, Brazil","institution_ids":["https://openalex.org/I4210098174"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011455678","display_name":"Armando Silva\u2010Cunha","orcid":"https://orcid.org/0000-0002-1161-8936","observed_orcids":["https://orcid.org/0000-0002-1161-8936"]},"institutions":[{"id":"https://openalex.org/I110200422","display_name":"Universidade Federal de Minas Gerais","ror":"https://ror.org/0176yjw32","country_code":"BR","type":"education","lineage":["https://openalex.org/I110200422"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Armando Silva Cunha","raw_affiliation_strings":["Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy, Federal University of Minas Gerais, Belo Horizonte, Brazil","institution_ids":["https://openalex.org/I110200422"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060599674"],"corresponding_institution_ids":["https://openalex.org/I4210098174"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":1.6084,"has_fulltext":false,"cited_by_count":50,"citation_normalized_percentile":{"value":0.78232429,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"103","issue":null,"first_page":"1107","last_page":"1114"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.7997999787330627,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.13989999890327454,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.018300000578165054,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imiquimod","display_name":"imiquimod","score":1.0},{"id":"https://openalex.org/keywords/polymeric-nanoparticles","display_name":"polymeric nanoparticles","score":0.996999979019165},{"id":"https://openalex.org/keywords/antiangiogenic-activity","display_name":"antiangiogenic activity","score":0.7799999713897705},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8920000195503235},{"id":"https://openalex.org/keywords/skin-cancer","display_name":"skin cancer","score":0.8159999847412109},{"id":"https://openalex.org/keywords/skin-carcinogenesis","display_name":"skin carcinogenesis","score":0.6309999823570251},{"id":"https://openalex.org/keywords/papilloma","display_name":"papilloma","score":0.6129999756813049},{"id":"https://openalex.org/keywords/chorioallantoic-membrane","display_name":"chorioallantoic membrane","score":0.828000009059906},{"id":"https://openalex.org/keywords/topical-drug-delivery","display_name":"topical drug delivery","score":0.8100000023841858},{"id":"https://openalex.org/keywords/chemoprevention","display_name":"chemoprevention","score":0.8669999837875366}],"concepts":[{"id":"https://openalex.org/C2779112978","wikidata":"https://www.wikidata.org/wiki/Q423417","display_name":"Imiquimod","level":2,"score":0.8884800672531128},{"id":"https://openalex.org/C97230052","wikidata":"https://www.wikidata.org/wiki/Q3854334","display_name":"Chorioallantoic membrane","level":3,"score":0.7138112783432007},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6411516666412354},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.533991277217865},{"id":"https://openalex.org/C50670333","wikidata":"https://www.wikidata.org/wiki/Q907651","display_name":"Permeation","level":3,"score":0.49711087346076965},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39192697405815125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35226118564605713},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3507670760154724},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.25540149211883545},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.19373467564582825},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.1791134476661682},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1128481924533844},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07060030102729797},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077271","descriptor_name":"Imiquimod","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000634","descriptor_name":"Aminoquinolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002642","descriptor_name":"Chick Embryo","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D010212","descriptor_name":"Papilloma","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000098","qualifier_name":"blood supply","is_major_topic":false},{"descriptor_ui":"D012878","descriptor_name":"Skin Neoplasms","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D049033","descriptor_name":"Chorioallantoic Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D065546","descriptor_name":"Drug Liberation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2018.04.079","doi":"https://doi.org/10.1016/j.biopha.2018.04.079","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopha.2018.04.079","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:29715754","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29715754","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320997","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","ror":"https://ror.org/02ddkpn78"},{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W92445081","https://openalex.org/W1274391881","https://openalex.org/W1977807321","https://openalex.org/W1983658188","https://openalex.org/W1990435317","https://openalex.org/W1992535790","https://openalex.org/W1995901066","https://openalex.org/W1996860725","https://openalex.org/W2000559124","https://openalex.org/W2001306312","https://openalex.org/W2010055898","https://openalex.org/W2015662321","https://openalex.org/W2022965630","https://openalex.org/W2027345202","https://openalex.org/W2030607086","https://openalex.org/W2035910980","https://openalex.org/W2053371370","https://openalex.org/W2060696563","https://openalex.org/W2064019766","https://openalex.org/W2071215562","https://openalex.org/W2072397912","https://openalex.org/W2074019221","https://openalex.org/W2133667721","https://openalex.org/W2144907950","https://openalex.org/W2154983077","https://openalex.org/W2172915374","https://openalex.org/W2270206506","https://openalex.org/W2291236027","https://openalex.org/W2414781026","https://openalex.org/W2489429174","https://openalex.org/W2520019715","https://openalex.org/W2536233390","https://openalex.org/W2585359117","https://openalex.org/W2586035224","https://openalex.org/W2587460329","https://openalex.org/W2592163017","https://openalex.org/W2598124668","https://openalex.org/W2615072878","https://openalex.org/W2759252443","https://openalex.org/W4242566504"],"related_works":["https://openalex.org/W7167739892","https://openalex.org/W4388341931","https://openalex.org/W1274391881","https://openalex.org/W7120339291","https://openalex.org/W4310946835","https://openalex.org/W4401093311","https://openalex.org/W4390013289","https://openalex.org/W2910079509","https://openalex.org/W4396744889","https://openalex.org/W2936896490"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}
