{"id":"https://openalex.org/W2802523624","doi":"https://doi.org/10.1002/bdr2.1334","title":"Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies","display_name":"Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies","publication_year":2018,"publication_date":"2018-05-06","ids":{"openalex":"https://openalex.org/W2802523624","doi":"https://doi.org/10.1002/bdr2.1334","mag":"2802523624","pmid":"https://pubmed.ncbi.nlm.nih.gov/29732742","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6276117"},"language":"en","primary_location":{"id":"doi:10.1002/bdr2.1334","doi":"https://doi.org/10.1002/bdr2.1334","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdr2.1334","pdf_url":null,"source":{"id":"https://openalex.org/S23975315","display_name":"Birth Defects Research","issn_l":"2472-1727","issn":["2472-1727"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6276117","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101424075","display_name":"Yu-Qi Dong","orcid":"https://orcid.org/0000-0003-0679-5062","observed_orcids":["https://orcid.org/0000-0003-0679-5062"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuqi Dong","raw_affiliation_strings":["Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-0679-5062","affiliations":[{"raw_affiliation_string":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348981","display_name":"Linlin Wang","orcid":"https://orcid.org/0000-0002-2033-9277","observed_orcids":["https://orcid.org/0000-0002-2033-9277"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linlin Wang","raw_affiliation_strings":["Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-2033-9277","affiliations":[{"raw_affiliation_string":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024860920","display_name":"Yunping Lei","orcid":"https://orcid.org/0000-0003-1504-0884","observed_orcids":["https://orcid.org/0000-0003-1504-0884"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yunping Lei","raw_affiliation_strings":["Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101650410","display_name":"Na Young Yang","orcid":"https://orcid.org/0009-0005-3192-9888","observed_orcids":["https://orcid.org/0009-0005-3192-9888"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Na Yang","raw_affiliation_strings":["Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006003706","display_name":"Robert M. Cabrera","orcid":"https://orcid.org/0000-0002-2998-0482","observed_orcids":["https://orcid.org/0000-0002-2998-0482"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert M. Cabrera","raw_affiliation_strings":["Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075319792","display_name":"Richard H. Finnell","orcid":"https://orcid.org/0000-0002-5962-8754","observed_orcids":["https://orcid.org/0000-0002-5962-8754"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard H. Finnell","raw_affiliation_strings":["Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Molecular and Cellular Biology and Medicine, Baylor College of Medicine, Houston, Texas","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072616581","display_name":"Aiguo Ren","orcid":"https://orcid.org/0000-0001-9115-5638","observed_orcids":["https://orcid.org/0000-0001-9115-5638"]},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aiguo Ren","raw_affiliation_strings":["Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China","institution_ids":["https://openalex.org/I20231570"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100348981"],"corresponding_institution_ids":["https://openalex.org/I20231570"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":null,"fwci":2.0586,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8422836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"110","issue":"12","first_page":"973","last_page":"981"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10978","display_name":"Prenatal Screening and Diagnostics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/folate-pathway-genes","display_name":"folate pathway genes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/genetic-polymorphism","display_name":"genetic polymorphism","score":0.8840000033378601},{"id":"https://openalex.org/keywords/dihydrofolate-reductase","display_name":"dihydrofolate reductase","score":0.7110000252723694},{"id":"https://openalex.org/keywords/pregnancy","display_name":"pregnancy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/developmental-disorders","display_name":"developmental disorders","score":0.34700000286102295},{"id":"https://openalex.org/keywords/folate-receptor","display_name":"folate receptor","score":0.6830000281333923}],"concepts":[{"id":"https://openalex.org/C163764329","wikidata":"https://www.wikidata.org/wiki/Q785022","display_name":"Autoantibody","level":3,"score":0.932949423789978},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.7846023440361023},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4950670301914215},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.4627423882484436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39234548807144165},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3755519390106201},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37111929059028625},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3662649393081665},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3030056357383728},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20160052180290222}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001323","descriptor_name":"Autoantibodies","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005492","descriptor_name":"Folic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006712","descriptor_name":"Homocystinuria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009128","descriptor_name":"Muscle Spasticity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009436","descriptor_name":"Neural Tube Defects","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011618","descriptor_name":"Psychotic Disorders","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058973","descriptor_name":"Folate Receptors, GPI-Anchored","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1002/bdr2.1334","doi":"https://doi.org/10.1002/bdr2.1334","is_oa":false,"landing_page_url":"https://doi.org/10.1002/bdr2.1334","pdf_url":null,"source":{"id":"https://openalex.org/S23975315","display_name":"Birth Defects Research","issn_l":"2472-1727","issn":["2472-1727"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-20","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth Defects Research","raw_type":"journal-article"},{"id":"pmid:29732742","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29732742","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Birth defects research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5243043","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6276117","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6276117","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6276117","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Birth Defects Res","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5243043","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6276117","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2001005887","display_name":"Risk Genes and Environmental Interactions in Neural Tube Defects","funder_award_id":"P01HD067244","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G284314952","display_name":null,"funder_award_id":"81472987","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6006596434","display_name":null,"funder_award_id":"7162094","funder_id":"https://openalex.org/F4320322919","funder_display_name":"Natural Science Foundation of Beijing Municipality"},{"id":"https://openalex.org/G6034439929","display_name":"Intervention Strategies for Non-Folate Responsive Neural Tube Defects","funder_award_id":"R01HD083809","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"},{"id":"https://openalex.org/G6963432142","display_name":null,"funder_award_id":"81773441","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8038903631","display_name":"Folic Acid, Parental Mutation Rates and the Risk for Neural Tube Defects","funder_award_id":"R01HD081216","funder_id":"https://openalex.org/F4320337611","funder_display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322919","display_name":"Natural Science Foundation of Beijing Municipality","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337611","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1597619535","https://openalex.org/W1785122941","https://openalex.org/W1965654753","https://openalex.org/W1967780117","https://openalex.org/W1973119008","https://openalex.org/W1987315246","https://openalex.org/W1989867776","https://openalex.org/W2003813779","https://openalex.org/W2012780102","https://openalex.org/W2022861477","https://openalex.org/W2031262735","https://openalex.org/W2038206762","https://openalex.org/W2048652376","https://openalex.org/W2063305714","https://openalex.org/W2086967210","https://openalex.org/W2089883166","https://openalex.org/W2091993675","https://openalex.org/W2105678378","https://openalex.org/W2108435240","https://openalex.org/W2111359369","https://openalex.org/W2115478902","https://openalex.org/W2120888343","https://openalex.org/W2127829100","https://openalex.org/W2146172890","https://openalex.org/W2154059422","https://openalex.org/W2162125295","https://openalex.org/W2176774432","https://openalex.org/W2325417132","https://openalex.org/W2331292814","https://openalex.org/W2394865895","https://openalex.org/W2404125412","https://openalex.org/W2474977034","https://openalex.org/W4253342868"],"related_works":["https://openalex.org/W2404125412","https://openalex.org/W2016386954","https://openalex.org/W2048652376","https://openalex.org/W2113579331","https://openalex.org/W4417095673","https://openalex.org/W2147973554","https://openalex.org/W2154059422","https://openalex.org/W4388899525","https://openalex.org/W2465444728","https://openalex.org/W7127038851"],"abstract_inverted_index":{"BACKGROUND:":[0],"Folate":[1],"receptors":[2],"(FRs)":[3],"facilitate":[4],"embryonic":[5,15],"uptake":[6],"of":[7,36,46,76,99,117,134,139,156,181,211,233,256],"folates":[8],"and":[9,84,103,132,247],"are":[10],"important":[11],"for":[12],"proper":[13],"early":[14],"development.":[16],"There":[17],"is":[18],"accumulating":[19],"evidence":[20],"that":[21],"blocking":[22],"FR":[23,37,54,68,77,121,135,140,182,212,238,257],"autoantibodies":[24,38,78,141,239],"contribute":[25],"to":[26,73,113,216],"developmental":[27],"diseases.":[28],"However,":[29],"genetic":[30,47,118,231],"factors":[31],"associated":[32,207,251],"with":[33,144,158,192,208,237,252],"the":[34,44,115,145,159,179,188,217,234],"expression":[35],"remain":[39],"unknown.":[40],"OBJECTIVE:":[41],"We":[42,60],"investigated":[43],"effects":[45,116],"polymorphisms":[48],"in":[49,57,65,88,142,187,244],"folate":[50],"pathway":[51],"genes":[52,249],"on":[53,120],"autoantibody":[55,122,183,213],"titers":[56],"women.":[58],"METHODS:":[59],"recruited":[61],"302":[62],"pregnant":[63],"women":[64,143,157],"China.":[66],"The":[67],"antigen-down":[69],"immunoassay":[70],"was":[71,111,206,228],"used":[72,112],"measure":[74],"levels":[75,133,138,210,255],"including":[79],"human":[80],"immunoglobulin":[81,85],"G":[82],"(IgG)":[83],"M":[86],"(IgM)":[87],"maternal":[89],"plasma.":[90],"Genotypes":[91],"were":[92,127,151,250],"identified":[93],"by":[94],"matrix-assisted":[95],"laser":[96],"desorption/ionization":[97],"time":[98],"flight":[100],"mass":[101],"spectrometry":[102],"polymerase":[104],"chain":[105],"reaction":[106],"methods.":[107],"General":[108],"linear":[109],"model":[110],"analyze":[114],"variants":[119,232],"levels.":[123,240],"RESULTS:":[124],"Significant":[125],"associations":[126],"observed":[128],"between":[129,230],"genotypic":[130],"variations":[131,243],"autoantibodies.":[136,258],"Plasma":[137],"TT":[146,189],"genotype":[147,161,190,194,204,219],"at":[148],"MTHFR":[149],"rs1801133":[150],"significantly":[152,185],"higher":[153],"than":[154],"those":[155],"CC":[160,193],"(IgG:":[162],"\u03b2":[163,170],"=":[164,171,196,221],"0.62,":[165],"95%":[166,173,198,223],"CI":[167,174,199,224],"0.21-1.04;":[168],"IgM:":[169],"0.42,":[172],"0.12-0.72).":[175],"For":[176,201],"DNMT3A":[177],"rs7560488,":[178],"level":[180],"IgG":[184],"increased":[186],"compared":[191,215],"(\u03b2":[195,220],"0.90,":[197],"0.20-1.59).":[200],"MTHFD2":[202,248],"rs828903,":[203],"GG":[205],"elevated":[209,253],"IgM":[214],"AA":[218],"0.60,":[222],"0.10-1.10).":[225],"No":[226],"association":[227],"detected":[229],"DHFR":[235],"gene":[236],"CONCLUSION:":[241],"Genetic":[242],"MTHFR,":[245],"DNMT3A,":[246],"plasma":[254]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2018-05-17T00:00:00"}
