{"id":"https://openalex.org/W2802414813","doi":"https://doi.org/10.1111/jch.13286","title":"Blood pressure is a beautiful (but imperfect) biomarker of hypertension. The quixotic quest that fuels the hypertension guideline industry","display_name":"Blood pressure is a beautiful (but imperfect) biomarker of hypertension. The quixotic quest that fuels the hypertension guideline industry","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2802414813","doi":"https://doi.org/10.1111/jch.13286","mag":"2802414813","pmid":"https://pubmed.ncbi.nlm.nih.gov/29741804","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8031240"},"language":"en","primary_location":{"id":"doi:10.1111/jch.13286","doi":"https://doi.org/10.1111/jch.13286","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jch.13286","pdf_url":null,"source":{"id":"https://openalex.org/S154226970","display_name":"Journal of Clinical Hypertension","issn_l":"1524-6175","issn":["1524-6175","1751-7176"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Hypertension","raw_type":"journal-article"},"volume":null,"type":"editorial","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8031240","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046628178","display_name":"Thomas D. Giles","orcid":"https://orcid.org/0000-0002-0476-7108","observed_orcids":["https://orcid.org/0000-0002-0476-7108"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas D. Giles","raw_affiliation_strings":["Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA, USA"],"raw_orcid":"https://orcid.org/0000-0002-0476-7108","affiliations":[{"raw_affiliation_string":"Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010988550","display_name":"John B. Kostis","orcid":"https://orcid.org/0000-0002-0335-3827","observed_orcids":["https://orcid.org/0000-0002-0335-3827"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John B. Kostis","raw_affiliation_strings":["Cardiovascular Institute, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Robert Wood Johnson Medical School, Rutgers University, New Brunswick, NJ, USA","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087350603","display_name":"Camilo Fernandez","orcid":"https://orcid.org/0000-0002-1828-2419","observed_orcids":["https://orcid.org/0000-0002-1828-2419"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Camilo Fernandez","raw_affiliation_strings":["Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Heart and Vascular Institute, Tulane University School of Medicine, New Orleans, LA, USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5010988550"],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":{"value":4000,"currency":"USD","value_usd":4000},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"5","first_page":"840","last_page":"841"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10144","display_name":"Blood Pressure and Hypertension Studies","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12664","display_name":"Clinical practice guidelines implementation","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10924","display_name":"Cardiovascular Health and Disease Prevention","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.9700000286102295},{"id":"https://openalex.org/keywords/blood-pressure","display_name":"blood pressure","score":0.8529999852180481},{"id":"https://openalex.org/keywords/hypertension-definition","display_name":"hypertension definition","score":0.6000000238418579},{"id":"https://openalex.org/keywords/blood-pressure-thresholds","display_name":"blood pressure thresholds","score":0.828000009059906},{"id":"https://openalex.org/keywords/jnc-7","display_name":"JNC 7","score":0.828000009059906},{"id":"https://openalex.org/keywords/cardiovascular-risk","display_name":"cardiovascular risk","score":0.6480000019073486},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.6790000200271606},{"id":"https://openalex.org/keywords/hypertension-classification","display_name":"hypertension classification","score":0.32600000500679016},{"id":"https://openalex.org/keywords/cardiovascular-morbidity-and-mortality","display_name":"cardiovascular morbidity and mortality","score":0.6039999723434448},{"id":"https://openalex.org/keywords/kidney-disease","display_name":"kidney disease","score":0.3400000035762787},{"id":"https://openalex.org/keywords/stroke","display_name":"stroke","score":0.6119999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9056031703948975},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.7736459970474243},{"id":"https://openalex.org/C2780182762","wikidata":"https://www.wikidata.org/wiki/Q1630279","display_name":"Guideline","level":2,"score":0.7269959449768066},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5806211829185486},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5343016982078552},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5211048722267151},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5001554489135742},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.4706057012081146},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4652826189994812},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.43432000279426575},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.09136611223220825},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.08977577090263367},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000572","descriptor_name":"American Heart Association","qualifier_ui":"Q000458","qualifier_name":"organization & administration","is_major_topic":false},{"descriptor_ui":"D001794","descriptor_name":"Blood Pressure","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001795","descriptor_name":"Blood Pressure Determination","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006973","descriptor_name":"Hypertension","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015995","descriptor_name":"Prevalence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017410","descriptor_name":"Practice Guidelines as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/jch.13286","doi":"https://doi.org/10.1111/jch.13286","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jch.13286","pdf_url":null,"source":{"id":"https://openalex.org/S154226970","display_name":"Journal of Clinical Hypertension","issn_l":"1524-6175","issn":["1524-6175","1751-7176"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Hypertension","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8031240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8031240","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Hypertens (Greenwich)","raw_type":"Text"},{"id":"pmid:29741804","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29741804","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical hypertension (Greenwich, Conn.)","raw_type":"Editorial"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8031240","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8031240","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Hypertens (Greenwich)","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W1572806581","https://openalex.org/W1971603726","https://openalex.org/W2131120290","https://openalex.org/W2770837559","https://openalex.org/W3150595609","https://openalex.org/W6979122449"],"related_works":["https://openalex.org/W2783341962","https://openalex.org/W4247647231","https://openalex.org/W2792600129","https://openalex.org/W28734473","https://openalex.org/W2903950834","https://openalex.org/W2889639000","https://openalex.org/W2792768430","https://openalex.org/W2783075735","https://openalex.org/W4238704520","https://openalex.org/W2809403628"],"abstract_inverted_index":{"Hypertension":[0,291],"is":[1,7,90,168,188,252,278,292,314,327,377,460,529,554,579,630,654,698,740,841,966],"a":[2,8,40,169,197,260,293,378,549,741,805,842],"disease;":[3],"blood":[4,972],"pressure":[5,167],"(BP)":[6],"biomarker.":[9,290,541],"However,":[10,134,225],"the":[11,22,42,47,57,61,82,93,98,152,268,271,283,289,306,341,362,385,408,443,476,519,522,534,540,544,555,559,572,577,591,604,608,634,788,797,819,829,837,869,872,885,933,935,980,1009,1020,1036],"2":[12],"terms":[13],"have":[14,506],"become":[15],"ineluctably":[16],"bound.":[17],"Based":[18],"on":[19,65,615,668,731,784,804,813,856],"BP":[20,34,103,146,185,218,262,312,324,451,469,483,497,547,562,573,664,693,981,1003],"measurements,":[21],"2017":[23],"American":[24],"College":[25],"of":[26,44,60,71,81,201,210,220,240,270,273,305,365,374,388,521,524,546,551,561,571,593,612,623,636,705,714,719,757,790,800,808,821,836,877,922,982,1002,1019,1022,1033,1038],"Cardiology/American":[27],"Heart":[28,369],"Association":[29],"(ACC/AHA)":[30],"guideline":[31,606,780],"defines":[32,889],"normal":[33,184,945,988],"as":[35,50,449,481,548,985,989,1016],"120/80":[36,106,222],"mm":[37,107,132,139,223,454,472,486,696],"Hg.":[38,133,140,224],"As":[39],"result,":[41],"number":[43,807],"individuals":[45],"in":[46,56,235,361,384,392,398,498,564,576,648,676,681,746,825,854,884,920,940],"US":[48],"classified":[49,320,447],"hypertensive":[51],"increased":[52,112],"from":[53,298,762],"72":[54],"million":[55],"Seventh":[58],"Report":[59],"Joint":[62],"National":[63],"Committee":[64],"Prevention,":[66],"Detection,":[67],"Evaluation,":[68],"and":[69,115,171,186,205,213,237,249,287,300,333,336,346,349,354,380,391,405,456,514,538,610,617,625,646,651,666,703,707,760,795,810,818,828,874,888,895,927,971,998,1008,1013],"Treatment":[70],"High":[72],"Blood":[73],"Pressure":[74],"(JNC":[75],"7)":[76],"to":[77,150,178,242,254,266,280,351,438,463,531,603,657,662,690,978,987],"over":[78,162,275,526],"100":[79],"million\u201445.6%":[80],"population,":[83],"with":[84,92,111,128,147,233,330,401,467,590,700,915,953,1004],"36.2%":[85],"needing":[86],"antihypertensive":[87,1023],"medication.1":[88],"This":[89,965],"consistent":[91],"longstanding":[94],"observation":[95],"made":[96],"by":[97,322,959],"insurance":[99],"industry":[100],"actuaries":[101],"that":[102,120,339,426,458,598,633,680,737,743,752,848,868,942,1028],"levels":[104,209,219,665],"above":[105,130,944],"Hg":[108],"were":[109,423,489],"associated":[110,329,699],"cardiovascular":[113,202,295,649,687,710,732],"morbidity":[114,353],"mortality.":[116],"Nevertheless,":[117,582],"they":[118,600],"suggest":[119],"drug":[121],"therapy":[122],"be":[123,144,319,411,419,439],"only":[124,461,599],"recommended":[125,507],"for":[126,155,247,259,394,435,492,512,607,686,951,969],"those":[127,919],"BPs":[129],"140/90":[131],"physicians":[135],"treat":[136],"patients,":[137],"not":[138,229,418,761],"Thus,":[141],"caregivers":[142],"should":[143,417,924,976],"discussing":[145],"their":[148,244,627,758,763],"patients":[149,466,682,726,923,930,952],"understand":[151,267,518],"appropriate":[153],"level":[154],"each":[156,983],"person.":[157],"Sir":[158],"George":[159],"Pickering":[160],"articulated":[161],"40":[163,433],"years":[164,434],"ago:":[165],"\u201cArterial":[166],"quantity":[170],"its":[172],"adverse":[173,1010],"effects":[174],"are":[175,308,601,735,834,946,1030],"related":[176],"numerically":[177],"it.":[179],"The":[180,671,712,779,1025],"dividing":[181],"line":[182],"(between":[183],"hypertension)":[187],"nothing":[189],"more":[190,509],"than":[191,728],"an":[192,412,729],"artifact.\u201d2":[193],"Epidemiologic":[194],"data":[195,574],"support":[196],"continuous,":[198],"incremental":[199],"risk":[200,685,742,1006],"disease,":[203],"stroke,":[204],"renal":[206],"disease":[207,284,535],"across":[208],"both":[211],"systolic":[212,496,692],"diastolic":[214,450,468,482],"BP,":[215,288,539,616],"beginning":[216],"at":[217,683,831,851],"approximately":[221],"this":[226,256,436,861,916,1039],"fact":[227,393],"has":[228,586,781],"deterred":[230],"every":[231,583],"organization":[232],"interest":[234,1034],"hypertension,":[236],"many":[238],"groups":[239,624],"individuals,":[241],"promote":[243,663],"own":[245],"guidelines":[246],"definition":[248,272,523],"treatment.":[250],"It":[251,431,629,653],"time":[253,656,791],"end":[255],"quixotic":[257],"quest":[258],"one-size-fits-all":[261],"number.":[263],"In":[264,356,441,474,567,860,913,932],"order":[265],"evolution":[269,520],"hypertension":[274,286,317,375,409,448,480,525,537,553,594,613,637],"time,":[276,527],"it":[277,424,528],"necessary":[279,530],"distinguish":[281,532],"between":[282,533,792,823],"called":[285,536],"progressive":[294],"syndrome":[296,307],"arising":[297],"complex":[299],"interrelated":[301],"etiologies.3":[302],"Early":[303],"markers":[304],"often":[309],"present":[310,386],"before":[311],"elevation":[313],"sustained;":[315],"therefore,":[316],"cannot":[318],"solely":[321],"discrete":[323],"thresholds.":[325],"Progression":[326],"strongly":[328],"functional,":[331],"endocrine,":[332],"structural":[334],"cardiac":[335],"vascular":[337],"abnormalities":[338],"damage":[340],"heart,":[342],"kidneys,":[343],"brain,":[344],"vasculature,":[345],"other":[347,1005],"organs":[348],"lead":[350],"premature":[352],"death.":[355],"1937,":[357],"Paul":[358,961],"Dudley":[359,962],"White":[360,963],"second":[363,477],"edition":[364],"his":[366],"book":[367],"entitled":[368,839],"Disease":[370],"wrote":[371],"\u201cThe":[372],"treatment":[373,611,689],"itself":[376],"difficult":[379],"almost":[381],"hopeless":[382],"task":[383],"state":[387],"our":[389,929],"knowledge,":[390],"aught":[395],"we":[396,427,975],"know,":[397],"advanced":[399],"cases":[400],"permanently":[402],"narrowed":[403],"coronary":[404],"cerebral":[406],"arteries":[407],"may":[410],"important":[413],"compensatory":[414],"mechanism":[415],"which":[416],"tampered":[420],"with,":[421],"even":[422,949],"certain":[425],"could":[428],"control":[429],"it.\u201d4":[430],"took":[432],"opinion":[437],"corrected.":[440],"1977,":[442],"first":[444,876],"JNC":[445,478,499,504],"report":[446],">":[452,470,484],"105":[453],"HG,":[455],"suggested":[457],"consideration":[459],"given":[462],"actively":[464],"treating":[465,495,515],"90":[471,485],"HG.":[473],"1980,":[475],"defined":[479],"HG.5":[487],"There":[488],"no":[490,1031],"recommendations":[491],"classifying":[493],"or":[494,501,948],"I":[500],"II.":[502],"Subsequent":[503],"reports":[505],"progressively":[508],"rigorous":[510],"criteria":[511],"defining":[513,552],"hypertension.":[516],"To":[517],"Further":[542],"complicating":[543],"use":[545,1021],"means":[550],"voluminous":[556],"literature":[557],"documenting":[558],"inaccuracy":[560],"measurements":[563],"clinical":[565,673,801,826],"settings.":[566],"fact,":[568],"virtually":[569],"all":[570,621,754,878,918],"used":[575],"\u201cguidelines\u201d":[578],"fatally":[580],"flawed.":[581],"person":[584],"who":[585],"had":[587],"any":[588],"association":[589],"field":[592],"will":[595,619],"immediately":[596],"conclude":[597],"privy":[602],"ideal":[605],"diagnosis":[609],"based":[614],"then":[618],"organize":[620],"description":[622],"publish":[626],"thoughts.":[628],"now":[631,655],"evident":[632],"development":[635],"involves":[638],"genetic,":[639,994],"epigenetic":[640],"factors,":[641],"autonomic":[642],"nervous":[643],"system":[644],"dysregulation,":[645],"alterations":[647],"structure":[650],"function.":[652],"abandon":[658],"these":[659],"expensive":[660],"attempts":[661],"concentrate":[667],"phenotypic":[669],"refinement.":[670],"SPRINT":[672,715],"trial,":[674],"published":[675],"late":[677],"2017,":[678],"showed":[679],"high":[684],"events":[688],"target":[691],"below":[694],"120":[695],"HG":[697],"lower":[701],"mortality":[702],"rates":[704],"fatal":[706],"nonfatal":[708],"major":[709],"events.6":[711],"publication":[713,1037],"created":[716],"several":[717,785],"types":[718],"reactions:":[720],"some":[721],"raised":[722],"concern":[723],"about":[724],"overmedicating":[725],"rather":[727],"emphasis":[730,803,812],"disease.":[733],"They":[734],"afraid":[736],"otherwise":[738],"there":[739,1029],"Moli\u00e8re's":[744],"statement":[745],"Malade":[747],"Imaginaire":[748],"(The":[749],"Imaginary":[750],"Invalid)":[751],"nearly":[753],"people":[755],"die":[756],"remedies":[759],"illnesses":[764],"(\u201cPresque":[765],"tous":[766],"les":[767],"hommes":[768],"meurent":[769],"de":[770,776],"leur":[771,777],"rem\u00e8des,":[772],"et":[773,908],"non":[774],"pas":[775],"maladies\u201d).":[778],"been":[782],"criticized":[783],"grounds,":[786],"including":[787],"length":[789],"hypothesis":[793],"generation":[794],"publication,":[796],"short":[798],"duration":[799],"trials,":[802],"small":[806],"studies":[809],"undue":[811],"frequentist":[814],"statistics":[815],"(P":[816],"values),":[817],"lack":[820],"similarity":[822],"participants":[824],"trials":[827],"population":[830],"large.":[832],"We":[833],"reminded":[835],"lecture":[838],"Existentialism":[840],"Humanism":[843],"(\u201cL'existentialisme":[844],"est":[845],"un":[846],"humanism\u201d)":[847],"Sartre":[849],"gave":[850],"Club":[852],"Maintenant":[853],"Paris":[855],"October":[857],"29,":[858],"1945.7":[859],"very":[862],"well":[863],"attended":[864],"lecture,":[865],"he":[866],"stated":[867,958],"existence":[870],"precedes":[871],"essence":[873],"\u201cman":[875],"exists,":[879],"encounters":[880],"himself,":[881],"surges":[882],"up":[883],"world":[886],"\u2013":[887],"himself":[890],"afterwards.\u201d":[891],"\u201cl'existence":[892],"pr\u00e9c\u00e8de":[893],"l'essence\u201d":[894],"\u201cCela":[896],"signifie":[897],"que":[898],"l'homme":[899],"existe":[900],"d'abord,":[901],"se":[902,910],"rencontre,":[903],"surgit":[904],"dans":[905],"le":[906],"monde,":[907],"qu'il":[909],"d\u00e9finit":[911],"apr\u00e8s.\u201d":[912],"keeping":[914],"concept,":[917],"charge":[921],"act":[925],"today":[926],"advise":[928],"appropriately.":[931],"past,":[934],"medical":[936],"profession":[937],"was":[938],"wrong":[939],"considering":[941,991],"values":[943],"acceptable":[947],"desirable":[950],"different":[954],"pathological":[955],"conditions":[956],"(as":[957],"Dr.":[960],"above).":[964],"also":[967],"true":[968],"cholesterol":[970],"glucose.":[973],"Today,":[974],"strive":[977],"bring":[979],"patient":[984,1014],"close":[986],"possible":[990],"individual":[992],"circumstances;":[993],"cultural,":[995],"physiological,":[996],"pathological,":[997],"psychological":[999],"differences;":[1000],"interactions":[1001],"factors;":[1007],"effects,":[1011],"expense,":[1012],"labeling":[1015],"sick":[1017],"because":[1018],"therapy.":[1024],"authors":[1026],"declare":[1027],"conflicts":[1032],"regarding":[1035],"article.":[1040]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}
