{"id":"https://openalex.org/W2802373044","doi":"https://doi.org/10.1111/jeb.13282","title":"Mutation accumulation in populations of varying size: large effect mutations cause most mutational decline in the rotifer Brachionus calyciflorus under UV\u2010C radiation","display_name":"Mutation accumulation in populations of varying size: large effect mutations cause most mutational decline in the rotifer Brachionus calyciflorus under UV\u2010C radiation","publication_year":2018,"publication_date":"2018-04-19","ids":{"openalex":"https://openalex.org/W2802373044","doi":"https://doi.org/10.1111/jeb.13282","mag":"2802373044","pmid":"https://pubmed.ncbi.nlm.nih.gov/29672987"},"language":"en","primary_location":{"id":"doi:10.1111/jeb.13282","doi":"https://doi.org/10.1111/jeb.13282","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jeb.13282","pdf_url":null,"source":{"id":"https://openalex.org/S138169916","display_name":"Journal of Evolutionary Biology","issn_l":"1010-061X","issn":["1010-061X","1420-9101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Evolutionary Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043527023","display_name":"Pepijn Luijckx","orcid":"https://orcid.org/0000-0002-8173-6727","observed_orcids":["https://orcid.org/0000-0002-8173-6727"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]},{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["CA","IE"],"is_corresponding":true,"raw_author_name":"Pepijn Luijckx","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada","Zoology, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland"],"raw_orcid":"https://orcid.org/0000-0002-8173-6727","affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]},{"raw_affiliation_string":"Zoology, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020281526","display_name":"Eddie K. H. Ho","orcid":"https://orcid.org/0000-0002-7692-394X","observed_orcids":["https://orcid.org/0000-0002-7692-394X"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Eddie K. H. Ho","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073204913","display_name":"Andrijana Stani\u0107","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Andrijana Stani\u0107","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026044480","display_name":"Aneil F. Agrawal","orcid":"https://orcid.org/0000-0003-2496-2733","observed_orcids":["https://orcid.org/0000-0003-2496-2733"]},"institutions":[{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Aneil F. Agrawal","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Toronto, Toronto, ON, Canada","institution_ids":["https://openalex.org/I185261750"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5043527023"],"corresponding_institution_ids":["https://openalex.org/I185261750","https://openalex.org/I205274468"],"apc_list":{"value":2368,"currency":"GBP","value_usd":3123},"apc_paid":null,"fwci":0.3939,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.57398942,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"31","issue":"6","first_page":"924","last_page":"932"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mutation-accumulation","display_name":"mutation accumulation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/population-size","display_name":"population size","score":0.8960000276565552},{"id":"https://openalex.org/keywords/brachionus-calyciflorus","display_name":"Brachionus calyciflorus","score":0.9120000004768372},{"id":"https://openalex.org/keywords/rotifers","display_name":"rotifers","score":0.7080000042915344},{"id":"https://openalex.org/keywords/uv-c-radiation","display_name":"UV-C radiation","score":0.9139999747276306},{"id":"https://openalex.org/keywords/mutational-load","display_name":"mutational load","score":0.46799999475479126},{"id":"https://openalex.org/keywords/physical-fitness-decline","display_name":"physical fitness decline","score":0.6269999742507935},{"id":"https://openalex.org/keywords/mutation-spectrum","display_name":"mutation spectrum","score":0.7910000085830688},{"id":"https://openalex.org/keywords/selection","display_name":"selection","score":0.37599998712539673},{"id":"https://openalex.org/keywords/lifetime-reproduction","display_name":"lifetime reproduction","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C2776279094","wikidata":"https://www.wikidata.org/wiki/Q2547210","display_name":"Brachionus calyciflorus","level":3,"score":0.9916955232620239},{"id":"https://openalex.org/C2777181938","wikidata":"https://www.wikidata.org/wiki/Q180148","display_name":"Rotifer","level":2,"score":0.9461292028427124},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9444896578788757},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5252087712287903},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5210901498794556},{"id":"https://openalex.org/C90856448","wikidata":"https://www.wikidata.org/wiki/Q431","display_name":"Zoology","level":1,"score":0.4938855767250061},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.353066086769104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11497718095779419}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012403","descriptor_name":"Rotifera","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012403","descriptor_name":"Rotifera","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056084","descriptor_name":"Genetic Fitness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/jeb.13282","doi":"https://doi.org/10.1111/jeb.13282","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jeb.13282","pdf_url":null,"source":{"id":"https://openalex.org/S138169916","display_name":"Journal of Evolutionary Biology","issn_l":"1010-061X","issn":["1010-061X","1420-9101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-2","ki-jl-2","medline","norway-2","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Evolutionary Biology","raw_type":"journal-article"},{"id":"pmid:29672987","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29672987","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of evolutionary biology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1420371875","display_name":null,"funder_award_id":"2015-05387","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8938657180","display_name":"Empirical testing of hypotheses explaining the paradox of sex","funder_award_id":"138671","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1485011392","https://openalex.org/W1528776873","https://openalex.org/W1544431211","https://openalex.org/W1930635754","https://openalex.org/W1959734830","https://openalex.org/W1989298969","https://openalex.org/W1989799201","https://openalex.org/W1992294575","https://openalex.org/W1995865334","https://openalex.org/W2004990674","https://openalex.org/W2006841412","https://openalex.org/W2013753628","https://openalex.org/W2022789570","https://openalex.org/W2026743476","https://openalex.org/W2032320097","https://openalex.org/W2033290951","https://openalex.org/W2062210712","https://openalex.org/W2071856489","https://openalex.org/W2076022698","https://openalex.org/W2081938446","https://openalex.org/W2084076901","https://openalex.org/W2096160674","https://openalex.org/W2117974897","https://openalex.org/W2121553632","https://openalex.org/W2124841766","https://openalex.org/W2128023973","https://openalex.org/W2135246115","https://openalex.org/W2139160625","https://openalex.org/W2140024267","https://openalex.org/W2140382310","https://openalex.org/W2142391696","https://openalex.org/W2144673831","https://openalex.org/W2144762955","https://openalex.org/W2147647730","https://openalex.org/W2161538889","https://openalex.org/W2162152219","https://openalex.org/W2167243456","https://openalex.org/W2178877129","https://openalex.org/W2179325918","https://openalex.org/W2226008396","https://openalex.org/W2303736144","https://openalex.org/W2536460826","https://openalex.org/W2570142701","https://openalex.org/W2582743722","https://openalex.org/W4249199998","https://openalex.org/W7075595837"],"related_works":["https://openalex.org/W1544431211","https://openalex.org/W6966945584","https://openalex.org/W2161538889","https://openalex.org/W7098636843","https://openalex.org/W2081938446","https://openalex.org/W4240006507","https://openalex.org/W2791231555","https://openalex.org/W6948690486","https://openalex.org/W136031496","https://openalex.org/W2084076901"],"abstract_inverted_index":{"Theory":[0],"predicts":[1],"that":[2,69,104,126,183,196],"fitness":[3,32,75,94,153,162],"decline":[4],"via":[5],"mutation":[6,40],"accumulation":[7,41],"will":[8],"depend":[9],"on":[10],"population":[11,53,81],"size,":[12],"but":[13],"there":[14],"are":[15,129],"only":[16],"a":[17,27,39,169,187],"few":[18],"direct":[19],"tests":[20],"of":[21,30,34,112,144,174,190],"this":[22,138,197],"key":[23],"idea.":[24],"To":[25],"gain":[26],"qualitative":[28],"understanding":[29],"the":[31,44,97,101,110,202],"effect":[33,114],"new":[35],"mutations,":[36],"we":[37,135],"performed":[38],"experiment":[42,102,171],"with":[43,79,172],"facultative":[45],"sexual":[46],"rotifer":[47],"Brachionus":[48],"calyciflorus":[49],"at":[50],"six":[51],"different":[52],"sizes":[54],"under":[55],"UV-C":[56,66],"radiation.":[57,209],"Lifetime":[58],"reproduction":[59],"assays":[60],"conducted":[61],"after":[62],"ten":[63],"and":[64],"sixteen":[65],"radiations":[67],"showed":[68],"while":[70],"small":[71,117,127],"populations":[72,99,128,143,173],"lost":[73],"fitness,":[74],"losses":[76],"diminished":[77],"rapidly":[78],"increasing":[80],"size.":[82,176],"Populations":[83],"kept":[84],"as":[85,87,159],"low":[86],"10":[88],"individuals":[89],"were":[90],"able":[91,107],"to":[92,96,108,124,132,146,181],"maintain":[93],"close":[95],"nonmutagenized":[98],"throughout":[100],"indicating":[103],"selection":[105],"was":[106],"remove":[109],"majority":[111],"large":[113,147,191],"mutations":[115,158],"in":[116,152],"populations.":[118],"Although":[119],"our":[120],"results":[121,194],"also":[122,199],"seem":[123],"imply":[125],"effectively":[130],"immune":[131],"mutational":[133,184,203],"decay,":[134],"caution":[136],"against":[137],"interpretation.":[139],"Given":[140],"sufficient":[141],"time,":[142],"moderate":[145,175],"size":[148],"can":[149],"experience":[150],"declines":[151],"from":[154,164,168],"accumulating":[155],"weakly":[156],"deleterious":[157],"demonstrated":[160],"by":[161,207],"estimates":[163],"simulations":[165],"and,":[166],"tentatively,":[167],"long-term":[170],"There":[177],"is":[178,198,205],"mounting":[179],"evidence":[180],"suggest":[182,195],"distributions":[185],"contain":[186],"heavier":[188],"tail":[189],"effects.":[192],"Our":[193],"true":[200],"when":[201],"spectrum":[204],"altered":[206],"UV":[208]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}
