{"id":"https://openalex.org/W2802321132","doi":"https://doi.org/10.1111/jfbc.12556","title":"Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal","display_name":"Potential anti-mutagenicity, antioxidant, and anti-inflammatory capacities of the extract from perilla seed meal","publication_year":2018,"publication_date":"2018-05-06","ids":{"openalex":"https://openalex.org/W2802321132","doi":"https://doi.org/10.1111/jfbc.12556","mag":"2802321132"},"language":"en","primary_location":{"id":"doi:10.1111/jfbc.12556","doi":"https://doi.org/10.1111/jfbc.12556","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jfbc.12556","pdf_url":null,"source":{"id":"https://openalex.org/S53703007","display_name":"Journal of Food Biochemistry","issn_l":"0145-8884","issn":["0145-8884","1745-4514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Biochemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065963046","display_name":"Orada Chumphukam","orcid":"https://orcid.org/0000-0002-6474-1356","observed_orcids":["https://orcid.org/0000-0002-6474-1356"]},"institutions":[{"id":"https://openalex.org/I4210090662","display_name":"University of Phayao","ror":"https://ror.org/00a5mh069","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210090662"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Orada Chumphukam","raw_affiliation_strings":["Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand","institution_ids":["https://openalex.org/I4210090662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053598005","display_name":"Komsak Pintha","orcid":"https://orcid.org/0000-0003-3547-6861","observed_orcids":["https://orcid.org/0000-0003-3547-6861"]},"institutions":[{"id":"https://openalex.org/I4210090662","display_name":"University of Phayao","ror":"https://ror.org/00a5mh069","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210090662"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Komsak Pintha","raw_affiliation_strings":["Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand","institution_ids":["https://openalex.org/I4210090662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074243016","display_name":"Chakkrit Khanaree","orcid":"https://orcid.org/0000-0003-4870-8465","observed_orcids":["https://orcid.org/0000-0003-4870-8465"]},"institutions":[{"id":"https://openalex.org/I4210090662","display_name":"University of Phayao","ror":"https://ror.org/00a5mh069","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210090662"]},{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Chakkrit Khanaree","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]},{"raw_affiliation_string":"Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand","institution_ids":["https://openalex.org/I4210090662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024070869","display_name":"Teera Chewonarin","orcid":"https://orcid.org/0000-0001-9044-3777","observed_orcids":["https://orcid.org/0000-0001-9044-3777"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Teera Chewonarin","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":"https://orcid.org/0000-0001-9044-3777","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000017910","display_name":"Wittaya Chaiwangyen","orcid":"https://orcid.org/0000-0002-2456-8106","observed_orcids":["https://orcid.org/0000-0002-2456-8106"]},"institutions":[{"id":"https://openalex.org/I4210090662","display_name":"University of Phayao","ror":"https://ror.org/00a5mh069","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210090662"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Wittaya Chaiwangyen","raw_affiliation_strings":["Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand","institution_ids":["https://openalex.org/I4210090662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028998386","display_name":"Payungsak Tantipaiboonwong","orcid":"https://orcid.org/0000-0003-1435-8882","observed_orcids":["https://orcid.org/0000-0003-1435-8882"]},"institutions":[{"id":"https://openalex.org/I4210090662","display_name":"University of Phayao","ror":"https://ror.org/00a5mh069","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210090662"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Payungsak Tantipaiboonwong","raw_affiliation_strings":["Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand","institution_ids":["https://openalex.org/I4210090662"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043732993","display_name":"Maitree Suttajit","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210090662","display_name":"University of Phayao","ror":"https://ror.org/00a5mh069","country_code":"TH","type":"education","lineage":["https://openalex.org/I4210090662"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Maitree Suttajit","raw_affiliation_strings":["Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biochemistry and Nutrition, School of Medical Sciences, University of Phayao, Phayao, Thailand","institution_ids":["https://openalex.org/I4210090662"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079395663","display_name":"Orawan Khantamat","orcid":"https://orcid.org/0000-0003-1328-3049","observed_orcids":["https://orcid.org/0000-0003-1328-3049"]},"institutions":[{"id":"https://openalex.org/I48076826","display_name":"Chiang Mai University","ror":"https://ror.org/05m2fqn25","country_code":"TH","type":"education","lineage":["https://openalex.org/I48076826"]}],"countries":["TH"],"is_corresponding":true,"raw_author_name":"Orawan Khantamat","raw_affiliation_strings":["Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"],"raw_orcid":"https://orcid.org/0000-0003-1328-3049","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand","institution_ids":["https://openalex.org/I48076826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079395663"],"corresponding_institution_ids":["https://openalex.org/I48076826"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":2.0779,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.84525119,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"42","issue":"5","first_page":"e12556","last_page":"e12556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10035","display_name":"Phytochemicals and Antioxidant Activities","score":0.9121000170707703,"subfield":{"id":"https://openalex.org/subfields/2704","display_name":"Biochemistry (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.06840000301599503,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0071000000461936,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perilla-seeds","display_name":"perilla seeds","score":0.8560000061988831},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9940000176429749},{"id":"https://openalex.org/keywords/anti-inflammatory-activity","display_name":"anti-inflammatory activity","score":0.9980000257492065},{"id":"https://openalex.org/keywords/rosmarinic-acid","display_name":"rosmarinic acid","score":0.7409999966621399},{"id":"https://openalex.org/keywords/total-phenolic-content","display_name":"total phenolic content","score":0.7940000295639038},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.9900000095367432},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.843999981880188},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.9639999866485596},{"id":"https://openalex.org/keywords/nitric-oxide-production","display_name":"nitric oxide production","score":0.8820000290870667},{"id":"https://openalex.org/keywords/inducible-nitric-oxide-synthase","display_name":"inducible nitric oxide synthase","score":0.7360000014305115},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9200000166893005},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/raw-264-7-macrophages","display_name":"RAW 264.7 macrophages","score":0.8830000162124634},{"id":"https://openalex.org/keywords/functional-foods","display_name":"functional foods","score":0.75},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.7998269200325012},{"id":"https://openalex.org/C17857428","wikidata":"https://www.wikidata.org/wiki/Q533025","display_name":"Nutraceutical","level":2,"score":0.7821027636528015},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7057695388793945},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.6667195558547974},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6656096577644348},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.6483389139175415},{"id":"https://openalex.org/C2776971262","wikidata":"https://www.wikidata.org/wiki/Q5597007","display_name":"Grape seed extract","level":3,"score":0.6228436231613159},{"id":"https://openalex.org/C2777259179","wikidata":"https://www.wikidata.org/wiki/Q1076038","display_name":"Perilla frutescens","level":2,"score":0.5633816719055176},{"id":"https://openalex.org/C2779956635","wikidata":"https://www.wikidata.org/wiki/Q7168518","display_name":"Perilla","level":3,"score":0.5528384447097778},{"id":"https://openalex.org/C2780132029","wikidata":"https://www.wikidata.org/wiki/Q752276","display_name":"Functional food","level":2,"score":0.4541652798652649},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.4493364691734314},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.4440543055534363},{"id":"https://openalex.org/C2778771215","wikidata":"https://www.wikidata.org/wiki/Q50380051","display_name":"Rosmarinic acid","level":3,"score":0.4189777970314026},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31980249285697937},{"id":"https://openalex.org/C206139338","wikidata":"https://www.wikidata.org/wiki/Q192355","display_name":"Raw material","level":2,"score":0.16639041900634766},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1111/jfbc.12556","doi":"https://doi.org/10.1111/jfbc.12556","is_oa":false,"landing_page_url":"https://doi.org/10.1111/jfbc.12556","pdf_url":null,"source":{"id":"https://openalex.org/S53703007","display_name":"Journal of Food Biochemistry","issn_l":"0145-8884","issn":["0145-8884","1745-4514"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Food Biochemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6875,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"},{"score":0.5683000087738037,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6835764043","display_name":null,"funder_award_id":"CRP5605021680","funder_id":"https://openalex.org/F4320323106","funder_display_name":"Agricultural Research Development Agency"}],"funders":[{"id":"https://openalex.org/F4320323106","display_name":"Agricultural Research Development Agency","ror":"https://ror.org/01shbv660"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1598791431","https://openalex.org/W1896062903","https://openalex.org/W1980831983","https://openalex.org/W1984526484","https://openalex.org/W2012992792","https://openalex.org/W2030115013","https://openalex.org/W2032017343","https://openalex.org/W2046558827","https://openalex.org/W2048673603","https://openalex.org/W2059303642","https://openalex.org/W2059411927","https://openalex.org/W2062753660","https://openalex.org/W2078733088","https://openalex.org/W2089243597","https://openalex.org/W2104599776","https://openalex.org/W2112301908","https://openalex.org/W2120664042","https://openalex.org/W2123139088","https://openalex.org/W2128380182","https://openalex.org/W2236270374","https://openalex.org/W2280110465","https://openalex.org/W2318647524","https://openalex.org/W2319316130","https://openalex.org/W2510536806","https://openalex.org/W2530157596","https://openalex.org/W2746876433","https://openalex.org/W2782183746","https://openalex.org/W6695408077"],"related_works":["https://openalex.org/W3200563840","https://openalex.org/W4413942599","https://openalex.org/W3212822525","https://openalex.org/W2940863552","https://openalex.org/W2352173623","https://openalex.org/W2901410385","https://openalex.org/W2595555391","https://openalex.org/W2000844659","https://openalex.org/W4399997951","https://openalex.org/W2322712335"],"abstract_inverted_index":{"The":[0,89,106,178],"objective":[1],"of":[2,16,97,108,181,203],"this":[3],"study":[4,154],"was":[5,55],"to":[6,51],"investigate":[7],"the":[8,14,19,137,157,204],"in":[9,18,46,58,128,196],"vitro":[10,129],"bioactivities":[11,185],"associated":[12],"with":[13,28],"content":[15,39,180],"phytochemicals":[17],"extracts":[20,76,90],"from":[21,162],"perilla":[22,139],"seed":[23,30,140,158,163,206],"meal":[24,141],"extract":[25],"(PSME)":[26],"compared":[27],"dietary":[29,172],"(PSE).":[31],"PSE":[32,68,123],"had":[33],"higher":[34],"total":[35],"phenolics":[36],"and":[37,63,69,73,81,110,124,132,176,183,192,194,198,212],"flavonoids":[38],"than":[40],"PSME.":[41],"However,":[42],"hydrophilic":[43],"phytochemical":[44],"contents":[45],"PSME":[47,70,125],"were":[48,71,112],"quantitatively":[49],"equivalent":[50],"PSE.":[52],"Rosmarinic":[53],"acid":[54],"predominantly":[56],"found":[57],"both":[59],"extracts.":[60,117],"Cell":[61],"viability":[62],"anti-mutagenicity":[64],"testing":[65],"demonstrated":[66],"that":[67,122,156],"biosecured":[72],"non-genotoxic.":[74],"Both":[75],"strongly":[77],"scavenged":[78],"free":[79],"radicals":[80],"significantly":[82],"reduced":[83],"reactive":[84],"oxygen":[85],"species":[86],"(ROS)":[87],"production.":[88,200],"drastically":[91],"diminished":[92],"nitric":[93],"oxide":[94],"(NO)":[95],"production":[96],"LPS-treated":[98],"RAW":[99],"264.7":[100],"cells":[101],"via":[102],"iNOS":[103],"mRNA":[104],"expression.":[105],"expression":[107],"IL-6":[109],"COX-2":[111],"evidently":[113],"inhibited":[114],"by":[115],"these":[116],"It":[118],"could":[119,142],"be":[120,143,167,187],"concluded":[121],"clearly":[126],"showed":[127],"anti-mutagenicity,":[130],"antioxidant":[131],"anti-inflammatory":[133],"capacities.":[134],"In":[135],"particular,":[136],"by-product":[138,161,205],"considered":[144],"as":[145,169,189],"a":[146,160,170],"high":[147,179],"nutritive":[148],"functional":[149,190],"food.":[150],"Practical":[151],"applications":[152],"This":[153],"suggests":[155],"meals,":[159],"oil":[164],"industry,":[165],"can":[166,186],"utilized":[168],"valuable":[171],"source":[173],"for":[174],"humans":[175],"animals.":[177],"polyphenols":[182],"their":[184],"developed":[188],"foods,":[191],"excipients":[193],"fillers":[195],"pharmaceuticals":[197],"nutraceuticals":[199],"Moreover,":[201],"recycling":[202],"meals":[207],"should":[208],"also":[209],"reduce":[210],"environmental":[211],"sanitary":[213],"pollution.":[214]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}