{"id":"https://openalex.org/W2802307705","doi":null,"title":"Efeito protetor do exerc\u00edcio f\u00edsico nas altera\u00e7\u00f5es bioqu\u00edmicas e cognitivas iniciais e tardias induzidas pelo traumatismo cranioencef\u00e1lico em ratos","display_name":"Efeito protetor do exerc\u00edcio f\u00edsico nas altera\u00e7\u00f5es bioqu\u00edmicas e cognitivas iniciais e tardias induzidas pelo traumatismo cranioencef\u00e1lico em ratos","publication_year":2014,"publication_date":"2014-08-23","ids":{"openalex":"https://openalex.org/W2802307705","mag":"2802307705"},"language":"pt","primary_location":{"id":"pmh:oai:americanae.aecid.es:1994431","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufsm.br/handle/1/11230","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es do UFSM","raw_type":"info:eu-repo/semantics/masterThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://repositorio.ufsm.br/handle/1/11230","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085603742","display_name":"Fernando da Silva Fiorin","orcid":"https://orcid.org/0000-0002-6517-7160","observed_orcids":["https://orcid.org/0000-0002-6517-7160"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Fernando da Silva Fiorin","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-6517-7160","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5085603742"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.7788000106811523,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10416","display_name":"Traumatic Brain Injury Research","score":0.21699999272823334,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11487","display_name":"Automotive and Human Injury Biomechanics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-brain-injury","display_name":"traumatic brain injury","score":0.984000027179718},{"id":"https://openalex.org/keywords/exercise","display_name":"physical activity","score":0.7210000157356262},{"id":"https://openalex.org/keywords/neuroprotection","display_name":"neuroprotection","score":0.9229999780654907},{"id":"https://openalex.org/keywords/swimming-training","display_name":"swimming training","score":0.7390000224113464},{"id":"https://openalex.org/keywords/fluid-percussion-injury","display_name":"fluid percussion injury","score":0.9580000042915344},{"id":"https://openalex.org/keywords/glutamate-transporters","display_name":"glutamate transporters","score":0.6299999952316284},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.8659999966621399},{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.996999979019165},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.6859999895095825},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.8820000290870667},{"id":"https://openalex.org/keywords/hsp70","display_name":"HSP70","score":0.8420000076293945},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/na-k-atpase","display_name":"Na+/K+-ATPase","score":0.8899999856948853},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.8069999814033508},{"id":"https://openalex.org/keywords/object-recognition-memory","display_name":"object recognition memory","score":0.8610000014305115},{"id":"https://openalex.org/keywords/motor-impairment","display_name":"motor impairment","score":0.6679999828338623},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.6399999856948853},{"id":"https://openalex.org/keywords/antioxidant-defense","display_name":"antioxidant defense","score":0.421999990940094}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4596611261367798}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:americanae.aecid.es:1994431","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufsm.br/handle/1/11230","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es do UFSM","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"pmh:oai:repositorio.ufsm.br:1/11230","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufsm.br/handle/1/11230","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"instacron:UFSM","raw_type":"info:eu-repo/semantics/masterThesis"},{"id":"mag:2802307705","doi":null,"is_oa":false,"landing_page_url":"http://cascavel.ufsm.br/tede//tde_busca/processaArquivo.php?codArquivo=6785","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:americanae.aecid.es:1994431","doi":null,"is_oa":true,"landing_page_url":"http://repositorio.ufsm.br/handle/1/11230","pdf_url":null,"source":{"id":"https://openalex.org/S4306400786","display_name":"Americanae (AECID Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"reponame:Biblioteca Digital de Teses e Disserta\u00e7\u00f5es do UFSM","raw_type":"info:eu-repo/semantics/masterThesis"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3194173651","https://openalex.org/W3005305286","https://openalex.org/W6987145053","https://openalex.org/W7120547868","https://openalex.org/W7015771607","https://openalex.org/W2342079170","https://openalex.org/W7048419033","https://openalex.org/W3001850178","https://openalex.org/W7039043291","https://openalex.org/W3178949284"],"abstract_inverted_index":{"Traumatic":[0],"brain":[1,30],"injury":[2,189,282],"(TBI)":[3],"is":[4,26],"a":[5,67,96,301],"major":[6],"cause":[7],"of":[8,35,38,48,56,72,104,130,151,237,267,291,339,342,376,414],"morbidity":[9],"and":[10,19,50,74,136,145,224,243,259,274,309,351,379,423,436],"mortality":[11],"in":[12,28,53,93,139,191,218,250,283,383,417],"industrialized":[13],"countries":[14],"leading":[15],"to":[16,172,264,397],"the":[17,33,39,42,75,80,102,127,133,167,174,178,216,230,248,251,288,337,428,445],"motor":[18,128,198],"cognitive":[20,43,77,87],"deficits.":[21],"Evidence":[22],"demonstrated":[23,64],"that":[24,85,183,316,332,392,430,443],"exercise":[25,36,91,117,335,404],"neuroprotective":[27],"traumatic":[29],"injury.":[31,108,373],"However,":[32],"effects":[34],"before":[37],"TBI":[40,97,123,184],"at":[41],"function":[44],"are":[45],"unknown.":[46],"Role":[47],"excitotoxicity":[49],"oxidative":[51],"damage":[52,55,73],"secondary":[54,441],"TBI,":[57],"however,":[58],"until":[59],"this":[60,111,328],"moment,":[61],"were":[62],"not":[63,233],"if":[65],"exists":[66],"relationship":[68],"between":[69],"early":[70,105,131,197,289],"phase":[71,106],"late":[76],"deficit.":[78],"In":[79,177,327],"current":[81],"study,":[82,180],"we":[83,165,181,330],"proposed":[84],"improvement":[86],"response":[88],"induced":[89,185,196,336,408],"by":[90,155,186,203,256,300,401,409],"prior":[92],"rats":[94,114,195,390,420],"after":[95,107,148,209,280,312,371,448],"can":[98],"be":[99],"associated":[100,396],"with":[101,388],"neuroprotection":[103],"To":[109],"demonstrate":[110],"hypotheses,":[112],"adult":[113,192],"practice":[115],"swimming":[116,213],"during":[118],"6":[119],"weeks":[120,208,311,425],"followed":[121,202,299],"for":[122],"operation.":[124],"We":[125],"assessed":[126,154],"alterations":[129,249],"phase,":[132],"glutamate":[134,238,275,343,364],"uptake":[135,276,365],"antioxidant":[137,398],"defense":[138,399],"twenty":[140],"four":[141],"hours":[142],"(24":[143],"h)":[144],"15":[146,161],"days":[147,160],"TBI.":[149,163,410,449],"Acquisition":[150],"memory":[152,217],"was":[153],"recognition":[156,220],"object":[157,219],"task":[158,221],"on":[159,324],"post":[162],"Moreover,":[164],"evaluated":[166],"brain-derived":[168,244],"neurotrophic":[169,245],"factor":[170,246,293,296],"(BDNF)":[171],"assessement":[173],"synaptic":[175],"plastic.":[176],"present":[179],"showed":[182,331],"fluid":[187],"percussion":[188],"(FPI)":[190],"male":[193],"Wistar":[194],"impairment":[199,266],"24":[200,278,307,369,421],"h,":[201],"learning":[204],"retention":[205],"deficit":[206],"(2":[207],"neuronal":[210,281,313,372,434],"injury).":[211],"Previous":[212],"training":[214],"improved":[215],"per":[222,353],"se":[223,354],"protected":[225],"against":[226,357,406],"FPI-related":[227],"disabilities.":[228],"Although":[229],"FPI":[231],"did":[232],"alter":[234],"hippocampal":[235,377],"expression":[236,394],"transporters":[239,344],"(EAAT1":[240],"/":[241],"EAAT2)":[242],"(BDNF),":[247],"redox":[252],"status,":[253],"herein":[254],"characterized":[255],"DCFH-DA":[257,367],"oxidation":[258,368],"SOD":[260,349],"activity":[261,272,432],"inhibition,":[262],"led":[263],"marked":[265],"protein":[268,393],"functionally":[269],"(Na+,":[270],"K+-ATPase":[271],"inhibition)":[273],"inhibition":[277,366],"h":[279,308,370,422],"sedentary":[284,389],"injured":[285,385,419],"rats.":[286],"Indeed,":[287],"increase":[290,338,413],"nuclear":[292],"erythroid":[294],"2-related":[295],"(pNRF2/NRF2":[297],"ratio)":[298],"repair":[302],"mechanism":[303],"(protein":[304],"HSP70":[305,352,380],"expression),":[306],"2":[310,424],"injury,":[314],"suggests":[315],"FPI-induced":[317,358],"signal":[318],"transduction":[319],"may":[320],"exert":[321],"compensatory":[322],"effect":[323],"pathophysiological":[325],"processes.":[326],"report":[329],"previous":[333,402],"physical":[334,403,431],"immune":[340,381],"content":[341,382],"(EAAT1/":[345],"EAAT2),":[346],"pNrf2/Nrf2":[347,378],"ratio,":[348],"enzyme":[350],"besides":[355],"preventing":[356],"Na+,":[359],"K+":[360],"-":[361],"ATPase":[362],"activity,":[363],"The":[374,411],"enhancement":[375],"trained":[384,418],"when":[386],"compared":[387],"suggest":[391],"modulation":[395],"elicited":[400],"prevent":[405],"toxicity":[407],"significant":[412],"BDNF":[415],"levels":[416],"strongly":[426],"reinforce":[427],"idea":[429],"alters":[433],"functions":[435],"thus":[437],"delays":[438],"or":[439],"prevents":[440],"cascades":[442],"leave":[444],"neurobehavioral":[446],"disability":[447]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2018-05-17T00:00:00"}