{"id":"https://openalex.org/W2802207592","doi":"https://doi.org/10.1242/dev.159426","title":"All in the family: proneural bHLH genes and neuronal diversity","display_name":"All in the family: proneural bHLH genes and neuronal diversity","publication_year":2018,"publication_date":"2018-05-01","ids":{"openalex":"https://openalex.org/W2802207592","doi":"https://doi.org/10.1242/dev.159426","mag":"2802207592","pmid":"https://pubmed.ncbi.nlm.nih.gov/29720483","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5992591"},"language":"en","primary_location":{"id":"doi:10.1242/dev.159426","doi":"https://doi.org/10.1242/dev.159426","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.159426","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5992591","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028529010","display_name":"Nicholas E. Baker","orcid":"https://orcid.org/0000-0002-4250-3488","observed_orcids":["https://orcid.org/0000-0002-4250-3488"]},"institutions":[{"id":"https://openalex.org/I129975664","display_name":"Albert Einstein College of Medicine","ror":"https://ror.org/05cf8a891","country_code":"US","type":"education","lineage":["https://openalex.org/I129975664","https://openalex.org/I4210112371"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicholas E. Baker","raw_affiliation_strings":["Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461\u2008USA"],"raw_orcid":"https://orcid.org/0000-0002-4250-3488","affiliations":[{"raw_affiliation_string":"Department of Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461\u2008USA","institution_ids":["https://openalex.org/I129975664"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069325928","display_name":"Nadean L. Brown","orcid":"https://orcid.org/0000-0002-4906-4625","observed_orcids":["https://orcid.org/0000-0002-4906-4625"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nadean L. Brown","raw_affiliation_strings":["Department of Cell Biology and Human Anatomy, University of California, One Shields Avenue, Davis, CA 95616\u2008USA"],"raw_orcid":"https://orcid.org/0000-0002-4906-4625","affiliations":[{"raw_affiliation_string":"Department of Cell Biology and Human Anatomy, University of California, One Shields Avenue, Davis, CA 95616\u2008USA","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7926,"has_fulltext":false,"cited_by_count":82,"citation_normalized_percentile":{"value":0.63298632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"145","issue":"9","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9639000296592712,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0348999984562397,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/proneural-genes","display_name":"proneural genes","score":0.8989999890327454},{"id":"https://openalex.org/keywords/bhlh-transcription-factors","display_name":"bHLH transcription factors","score":0.8980000019073486},{"id":"https://openalex.org/keywords/neuronal-heterogeneity","display_name":"neuronal heterogeneity","score":0.7129999995231628},{"id":"https://openalex.org/keywords/atonal","display_name":"atonal","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gene-duplication","display_name":"gene duplication","score":0.5849999785423279},{"id":"https://openalex.org/keywords/gene-divergence","display_name":"gene divergence","score":0.6320000290870667},{"id":"https://openalex.org/keywords/functional-equivalence","display_name":"functional equivalence","score":0.4180000126361847},{"id":"https://openalex.org/keywords/neural-progenitor-cells","display_name":"neural progenitor cells","score":0.609000027179718},{"id":"https://openalex.org/keywords/drosophila-nervous-system","display_name":"Drosophila nervous system","score":0.8610000014305115},{"id":"https://openalex.org/keywords/vertebrate-nervous-system","display_name":"vertebrate nervous system","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9702897071838379},{"id":"https://openalex.org/C129189402","wikidata":"https://www.wikidata.org/wiki/Q17165234","display_name":"Proneural genes","level":4,"score":0.9151930212974548},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6703436374664307},{"id":"https://openalex.org/C7602840","wikidata":"https://www.wikidata.org/wiki/Q746284","display_name":"Gene duplication","level":3,"score":0.5595857501029968},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5351482629776001},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.47171279788017273},{"id":"https://openalex.org/C5911399","wikidata":"https://www.wikidata.org/wiki/Q2278983","display_name":"Gene family","level":4,"score":0.4190797209739685},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38919079303741455},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.17211505770683289}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009419","descriptor_name":"Nerve Tissue Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009420","descriptor_name":"Nervous System","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1242/dev.159426","doi":"https://doi.org/10.1242/dev.159426","is_oa":false,"landing_page_url":"https://doi.org/10.1242/dev.159426","pdf_url":null,"source":{"id":"https://openalex.org/S86558740","display_name":"Development","issn_l":"0950-1991","issn":["0950-1991","1477-9129"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311847","host_organization_name":"The Company of Biologists","host_organization_lineage":["https://openalex.org/P4310311847"],"host_organization_lineage_names":["The Company of Biologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5992591","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5992591","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},{"id":"pmid:29720483","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29720483","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:develop:145/9/dev159426","doi":null,"is_oa":false,"landing_page_url":"http://dev.biologists.org/cgi/content/short/145/9/dev159426","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:5992591","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5992591","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Development","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2937876178","display_name":"Investigation of Mammalian Retinal Neuron Development","funder_award_id":"R01EY013612","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G7180588733","display_name":"Cell-Cell Interactions in Developing Retina","funder_award_id":"R01GM047892","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":103,"referenced_works":["https://openalex.org/W191342842","https://openalex.org/W1504327675","https://openalex.org/W1582397524","https://openalex.org/W1888138328","https://openalex.org/W1895998181","https://openalex.org/W1898205487","https://openalex.org/W1963804798","https://openalex.org/W1964349154","https://openalex.org/W1967914573","https://openalex.org/W1968740861","https://openalex.org/W1971534370","https://openalex.org/W1971840554","https://openalex.org/W1977630266","https://openalex.org/W1979881566","https://openalex.org/W1984500085","https://openalex.org/W1988011675","https://openalex.org/W1988204576","https://openalex.org/W1990433739","https://openalex.org/W1991954192","https://openalex.org/W1992098212","https://openalex.org/W1996543394","https://openalex.org/W1997955636","https://openalex.org/W2003541496","https://openalex.org/W2008742718","https://openalex.org/W2009838194","https://openalex.org/W2013935392","https://openalex.org/W2024923255","https://openalex.org/W2025187874","https://openalex.org/W2025441171","https://openalex.org/W2026170507","https://openalex.org/W2031387082","https://openalex.org/W2033937556","https://openalex.org/W2035293839","https://openalex.org/W2035806445","https://openalex.org/W2036463618","https://openalex.org/W2037530397","https://openalex.org/W2037576456","https://openalex.org/W2040633563","https://openalex.org/W2042378303","https://openalex.org/W2043655216","https://openalex.org/W2046553148","https://openalex.org/W2049279317","https://openalex.org/W2049406851","https://openalex.org/W2050114117","https://openalex.org/W2056915996","https://openalex.org/W2060802097","https://openalex.org/W2063625751","https://openalex.org/W2071151411","https://openalex.org/W2071698836","https://openalex.org/W2072966096","https://openalex.org/W2073746288","https://openalex.org/W2075453897","https://openalex.org/W2075671933","https://openalex.org/W2079269655","https://openalex.org/W2087752456","https://openalex.org/W2088176129","https://openalex.org/W2088292216","https://openalex.org/W2088305049","https://openalex.org/W2090698995","https://openalex.org/W2101728847","https://openalex.org/W2102171053","https://openalex.org/W2103111028","https://openalex.org/W2109126669","https://openalex.org/W2113678630","https://openalex.org/W2115323964","https://openalex.org/W2120028191","https://openalex.org/W2129708593","https://openalex.org/W2131215325","https://openalex.org/W2133943800","https://openalex.org/W2140299471","https://openalex.org/W2141804202","https://openalex.org/W2143331812","https://openalex.org/W2147185823","https://openalex.org/W2147635933","https://openalex.org/W2147855254","https://openalex.org/W2149353806","https://openalex.org/W2151874656","https://openalex.org/W2152075687","https://openalex.org/W2155831440","https://openalex.org/W2157739471","https://openalex.org/W2160938187","https://openalex.org/W2163517157","https://openalex.org/W2164044753","https://openalex.org/W2164330963","https://openalex.org/W2166085889","https://openalex.org/W2166356357","https://openalex.org/W2167179102","https://openalex.org/W2167211673","https://openalex.org/W2169378217","https://openalex.org/W2258212760","https://openalex.org/W2269967393","https://openalex.org/W2409384585","https://openalex.org/W2525494724","https://openalex.org/W2547187957","https://openalex.org/W2564225558","https://openalex.org/W2607300406","https://openalex.org/W2607879901","https://openalex.org/W2608406261","https://openalex.org/W2738712446","https://openalex.org/W2802655346","https://openalex.org/W6660570588","https://openalex.org/W6836464389","https://openalex.org/W7052477098"],"related_works":["https://openalex.org/W1980834269","https://openalex.org/W2003990690","https://openalex.org/W7096107364","https://openalex.org/W2059879418","https://openalex.org/W2409384585","https://openalex.org/W616480622","https://openalex.org/W7000610811","https://openalex.org/W2128152788","https://openalex.org/W1598723573","https://openalex.org/W4250757911"],"abstract_inverted_index":{"ABSTRACT":[0],"Proneural":[1],"basic":[2],"Helix-Loop-Helix":[3],"(bHLH)":[4],"proteins":[5],"are":[6,22,85],"required":[7],"for":[8,59],"neuronal":[9,88],"determination":[10],"and":[11,40,45,64,83],"the":[12,43,51],"differentiation":[13],"of":[14],"most":[15],"neural":[16],"precursor":[17],"cells.":[18],"These":[19],"transcription":[20],"factors":[21],"expressed":[23],"in":[24,42],"vastly":[25],"divergent":[26],"organisms,":[27],"ranging":[28],"from":[29],"sponges":[30],"to":[31],"primates.":[32],"Here,":[33],"we":[34],"review":[35],"proneural":[36,61,75,80],"bHLH":[37],"gene":[38,53,62,81],"evolution":[39],"function":[41],"Drosophila":[44,52],"vertebrate":[46],"nervous":[47],"systems,":[48],"arguing":[49],"that":[50],"atonal":[54],"provides":[55],"a":[56],"useful":[57],"platform":[58],"understanding":[60],"structure":[63],"regulation.":[65],"We":[66],"also":[67],"discuss":[68],"how":[69,79],"functional":[70],"equivalency":[71],"experiments":[72],"using":[73],"distinct":[74],"genes":[76],"can":[77],"reveal":[78],"duplication":[82],"divergence":[84],"interwoven":[86],"with":[87],"complexity.":[89]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}