{"id":"https://openalex.org/W2802194598","doi":"https://doi.org/10.17135/jdhs.2018.18.2.76","title":"The Cytotoxic Effect of Oral Wet Wipes on Gingival Cells","display_name":"The Cytotoxic Effect of Oral Wet Wipes on Gingival Cells","publication_year":2018,"publication_date":"2018-04-30","ids":{"openalex":"https://openalex.org/W2802194598","doi":"https://doi.org/10.17135/jdhs.2018.18.2.76","mag":"2802194598"},"language":"en","primary_location":{"id":"doi:10.17135/jdhs.2018.18.2.76","doi":"https://doi.org/10.17135/jdhs.2018.18.2.76","is_oa":true,"landing_page_url":"https://doi.org/10.17135/jdhs.2018.18.2.76","pdf_url":null,"source":{"id":"https://openalex.org/S4306515480","display_name":"Journal of dental hygiene science","issn_l":"1598-4478","issn":["1598-4478","2233-7679"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Hygiene Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.17135/jdhs.2018.18.2.76","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052631392","display_name":"Im\u2010Hee Jung","orcid":"https://orcid.org/0000-0002-8645-1587","observed_orcids":["https://orcid.org/0000-0002-8645-1587"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Im-hee Jung","raw_affiliation_strings":["Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam 13135, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam 13135, Korea","institution_ids":["https://openalex.org/I21028721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110798637","display_name":"Ji Hyeon Park","orcid":"https://orcid.org/0000-0002-3272-0067","observed_orcids":["https://orcid.org/0000-0002-3272-0067"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ji Hyeon Park","raw_affiliation_strings":["Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam 13135, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam 13135, Korea","institution_ids":["https://openalex.org/I21028721"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034745195","display_name":"Min Kyeng Lee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Min Kyeng Lee","raw_affiliation_strings":["Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam 13135, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam 13135, Korea","institution_ids":["https://openalex.org/I21028721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077325040","display_name":"Young Sun Hwang","orcid":"https://orcid.org/0000-0001-7012-3434","observed_orcids":["https://orcid.org/0000-0001-7012-3434"]},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Young Sun Hwang","raw_affiliation_strings":["Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam 13135, Korea"],"raw_orcid":"https://orcid.org/0000-0001-7012-3434","affiliations":[{"raw_affiliation_string":"Department of Dental Hygiene, College of Health Science, Eulji University, Seongnam 13135, Korea","institution_ids":["https://openalex.org/I21028721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5077325040"],"corresponding_institution_ids":["https://openalex.org/I21028721"],"apc_list":null,"apc_paid":null,"fwci":0.1843,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.52822787,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"18","issue":"2","first_page":"76","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10257","display_name":"Oral microbiology and periodontitis research","score":0.7559000253677368,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11452","display_name":"Oral Health Pathology and Treatment","score":0.1039000004529953,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.038600001484155655,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/gingival-epithelial-cells","display_name":"gingival epithelial cells","score":0.9869999885559082},{"id":"https://openalex.org/keywords/gingival-fibroblasts","display_name":"gingival fibroblasts","score":0.9980000257492065},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9610000252723694},{"id":"https://openalex.org/keywords/antibacterial-activity","display_name":"antibacterial activity","score":0.7850000262260437},{"id":"https://openalex.org/keywords/oral-hygiene-products","display_name":"oral care products","score":0.7110000252723694},{"id":"https://openalex.org/keywords/infant-oral-care","display_name":"infant oral care","score":0.7870000004768372},{"id":"https://openalex.org/keywords/g2-m-cell-cycle-arrest","display_name":"G2/M cell cycle arrest","score":0.9150000214576721},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.7720000147819519},{"id":"https://openalex.org/keywords/cdk4","display_name":"CDK4","score":0.9810000061988831},{"id":"https://openalex.org/keywords/poly-adp-ribose-polymerase","display_name":"poly(ADP-ribose) polymerase","score":0.9449999928474426},{"id":"https://openalex.org/keywords/product-safety","display_name":"product safety","score":0.875}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6957023739814758},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.5415887832641602},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4024955630302429},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.33820840716362},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0823453962802887},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.055954188108444214}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.17135/jdhs.2018.18.2.76","doi":"https://doi.org/10.17135/jdhs.2018.18.2.76","is_oa":true,"landing_page_url":"https://doi.org/10.17135/jdhs.2018.18.2.76","pdf_url":null,"source":{"id":"https://openalex.org/S4306515480","display_name":"Journal of dental hygiene science","issn_l":"1598-4478","issn":["1598-4478","2233-7679"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Hygiene Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.17135/jdhs.2018.18.2.76","doi":"https://doi.org/10.17135/jdhs.2018.18.2.76","is_oa":true,"landing_page_url":"https://doi.org/10.17135/jdhs.2018.18.2.76","pdf_url":null,"source":{"id":"https://openalex.org/S4306515480","display_name":"Journal of dental hygiene science","issn_l":"1598-4478","issn":["1598-4478","2233-7679"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","kci-registered"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Dental Hygiene Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G45793116","display_name":null,"funder_award_id":"2015R1D1A1A01056946","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320321408","display_name":"Ministry of Education","ror":"https://ror.org/01p262204"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W14474160","https://openalex.org/W1761043628","https://openalex.org/W1965912776","https://openalex.org/W1984577042","https://openalex.org/W1990543688","https://openalex.org/W2020341213","https://openalex.org/W2021505095","https://openalex.org/W2060347699","https://openalex.org/W2115868186","https://openalex.org/W2331876344","https://openalex.org/W2345509577","https://openalex.org/W2740488025","https://openalex.org/W2945680432","https://openalex.org/W3094841165"],"related_works":["https://openalex.org/W7167742785","https://openalex.org/W4408466440","https://openalex.org/W4221030850","https://openalex.org/W6939700026","https://openalex.org/W3203330309","https://openalex.org/W3047048626","https://openalex.org/W2055761023","https://openalex.org/W2595891098","https://openalex.org/W6958492246","https://openalex.org/W2145126795"],"abstract_inverted_index":{"Wet":[0],"wipes":[1,13,31,69,88,100,114,144,179,263],"are":[2,14,44,273],"being":[3],"increasingly":[4],"used":[5],"because":[6],"of":[7,19,28,42,67,85,97,111,139,176,225,237,249],"their":[8,79],"convenience.":[9],"Particularly,":[10],"oral":[11,29,72,86,98,112,142,177,209,261,269],"wet":[12,30,68,87,99,113,143,178,262],"useful":[15],"for":[16,78,282],"regular":[17],"cleaning":[18],"a":[20,40,126,154],"baby's":[21],"mouth":[22],"after":[23],"birth.":[24],"Therefore,":[25],"the":[26,35,65,83,91,104,215],"consumption":[27],"has":[32],"increased":[33],"over":[34],"past":[36],"few":[37],"years":[38],"and":[39,56,75,89,123,135,153,182,187,198,218,229,242,247,276,284],"variety":[41],"products":[43,184],"commercially":[45],"available.":[46],"However,":[47],"product":[48],"information":[49,77],"on":[50,118,194,208,223,268],"safety":[51,66],"is":[52,279],"not":[53],"sufficiently":[54],"provided":[55],"still":[57],"raises":[58],"doubts":[59],"regarding":[60],"adverse":[61],"effects.":[62],"To":[63],"confirm":[64],"as":[70],"an":[71],"hygiene":[73],"item":[74],"provide":[76],"use,":[80],"we":[81],"investigated":[82],"cytotoxicity":[84],"verified":[90],"underlying":[92],"mechanism.":[93],"The":[94,108],"anti-bacterial":[95,206,274],"effect":[96],"was":[101,145],"analyzed":[102,170],"using":[103,121,125,147,171],"disk":[105],"diffusion":[106],"method.":[107],"cytotoxic":[109,192,266],"effects":[110,193,207],"were":[115,168,180,220,253],"observed":[116,221],"based":[117,222],"morphological":[119],"changes":[120],"microscopy":[122],"determined":[124],"3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium":[127],"bromide":[128],"(MTT)":[129],"assay":[130],"in":[131,214],"gingival":[132,136],"epithelial":[133,196],"cells":[134,197],"fibroblasts.":[137],"Evaluation":[138],"apoptosis":[140,219],"by":[141],"explored":[146],"propidium":[148],"iodide":[149],"flow":[150],"cytometric":[151],"analysis":[152],"terminal":[155],"deoxynucleotidyl":[156],"transferase":[157],"(TdT)-mediated":[158],"deoxyuridine":[159],"triphosphate":[160],"(dUTP)":[161],"nick-end":[162],"labeling":[163],"(TUNEL)":[164],"assay.":[165],"Apoptosis-related":[166],"molecules":[167],"also":[169,203,254],"western":[172],"blotting.":[173],"Five":[174],"types":[175],"tested,":[181],"two":[183],"from":[185,227],"Fisher-Price":[186,228],"Dr.":[188,230],"Kennedy":[189],"revealed":[190],"strong":[191],"gingiva":[195,199],"fibroblasts,":[200],"although":[201,271],"they":[202],"showed":[204],"intense":[205],"bacteria.":[210],"Cell":[211],"cycle":[212],"arrest":[213],"G2/M":[216],"phase":[217],"treatment":[224],"extracts":[226],"KENNEDY.":[231],"Relatively":[232],"high":[233],"TUNEL":[234],"levels,":[235],"reduction":[236],"proliferating":[238],"cell":[239],"nuclear":[240],"antigen":[241],"cyclin-dependent":[243],"kinase":[244],"4":[245],"expression,":[246],"fragmentation":[248],"poly":[250],"(ADP-ribose)":[251],"polymerase":[252],"elucidated.":[255],"These":[256],"results":[257],"suggest":[258],"that":[259],"commercial":[260],"could":[264],"exert":[265],"influences":[267],"tissue,":[270],"there":[272],"effects,":[275],"careful":[277],"attention":[278],"required,":[280],"especially":[281],"infants":[283],"toddlers.":[285]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2018-05-17T00:00:00"}