{"id":"https://openalex.org/W2802180712","doi":null,"title":"Reduced beta 2 glycoprotein I prevents high glucose-induced cell death in HUVECs through miR-21/PTEN.","display_name":"Reduced beta 2 glycoprotein I prevents high glucose-induced cell death in HUVECs through miR-21/PTEN.","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2802180712","mag":"2802180712","pmid":"https://pubmed.ncbi.nlm.nih.gov/28979671","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5622240"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:4551070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5622240","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5622240","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jing-Yun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Yun Zhang","raw_affiliation_strings":["Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115590313","display_name":"Jun Ma","orcid":"https://orcid.org/0000-0002-4077-7928","observed_orcids":["https://orcid.org/0000-0002-4077-7928"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Ma","raw_affiliation_strings":["Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048649554","display_name":"Pei Yu","orcid":"https://orcid.org/0000-0001-7992-0480","observed_orcids":["https://orcid.org/0000-0001-7992-0480"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pei Yu","raw_affiliation_strings":["Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048122982","display_name":"Guang-Jie Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guang-Jie Tang","raw_affiliation_strings":["Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032427631","display_name":"Chunjun Li","orcid":"https://orcid.org/0000-0003-4857-8146","observed_orcids":["https://orcid.org/0000-0003-4857-8146"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chun-Jun Li","raw_affiliation_strings":["Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101680109","display_name":"Demin M. Yu","orcid":"https://orcid.org/0000-0001-7658-9200","observed_orcids":["https://orcid.org/0000-0001-7658-9200"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"De-Min Yu","raw_affiliation_strings":["Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110056977","display_name":"Qiu-Mei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiu-Mei Zhang","raw_affiliation_strings":["Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University300070 Tianjin, China","institution_ids":["https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I5740404"],"apc_list":null,"apc_paid":null,"fwci":0.8317,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.64960057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"9","issue":"9","first_page":"3935","last_page":"3949"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.788100004196167,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11142","display_name":"Advanced Glycation End Products research","score":0.07699999958276749,"subfield":{"id":"https://openalex.org/subfields/1308","display_name":"Clinical Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.03759999945759773,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/beta2-glycoprotein-i","display_name":"beta2-glycoprotein I","score":0.8799999952316284},{"id":"https://openalex.org/keywords/high-glucose","display_name":"high glucose","score":0.859000027179718},{"id":"https://openalex.org/keywords/endothelial-cell-death","display_name":"endothelial cell death","score":0.8730000257492065},{"id":"https://openalex.org/keywords/human-umbilical-vein-endothelial-cells","display_name":"human umbilical vein endothelial cells","score":0.8790000081062317},{"id":"https://openalex.org/keywords/mir-21","display_name":"miR-21","score":0.9660000205039978},{"id":"https://openalex.org/keywords/pten","display_name":"PTEN","score":1.0},{"id":"https://openalex.org/keywords/diabetic-vascular-injury","display_name":"diabetic vascular injury","score":0.906000018119812},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C2777609662","wikidata":"https://www.wikidata.org/wiki/Q416356","display_name":"PTEN","level":4,"score":0.9118682146072388},{"id":"https://openalex.org/C2779549131","wikidata":"https://www.wikidata.org/wiki/Q83167294","display_name":"Tensin","level":5,"score":0.8515468835830688},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.5802215337753296},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48302897810935974},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.4782889485359192},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4621127247810364},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.439720094203949},{"id":"https://openalex.org/C2777411675","wikidata":"https://www.wikidata.org/wiki/Q1232438","display_name":"Umbilical vein","level":3,"score":0.43783053755760193},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.4319433569908142},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.39439138770103455},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.376889169216156},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35764050483703613},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3378082811832428},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.1613152027130127},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13774731755256653},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:4551070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5622240","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:28979671","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28979671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of translational research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5622240","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5622240/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Am J Transl Res","raw_type":"Text"},{"id":"mag:2802180712","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/28979671","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:4551070","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5622240","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W974353170","https://openalex.org/W1547996487","https://openalex.org/W1587866768","https://openalex.org/W1701760291","https://openalex.org/W1969721111","https://openalex.org/W1981177602","https://openalex.org/W1998038367","https://openalex.org/W2002239776","https://openalex.org/W2005477697","https://openalex.org/W2007660847","https://openalex.org/W2013551633","https://openalex.org/W2031994623","https://openalex.org/W2033566611","https://openalex.org/W2034401989","https://openalex.org/W2037264667","https://openalex.org/W2038147480","https://openalex.org/W2039264995","https://openalex.org/W2039996236","https://openalex.org/W2044258256","https://openalex.org/W2048075898","https://openalex.org/W2048186369","https://openalex.org/W2058654367","https://openalex.org/W2074915971","https://openalex.org/W2077535449","https://openalex.org/W2077806147","https://openalex.org/W2079825005","https://openalex.org/W2120704605","https://openalex.org/W2129546321","https://openalex.org/W2144927320","https://openalex.org/W2148959543","https://openalex.org/W2150073981","https://openalex.org/W2154015554","https://openalex.org/W2155905771","https://openalex.org/W2160957830","https://openalex.org/W2314459420","https://openalex.org/W2346854966","https://openalex.org/W2404556360","https://openalex.org/W2413938807","https://openalex.org/W2468394220","https://openalex.org/W2477345637","https://openalex.org/W2491729726","https://openalex.org/W2508133346","https://openalex.org/W2517068473","https://openalex.org/W2519536692","https://openalex.org/W2530405129","https://openalex.org/W2531620033","https://openalex.org/W2565524872"],"related_works":["https://openalex.org/W2737296415","https://openalex.org/W2745642725","https://openalex.org/W2047023884","https://openalex.org/W2404556360","https://openalex.org/W2405949472","https://openalex.org/W2903641236","https://openalex.org/W2884172234","https://openalex.org/W2315106266","https://openalex.org/W1443434402","https://openalex.org/W4292658913"],"abstract_inverted_index":{"data":[0],"supporting":[1],"the":[2],"therapeutic":[3],"effect":[4],"of":[5],"R\u03b22GPI":[6],"in":[7],"diabetic":[8],"vascular":[9],"injury.":[10]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":6},{"year":2018,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-05-17T00:00:00"}