{"id":"https://openalex.org/W2802177262","doi":"https://doi.org/10.1038/s41398-018-0131-9","title":"Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist","display_name":"Signaling pathways responsible for the rapid antidepressant-like effects of a GluN2A-preferring NMDA receptor antagonist","publication_year":2018,"publication_date":"2018-04-17","ids":{"openalex":"https://openalex.org/W2802177262","doi":"https://doi.org/10.1038/s41398-018-0131-9","mag":"2802177262","pmid":"https://pubmed.ncbi.nlm.nih.gov/29666360","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5904130"},"language":"en","primary_location":{"id":"doi:10.1038/s41398-018-0131-9","doi":"https://doi.org/10.1038/s41398-018-0131-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0131-9","pdf_url":"https://www.nature.com/articles/s41398-018-0131-9.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41398-018-0131-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045055352","display_name":"Marta Gordillo-Salas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Gordillo-Salas","raw_affiliation_strings":["Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, IBBTEC (CSIC, Universidad de Cantabria), Santander, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, IBBTEC (CSIC, Universidad de Cantabria), Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083352205","display_name":"Fuencisla Pilar-Cu\u00e9llar","orcid":"https://orcid.org/0000-0003-1229-001X","observed_orcids":["https://orcid.org/0000-0003-1229-001X"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fuencisla Pilar-Cu\u00e9llar","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain","Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Facultad de Medicina, Universidad de Cantabria, Santander, Spain","Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, IBBTEC (CSIC, Universidad de Cantabria), Santander, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Departamento de Fisiolog\u00eda y Farmacolog\u00eda, Facultad de Medicina, Universidad de Cantabria, Santander, Spain","institution_ids":["https://openalex.org/I13134134"]},{"raw_affiliation_string":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, IBBTEC (CSIC, Universidad de Cantabria), Santander, Spain","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022765017","display_name":"Yves P. Auberson","orcid":"https://orcid.org/0000-0001-5800-4811","observed_orcids":["https://orcid.org/0000-0001-5800-4811"]},"institutions":[{"id":"https://openalex.org/I4400600974","display_name":"Novartis Institutes for BioMedical Research","ror":"https://ror.org/053gv2m95","country_code":"CH","type":"funder","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4400600974"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Yves P. Auberson","raw_affiliation_strings":["Novartis Institutes for Biomedical Research, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Institutes for Biomedical Research, Basel, Switzerland","institution_ids":["https://openalex.org/I4400600974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045533329","display_name":"Albert Adell","orcid":"https://orcid.org/0000-0003-0570-4931","observed_orcids":["https://orcid.org/0000-0003-0570-4931"]},"institutions":[{"id":"https://openalex.org/I13134134","display_name":"Universidad de Cantabria","ror":"https://ror.org/046ffzj20","country_code":"ES","type":"education","lineage":["https://openalex.org/I13134134"]},{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210090703","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210102893","display_name":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria","ror":"https://ror.org/01d963745","country_code":"ES","type":"facility","lineage":["https://openalex.org/I13134134","https://openalex.org/I134820265","https://openalex.org/I4210102893"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Albert Adell","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. albert.adell@unican.es","Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, IBBTEC (CSIC, Universidad de Cantabria), Santander, Spain. albert.adell@unican.es","Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain"],"raw_orcid":"https://orcid.org/0000-0003-0570-4931","affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain. albert.adell@unican.es","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703"]},{"raw_affiliation_string":"Instituto de Biomedicina y Biotecnolog\u00eda de Cantabria, IBBTEC (CSIC, Universidad de Cantabria), Santander, Spain. albert.adell@unican.es","institution_ids":["https://openalex.org/I13134134","https://openalex.org/I4210102893"]},{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210090703"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5045533329"],"corresponding_institution_ids":["https://openalex.org/I13134134","https://openalex.org/I2801357902","https://openalex.org/I4210090703","https://openalex.org/I4210102893"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":1.3234,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.7645187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"8","issue":"1","first_page":"84","last_page":"84"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.004399999976158142,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.7549999952316284},{"id":"https://openalex.org/keywords/glun2a","display_name":"GluN2A","score":0.8669999837875366},{"id":"https://openalex.org/keywords/nvp-aam077","display_name":"NVP-AAM077","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antidepressant-like-effects","display_name":"antidepressant-like effects","score":0.8759999871253967},{"id":"https://openalex.org/keywords/rapid-antidepressant-response","display_name":"rapid antidepressant response","score":0.7350000143051147},{"id":"https://openalex.org/keywords/forced-swim-test","display_name":"forced swim test","score":0.6990000009536743},{"id":"https://openalex.org/keywords/medial-prefrontal-cortex","display_name":"medial prefrontal cortex","score":0.8980000019073486},{"id":"https://openalex.org/keywords/glua1-subunit","display_name":"GluA1 subunit","score":0.7459999918937683},{"id":"https://openalex.org/keywords/ampa-receptors","display_name":"AMPA receptors","score":0.8360000252723694},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":1.0},{"id":"https://openalex.org/keywords/glial-fibrillary-acidic-protein","display_name":"glial fibrillary acidic protein","score":0.8730000257492065},{"id":"https://openalex.org/keywords/glast","display_name":"GLAST","score":0.9319999814033508},{"id":"https://openalex.org/keywords/brain-derived-neurotrophic-factor","display_name":"brain-derived neurotrophic factor","score":0.6589999794960022},{"id":"https://openalex.org/keywords/glutamate-release","display_name":"glutamate release","score":0.9139999747276306},{"id":"https://openalex.org/keywords/serotonin-release","display_name":"serotonin release","score":0.7730000019073486},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.3779999911785126}],"concepts":[{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.7464015483856201},{"id":"https://openalex.org/C136569192","wikidata":"https://www.wikidata.org/wiki/Q4880745","display_name":"Behavioural despair test","level":4,"score":0.6601434946060181},{"id":"https://openalex.org/C2780495277","wikidata":"https://www.wikidata.org/wiki/Q905442","display_name":"Glial fibrillary acidic protein","level":3,"score":0.5795860886573792},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.5662733912467957},{"id":"https://openalex.org/C67018056","wikidata":"https://www.wikidata.org/wiki/Q414896","display_name":"NMDA receptor","level":3,"score":0.5569486618041992},{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.5515435338020325},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.5143088102340698},{"id":"https://openalex.org/C2778790584","wikidata":"https://www.wikidata.org/wiki/Q123045","display_name":"Brain-derived neurotrophic factor","level":4,"score":0.49432373046875},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.45078057050704956},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40414661169052124},{"id":"https://openalex.org/C2779177272","wikidata":"https://www.wikidata.org/wiki/Q76560","display_name":"Antidepressant","level":3,"score":0.3577401638031006},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3491813540458679},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.345893919467926},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.3448938727378845},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2625751495361328},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2523074150085449},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2371785044670105},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.0},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000928","descriptor_name":"Antidepressive Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D001522","descriptor_name":"Behavior, Animal","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003863","descriptor_name":"Depression","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011810","descriptor_name":"Quinoxalines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017397","descriptor_name":"Prefrontal Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018091","descriptor_name":"Receptors, AMPA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019208","descriptor_name":"Brain-Derived Neurotrophic Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1038/s41398-018-0131-9","doi":"https://doi.org/10.1038/s41398-018-0131-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0131-9","pdf_url":"https://www.nature.com/articles/s41398-018-0131-9.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4835455","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC5904130","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:29666360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29666360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational psychiatry","raw_type":"Journal Article"},{"id":"pmh:oai:dnet:ucreareposit::3a7146fb1d945191498867eabc9e409c","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10902/15701","pdf_url":null,"source":{"id":"https://openalex.org/S4306402641","display_name":"LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Cient\u00edficas)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4383465926","host_organization_name":"LA Referencia","host_organization_lineage":["https://openalex.org/I4383465926"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry. 2018 Apr 18;8(1):84","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:pubmedcentral.nih.gov:5904130","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC5904130/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transl Psychiatry","raw_type":"Text"},{"id":"pmh:oai:digital.csic.es:10261/249067","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/249067","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"},{"id":"pmh:oai:doaj.org/article:864f97ece933481793d1ffa1909a19cf","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/864f97ece933481793d1ffa1909a19cf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Translational Psychiatry, Vol 8, Iss 1, Pp 1-9 (2018)","raw_type":"article"},{"id":"pmh:oai:repositorio.unican.es:10902/15701","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10902/15701","pdf_url":null,"source":{"id":"https://openalex.org/S4306400398","display_name":"UCrea (University of Cantabria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I13134134","host_organization_name":"Universidad de Cantabria","host_organization_lineage":["https://openalex.org/I13134134"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transl Psychiatry. 2018 Apr 18;8(1):84","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1038/s41398-018-0131-9","doi":"https://doi.org/10.1038/s41398-018-0131-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41398-018-0131-9","pdf_url":"https://www.nature.com/articles/s41398-018-0131-9.pdf","source":{"id":"https://openalex.org/S163345920","display_name":"Translational Psychiatry","issn_l":"2158-3188","issn":["2158-3188"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Psychiatry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1075404386","display_name":null,"funder_award_id":"PI16/","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G6563640028","display_name":"Alteraciones de la conectividad entre la corteza prefrontal y los n\u00facleos monoamin\u00e9rgicos del tronco cerebral en la depresi\u00f3n y su papel en la respuesta antidepresiva r\u00e1pida.","funder_award_id":"PI16/00217","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G7095360680","display_name":"Identificaci\u00f3n de biomarcadores en depresi\u00f3n y su respuesta a nuevas terapias antidepresivas de acci\u00f3n r\u00e1pida. Estudio con modelos animales","funder_award_id":"PI13/00038","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320324085","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Salud Mental","ror":"https://ror.org/009byq155"},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2802177262.pdf","grobid_xml":"https://content.openalex.org/works/W2802177262.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1914381346","https://openalex.org/W1950744654","https://openalex.org/W1971924693","https://openalex.org/W1973125755","https://openalex.org/W1973810774","https://openalex.org/W1977689367","https://openalex.org/W1978930750","https://openalex.org/W1980620165","https://openalex.org/W1981097208","https://openalex.org/W1984754469","https://openalex.org/W1985893437","https://openalex.org/W1989115458","https://openalex.org/W1991551000","https://openalex.org/W2003982930","https://openalex.org/W2014192652","https://openalex.org/W2023081218","https://openalex.org/W2023979631","https://openalex.org/W2024380057","https://openalex.org/W2026813655","https://openalex.org/W2032739515","https://openalex.org/W2035741946","https://openalex.org/W2036877455","https://openalex.org/W2037852973","https://openalex.org/W2047397795","https://openalex.org/W2049563161","https://openalex.org/W2053544091","https://openalex.org/W2057200138","https://openalex.org/W2065169750","https://openalex.org/W2077208751","https://openalex.org/W2083739539","https://openalex.org/W2087002084","https://openalex.org/W2089351762","https://openalex.org/W2095159395","https://openalex.org/W2103903531","https://openalex.org/W2106623141","https://openalex.org/W2108403304","https://openalex.org/W2109334244","https://openalex.org/W2114201779","https://openalex.org/W2117187481","https://openalex.org/W2123488676","https://openalex.org/W2136869363","https://openalex.org/W2138643360","https://openalex.org/W2150002111","https://openalex.org/W2154142567","https://openalex.org/W2154178019","https://openalex.org/W2162690960","https://openalex.org/W2318283658","https://openalex.org/W2330587564","https://openalex.org/W2565604828","https://openalex.org/W2589439677","https://openalex.org/W2595110790","https://openalex.org/W2611061689","https://openalex.org/W2625549381","https://openalex.org/W2749684885","https://openalex.org/W3189715865"],"related_works":["https://openalex.org/W3092669895","https://openalex.org/W1981524444","https://openalex.org/W2052617026","https://openalex.org/W3030621996","https://openalex.org/W2362415004","https://openalex.org/W2905184594","https://openalex.org/W1987239750","https://openalex.org/W3024236733","https://openalex.org/W1986035671","https://openalex.org/W2306738361"],"abstract_inverted_index":{"In":[0,37],"a":[1,128],"previous":[2],"study":[3],"we":[4,41],"found":[5],"that":[6,22,61],"the":[7,18,26,33,38,45,54,64,67,97,140],"preferring":[8],"GluN2A":[9],"receptor":[10],"antagonist,":[11],"NVP-AAM077,":[12],"elicited":[13],"rapid":[14,87,129],"antidepressant-like":[15,88],"effects":[16],"in":[17,32,66,96,139],"forced":[19,68],"swim":[20,69],"test":[21,70],"was":[23],"related":[24],"to":[25,43,91],"release":[27],"of":[28,47,100,107,131,134],"glutamate":[29],"and":[30,73,120,127],"serotonin":[31],"medial":[34,141],"prefrontal":[35,142],"cortex.":[36,143],"present":[39],"work":[40],"sought":[42],"examine":[44],"duration":[46],"this":[48,80],"behavioral":[49],"effect":[50,81],"as":[51,53,114],"well":[52],"molecular":[55],"readouts":[56],"involved.":[57],"Our":[58],"results":[59],"showed":[60],"NVP-AAM077":[62],"reduced":[63],"immobility":[65],"30":[71],"min":[72],"24":[74],"h":[75],"after":[76],"its":[77],"administration.":[78],"However,":[79],"waned":[82],"7":[83],"days":[84],"later.":[85],"The":[86],"response":[89],"seems":[90],"be":[92],"associated":[93],"with":[94],"increases":[95],"GluA1":[98],"subunit":[99],"\u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic":[101],"acid":[102,123],"(AMPA)":[103],"receptors,":[104],"mammalian":[105],"target":[106],"rapamycin":[108],"(mTOR)":[109],"signaling,":[110],"glia":[111],"markers":[112],"such":[113],"glial":[115],"fibrillary":[116],"acidic":[117],"protein":[118],"(GFAP)":[119],"excitatory":[121],"amino":[122],"transporter":[124],"1":[125],"(EAAT1),":[126],"mobilization":[130],"intracellular":[132],"stores":[133],"brain-derived":[135],"neurotrophic":[136],"factor":[137],"(BDNF)":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2018-05-17T00:00:00"}