{"id":"https://openalex.org/W2802031180","doi":"https://doi.org/10.3233/jad-170828","title":"Inflammatory Cytokine, IL-1\u03b2, Regulates Glial Glutamate Transporter via microRNA-181a in vitro","display_name":"Inflammatory Cytokine, IL-1\u03b2, Regulates Glial Glutamate Transporter via microRNA-181a in vitro","publication_year":2018,"publication_date":"2018-04-29","ids":{"openalex":"https://openalex.org/W2802031180","doi":"https://doi.org/10.3233/jad-170828","mag":"2802031180","pmid":"https://pubmed.ncbi.nlm.nih.gov/29710703","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7325598"},"language":"en","primary_location":{"id":"doi:10.3233/jad-170828","doi":"https://doi.org/10.3233/jad-170828","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-170828","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7325598","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065235576","display_name":"Joannee Zumkehr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I156087764","display_name":"University of California, Merced","ror":"https://ror.org/00d9ah105","country_code":"US","type":"education","lineage":["https://openalex.org/I156087764"]},{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joannee Zumkehr","raw_affiliation_strings":["Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA","School of Natural Sciences, University of California, Merced, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"School of Natural Sciences, University of California, Merced, CA, USA","institution_ids":["https://openalex.org/I156087764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078725664","display_name":"Carlos J. Rodr\u00edguez\u2010Ortiz","orcid":"https://orcid.org/0000-0003-2688-947X","observed_orcids":["https://orcid.org/0000-0003-2688-947X"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos J. Rodriguez-Ortiz","raw_affiliation_strings":["Department of Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037612690","display_name":"Rodrigo Medeiros","orcid":"https://orcid.org/0000-0002-9399-7852","observed_orcids":["https://orcid.org/0000-0002-9399-7852"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Rodrigo Medeiros","raw_affiliation_strings":["Queensland Brain Institute, The University of Queensland, St Lucia QLD, Australia","E-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Queensland Brain Institute, The University of Queensland, St Lucia QLD, Australia","institution_ids":["https://openalex.org/I165143802"]},{"raw_affiliation_string":"E-mail:","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009317100","display_name":"Masashi Kitazawa","orcid":"https://orcid.org/0000-0003-2165-8197","observed_orcids":["https://orcid.org/0000-0003-2165-8197"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Masashi Kitazawa","raw_affiliation_strings":["Department of Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Center for Occupational and Environmental Health, University of California, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5009317100"],"corresponding_institution_ids":["https://openalex.org/I204250578"],"apc_list":null,"apc_paid":null,"fwci":0.6731,"has_fulltext":false,"cited_by_count":28,"citation_normalized_percentile":{"value":0.65717836,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"63","issue":"3","first_page":"965","last_page":"975"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.031099999323487282,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glt-1","display_name":"GLT-1","score":0.9559999704360962}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.7377020120620728},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6948363780975342},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.689744770526886},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6639794707298279},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5612021088600159},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5306680798530579},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.49756768345832825},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.43633705377578735},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43266257643699646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3848852813243866},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3521402180194855},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2969626188278198},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2766563892364502},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22747066617012024},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.1971713900566101},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.06103190779685974},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000831","descriptor_name":"Animals, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001253","descriptor_name":"Astrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016466","descriptor_name":"CHO Cells","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D027322","descriptor_name":"Amino Acid Transport System X-AG","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3233/jad-170828","doi":"https://doi.org/10.3233/jad-170828","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-170828","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:29710703","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29710703","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7325598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7325598","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt23b3v62n","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/23b3v62n","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Alzheimer\u2019s Disease, vol 63, iss 3","raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:7325598","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7325598","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Alzheimers Dis","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8564612425","display_name":"Astrocyte dysfunction in Alzheimer's disease","funder_award_id":"F31AG048705","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W32204808","https://openalex.org/W91734731","https://openalex.org/W118386170","https://openalex.org/W1555289101","https://openalex.org/W1644388421","https://openalex.org/W1920972969","https://openalex.org/W1970891635","https://openalex.org/W1979889191","https://openalex.org/W1984772099","https://openalex.org/W2001261203","https://openalex.org/W2005864274","https://openalex.org/W2012865678","https://openalex.org/W2016061869","https://openalex.org/W2017699601","https://openalex.org/W2018101299","https://openalex.org/W2022532556","https://openalex.org/W2022671065","https://openalex.org/W2042360443","https://openalex.org/W2050523782","https://openalex.org/W2059709590","https://openalex.org/W2063824422","https://openalex.org/W2066278148","https://openalex.org/W2067150920","https://openalex.org/W2068966740","https://openalex.org/W2073518622","https://openalex.org/W2075770826","https://openalex.org/W2081282178","https://openalex.org/W2082429191","https://openalex.org/W2085024815","https://openalex.org/W2086603898","https://openalex.org/W2087243986","https://openalex.org/W2090183355","https://openalex.org/W2097102677","https://openalex.org/W2097547448","https://openalex.org/W2108370047","https://openalex.org/W2112541356","https://openalex.org/W2119588378","https://openalex.org/W2132680120","https://openalex.org/W2134486111","https://openalex.org/W2141079611","https://openalex.org/W2150999725","https://openalex.org/W2163329040","https://openalex.org/W2169630182","https://openalex.org/W2171314958","https://openalex.org/W2191292005","https://openalex.org/W2429572096","https://openalex.org/W2586834816","https://openalex.org/W2592178905","https://openalex.org/W2602738773","https://openalex.org/W4210821243","https://openalex.org/W4294253695"],"related_works":["https://openalex.org/W2030279292","https://openalex.org/W2018101299","https://openalex.org/W7096687650","https://openalex.org/W3003579879","https://openalex.org/W2019644954","https://openalex.org/W2035036667","https://openalex.org/W2411302592","https://openalex.org/W2112541356","https://openalex.org/W2132493492","https://openalex.org/W2322854753"],"abstract_inverted_index":{"Glutamate":[0,17],"overload":[1],"triggers":[2],"synaptic":[3,22,218],"and":[4,19,57,65,95,145,163,180,208],"neuronal":[5],"loss":[6],"that":[7,35],"potentially":[8],"contributes":[9],"to":[10,124,157],"neurodegenerative":[11],"diseases":[12],"including":[13],"Alzheimer's":[14],"disease":[15],"(AD).":[16],"clearance":[18],"regulation":[20],"at":[21],"clefts":[23],"is":[24],"primarily":[25],"mediated":[26],"by":[27],"glial":[28],"glutamate":[29],"transporter":[30],"1":[31],"(GLT-1).":[32],"We":[33],"determined":[34],"inflammatory":[36,92],"cytokines":[37],"significantly":[38,100,130],"upregulated":[39],"GLT-1":[40,51,102,113,162,173,200,212],"through":[41,116],"microRNA-181a-mediated":[42],"post-transcriptional":[43,117],"modifications.":[44,118],"Unveiling":[45],"the":[46,111,120,133,149,159,181],"key":[47],"underlying":[48],"mechanisms":[49],"modulating":[50],"helps":[52],"better":[53],"understand":[54],"its":[55],"physiological":[56,215],"pathological":[58,229],"interactions":[59],"with":[60,91],"cytokines.":[61],"Primary":[62],"murine":[63],"astrocyte":[64],"neuron":[66],"co-culture":[67],"received":[68],"20":[69],"ng/mL":[70],"IL-1\u03b2,":[71],"TNF-\u03b1,":[72,96],"or":[73,80],"IL-6":[74],"for":[75,87],"48":[76],"h.":[77],"Soluble":[78],"proteins":[79],"total":[81],"RNA":[82],"were":[83],"extracted":[84],"after":[85],"treatment":[86,135],"further":[88],"analyses.":[89],"Treatment":[90],"cytokines,":[93],"IL-1\u03b2":[94,134],"but":[97],"not":[98],"IL-6,":[99],"increased":[101],"steady-state":[103],"levels":[104,201],"(p\u22640.05)":[105],"without":[106],"affecting":[107],"mRNA":[108],"levels,":[109],"suggesting":[110],"cytokine-induced":[112],"was":[114,129,174],"regulated":[115],"Among":[119],"candidate":[121],"microRNAs":[122],"predicted":[123],"modulate":[125],"GLT-1,":[126],"only":[127],"microRNA-181a":[128,139,164,185,188,207,224],"decreased":[131],"following":[132],"(p\u22640.05).":[136],"Co-treatment":[137],"of":[138,152,172,183,199,206,211,223],"mimic":[140],"in":[141,165,176,193,202,217,228,231],"IL-1\u03b2-treated":[142],"primary":[143,187],"astrocytes":[144],"neurons":[146],"effectively":[147],"blocked":[148],"IL-1\u03b2-induced":[150],"upregulation":[151,210],"GLT-1.":[153],"Lastly,":[154],"we":[155],"attempted":[156],"determine":[158],"link":[160],"between":[161],"human":[166],"AD":[167,177],"brains.":[168],"A":[169],"significant":[170],"reduction":[171],"found":[175],"hippocampus":[178],"tissues,":[179],"ratio":[182],"mature":[184],"over":[186],"had":[189],"an":[190],"increasing":[191],"tendency":[192],"AD.":[194,232],"MicroRNA-181a":[195],"controls":[196],"rapid":[197],"modifications":[198],"astrocytes.":[203],"Cytokine-induced":[204],"inhibition":[205],"subsequent":[209],"may":[213,225],"have":[214],"implications":[216],"plasticity":[219],"while":[220],"aberrant":[221],"maturation":[222],"be":[226],"involved":[227],"consequences":[230]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}