{"id":"https://openalex.org/W2802013144","doi":"https://doi.org/10.21037/tlcr.2018.04.01","title":"Considerations when treating lung cancer with passive scatter or active scanning proton therapy","display_name":"Considerations when treating lung cancer with passive scatter or active scanning proton therapy","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2802013144","doi":"https://doi.org/10.21037/tlcr.2018.04.01","mag":"2802013144","pmid":"https://pubmed.ncbi.nlm.nih.gov/29876321"},"language":"en","primary_location":{"id":"doi:10.21037/tlcr.2018.04.01","doi":"https://doi.org/10.21037/tlcr.2018.04.01","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr.2018.04.01","pdf_url":null,"source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.21037/tlcr.2018.04.01","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016864113","display_name":"Sara St. James","orcid":"https://orcid.org/0000-0002-8081-2433","observed_orcids":["https://orcid.org/0000-0002-8081-2433"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sara St. James","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072499473","display_name":"Clemens Grassberger","orcid":"https://orcid.org/0000-0002-4425-4489","observed_orcids":["https://orcid.org/0000-0002-4425-4489"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clemens Grassberger","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079087895","display_name":"Hsiao\u2010Ming Lu","orcid":"https://orcid.org/0000-0001-6144-3161","observed_orcids":["https://orcid.org/0000-0001-6144-3161"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hsiao-Ming Lu","raw_affiliation_strings":["Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.8595,"has_fulltext":false,"cited_by_count":22,"citation_normalized_percentile":{"value":0.85733227,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"7","issue":"2","first_page":"210","last_page":"215"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10358","display_name":"Advanced Radiotherapy Techniques","score":0.006200000178068876,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.9940000176429749},{"id":"https://openalex.org/keywords/proton-therapy","display_name":"proton therapy","score":0.9929999709129333},{"id":"https://openalex.org/keywords/lung-sparing","display_name":"lung sparing","score":0.6050000190734863},{"id":"https://openalex.org/keywords/cardiac-dose-reduction","display_name":"heart dose reduction","score":0.7590000033378601},{"id":"https://openalex.org/keywords/proton-range","display_name":"proton range","score":0.527999997138977},{"id":"https://openalex.org/keywords/temporal-effects","display_name":"time effects","score":0.597000002861023},{"id":"https://openalex.org/keywords/dose-discrepancies","display_name":"dose discrepancies","score":0.9440000057220459},{"id":"https://openalex.org/keywords/treatment-planning-system","display_name":"treatment planning system","score":0.8349999785423279},{"id":"https://openalex.org/keywords/radiation-toxicity","display_name":"radiation toxicity","score":0.4580000042915344}],"concepts":[{"id":"https://openalex.org/C2779244869","wikidata":"https://www.wikidata.org/wiki/Q507667","display_name":"Proton therapy","level":3,"score":0.9430805444717407},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8517805337905884},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.7533032894134521},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6761950850486755},{"id":"https://openalex.org/C201645570","wikidata":"https://www.wikidata.org/wiki/Q830637","display_name":"Radiation treatment planning","level":3,"score":0.6602998971939087},{"id":"https://openalex.org/C2775881188","wikidata":"https://www.wikidata.org/wiki/Q7162317","display_name":"Pencil-beam scanning","level":4,"score":0.6311365962028503},{"id":"https://openalex.org/C54516573","wikidata":"https://www.wikidata.org/wiki/Q2294","display_name":"Proton","level":2,"score":0.5312367081642151},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.507194995880127},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.4642515778541565},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.35750290751457214},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3479335904121399},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2133883833885193},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17206719517707825},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.05722242593765259},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.21037/tlcr.2018.04.01","doi":"https://doi.org/10.21037/tlcr.2018.04.01","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr.2018.04.01","pdf_url":null,"source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},{"id":"pmid:29876321","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29876321","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational lung cancer research","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:4941820","doi":null,"is_oa":false,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5960655","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5960655","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5960655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Transl Lung Cancer Res","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.21037/tlcr.2018.04.01","doi":"https://doi.org/10.21037/tlcr.2018.04.01","is_oa":true,"landing_page_url":"https://doi.org/10.21037/tlcr.2018.04.01","pdf_url":null,"source":{"id":"https://openalex.org/S2764539079","display_name":"Translational Lung Cancer Research","issn_l":"2218-6751","issn":["2218-6751","2226-4477"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Translational Lung Cancer Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1978103445","https://openalex.org/W1980098076","https://openalex.org/W1983490139","https://openalex.org/W1987134214","https://openalex.org/W1988346933","https://openalex.org/W1995766420","https://openalex.org/W1998759803","https://openalex.org/W1999189079","https://openalex.org/W2005862478","https://openalex.org/W2052562810","https://openalex.org/W2059950254","https://openalex.org/W2071042777","https://openalex.org/W2093338140","https://openalex.org/W2129065779","https://openalex.org/W2133147741","https://openalex.org/W2133531250","https://openalex.org/W2155758197","https://openalex.org/W2163827108","https://openalex.org/W2600896084","https://openalex.org/W2625610786","https://openalex.org/W2771240168"],"related_works":["https://openalex.org/W2799737879","https://openalex.org/W2946608664","https://openalex.org/W2461335443","https://openalex.org/W2610283735","https://openalex.org/W1973124468","https://openalex.org/W2463896968","https://openalex.org/W4206110157","https://openalex.org/W1013145701","https://openalex.org/W2053144828","https://openalex.org/W2089143449"],"abstract_inverted_index":{"Lung":[0],"cancer,":[1],"due":[2],"to":[3,24,42,47,56,77,100,104],"its":[4],"poor":[5],"clinical":[6],"outcomes":[7],"and":[8,131,158],"significant":[9,67],"toxicity":[10],"associated":[11],"with":[12,30,79,93,107],"standard":[13],"photon-based":[14],"radiation,":[15],"is":[16,39,75,144],"a":[17],"disease":[18],"site":[19],"that":[20],"has":[21],"the":[22,40,44,48,53,70,86,117,123,139,147],"potential":[23,35,128],"greatly":[25],"benefit":[26],"from":[27],"accurate":[28],"treatment":[29,135],"proton":[31,37,94,150,155,161],"radiation":[32,45,54,111],"therapy.":[33,112,162],"The":[34],"of":[36,69,120],"therapy":[38,151,156],"ability":[41],"increase":[43],"dose":[46,55,129],"tumor":[49],"while":[50],"simultaneously":[51],"decreasing":[52,85],"surrounding":[57],"healthy":[58,72],"tissues.":[59],"For":[60],"lung":[61,91],"cancer":[62,92],"treatment,":[63],"this":[64],"could":[65],"mean":[66],"sparing":[68],"uninvolved":[71],"lung,":[73],"which":[74],"difficult":[76],"achieve":[78],"external":[80,108],"photon":[81,109],"beam":[82,110],"therapy,":[83,95],"or":[84],"heart":[87],"dose.":[88],"In":[89],"treating":[90,105],"some":[96],"additional":[97],"considerations":[98],"need":[99],"be":[101],"made":[102],"compared":[103],"patients":[106],"These":[113],"include":[114],"accounting":[115],"for":[116,138],"finite":[118],"range":[119],"protons":[121],"in":[122],"patient,":[124],"understanding":[125],"temporal":[126],"effects,":[127],"discrepancies":[130],"choosing":[132],"an":[133],"appropriate":[134],"planning":[136],"system":[137],"task.":[140],"One":[141],"final":[142],"consideration":[143],"differences":[145],"between":[146],"different":[148],"available":[149],"delivery":[152],"systems-passive":[153],"scattered":[154],"(PSPT)":[157],"active":[159],"scanning":[160]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2025-10-10T00:00:00"}
