{"id":"https://openalex.org/W28019520","doi":null,"title":"GABA-steroid effects in healthy subjects and women with polycystic ovary syndrome","display_name":"GABA-steroid effects in healthy subjects and women with polycystic ovary syndrome","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W28019520","mag":"28019520"},"language":"en","primary_location":{"id":"pmh:oai:DiVA.org:umu-49375","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49375","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49375","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5010982573","display_name":"Helena Hedstr\u00f6m","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Helena Hedstr\u00f6m","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5010982573"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.8949999809265137,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.07259999960660934,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10960","display_name":"Hypothalamic control of reproductive hormones","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allopregnanolone","display_name":"allopregnanolone","score":0.9750000238418579},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.7319999933242798},{"id":"https://openalex.org/keywords/polycystic-ovary-syndrome","display_name":"polycystic ovary syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/gonadotropin-secretion","display_name":"gonadotropin secretion","score":0.9419999718666077},{"id":"https://openalex.org/keywords/progesterone-metabolites","display_name":"progesterone metabolites","score":0.9330000281333923},{"id":"https://openalex.org/keywords/androstanediol","display_name":"androstanediol","score":0.7979999780654907},{"id":"https://openalex.org/keywords/menstrual-cycle-phase","display_name":"menstrual cycle phases","score":0.6489999890327454},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.8080000281333923},{"id":"https://openalex.org/keywords/pharmacodynamics","display_name":"pharmacodynamics","score":0.7950000166893005},{"id":"https://openalex.org/keywords/women-s-health","display_name":"women's health","score":0.5360000133514404},{"id":"https://openalex.org/keywords/sedation","display_name":"sedation","score":0.5889999866485596},{"id":"https://openalex.org/keywords/hyperandrogenism","display_name":"hyperandrogenism","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C3018442814","wikidata":"https://www.wikidata.org/wiki/Q500816","display_name":"Polycystic ovary","level":4,"score":0.9056858420372009},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.569841206073761},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5330938696861267},{"id":"https://openalex.org/C2778324911","wikidata":"https://www.wikidata.org/wiki/Q9631","display_name":"Ovary","level":2,"score":0.515063464641571},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4844686985015869},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.479801207780838},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.22948041558265686},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.10019978880882263},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:DiVA.org:umu-49375","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49375","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:28019520","doi":null,"is_oa":false,"landing_page_url":"http://umu.diva-portal.org/smash/get/diva2:455484/FULLTEXT01","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:DiVA.org:umu-49375","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-49375","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":255,"referenced_works":["https://openalex.org/W162491450","https://openalex.org/W169750346","https://openalex.org/W204867062","https://openalex.org/W374314111","https://openalex.org/W827049731","https://openalex.org/W1496951129","https://openalex.org/W1512219751","https://openalex.org/W1514638066","https://openalex.org/W1522096759","https://openalex.org/W1573410599","https://openalex.org/W1760151818","https://openalex.org/W1798753198","https://openalex.org/W1901523133","https://openalex.org/W1907235146","https://openalex.org/W1910892035","https://openalex.org/W1941257661","https://openalex.org/W1957435031","https://openalex.org/W1963664255","https://openalex.org/W1963684492","https://openalex.org/W1964865909","https://openalex.org/W1967596820","https://openalex.org/W1967963412","https://openalex.org/W1968397374","https://openalex.org/W1968453229","https://openalex.org/W1972888313","https://openalex.org/W1973558589","https://openalex.org/W1975142886","https://openalex.org/W1975743909","https://openalex.org/W1976149644","https://openalex.org/W1976541018","https://openalex.org/W1976995330","https://openalex.org/W1977787204","https://openalex.org/W1979588495","https://openalex.org/W1980333362","https://openalex.org/W1981996879","https://openalex.org/W1984067141","https://openalex.org/W1986225558","https://openalex.org/W1988688671","https://openalex.org/W1988819654","https://openalex.org/W1992243003","https://openalex.org/W1992589532","https://openalex.org/W1994799801","https://openalex.org/W1994826393","https://openalex.org/W1997020109","https://openalex.org/W1998765262","https://openalex.org/W1999773111","https://openalex.org/W2000904191","https://openalex.org/W2001174135","https://openalex.org/W2001346327","https://openalex.org/W2001619275","https://openalex.org/W2001876739","https://openalex.org/W2002862204","https://openalex.org/W2002925968","https://openalex.org/W2003498455","https://openalex.org/W2004123621","https://openalex.org/W2005822235","https://openalex.org/W2006695602","https://openalex.org/W2008392190","https://openalex.org/W2008744891","https://openalex.org/W2009410204","https://openalex.org/W2009415563","https://openalex.org/W2009753706","https://openalex.org/W2010105282","https://openalex.org/W2010359396","https://openalex.org/W2012453718","https://openalex.org/W2012498131","https://openalex.org/W2012767314","https://openalex.org/W2013544816","https://openalex.org/W2014226127","https://openalex.org/W2015632816","https://openalex.org/W2017460642","https://openalex.org/W2018894245","https://openalex.org/W2019269880","https://openalex.org/W2020592888","https://openalex.org/W2021217579","https://openalex.org/W2021471098","https://openalex.org/W2021802578","https://openalex.org/W2022378061","https://openalex.org/W2024015272","https://openalex.org/W2024344189","https://openalex.org/W2025114171","https://openalex.org/W2025462570","https://openalex.org/W2026071202","https://openalex.org/W2026162157","https://openalex.org/W2027761185","https://openalex.org/W2029414473","https://openalex.org/W2029466154","https://openalex.org/W2031206742","https://openalex.org/W2032005206","https://openalex.org/W2032668395","https://openalex.org/W2032844562","https://openalex.org/W2033769761","https://openalex.org/W2033885429","https://openalex.org/W2034003606","https://openalex.org/W2034351075","https://openalex.org/W2034812041","https://openalex.org/W2034960248","https://openalex.org/W2035217519","https://openalex.org/W2036047888","https://openalex.org/W2036583721","https://openalex.org/W2036628110","https://openalex.org/W2036690788","https://openalex.org/W2037046144","https://openalex.org/W2038415949","https://openalex.org/W2038868525","https://openalex.org/W2038995495","https://openalex.org/W2040712940","https://openalex.org/W2040944991","https://openalex.org/W2042409013","https://openalex.org/W2042947181","https://openalex.org/W2043231683","https://openalex.org/W2043414873","https://openalex.org/W2043915680","https://openalex.org/W2044420664","https://openalex.org/W2044970382","https://openalex.org/W2045313473","https://openalex.org/W2045355683","https://openalex.org/W2046859247","https://openalex.org/W2047024068","https://openalex.org/W2047140715","https://openalex.org/W2048591573","https://openalex.org/W2049116118","https://openalex.org/W2050966618","https://openalex.org/W2051197176","https://openalex.org/W2052008533","https://openalex.org/W2053600882","https://openalex.org/W2054664043","https://openalex.org/W2056041077","https://openalex.org/W2057415531","https://openalex.org/W2058002380","https://openalex.org/W2058223478","https://openalex.org/W2059046744","https://openalex.org/W2059321980","https://openalex.org/W2059497272","https://openalex.org/W2063301591","https://openalex.org/W2063439191","https://openalex.org/W2063583373","https://openalex.org/W2065556700","https://openalex.org/W2066972744","https://openalex.org/W2067083885","https://openalex.org/W2067201491","https://openalex.org/W2067954470","https://openalex.org/W2068298897","https://openalex.org/W2069302715","https://openalex.org/W2070507211","https://openalex.org/W2070745891","https://openalex.org/W2071275159","https://openalex.org/W2071690153","https://openalex.org/W2071873481","https://openalex.org/W2074113629","https://openalex.org/W2074390708","https://openalex.org/W2075327557","https://openalex.org/W2076507599","https://openalex.org/W2078558962","https://openalex.org/W2079729898","https://openalex.org/W2081649719","https://openalex.org/W2082771245","https://openalex.org/W2083447043","https://openalex.org/W2083552615","https://openalex.org/W2084184891","https://openalex.org/W2084658093","https://openalex.org/W2084754905","https://openalex.org/W2090257440","https://openalex.org/W2090554221","https://openalex.org/W2090798099","https://openalex.org/W2096887626","https://openalex.org/W2098057713","https://openalex.org/W2098532856","https://openalex.org/W2099680004","https://openalex.org/W2100095860","https://openalex.org/W2100192487","https://openalex.org/W2101524100","https://openalex.org/W2102075553","https://openalex.org/W2102298931","https://openalex.org/W2103329833","https://openalex.org/W2104231345","https://openalex.org/W2104300853","https://openalex.org/W2104443550","https://openalex.org/W2106709706","https://openalex.org/W2106915249","https://openalex.org/W2108112484","https://openalex.org/W2108380448","https://openalex.org/W2108920926","https://openalex.org/W2110868573","https://openalex.org/W2111715905","https://openalex.org/W2111915256","https://openalex.org/W2112419921","https://openalex.org/W2112445335","https://openalex.org/W2113042263","https://openalex.org/W2114772172","https://openalex.org/W2115599356","https://openalex.org/W2115819312","https://openalex.org/W2119460554","https://openalex.org/W2120376036","https://openalex.org/W2121237571","https://openalex.org/W2121911836","https://openalex.org/W2122860707","https://openalex.org/W2123331750","https://openalex.org/W2124026735","https://openalex.org/W2126816212","https://openalex.org/W2127483997","https://openalex.org/W2130919292","https://openalex.org/W2131801472","https://openalex.org/W2132726881","https://openalex.org/W2133340534","https://openalex.org/W2135886148","https://openalex.org/W2137471600","https://openalex.org/W2137616148","https://openalex.org/W2138349706","https://openalex.org/W2138808993","https://openalex.org/W2138840482","https://openalex.org/W2139915659","https://openalex.org/W2140449396","https://openalex.org/W2140896143","https://openalex.org/W2142272530","https://openalex.org/W2142621915","https://openalex.org/W2143098549","https://openalex.org/W2146894298","https://openalex.org/W2148412570","https://openalex.org/W2149121207","https://openalex.org/W2149183746","https://openalex.org/W2150468895","https://openalex.org/W2150746764","https://openalex.org/W2153849256","https://openalex.org/W2154087463","https://openalex.org/W2154971062","https://openalex.org/W2157264338","https://openalex.org/W2157699773","https://openalex.org/W2159658551","https://openalex.org/W2163069137","https://openalex.org/W2163191129","https://openalex.org/W2163694918","https://openalex.org/W2164835849","https://openalex.org/W2165223719","https://openalex.org/W2166202892","https://openalex.org/W2166460167","https://openalex.org/W2166871975","https://openalex.org/W2169213189","https://openalex.org/W2170244784","https://openalex.org/W2171196764","https://openalex.org/W2192386124","https://openalex.org/W2294856982","https://openalex.org/W2321307450","https://openalex.org/W2322332350","https://openalex.org/W2324024668","https://openalex.org/W2324379664","https://openalex.org/W2394995650","https://openalex.org/W2396727443","https://openalex.org/W2397485493","https://openalex.org/W2404494855","https://openalex.org/W2411720062","https://openalex.org/W2437586771","https://openalex.org/W2472195961","https://openalex.org/W2986082729","https://openalex.org/W2991190608"],"related_works":["https://openalex.org/W2165182626","https://openalex.org/W82603366","https://openalex.org/W1965774807","https://openalex.org/W7017353600","https://openalex.org/W1891610553","https://openalex.org/W1971715067","https://openalex.org/W3186738270","https://openalex.org/W2031825445","https://openalex.org/W2036690788","https://openalex.org/W2766874411"],"abstract_inverted_index":{"Background:":[0],"The":[1,420,435],"progesterone":[2,168],"metabolite":[3,133],"allopregnanolone":[4,67,119,175,208,216,222,256,273,293,347,367,422],"is":[5,18,49,57,68,92,135,165,171,378],"involved":[6,69],"in":[7,11,47,70,86,121,162,228,267,277,287,312,321,324,335,364,398,406,410,427,432],"several":[8],"clinical":[9],"conditions":[10,409],"women,":[12],"e.g.":[13,31,61],"premenstrual":[14],"dysphoric":[15],"disorder.":[16],"It":[17,153],"a":[19,387,404],"very":[20],"potent":[21],"GABA-steroid":[22,405,421],"with":[23,337,416],"GABA-A":[24,45,78,137,159,184,218,303,400,448],"receptor":[25,46,138,160,185,219,304,401],"effects":[26,42,206,224,278],"similar":[27],"to":[28,40,50,147,181,196,200,221,366,403],"other":[29],"GABA-agonists,":[30,60],"benzodiazepines,":[32],"and":[33,111,209,223,232,238,264,274,292,296,302],"it":[34,191],"causes":[35],"sedation.":[36],"An":[37],"objective":[38],"way":[39],"examine":[41,236],"on":[43,211,225,259,279,332,374,383,439],"the":[44,71,77,93,172,205,245,253,275,298,399,447],"humans":[48],"measure":[51],"saccadic":[52,417],"eye":[53,418],"velocity":[54],"(SEV),":[55],"which":[56,134],"reduced":[58],"by":[59,105,386,441],"allopregnanolone.":[62,201,392],"Animal":[63],"studies":[64],"suggest":[65],"that":[66],"regulation":[72],"of":[73,100,129,150,174,187,207,255,290,346,381,389,412,437,446],"gonadotropin":[74,212,226,260,318,333,375,424],"secretion":[75,227,334],"via":[76],"receptor,":[79],"but":[80,176,328,352,430],"this":[81],"has":[82,154,177,192,329,371],"not":[83,155,178,431],"been":[84,156,179,194],"studied":[85,157],"humans.":[87],"Polycystic":[88],"ovary":[89],"syndrome":[90],"(PCOS)":[91],"most":[94],"common":[95],"endocrine":[96,408],"disturbance":[97],"among":[98],"women":[99,125,164,249,263,266,336,340,360,411,429],"fertile":[101,413],"age":[102,414],"(5\u201310%),":[103],"characterized":[104],"polycystic":[106],"ovaries,":[107],"menstrual":[108],"dysfunction,":[109],"hyperandrogenity,":[110],"50%":[112],"have":[113,116,126,182,341],"obesity.":[114],"Studies":[115],"shown":[117,180],"higher":[118,342],"levels":[120,128,149,289,320,345,354,426],"overweight":[122],"people.":[123],"PCOS":[124,163,233,262,339,359,433],"increased":[127],"androstanediol,":[130],"an":[131,136,379,444],"androgen":[132],"agonist.":[139],"Tolerance":[140],"often":[141,193],"occurs":[142],"when":[143],"persons":[144],"are":[145,395],"exposed":[146],"high":[148],"GABAergic":[151],"modulators.":[152],"whether":[158],"sensitivity":[161,220,305],"changed.":[166],"Another":[167],"metabolite,":[169],"isoallopregnanolone,":[170],"stereoisomere":[173],"any":[183],"effect":[186,254,331,373,380,438],"its":[188],"own.":[189],"Instead":[190],"used":[195],"control":[197],"steroid":[198],"specificity":[199],"Aims:":[202],"To":[203,214,235],"compare":[204,215],"isoallopregnanolone":[210,258,311,382,390,442],"secretion.":[213,261,376],"levels,":[217],"both":[229,268,325],"cycle":[230,269,326],"phases":[231,270],"conditions.":[234],"pharmacokinetics":[237],"pharmacodynamic":[239],"properties":[240],"for":[241,252,310],"isoallopregnanolone.":[242],"Method:":[243],"In":[244],"follicular":[246,349],"phase":[247,350,357],"healthy":[248,265,313,322,428],"were":[250,271,281,308],"examined":[251,415],"or":[257],"given":[272],"differences":[276,397],"SEV":[280,307,365],"examined,":[282],"as":[283,285],"well":[284],"changes":[286],"serum":[288,319,344,425],"gonadotropins":[291,440],"at":[294],"baseline":[295,343],"during":[297],"test":[299],"day.":[300],"Pharmacokinetics":[301],"using":[306],"explored":[309],"women.":[314,434],"Results:":[315],"Allopregnanolone":[316],"decreases":[317,423],"controls":[323],"phases,":[327],"no":[330,372],"PCOS.":[338],"than":[348,355,368],"controls,":[351],"lower":[353],"luteal":[356],"controls.":[358,369],"show":[361],"greater":[362],"reduction":[363],"Isoallopregnanolone":[370],"There":[377,394],"SEV,":[384],"explained":[385],"metabolism":[388],"into":[391],"Conclusion:":[393],"significant":[396],"response":[402],"different":[407],"velocity.":[419],"lack":[436],"suggests":[443],"involvement":[445],"receptor.":[449]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
