{"id":"https://openalex.org/W2801950316","doi":"https://doi.org/10.1039/c8cc01263f","title":"The distinct structural preferences of tau protein repeat domains","display_name":"The distinct structural preferences of tau protein repeat domains","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2801950316","doi":"https://doi.org/10.1039/c8cc01263f","mag":"2801950316","pmid":"https://pubmed.ncbi.nlm.nih.gov/29774342","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986281"},"language":"en","primary_location":{"id":"doi:10.1039/c8cc01263f","doi":"https://doi.org/10.1039/c8cc01263f","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8cc01263f","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986281","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024365576","display_name":"Xuhua Li","orcid":"https://orcid.org/0000-0003-3253-0746","observed_orcids":["https://orcid.org/0000-0003-3253-0746"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210140493","display_name":"Collaborative Innovation Center of Advanced Microstructures","ror":"https://ror.org/04ttadj76","country_code":"CN","type":"facility","lineage":["https://openalex.org/I126520041","https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I24943067","https://openalex.org/I2802624667","https://openalex.org/I4210140493","https://openalex.org/I76130692","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I4391768224","display_name":"State Key Laboratory of Surface Physics","ror":"https://ror.org/000nbq540","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768224"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuhua Li","raw_affiliation_strings":["Collaborative Innovation Center of Advanced Microstructures (Nanjing)","Department of Physics","Fudan University","Key Laboratory for Computational Physical Science (Ministry of Education)","State Key Laboratory of Surface Physics","Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Science (Ministry of Education), Collaborative Innovation Center of Advanced Microstructures (Nanjing), Fudan University, Shanghai 200433, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0003-3253-0746","affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Advanced Microstructures (Nanjing)","institution_ids":["https://openalex.org/I4210140493"]},{"raw_affiliation_string":"Department of Physics","institution_ids":[]},{"raw_affiliation_string":"Fudan University","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Key Laboratory for Computational Physical Science (Ministry of Education)","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Surface Physics","institution_ids":["https://openalex.org/I4391768224"]},{"raw_affiliation_string":"Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Science (Ministry of Education), Collaborative Innovation Center of Advanced Microstructures (Nanjing), Fudan University, Shanghai 200433, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210140493","https://openalex.org/I4391768224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046687443","display_name":"Xuewei Dong","orcid":"https://orcid.org/0000-0002-5139-2601","observed_orcids":["https://orcid.org/0000-0002-5139-2601"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210140493","display_name":"Collaborative Innovation Center of Advanced Microstructures","ror":"https://ror.org/04ttadj76","country_code":"CN","type":"facility","lineage":["https://openalex.org/I126520041","https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I24943067","https://openalex.org/I2802624667","https://openalex.org/I4210140493","https://openalex.org/I76130692","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I4391768224","display_name":"State Key Laboratory of Surface Physics","ror":"https://ror.org/000nbq540","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768224"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuewei Dong","raw_affiliation_strings":["Collaborative Innovation Center of Advanced Microstructures (Nanjing)","Department of Physics","Fudan University","Key Laboratory for Computational Physical Science (Ministry of Education)","State Key Laboratory of Surface Physics","Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Science (Ministry of Education), Collaborative Innovation Center of Advanced Microstructures (Nanjing), Fudan University, Shanghai 200433, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Advanced Microstructures (Nanjing)","institution_ids":["https://openalex.org/I4210140493"]},{"raw_affiliation_string":"Department of Physics","institution_ids":[]},{"raw_affiliation_string":"Fudan University","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Key Laboratory for Computational Physical Science (Ministry of Education)","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Surface Physics","institution_ids":["https://openalex.org/I4391768224"]},{"raw_affiliation_string":"Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Science (Ministry of Education), Collaborative Innovation Center of Advanced Microstructures (Nanjing), Fudan University, Shanghai 200433, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210140493","https://openalex.org/I4391768224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007399260","display_name":"Guanghong Wei","orcid":"https://orcid.org/0000-0001-5814-3328","observed_orcids":["https://orcid.org/0000-0001-5814-3328"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210140493","display_name":"Collaborative Innovation Center of Advanced Microstructures","ror":"https://ror.org/04ttadj76","country_code":"CN","type":"facility","lineage":["https://openalex.org/I126520041","https://openalex.org/I183067930","https://openalex.org/I19820366","https://openalex.org/I24943067","https://openalex.org/I2802624667","https://openalex.org/I4210140493","https://openalex.org/I76130692","https://openalex.org/I881766915"]},{"id":"https://openalex.org/I4391768224","display_name":"State Key Laboratory of Surface Physics","ror":"https://ror.org/000nbq540","country_code":"CN","type":"facility","lineage":["https://openalex.org/I24943067","https://openalex.org/I4391768224"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guanghong Wei","raw_affiliation_strings":["Collaborative Innovation Center of Advanced Microstructures (Nanjing)","Department of Physics","Fudan University","Key Laboratory for Computational Physical Science (Ministry of Education)","State Key Laboratory of Surface Physics","Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Science (Ministry of Education), Collaborative Innovation Center of Advanced Microstructures (Nanjing), Fudan University, Shanghai 200433, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0001-5814-3328","affiliations":[{"raw_affiliation_string":"Collaborative Innovation Center of Advanced Microstructures (Nanjing)","institution_ids":["https://openalex.org/I4210140493"]},{"raw_affiliation_string":"Department of Physics","institution_ids":[]},{"raw_affiliation_string":"Fudan University","institution_ids":["https://openalex.org/I24943067"]},{"raw_affiliation_string":"Key Laboratory for Computational Physical Science (Ministry of Education)","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Surface Physics","institution_ids":["https://openalex.org/I4391768224"]},{"raw_affiliation_string":"Department of Physics, State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Science (Ministry of Education), Collaborative Innovation Center of Advanced Microstructures (Nanjing), Fudan University, Shanghai 200433, People's Republic of China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210140493","https://openalex.org/I4391768224"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057250140","display_name":"Martin Margittai","orcid":"https://orcid.org/0000-0003-1903-5927","observed_orcids":["https://orcid.org/0000-0003-1903-5927"]},"institutions":[{"id":"https://openalex.org/I131651094","display_name":"University of Denver","ror":"https://ror.org/04w7skc03","country_code":"US","type":"education","lineage":["https://openalex.org/I131651094"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Margittai","raw_affiliation_strings":["Denver","Department of Chemistry and Biochemistry","USA","University of Denver","Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Denver","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry","institution_ids":[]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"University of Denver","institution_ids":["https://openalex.org/I131651094"]},{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Denver, Denver, CO 80208, USA","institution_ids":["https://openalex.org/I131651094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025357844","display_name":"Ruth Nussinov","orcid":"https://orcid.org/0000-0002-8115-6415","observed_orcids":["https://orcid.org/0000-0002-8115-6415"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["IL","US"],"is_corresponding":true,"raw_author_name":"Ruth Nussinov","raw_affiliation_strings":["Basic Science Program","Israel","Leidos Biomedical Research, Inc. Cancer and Inflammation Program","Sackler Inst. of Molecular Medicine Department of Human Genetics and Molecular Medicine Sackler School of Medicine","Tel Aviv University","Basic Science Program, Leidos Biomedical Research, Inc. Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA","Sackler Inst. of Molecular Medicine Department of Human Genetics and Molecular Medicine Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":"https://orcid.org/0000-0002-8115-6415","affiliations":[{"raw_affiliation_string":"Basic Science Program","institution_ids":[]},{"raw_affiliation_string":"Israel","institution_ids":[]},{"raw_affiliation_string":"Leidos Biomedical Research, Inc. Cancer and Inflammation Program","institution_ids":["https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Sackler Inst. of Molecular Medicine Department of Human Genetics and Molecular Medicine Sackler School of Medicine","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Tel Aviv University","institution_ids":["https://openalex.org/I16391192"]},{"raw_affiliation_string":"Basic Science Program, Leidos Biomedical Research, Inc. Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4396570585"]},{"raw_affiliation_string":"Sackler Inst. of Molecular Medicine Department of Human Genetics and Molecular Medicine Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076498226","display_name":"Buyong Ma","orcid":"https://orcid.org/0000-0002-7383-719X","observed_orcids":["https://orcid.org/0000-0002-7383-719X"]},"institutions":[{"id":"https://openalex.org/I4210140884","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210140884"]},{"id":"https://openalex.org/I4396570585","display_name":"Leidos Biomedical Research Inc. (United States)","ror":"https://ror.org/00bardy64","country_code":"US","type":"company","lineage":["https://openalex.org/I114662689","https://openalex.org/I4396570585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Buyong Ma","raw_affiliation_strings":["Basic Science Program","Frederick","Leidos Biomedical Research, Inc. Cancer and Inflammation Program","National Cancer Institute","USA","Basic Science Program, Leidos Biomedical Research, Inc. Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA"],"raw_orcid":"https://orcid.org/0000-0002-7383-719X","affiliations":[{"raw_affiliation_string":"Basic Science Program","institution_ids":[]},{"raw_affiliation_string":"Frederick","institution_ids":[]},{"raw_affiliation_string":"Leidos Biomedical Research, Inc. Cancer and Inflammation Program","institution_ids":["https://openalex.org/I4396570585"]},{"raw_affiliation_string":"National Cancer Institute","institution_ids":["https://openalex.org/I4210140884"]},{"raw_affiliation_string":"USA","institution_ids":[]},{"raw_affiliation_string":"Basic Science Program, Leidos Biomedical Research, Inc. Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, USA","institution_ids":["https://openalex.org/I4210140884","https://openalex.org/I4396570585"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5007399260","https://openalex.org/A5025357844"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I24943067","https://openalex.org/I4210140493","https://openalex.org/I4210140884","https://openalex.org/I4391768224","https://openalex.org/I4396570585"],"apc_list":null,"apc_paid":null,"fwci":2.0584,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.86051795,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"54","issue":"45","first_page":"5700","last_page":"5703"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11335","display_name":"Prion Diseases and Protein Misfolding","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tau-protein","display_name":"tau protein","score":0.9980000257492065},{"id":"https://openalex.org/keywords/tau-repeat-domain","display_name":"tau repeat domain","score":0.824999988079071},{"id":"https://openalex.org/keywords/tau-fibrils","display_name":"tau fibrils","score":0.6909999847412109},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9039999842643738},{"id":"https://openalex.org/keywords/heparin","display_name":"heparin","score":0.7929999828338623},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.4129999876022339},{"id":"https://openalex.org/keywords/structural-stability","display_name":"structural stability","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C132677234","wikidata":"https://www.wikidata.org/wiki/Q3273544","display_name":"Structural motif","level":2,"score":0.5164902210235596},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.46194347739219666},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43834444880485535},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.43348023295402527},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38868486881256104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24302399158477783},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1881786584854126}],"mesh":[{"descriptor_ui":"D000072417","descriptor_name":"Protein Domains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006493","descriptor_name":"Heparin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006860","descriptor_name":"Hydrogen Bonding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016875","descriptor_name":"tau Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D017433","descriptor_name":"Protein Structure, Secondary","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020449","descriptor_name":"Repetitive Sequences, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055550","descriptor_name":"Protein Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056004","descriptor_name":"Molecular Dynamics Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066329","descriptor_name":"Protein Aggregates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1039/c8cc01263f","doi":"https://doi.org/10.1039/c8cc01263f","is_oa":false,"landing_page_url":"https://doi.org/10.1039/c8cc01263f","pdf_url":null,"source":{"id":"https://openalex.org/S152760256","display_name":"Chemical Communications","issn_l":"1359-7345","issn":["1359-7345","1364-548X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-2","ki-jl-1","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Communications","raw_type":"journal-article"},{"id":"pmid:29774342","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29774342","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical communications (Cambridge, England)","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:5507948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986281","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5986281","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986281","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Chem Commun (Camb)","raw_type":"Text"},{"id":"pmh:oai:digitalcommons.du.edu:chemistryandbiochemistryfaculty-1047","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.du.edu/chemistryandbiochemistryfaculty/46","pdf_url":null,"source":{"id":"https://openalex.org/S4377196520","display_name":"Digital Commons - DU (University of Denver)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I131651094","host_organization_name":"University of Denver","host_organization_lineage":["https://openalex.org/I131651094"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Chemistry and Biochemistry: Faculty Scholarship","raw_type":"text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5507948","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5986281","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1625724531","display_name":"Protein Structure, Stability, and Amyloid Formation","funder_award_id":"Z01BC010440","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3503792436","display_name":null,"funder_award_id":"#HHSN261200800001E","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G386607036","display_name":null,"funder_award_id":"HHSN261200800001E)","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G4048633378","display_name":"\u5929\u7136\u5c0f\u5206\u5b50\u5316\u5408\u7269\u6291\u5236\u56fa\u6709\u65e0\u5e8f\u86cb\u767d\u805a\u96c6\u7684\u5fae\u89c2\u673a\u7406\u7814\u7a76","funder_award_id":"11674065","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5888954722","display_name":null,"funder_award_id":"HHSN261200800001C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320311473","display_name":"Council for Chemical Research","ror":"https://ror.org/04ct7vj52"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W1600934558","https://openalex.org/W1967285029","https://openalex.org/W1975700794","https://openalex.org/W1979891321","https://openalex.org/W2014858798","https://openalex.org/W2021914048","https://openalex.org/W2023616226","https://openalex.org/W2028510176","https://openalex.org/W2033682190","https://openalex.org/W2046436217","https://openalex.org/W2091305524","https://openalex.org/W2120843434","https://openalex.org/W2124019813","https://openalex.org/W2153323361","https://openalex.org/W2272362840","https://openalex.org/W2518794962","https://openalex.org/W2589440020","https://openalex.org/W2598328231","https://openalex.org/W2727929522","https://openalex.org/W2762378928","https://openalex.org/W2772202429","https://openalex.org/W2772451653"],"related_works":["https://openalex.org/W2157583738","https://openalex.org/W2580853259","https://openalex.org/W3161071856","https://openalex.org/W2034942377","https://openalex.org/W2084136879","https://openalex.org/W2037330121","https://openalex.org/W3023029299","https://openalex.org/W3013140349","https://openalex.org/W2324362294","https://openalex.org/W4384282536"],"abstract_inverted_index":{"The":[0],"tau":[1],"fibrillar":[2],"structures":[3],"from":[4],"the":[5,19,30,52,61],"brain":[6],"of":[7,18],"an":[8],"Alzheimer's":[9],"patient":[10],"have":[11],"a":[12,15],"core":[13],"with":[14],"C-shaped":[16,31,62],"motif":[17,32],"third":[20],"and":[21],"fourth":[22],"repeat":[23],"domains":[24],"(R3-R4).":[25],"Our":[26],"simulations":[27],"indicated":[28],"that":[29],"is":[33],"only":[34],"stable":[35,54],"for":[36],"R3-R4,":[37],"while":[38],"R1-R2":[39],"tends":[40],"to":[41],"be":[42],"linear":[43],"in":[44,51],"shape.":[45],"These":[46],"two":[47],"structural":[48],"motifs":[49],"appear":[50],"most":[53],"K18":[55],"protofilament.":[56],"Heparin":[57],"can":[58],"further":[59],"stabilize":[60],"R3-R4":[63],"motif,":[64],"but":[65],"not":[66],"other":[67],"repeats.":[68]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}
