{"id":"https://openalex.org/W2801469852","doi":"https://doi.org/10.3233/jad-180161","title":"Memory Loss and the Onset of Alzheimer\u2019s Disease Could Be Under the Control of Extracellular Heat Shock Proteins","display_name":"Memory Loss and the Onset of Alzheimer\u2019s Disease Could Be Under the Control of Extracellular Heat Shock Proteins","publication_year":2018,"publication_date":"2018-04-17","ids":{"openalex":"https://openalex.org/W2801469852","doi":"https://doi.org/10.3233/jad-180161","mag":"2801469852","pmid":"https://pubmed.ncbi.nlm.nih.gov/29689729"},"language":"en","primary_location":{"id":"doi:10.3233/jad-180161","doi":"https://doi.org/10.3233/jad-180161","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-180161","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5034755455","display_name":"Nelson J. Arispe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I148314036","display_name":"Uniformed Services University of the Health Sciences","ror":"https://ror.org/04r3kq386","country_code":"US","type":"education","lineage":["https://openalex.org/I148314036"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nelson Arispe","raw_affiliation_strings":["Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA","institution_ids":["https://openalex.org/I148314036"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077756823","display_name":"Antonio De Maio","orcid":"https://orcid.org/0000-0002-1520-6381","observed_orcids":["https://orcid.org/0000-0002-1520-6381"]},"institutions":[{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Antonio De Maio","raw_affiliation_strings":["Department of Surgery and Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, USA","E-mail:"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Neurosciences, University of California, San Diego, School of Medicine, La Jolla, CA, USA","institution_ids":["https://openalex.org/I36258959"]},{"raw_affiliation_string":"E-mail:","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5034755455"],"corresponding_institution_ids":["https://openalex.org/I148314036"],"apc_list":null,"apc_paid":null,"fwci":1.2081,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.77668057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"63","issue":"3","first_page":"927","last_page":"934"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9545999765396118,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10934","display_name":"Heat shock proteins research","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7557674646377563},{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.606736958026886},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5720131397247314},{"id":"https://openalex.org/C2781300812","wikidata":"https://www.wikidata.org/wiki/Q178061","display_name":"Shock (circulatory)","level":2,"score":0.5582305788993835},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.472948282957077},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.4164665937423706},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40128791332244873},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.34731635451316833},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31478095054626465},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.30091792345046997},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.19790154695510864},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19247528910636902},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006360","descriptor_name":"Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D008569","descriptor_name":"Memory Disorders","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016229","descriptor_name":"Amyloid beta-Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017668","descriptor_name":"Age of Onset","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045604","descriptor_name":"Extracellular Fluid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3233/jad-180161","doi":"https://doi.org/10.3233/jad-180161","is_oa":false,"landing_page_url":"https://doi.org/10.3233/jad-180161","pdf_url":null,"source":{"id":"https://openalex.org/S25155249","display_name":"Journal of Alzheimer s Disease","issn_l":"1387-2877","issn":["1387-2877","1875-8908"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310318577","host_organization_name":"IOS Press","host_organization_lineage":["https://openalex.org/P4310318577"],"host_organization_lineage_names":["IOS Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's Disease","raw_type":"journal-article"},{"id":"pmid:29689729","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29689729","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Alzheimer's disease : JAD","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.979200005531311,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":86,"referenced_works":["https://openalex.org/W160183570","https://openalex.org/W380069984","https://openalex.org/W1149434589","https://openalex.org/W1516940938","https://openalex.org/W1587711235","https://openalex.org/W1771394546","https://openalex.org/W1813970224","https://openalex.org/W1866826175","https://openalex.org/W1896340197","https://openalex.org/W1899777911","https://openalex.org/W1965837501","https://openalex.org/W1966923623","https://openalex.org/W1968900405","https://openalex.org/W1968906927","https://openalex.org/W1976619017","https://openalex.org/W1984118541","https://openalex.org/W1985299119","https://openalex.org/W1986321004","https://openalex.org/W1988687954","https://openalex.org/W1989142174","https://openalex.org/W1990034546","https://openalex.org/W1991629545","https://openalex.org/W1997822484","https://openalex.org/W2001646866","https://openalex.org/W2006534012","https://openalex.org/W2010986687","https://openalex.org/W2015535625","https://openalex.org/W2017117197","https://openalex.org/W2021180495","https://openalex.org/W2025070688","https://openalex.org/W2029181535","https://openalex.org/W2030514070","https://openalex.org/W2035677139","https://openalex.org/W2041464039","https://openalex.org/W2042677460","https://openalex.org/W2048350253","https://openalex.org/W2049438990","https://openalex.org/W2049980156","https://openalex.org/W2060914703","https://openalex.org/W2067414008","https://openalex.org/W2073686561","https://openalex.org/W2073810813","https://openalex.org/W2074619433","https://openalex.org/W2075930760","https://openalex.org/W2077362716","https://openalex.org/W2077662803","https://openalex.org/W2078010704","https://openalex.org/W2078408808","https://openalex.org/W2080225612","https://openalex.org/W2081263409","https://openalex.org/W2081673421","https://openalex.org/W2084969119","https://openalex.org/W2085287800","https://openalex.org/W2087689873","https://openalex.org/W2087973596","https://openalex.org/W2091514612","https://openalex.org/W2093763202","https://openalex.org/W2097680048","https://openalex.org/W2100378348","https://openalex.org/W2103440561","https://openalex.org/W2105949921","https://openalex.org/W2110165876","https://openalex.org/W2114262875","https://openalex.org/W2134909516","https://openalex.org/W2135957529","https://openalex.org/W2137417707","https://openalex.org/W2139051378","https://openalex.org/W2148026632","https://openalex.org/W2148999943","https://openalex.org/W2150351373","https://openalex.org/W2158717151","https://openalex.org/W2159975571","https://openalex.org/W2167653735","https://openalex.org/W2169048699","https://openalex.org/W2169245015","https://openalex.org/W2292195417","https://openalex.org/W2294197314","https://openalex.org/W2518303202","https://openalex.org/W2524204318","https://openalex.org/W2593036876","https://openalex.org/W2594497091","https://openalex.org/W2617072792","https://openalex.org/W2750745925","https://openalex.org/W2758511500","https://openalex.org/W2772907481","https://openalex.org/W2774947569"],"related_works":["https://openalex.org/W2583290641","https://openalex.org/W2758511500","https://openalex.org/W2056373089","https://openalex.org/W2018806493","https://openalex.org/W2620833995","https://openalex.org/W2115779453","https://openalex.org/W1899777911","https://openalex.org/W2119221350","https://openalex.org/W2049438990","https://openalex.org/W7140125208"],"abstract_inverted_index":{"Alzheimer's":[0],"disease":[1],"(AD)":[2],"is":[3,47],"a":[4,31,34,155],"major":[5],"contemporary":[6],"and":[7,44,61,82,106,114,118,130,189,198,218,245],"escalating":[8],"malady":[9],"in":[10,27,41,99,120,154,160,213,221],"which":[11],"amyloid-\u03b2":[12],"(A\u03b2)":[13],"peptides":[14,22,73],"are":[15,65,74,97],"the":[16,52,66,79,91,100,110,121,125,139,144,163,167,179,183,190,196,214,222,229,232,240,246],"most":[17],"likely":[18],"causative":[19],"agent.":[20],"A\u03b2":[21,67,72,115,150,186,219,235],"spontaneously":[23],"tend":[24],"to":[25,56],"aggregate":[26],"extracellular":[28,80,101,122],"fluids":[29,225],"following":[30],"progression":[32],"from":[33,85],"monomeric":[35],"state,":[36],"through":[37],"intermediate":[38,68],"forms,":[39],"ending":[40],"amyloid":[42],"fibers":[43],"plaques.":[45],"It":[46],"generally":[48],"accepted":[49],"now":[50],"that":[51,112,138,171,211],"neurotoxic":[53],"agents":[54],"leading":[55],"cellular":[57,158],"death,":[58],"memory":[59],"loss,":[60],"other":[62],"AD":[63],"characteristics":[64],"aggregated":[69],"states.":[70],"However,":[71],"continuously":[75],"produced,":[76],"released":[77],"into":[78],"space,":[81],"rapidly":[83],"cleared":[84],"healthy":[86,104],"brains.":[87],"Coincidentally,":[88],"members":[89],"of":[90,103,124,141,146,157,162,166,181,185,192,201,216,231,234,248],"heat":[92],"shock":[93],"proteins":[94],"(hsp)":[95],"family":[96],"present":[98],"medium":[102],"cells":[105],"body":[107],"fluids,":[108],"opening":[109],"possibility":[111],"hsps":[113],"could":[116],"meet":[117],"interact":[119],"milieu":[123],"brain.":[126],"In":[127],"this":[128],"perspective":[129],"reflection":[131],"article,":[132],"we":[133,209],"place":[134],"our":[135],"investigation":[136],"showing":[137],"presence":[140,180],"Hsp70s":[142,217],"mitigate":[143],"formation":[145,233],"low":[147],"molecular":[148],"weight":[149],"peptide":[151],"oligomers":[152],"resulting":[153],"reduction":[156],"toxicity,":[159],"context":[161],"current":[164],"understanding":[165],"disease.":[168],"We":[169],"propose":[170,210],"it":[172],"may":[173],"be":[174],"an":[175],"inverse":[176],"relationship":[177],"between":[178],"Hsp70,":[182],"stage":[184],"oligomers,":[187],"neurotoxicity,":[188],"incidence":[191,247],"AD,":[193],"particularly":[194],"since":[195],"expression":[197],"circulating":[199,223],"levels":[200],"hsp":[202],"decrease":[203],"with":[204],"aging.":[205],"Combining":[206],"these":[207],"observations,":[208],"changes":[212],"dynamics":[215],"concentrations":[220],"brain":[224],"during":[226],"aging":[227],"defines":[228],"control":[230],"toxic":[236],"aggregates,":[237],"thus":[238],"determining":[239],"conditions":[241],"for":[242],"neuron":[243],"degeneration":[244],"AD.":[249]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2018-05-17T00:00:00"}