{"id":"https://openalex.org/W2801463556","doi":"https://doi.org/10.48550/arxiv.1805.02760","title":"Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer invasion via extracellular signal-regulated kinase 2","display_name":"Rigidity controls human desmoplastic matrix anisotropy to enable pancreatic cancer invasion via extracellular signal-regulated kinase 2","publication_year":2018,"publication_date":"2018-05-07","ids":{"openalex":"https://openalex.org/W2801463556","doi":"https://doi.org/10.48550/arxiv.1805.02760","mag":"2801463556"},"language":"en","primary_location":{"id":"pmh:oai:arXiv.org:1805.02760","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1805.02760","pdf_url":"https://arxiv.org/pdf/1805.02760","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"preprint","indexed_in":["arxiv","datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/1805.02760","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Malik, Ruchi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]},{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malik, Ruchi","raw_affiliation_strings":["Cancer Biology Program at Fox Chase Cancer Center","Department of Bioengineering at Temple University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Program at Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]},{"raw_affiliation_string":"Department of Bioengineering at Temple University","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112661881","display_name":"Tiffany Luong","orcid":"https://orcid.org/0000-0001-9702-7362","observed_orcids":["https://orcid.org/0000-0001-9702-7362"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luong, Tiffany","raw_affiliation_strings":["Cancer Biology Program at Fox Chase Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Program at Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003198921","display_name":"Xuan Cao","orcid":"https://orcid.org/0000-0001-9713-4192","observed_orcids":["https://orcid.org/0000-0001-9713-4192","https://orcid.org/0009-0005-4628-8788"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cao, Xuan","raw_affiliation_strings":["Materials Science and Engineering at the University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials Science and Engineering at the University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100657203","display_name":"Biao Han","orcid":"https://orcid.org/0000-0002-7474-4454","observed_orcids":["https://orcid.org/0000-0002-7474-4454"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han, Biao","raw_affiliation_strings":["School of Biomedical Engineering at Drexel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering at Drexel University","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shah, Neelima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shah, Neelima","raw_affiliation_strings":["Cancer Biology Program at Fox Chase Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Program at Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074728058","display_name":"Lin Han","orcid":"https://orcid.org/0000-0003-4180-1288","observed_orcids":["https://orcid.org/0000-0003-4180-1288"]},"institutions":[{"id":"https://openalex.org/I72816309","display_name":"Drexel University","ror":"https://ror.org/04bdffz58","country_code":"US","type":"education","lineage":["https://openalex.org/I72816309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Han, Lin","raw_affiliation_strings":["School of Biomedical Engineering at Drexel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering at Drexel University","institution_ids":["https://openalex.org/I72816309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011906405","display_name":"Vivek B. Shenoy","orcid":"https://orcid.org/0000-0002-2645-1016","observed_orcids":["https://orcid.org/0000-0002-2645-1016"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shenoy, Vivek B.","raw_affiliation_strings":["Materials Science and Engineering at the University of Pennsylvania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Materials Science and Engineering at the University of Pennsylvania","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040485847","display_name":"Peter I. Lelkes","orcid":"https://orcid.org/0000-0003-4954-3498","observed_orcids":["https://orcid.org/0000-0003-4954-3498"]},"institutions":[{"id":"https://openalex.org/I84392919","display_name":"Temple University","ror":"https://ror.org/00kx1jb78","country_code":"US","type":"education","lineage":["https://openalex.org/I84392919"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lelkes, Peter I.","raw_affiliation_strings":["Department of Bioengineering at Temple University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering at Temple University","institution_ids":["https://openalex.org/I84392919"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038454044","display_name":"Edna Cukierman","orcid":"https://orcid.org/0000-0002-1452-9576","observed_orcids":["https://orcid.org/0000-0002-1452-9576"]},"institutions":[{"id":"https://openalex.org/I1289437631","display_name":"Fox Chase Cancer Center","ror":"https://ror.org/0567t7073","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1289437631","https://openalex.org/I4210122924"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cukierman, Edna","raw_affiliation_strings":["Cancer Biology Program at Fox Chase Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Biology Program at Fox Chase Cancer Center","institution_ids":["https://openalex.org/I1289437631"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.03200000151991844,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pancreatic-ductal-adenocarcinoma","display_name":"pancreatic ductal adenocarcinoma","score":0.9959999918937683},{"id":"https://openalex.org/keywords/desmoplasia","display_name":"desmoplasia","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cancer-associated-fibroblasts","display_name":"cancer-associated fibroblasts","score":0.8650000095367432},{"id":"https://openalex.org/keywords/substrate-stiffness","display_name":"substrate stiffness","score":0.8519999980926514},{"id":"https://openalex.org/keywords/erk2","display_name":"ERK2","score":0.7279999852180481},{"id":"https://openalex.org/keywords/tumor-invasion","display_name":"tumor invasion","score":0.7900000214576721},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9319999814033508},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.5509999990463257},{"id":"https://openalex.org/keywords/extracellular-matrix-architecture","display_name":"extracellular matrix architecture","score":0.6470000147819519}],"concepts":[{"id":"https://openalex.org/C2781005279","wikidata":"https://www.wikidata.org/wiki/Q5264825","display_name":"Desmoplasia","level":4,"score":0.9948233366012573},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7829607725143433},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6563922166824341},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.6370779871940613},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.6324843168258667},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5438551902770996},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.5225426554679871},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5027055740356445},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49240386486053467},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.48084911704063416},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4626382887363434},{"id":"https://openalex.org/C2776340970","wikidata":"https://www.wikidata.org/wiki/Q32838","display_name":"Mesenchyme","level":3,"score":0.4550609588623047},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.44468605518341064},{"id":"https://openalex.org/C64837602","wikidata":"https://www.wikidata.org/wiki/Q2565770","display_name":"Van Gieson's stain","level":4,"score":0.41152051091194153},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38224008679389954},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32602328062057495},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2917306423187256},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2025594711303711},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.15286386013031006},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.11385241150856018},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.11002367734909058},{"id":"https://openalex.org/C125473707","wikidata":"https://www.wikidata.org/wiki/Q9914","display_name":"H&E stain","level":3,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:arXiv.org:1805.02760","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1805.02760","pdf_url":"https://arxiv.org/pdf/1805.02760","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"doi:10.48550/arxiv.1805.02760","doi":"https://doi.org/10.48550/arxiv.1805.02760","is_oa":true,"landing_page_url":"https://doi.org/10.48550/arxiv.1805.02760","pdf_url":null,"source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:1805.02760","doi":null,"is_oa":true,"landing_page_url":"http://arxiv.org/abs/1805.02760","pdf_url":"https://arxiv.org/pdf/1805.02760","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":"2331-8422","issn":["2331-8422"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.800000011920929,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2134529434","https://openalex.org/W3000817431","https://openalex.org/W4254548253","https://openalex.org/W1991707690","https://openalex.org/W3093446721","https://openalex.org/W2035444100","https://openalex.org/W3191138941","https://openalex.org/W3047538947","https://openalex.org/W2958700011","https://openalex.org/W2410627897"],"abstract_inverted_index":{"Only":[0],"about":[1],"8":[2],"percent":[3],"of":[4,41,60,126],"patients":[5],"with":[6],"pancreatic":[7],"ductal":[8],"adenocarcinoma,":[9],"PDAC,":[10],"live":[11],"up":[12],"to":[13,64,70,91,131,145],"5":[14],"years":[15],"following":[16,97],"diagnosis;":[17],"by":[18,48],"2020":[19],"PDAC":[20,32,161],"will":[21],"become":[22,146],"the":[23,29,42,124],"second":[24],"most":[25,40],"lethal":[26],"cancer":[27],"in":[28],"United":[30],"States.":[31],"includes":[33],"an":[34],"anisotropic":[35],"fibrous-like":[36],"stroma,":[37],"desmoplasia,":[38],"encompassing":[39],"tumor":[43],"mass.":[44],"Desmoplasia":[45],"is":[46,62,73],"produced":[47],"cancer-associated":[49],"fibroblasts,":[50],"CAFs,":[51],"and":[52,89,114],"their":[53],"cell-derived":[54],"extracellular":[55],"matrices,":[56],"CDMs.":[57],"Since":[58],"elimination":[59],"CAFs":[61],"detrimental":[63],"patients,":[65],"CDM":[66,87],"reprogramming,":[67],"as":[68],"opposed":[69],"desmoplasia":[71,144],"ablation,":[72],"therapeutically":[74],"desirable.":[75],"In":[76],"this":[77],"study":[78,92],"we":[79],"used":[80],"a":[81,133],"human":[82,115],"mimetic":[83],"three-dimensional":[84],"CAF":[85],"producing":[86],"system":[88],"proceeded":[90],"its":[93],"dynamic":[94],"architectural":[95],"modifications,":[96],"underlying":[98],"substrate":[99],"stiffness":[100],"alterations,":[101],"using":[102],"digital":[103],"imaging":[104],"analyses,":[105],"atomic":[106],"force":[107],"microscopy,":[108],"mathematical":[109],"modeling,":[110],"cell":[111],"biology,":[112],"biochemistry":[113],"tissue":[116],"quantitative":[117],"simultaneous":[118],"multiplex":[119],"immunofluorescence.":[120],"Results":[121],"suggested":[122],"that":[123,138,141,149],"architecture":[125],"CDMs":[127],"can":[128],"be":[129],"manipulated":[130],"render":[132],"tumor-suppressive":[134],"microenvironment.":[135],"We":[136],"posit":[137],"perhaps":[139],"treatments":[140],"could":[142,150],"reprogram":[143],"tumor-restrictive":[147],"or":[148],"target":[151],"tumoral":[152],"ERK2":[153],"might":[154],"provide":[155],"future":[156],"new":[157],"means":[158],"for":[159],"treating":[160],"patients.":[162]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2018-05-17T00:00:00"}