{"id":"https://openalex.org/W2801370520","doi":null,"title":"Human milk oligosaccharide supplementation did not affect gut development in the healthy neonatal piglet","display_name":"Human milk oligosaccharide supplementation did not affect gut development in the healthy neonatal piglet","publication_year":2017,"publication_date":"2017-11-13","ids":{"openalex":"https://openalex.org/W2801370520","mag":"2801370520"},"language":"en","primary_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/99311","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/99311","pdf_url":"https://www.ideals.illinois.edu/items/105275/bitstreams/333319/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ideals.illinois.edu/items/105275/bitstreams/333319/data.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024122689","display_name":"Louisa Xue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Louisa Xue","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5024122689"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12489","display_name":"Microbial Metabolites in Food Biotechnology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-milk-oligosaccharides","display_name":"human milk oligosaccharides","score":0.9929999709129333},{"id":"https://openalex.org/keywords/2-fucosyllactose","display_name":"2'-fucosyllactose","score":0.9509999752044678},{"id":"https://openalex.org/keywords/intrauterine-growth-restriction","display_name":"fetal growth restriction","score":0.9470000267028809},{"id":"https://openalex.org/keywords/intestinal-development","display_name":"intestinal development","score":0.8690000176429749},{"id":"https://openalex.org/keywords/enteroendocrine-cells","display_name":"enteroendocrine cells","score":0.875},{"id":"https://openalex.org/keywords/chromogranin-a","display_name":"chromogranin A","score":0.9570000171661377},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.8650000095367432},{"id":"https://openalex.org/keywords/somatostatin","display_name":"somatostatin","score":0.996999979019165},{"id":"https://openalex.org/keywords/neonatal-piglets","display_name":"newborn piglets","score":0.7260000109672546},{"id":"https://openalex.org/keywords/infant-formula-supplementation","display_name":"infant formula supplementation","score":0.4950000047683716},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.5609999895095825},{"id":"https://openalex.org/keywords/birth-weight","display_name":"birth weight","score":0.414000004529953}],"concepts":[{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.5563651919364929},{"id":"https://openalex.org/C2777726330","wikidata":"https://www.wikidata.org/wiki/Q320607","display_name":"Oligosaccharide","level":2,"score":0.533645749092102},{"id":"https://openalex.org/C2909812603","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microflora","level":3,"score":0.47892364859580994},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4517270624637604},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3971220850944519},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.38054266571998596},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3793081045150757},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.14621087908744812},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13250818848609924},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0857742428779602},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.06804457306861877},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:www.ideals.illinois.edu:2142/99311","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/99311","pdf_url":"https://www.ideals.illinois.edu/items/105275/bitstreams/333319/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"mag:2801370520","doi":null,"is_oa":false,"landing_page_url":"https://www.ideals.illinois.edu/handle/2142/99311","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:www.ideals.illinois.edu:2142/99311","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/2142/99311","pdf_url":"https://www.ideals.illinois.edu/items/105275/bitstreams/333319/data.pdf","source":{"id":"https://openalex.org/S4306401358","display_name":"Illinois Digital Environment for Access to Learning and Scholarship (University of Illinois at Urbana-Champaign)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801919071","host_organization_name":"University of Illinois System","host_organization_lineage":["https://openalex.org/I2801919071"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[{"score":0.958299994468689,"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2"},{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2801370520.pdf","grobid_xml":"https://content.openalex.org/works/W2801370520.grobid-xml"},"referenced_works_count":145,"referenced_works":["https://openalex.org/W58061864","https://openalex.org/W118639794","https://openalex.org/W151105582","https://openalex.org/W173145596","https://openalex.org/W204171329","https://openalex.org/W307039706","https://openalex.org/W1487408910","https://openalex.org/W1565002994","https://openalex.org/W1566638399","https://openalex.org/W1566866500","https://openalex.org/W1590853169","https://openalex.org/W1605946587","https://openalex.org/W1619707557","https://openalex.org/W1689501805","https://openalex.org/W1832400618","https://openalex.org/W1861415832","https://openalex.org/W1963958199","https://openalex.org/W1965312967","https://openalex.org/W1966154775","https://openalex.org/W1968827093","https://openalex.org/W1973011511","https://openalex.org/W1974248149","https://openalex.org/W1975453499","https://openalex.org/W1984181078","https://openalex.org/W1984510366","https://openalex.org/W1986797986","https://openalex.org/W1989874363","https://openalex.org/W1992011957","https://openalex.org/W1995030215","https://openalex.org/W1996936531","https://openalex.org/W1997066133","https://openalex.org/W1997311974","https://openalex.org/W1999914868","https://openalex.org/W2000263179","https://openalex.org/W2002962269","https://openalex.org/W2006646681","https://openalex.org/W2007214172","https://openalex.org/W2009265841","https://openalex.org/W2011037246","https://openalex.org/W2012074781","https://openalex.org/W2014209146","https://openalex.org/W2015321769","https://openalex.org/W2018148049","https://openalex.org/W2018855737","https://openalex.org/W2022355336","https://openalex.org/W2026452111","https://openalex.org/W2026506757","https://openalex.org/W2031792984","https://openalex.org/W2033509297","https://openalex.org/W2036676738","https://openalex.org/W2037379652","https://openalex.org/W2037602019","https://openalex.org/W2038527729","https://openalex.org/W2038756754","https://openalex.org/W2042533820","https://openalex.org/W2043837995","https://openalex.org/W2044156152","https://openalex.org/W2044189638","https://openalex.org/W2044837335","https://openalex.org/W2045031987","https://openalex.org/W2046645147","https://openalex.org/W2046867503","https://openalex.org/W2046874147","https://openalex.org/W2048234569","https://openalex.org/W2052014447","https://openalex.org/W2052429320","https://openalex.org/W2053504394","https://openalex.org/W2053570362","https://openalex.org/W2053908167","https://openalex.org/W2055053121","https://openalex.org/W2055295898","https://openalex.org/W2057627745","https://openalex.org/W2061764094","https://openalex.org/W2062344498","https://openalex.org/W2064927305","https://openalex.org/W2065818402","https://openalex.org/W2066147003","https://openalex.org/W2067398413","https://openalex.org/W2068312357","https://openalex.org/W2071667853","https://openalex.org/W2072287846","https://openalex.org/W2072786998","https://openalex.org/W2073022646","https://openalex.org/W2073079080","https://openalex.org/W2073355664","https://openalex.org/W2075583206","https://openalex.org/W2076892627","https://openalex.org/W2078930606","https://openalex.org/W2087081536","https://openalex.org/W2087474693","https://openalex.org/W2088284462","https://openalex.org/W2093559962","https://openalex.org/W2096160920","https://openalex.org/W2097785193","https://openalex.org/W2099745663","https://openalex.org/W2107978987","https://openalex.org/W2108103709","https://openalex.org/W2112881025","https://openalex.org/W2113638222","https://openalex.org/W2114956655","https://openalex.org/W2115290326","https://openalex.org/W2120962670","https://openalex.org/W2125500166","https://openalex.org/W2127501908","https://openalex.org/W2131538638","https://openalex.org/W2134080725","https://openalex.org/W2135080739","https://openalex.org/W2135190897","https://openalex.org/W2138174591","https://openalex.org/W2140058116","https://openalex.org/W2140605090","https://openalex.org/W2141946547","https://openalex.org/W2150880737","https://openalex.org/W2155948158","https://openalex.org/W2156124962","https://openalex.org/W2156751159","https://openalex.org/W2157542971","https://openalex.org/W2160204304","https://openalex.org/W2163418240","https://openalex.org/W2167343594","https://openalex.org/W2169795300","https://openalex.org/W2171024463","https://openalex.org/W2183920415","https://openalex.org/W2197772497","https://openalex.org/W2253186148","https://openalex.org/W2261040783","https://openalex.org/W2271197565","https://openalex.org/W2289378992","https://openalex.org/W2291236822","https://openalex.org/W2312858085","https://openalex.org/W2327235090","https://openalex.org/W2330678748","https://openalex.org/W2416145103","https://openalex.org/W2416628213","https://openalex.org/W2418851230","https://openalex.org/W2443075657","https://openalex.org/W2462528978","https://openalex.org/W2462675128","https://openalex.org/W2512384073","https://openalex.org/W2513325891","https://openalex.org/W2518555365","https://openalex.org/W2587452139","https://openalex.org/W2796318258","https://openalex.org/W4205582135","https://openalex.org/W4390050003"],"related_works":["https://openalex.org/W4200062712","https://openalex.org/W4205119210","https://openalex.org/W7220973040","https://openalex.org/W2922097114","https://openalex.org/W3170545974","https://openalex.org/W3028349329","https://openalex.org/W3015932958","https://openalex.org/W2897232468","https://openalex.org/W2397318552","https://openalex.org/W2548626717"],"abstract_inverted_index":{"Background:":[0],"Intrauterine":[1],"growth":[2,367],"restricted":[3],"(IUGR)":[4],"is":[5,47,52,72,384,400],"a":[6,28,32,83,392,411],"category":[7],"of":[8,34,61,78,103,116,118,152,193,196,288,298,329,365,396,423],"infants":[9],"that":[10,353,386],"are":[11,26,108],"born":[12],"underweight":[13],"for":[14,31,74,131,157],"their":[15],"gestational":[16,132],"age":[17,133],"due":[18],"to":[19,54,93,165,279,319,402,420],"nutrient":[20],"deficiency":[21],"in":[22,38,57,100,120,126,220,230,243,285,295,305,338,361,363,394,426],"the":[23,45,62,65,75,79,91,101,104,114,180,185,221,231,244,289,299,306,326,330,339,345,427],"womb.":[24],"They":[25],"at":[27],"higher":[29,263,271],"risk":[30],"variety":[33],"health":[35,77,360],"issues":[36],"later":[37],"life,":[39],"which":[40],"can":[41],"be":[42,421],"exacerbated":[43],"if":[44],"infant":[46,55],"not":[48,254,277,309,387],"breast-fed.":[49],"Breast":[50],"milk":[51,67,177,187],"superior":[53],"formula":[56,122],"multiple":[58],"ways,":[59],"one":[60],"advantages":[63],"being":[64],"human":[66],"oligosaccharide":[68],"(HMO)":[69],"content.":[70],"HMO":[71],"beneficial":[73],"immune":[76],"baby":[80],"and":[81,135,138,143,161,200,208,210,215,225,238,246,341,344,349,368,380],"cultivating":[82],"healthy":[84,105],"gut":[85,95,102,124,359,397,415],"microbiota":[86],"population.":[87],"It":[88,399],"also":[89,317],"has":[90,355],"ability":[92],"modulate":[94],"function,":[96],"but":[97],"its":[98],"effects":[99,324],"IUGR":[106,127,136,268,314,342,381,389,428],"piglet":[107,121,176],"largely":[109],"unknown.":[110],"Objective:":[111],"To":[112],"investigate":[113],"effect":[115,357,413],"supplementation":[117],"HMOs":[119],"on":[123,145,205,325,358,414],"development":[125,328,416],"piglets.":[128,331],"Methods:":[129],"Appropriate":[130],"(AGA)":[134],"sex-":[137],"litter-paired":[139],"piglets":[140,153,261,269,343,362,390],"were":[141,163,203,218,241,376],"weaned":[142],"taken":[144],"postnatal":[146],"day":[147],"(PD)":[148],"1.":[149],"A":[150,303],"subset":[151],"was":[154,173,183,228,253,276,308,316],"euthanized":[155],"immediately":[156],"tissue":[158],"sample":[159],"collection":[160],"others":[162],"assigned":[164],"control":[166,171,350],"or":[167,282],"experimental":[168],"diet.":[169,257],"The":[170],"group":[172,182],"given":[174,184],"standard":[175],"replacer,":[178],"while":[179,267],"test":[181],"same":[186],"replacer":[188],"with":[189,212],"0.351g":[190],"per":[191],"kg":[192],"body":[194],"weight":[195,251,260,265,273],"2\u2019fucosyllactose":[197],"(2\u2019FL).":[198],"Gastric":[199],"intestinal":[201,223,233,327],"samples":[202],"harvested":[204],"PD1,":[206],"PD14,":[207],"PD28":[209],"analyzed":[211],"immunohistochemistry.":[213],"Villus":[214],"crypt":[216,283],"lengths":[217],"measured":[219,229],"small":[222,247,290],"sections,":[224],"mucosal":[226,293],"thickness":[227],"large":[232,300],"sections.":[234],"Chromogranin":[235,302],"A,":[236],"serotonin":[237],"somatostatin":[239],"densities":[240],"quantified":[242],"stomach":[245,307],"intestine.":[248,301],"Results:":[249],"Body":[250],"gain":[252,266],"affected":[255],"by":[256,311],"AGA":[258,340,379],"birth":[259],"had":[262,270,410],"absolute":[264],"proportional":[272],"gain.":[274],"2\u2019-FL":[275,354,406],"found":[278,318,335,377],"improve":[280],"villi":[281],"length":[284],"any":[286,296],"segment":[287],"intestine":[291],"nor":[292],"height":[294],"part":[297],"abundance":[304],"enhanced":[310],"2\u2019FL":[312],"either.":[313],"status":[315],"have":[320,391,409],"very":[321],"few":[322,336,374],"significant":[323],"Conclusion:":[332],"Overall,":[333],"we":[334],"differences":[337,375],"groups":[346],"fed":[347],"supplemented":[348],"formula,":[351],"suggesting":[352],"little":[356],"terms":[364,395],"morphological":[366],"enteroendocrine":[369],"cell":[370],"development.":[371,398],"Because":[372],"so":[373],"between":[378],"piglets,":[382],"it":[383],"concluded":[385],"all":[388],"disadvantage":[393],"difficult":[401],"definitively":[403],"conclude":[404],"whether":[405],"potentially":[407],"may":[408],"positive":[412],"because":[417],"there":[418],"seemed":[419],"lack":[422],"an":[424],"impairment":[425],"cohort.":[429]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2018-05-17T00:00:00"}
