{"id":"https://openalex.org/W2801326558","doi":"https://doi.org/10.1016/j.biopha.2018.04.150","title":"Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system","display_name":"Taurine enhances the protective effect of Dexmedetomidine on sepsis-induced acute lung injury via balancing the immunological system","publication_year":2018,"publication_date":"2018-05-07","ids":{"openalex":"https://openalex.org/W2801326558","doi":"https://doi.org/10.1016/j.biopha.2018.04.150","mag":"2801326558","pmid":"https://pubmed.ncbi.nlm.nih.gov/29864919"},"language":"en","primary_location":{"id":"doi:10.1016/j.biopha.2018.04.150","doi":"https://doi.org/10.1016/j.biopha.2018.04.150","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopha.2018.04.150","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101425691","display_name":"Wei Zhao","orcid":"https://orcid.org/0000-0001-8557-297X","observed_orcids":["https://orcid.org/0000-0001-8557-297X"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhao","raw_affiliation_strings":["Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Ling Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ling Jia","raw_affiliation_strings":["Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hui-Jing Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui-Jing Yang","raw_affiliation_strings":["Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Xiang Xue","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Xue","raw_affiliation_strings":["Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075756506","display_name":"Weixiao Xu","orcid":"https://orcid.org/0009-0005-7678-0335","observed_orcids":["https://orcid.org/0009-0005-7678-0335"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei-Xiao Xu","raw_affiliation_strings":["Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073351775","display_name":"Jianqin Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian-Qin Cai","raw_affiliation_strings":["Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui-Juan Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui-Juan Guo","raw_affiliation_strings":["Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Intensive Care Unit, Sir Run Run Hospital, Nanjing Medical Univercity, 211100, PR China","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018144456","display_name":"Changchun Cao","orcid":"https://orcid.org/0000-0003-1992-4257","observed_orcids":["https://orcid.org/0000-0003-1992-4257","https://orcid.org/0000-0003-2146-1423"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chang-Chun Cao","raw_affiliation_strings":["Sir Run Run Hospital, Nanjing Medical Univercity, No. 109 Longmian Road, Jiangning Disctrict, Nanjing, Jiangsu, 211100, PR China. Electronic address: cyjgudkvfxz88@163.com","Sir Run Run Hospital, Nanjing Medical Univercity, No. 109 Longmian Road, Jiangning Disctrict, Nanjing, Jiangsu, 211100, PR China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sir Run Run Hospital, Nanjing Medical Univercity, No. 109 Longmian Road, Jiangning Disctrict, Nanjing, Jiangsu, 211100, PR China. Electronic address: cyjgudkvfxz88@163.com","institution_ids":["https://openalex.org/I83519826"]},{"raw_affiliation_string":"Sir Run Run Hospital, Nanjing Medical Univercity, No. 109 Longmian Road, Jiangning Disctrict, Nanjing, Jiangsu, 211100, PR China","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5018144456"],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":{"value":3610,"currency":"USD","value_usd":3610},"apc_paid":null,"fwci":3.2528,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.92380594,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"103","issue":null,"first_page":"1362","last_page":"1368"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.8779000043869019,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12533","display_name":"Aldose Reductase and Taurine","score":0.06669999659061432,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10322","display_name":"Respiratory Support and Mechanisms","score":0.013899999670684338,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.9679999947547913},{"id":"https://openalex.org/keywords/dexmedetomidine","display_name":"dexmedetomidine","score":1.0},{"id":"https://openalex.org/keywords/sepsis","display_name":"sepsis","score":0.843999981880188},{"id":"https://openalex.org/keywords/acute-lung-injury","display_name":"acute lung injury","score":0.9750000238418579},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.7620000243186951},{"id":"https://openalex.org/keywords/caspase-3","display_name":"caspase-3","score":0.9819999933242798},{"id":"https://openalex.org/keywords/nf-kappab-signaling","display_name":"NF-\u03baB signaling","score":0.8489999771118164},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7110000252723694},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/th1-th2-balance","display_name":"Th1/Th2 balance","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cecal-ligation-and-puncture","display_name":"cecal ligation and puncture","score":0.8939999938011169},{"id":"https://openalex.org/keywords/alpha-2-adrenergic-agonists","display_name":"alpha-2 adrenergic agonists","score":0.796999990940094}],"concepts":[{"id":"https://openalex.org/C2779701627","wikidata":"https://www.wikidata.org/wiki/Q207051","display_name":"Taurine","level":3,"score":0.9728292226791382},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6572718620300293},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6229706406593323},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.6146763563156128},{"id":"https://openalex.org/C2781302539","wikidata":"https://www.wikidata.org/wiki/Q412133","display_name":"Dexmedetomidine","level":3,"score":0.6140000820159912},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.5020327568054199},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.28981509804725647},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2606457471847534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1493985950946808},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.10513225197792053},{"id":"https://openalex.org/C2776814716","wikidata":"https://www.wikidata.org/wiki/Q574801","display_name":"Sedation","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007107","descriptor_name":"Immune System","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D013654","descriptor_name":"Taurine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D018805","descriptor_name":"Sepsis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020011","descriptor_name":"Protective Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D020927","descriptor_name":"Dexmedetomidine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D055371","descriptor_name":"Acute Lung Injury","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.biopha.2018.04.150","doi":"https://doi.org/10.1016/j.biopha.2018.04.150","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.biopha.2018.04.150","pdf_url":null,"source":{"id":"https://openalex.org/S15111687","display_name":"Biomedicine & Pharmacotherapy","issn_l":"0753-3322","issn":["0753-3322","1950-6007"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","jufo-2","ki-jl-1","medline","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine &amp; Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:29864919","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29864919","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W631161528","https://openalex.org/W948999458","https://openalex.org/W1984552110","https://openalex.org/W2000302315","https://openalex.org/W2004881117","https://openalex.org/W2018306907","https://openalex.org/W2024759299","https://openalex.org/W2058995071","https://openalex.org/W2064926596","https://openalex.org/W2078142671","https://openalex.org/W2079401547","https://openalex.org/W2085206681","https://openalex.org/W2091130912","https://openalex.org/W2093852073","https://openalex.org/W2101321993","https://openalex.org/W2168877546","https://openalex.org/W2170350089","https://openalex.org/W2191753595","https://openalex.org/W2203823838","https://openalex.org/W2226827265","https://openalex.org/W2233682693","https://openalex.org/W2395548989","https://openalex.org/W2411449023","https://openalex.org/W2540365220","https://openalex.org/W2560120525","https://openalex.org/W2582911000","https://openalex.org/W2587977811","https://openalex.org/W2590281460","https://openalex.org/W2614716166","https://openalex.org/W2724782993","https://openalex.org/W2747635880","https://openalex.org/W2750127285","https://openalex.org/W2753785995","https://openalex.org/W2761173982","https://openalex.org/W2762670382","https://openalex.org/W2765765288","https://openalex.org/W3010430303","https://openalex.org/W4294658238","https://openalex.org/W6620305890","https://openalex.org/W6670481145"],"related_works":["https://openalex.org/W2999902161","https://openalex.org/W2344885752","https://openalex.org/W3138235639","https://openalex.org/W3156290452","https://openalex.org/W7213668847","https://openalex.org/W4293195613","https://openalex.org/W4412049300","https://openalex.org/W6925009874","https://openalex.org/W2985750276","https://openalex.org/W2973150927"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}
