{"id":"https://openalex.org/W2801312657","doi":"https://doi.org/10.1016/j.jacbts.2017.12.007","title":"Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model","display_name":"Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2801312657","doi":"https://doi.org/10.1016/j.jacbts.2017.12.007","mag":"2801312657","pmid":"https://pubmed.ncbi.nlm.nih.gov/30062212","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6059907"},"language":"en","primary_location":{"id":"doi:10.1016/j.jacbts.2017.12.007","doi":"https://doi.org/10.1016/j.jacbts.2017.12.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2017.12.007","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S2452302X1830010X-fx1_lrg.jpg","source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://ars.els-cdn.com/content/image/1-s2.0-S2452302X1830010X-fx1_lrg.jpg","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082819497","display_name":"Rachel Truitt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Truitt","raw_affiliation_strings":["Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania","Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Bioengineering, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002220315","display_name":"Anbin Mu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anbin Mu","raw_affiliation_strings":["Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066493672","display_name":"Elise A. Corbin","orcid":"https://orcid.org/0000-0003-2373-0420","observed_orcids":["https://orcid.org/0000-0003-2373-0420"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elise A. Corbin","raw_affiliation_strings":["Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","Department of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania","Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Department of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Department of Mechanical Engineering and Applied Mechanics, School of Engineering and Applied Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027680564","display_name":"Alexia Vite","orcid":"https://orcid.org/0000-0002-6589-8996","observed_orcids":["https://orcid.org/0000-0002-6589-8996"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alexia Vite","raw_affiliation_strings":["Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000966153","display_name":"Jeffrey Brandimarto","orcid":"https://orcid.org/0000-0002-9348-2349","observed_orcids":["https://orcid.org/0000-0002-9348-2349"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey Brandimarto","raw_affiliation_strings":["Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084265906","display_name":"Bonnie Ky","orcid":"https://orcid.org/0000-0002-6628-9981","observed_orcids":["https://orcid.org/0000-0002-6628-9981"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bonnie Ky","raw_affiliation_strings":["Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003776673","display_name":"Kenneth B. Margulies","orcid":"https://orcid.org/0000-0002-8093-4465","observed_orcids":["https://orcid.org/0000-0002-8093-4465","https://orcid.org/0000-0003-3588-9324"]},"institutions":[{"id":"https://openalex.org/I79576946","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10","country_code":"US","type":"education","lineage":["https://openalex.org/I79576946"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth B. Margulies","raw_affiliation_strings":["Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania","institution_ids":["https://openalex.org/I79576946"]},{"raw_affiliation_string":"Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA","institution_ids":["https://openalex.org/I79576946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003776673"],"corresponding_institution_ids":["https://openalex.org/I79576946"],"apc_list":{"value":4750,"currency":"USD","value_usd":4750},"apc_paid":{"value":4750,"currency":"USD","value_usd":4750},"fwci":5.318,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.96706963,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"3","issue":"2","first_page":"265","last_page":"276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12082","display_name":"Takotsubo Cardiomyopathy and Associated Phenomena","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sunitinib","display_name":"sunitinib","score":0.996999979019165},{"id":"https://openalex.org/keywords/cardiotoxicity","display_name":"cardiotoxicity","score":0.9860000014305115},{"id":"https://openalex.org/keywords/afterload","display_name":"afterload","score":0.9509999752044678},{"id":"https://openalex.org/keywords/left-ventricular-dysfunction","display_name":"left ventricular dysfunction","score":0.8289999961853027},{"id":"https://openalex.org/keywords/cardiomyocyte-death","display_name":"cardiomyocyte death","score":0.859000027179718},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.8140000104904175},{"id":"https://openalex.org/keywords/hypertension","display_name":"hypertension","score":0.8320000171661377},{"id":"https://openalex.org/keywords/antihypertensive-therapy","display_name":"antihypertensive therapy","score":0.9660000205039978},{"id":"https://openalex.org/keywords/drug-induced-cardiomyopathy","display_name":"drug-induced cardiomyopathy","score":0.5170000195503235}],"concepts":[{"id":"https://openalex.org/C2779490328","wikidata":"https://www.wikidata.org/wiki/Q417542","display_name":"Sunitinib","level":3,"score":0.9657347202301025},{"id":"https://openalex.org/C2778233292","wikidata":"https://www.wikidata.org/wiki/Q2118956","display_name":"Cardiotoxicity","level":3,"score":0.9400033354759216},{"id":"https://openalex.org/C123576724","wikidata":"https://www.wikidata.org/wiki/Q1299082","display_name":"Afterload","level":3,"score":0.8291372656822205},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8089309930801392},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5778999328613281},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4520920217037201},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4505905210971832},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44692984223365784},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2598843574523926},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.18962568044662476},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.17902427911758423}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jacbts.2017.12.007","doi":"https://doi.org/10.1016/j.jacbts.2017.12.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2017.12.007","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S2452302X1830010X-fx1_lrg.jpg","source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5016086","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6059907","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6059907","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6059907","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC Basic Transl Sci","raw_type":"Text"},{"id":"pmid:30062212","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30062212","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC. Basic to translational science","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:8a7b6c28cc9d40ae987798036a3109ae","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/8a7b6c28cc9d40ae987798036a3109ae","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"JACC: Basic to Translational Science, Vol 3, Iss 2, Pp 265-276 (2018)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.jacbts.2017.12.007","doi":"https://doi.org/10.1016/j.jacbts.2017.12.007","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jacbts.2017.12.007","pdf_url":"https://ars.els-cdn.com/content/image/1-s2.0-S2452302X1830010X-fx1_lrg.jpg","source":{"id":"https://openalex.org/S2898156683","display_name":"JACC Basic to Translational Science","issn_l":"2452-302X","issn":["2452-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","norway-1","oarl","poland-100"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JACC: Basic to Translational Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.98580002784729,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3340927746","display_name":null,"funder_award_id":"UL1-TR-000003","funder_id":"https://openalex.org/F4320309370","funder_display_name":"University of Pennsylvania"},{"id":"https://openalex.org/G4096025145","display_name":null,"funder_award_id":"UL1TR000003","funder_id":"https://openalex.org/F4320310180","funder_display_name":"Institute for Translational Medicine and Therapeutics"},{"id":"https://openalex.org/G5359544430","display_name":"Institutional Clinical and Translational Science Award","funder_award_id":"UL1RR024134","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G7683699529","display_name":"Institutional Clinical and Translational Science Award","funder_award_id":"UL1TR000003","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000909771","display_name":"Training Program in Cardiovascular Biology and Medicine","funder_award_id":"T32HL007843","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"},{"id":"https://openalex.org/F4320309370","display_name":"University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320310180","display_name":"Institute for Translational Medicine and Therapeutics","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332608","display_name":"Perelman School of Medicine, University of Pennsylvania","ror":"https://ror.org/00b30xv10"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"},{"id":"https://openalex.org/F4320337472","display_name":"National Center for Advancing Translational Sciences","ror":"https://ror.org/04pw6fb54"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2801312657.pdf","grobid_xml":"https://content.openalex.org/works/W2801312657.grobid-xml"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W355051652","https://openalex.org/W1013005383","https://openalex.org/W1557061959","https://openalex.org/W1581728180","https://openalex.org/W1887119011","https://openalex.org/W1963699880","https://openalex.org/W1969206151","https://openalex.org/W1970104310","https://openalex.org/W1998028009","https://openalex.org/W2008304021","https://openalex.org/W2010020475","https://openalex.org/W2012109119","https://openalex.org/W2014582878","https://openalex.org/W2015138192","https://openalex.org/W2018346270","https://openalex.org/W2018822308","https://openalex.org/W2021908772","https://openalex.org/W2021988356","https://openalex.org/W2024946751","https://openalex.org/W2039155298","https://openalex.org/W2056763771","https://openalex.org/W2070163108","https://openalex.org/W2070202276","https://openalex.org/W2085320707","https://openalex.org/W2087892120","https://openalex.org/W2091347388","https://openalex.org/W2099359513","https://openalex.org/W2120240698","https://openalex.org/W2120608237","https://openalex.org/W2132925893","https://openalex.org/W2139118223","https://openalex.org/W2139511378","https://openalex.org/W2148200348","https://openalex.org/W2149456801","https://openalex.org/W2150352336","https://openalex.org/W2159583680","https://openalex.org/W2159594706","https://openalex.org/W2161771297","https://openalex.org/W2169199162","https://openalex.org/W2170484522","https://openalex.org/W2197670103","https://openalex.org/W2471819243","https://openalex.org/W2497244415","https://openalex.org/W2508734629","https://openalex.org/W2560560709","https://openalex.org/W2563828279","https://openalex.org/W2569255280","https://openalex.org/W2800400752"],"related_works":["https://openalex.org/W2760741995","https://openalex.org/W7064633259","https://openalex.org/W2981088512","https://openalex.org/W3173477468","https://openalex.org/W2168398024","https://openalex.org/W1032907201","https://openalex.org/W3130929411","https://openalex.org/W2099359513","https://openalex.org/W2005735413","https://openalex.org/W2154937515"],"abstract_inverted_index":{"Sunitinib,":[0],"a":[1,47,91],"multitargeted":[2],"oral":[3],"tyrosine":[4],"kinase":[5],"inhibitor,":[6],"used":[7],"widely":[8],"to":[9,18,26,93],"treat":[10],"solid":[11],"tumors,":[12],"results":[13],"in":[14,16,24,61,73,78,98],"hypertension":[15],"up":[17,25],"47%":[19],"and":[20,64,81],"left":[21,95],"ventricular":[22,96],"dysfunction":[23,39,97],"19%":[27],"of":[28,34,50],"treated":[29,100],"individuals.":[30],"The":[31],"relative":[32],"contribution":[33],"afterload":[35,74],"toward":[36],"inducing":[37],"cardiac":[38],"with":[40,101],"sunitinib":[41,51,76],"treatment":[42],"remains":[43],"unknown.":[44],"We":[45],"created":[46],"preclinical":[48],"model":[49],"cardiotoxicity":[52,77],"using":[53],"engineered":[54],"microtissues":[55],"that":[56,86],"exhibited":[57],"cardiomyocyte":[58],"death,":[59],"decreases":[60],"force":[62],"generation,":[63],"spontaneous":[65],"beating":[66],"at":[67],"clinically":[68],"relevant":[69],"doses.":[70],"Simulated":[71],"increases":[72],"augmented":[75],"both":[79],"rat":[80],"human":[82],"microtissues,":[83],"which":[84],"suggest":[85],"antihypertensive":[87],"therapy":[88],"may":[89],"be":[90],"strategy":[92],"prevent":[94],"patients":[99],"sunitinib.":[102]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}
