{"id":"https://openalex.org/W2801201490","doi":"https://doi.org/10.1073/pnas.1807613115","title":"Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen","display_name":"Amycomicin is a potent and specific antibiotic discovered with a targeted interaction screen","publication_year":2018,"publication_date":"2018-09-18","ids":{"openalex":"https://openalex.org/W2801201490","doi":"https://doi.org/10.1073/pnas.1807613115","mag":"2801201490","pmid":"https://pubmed.ncbi.nlm.nih.gov/30228116","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6176635"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1807613115","doi":"https://doi.org/10.1073/pnas.1807613115","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1807613115","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2018/05/08/317362.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045050491","display_name":"Gleb Pishchany","orcid":"https://orcid.org/0000-0001-9303-010X","observed_orcids":["https://orcid.org/0000-0001-9303-010X"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gleb Pishchany","raw_affiliation_strings":["Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031625191","display_name":"Emily E. Mevers","orcid":"https://orcid.org/0000-0001-7986-5610","observed_orcids":["https://orcid.org/0000-0001-7986-5610"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emily Mevers","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073130932","display_name":"Sula Ndousse-Fetter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sula Ndousse-Fetter","raw_affiliation_strings":["Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043416343","display_name":"Dennis J. Horvath","orcid":"https://orcid.org/0000-0001-9310-536X","observed_orcids":["https://orcid.org/0000-0001-9310-536X"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dennis J. Horvath","raw_affiliation_strings":["Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047867597","display_name":"Camila Raquel Paludo","orcid":"https://orcid.org/0000-0002-5816-3334","observed_orcids":["https://orcid.org/0000-0002-5816-3334"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Camila R. Paludo","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;","Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo 14040-903, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo 14040-903, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036665144","display_name":"Eduardo Afonso da Silva-Junior","orcid":"https://orcid.org/0000-0003-2682-0747","observed_orcids":["https://orcid.org/0000-0003-2682-0747"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I17974374","display_name":"Universidade de S\u00e3o Paulo","ror":"https://ror.org/036rp1748","country_code":"BR","type":"education","lineage":["https://openalex.org/I17974374"]}],"countries":["BR","US"],"is_corresponding":false,"raw_author_name":"Eduardo A. Silva-Junior","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;","School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo 14040-903, Brazil;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences of Ribeir\u00e3o Preto, University of S\u00e3o Paulo, Ribeir\u00e3o Preto, S\u00e3o Paulo 14040-903, Brazil;","institution_ids":["https://openalex.org/I17974374"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042603880","display_name":"Sergey Koren","orcid":"https://orcid.org/0000-0002-1472-8962","observed_orcids":["https://orcid.org/0000-0002-1472-8962"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210090236","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sergey Koren","raw_affiliation_strings":["Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genome Informatics Section, Computational and Statistical Genomics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210090236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082616273","display_name":"Eric Patrick Skaar","orcid":"https://orcid.org/0000-0001-5094-8105","observed_orcids":["https://orcid.org/0000-0001-5094-8105","https://orcid.org/0000-0002-6533-2458"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric P. Skaar","raw_affiliation_strings":["Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN 37232;","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008067693","display_name":"Jon Clardy","orcid":"https://orcid.org/0000-0003-0213-8356","observed_orcids":["https://orcid.org/0000-0003-0213-8356"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jon Clardy","raw_affiliation_strings":["Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;"],"raw_orcid":"https://orcid.org/0000-0003-0213-8356","affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076614279","display_name":"Roberto Kolter","orcid":"https://orcid.org/0000-0001-9548-1481","observed_orcids":["https://orcid.org/0000-0001-9548-1481"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roberto Kolter","raw_affiliation_strings":["Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115;","institution_ids":["https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":7.1935,"has_fulltext":true,"cited_by_count":105,"citation_normalized_percentile":{"value":0.98435316,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"115","issue":"40","first_page":"10124","last_page":"10129"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antibiotic-discovery","display_name":"antibiotic discovery","score":0.8849999904632568},{"id":"https://openalex.org/keywords/amycolatopsis","display_name":"Amycolatopsis","score":0.7670000195503235},{"id":"https://openalex.org/keywords/streptomyces-coelicolor","display_name":"Streptomyces coelicolor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/staphylococcus-aureus","display_name":"Staphylococcus aureus","score":0.9610000252723694},{"id":"https://openalex.org/keywords/fatty-acid-synthesis","display_name":"fatty acid synthesis","score":0.9570000171661377},{"id":"https://openalex.org/keywords/antibiotic-resistance","display_name":"antibiotic resistance","score":0.5120000243186951},{"id":"https://openalex.org/keywords/bioassay-guided-isolation","display_name":"bioassay-guided isolation","score":0.7580000162124634}],"concepts":[{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.7192297577857971},{"id":"https://openalex.org/C2778265057","wikidata":"https://www.wikidata.org/wiki/Q537299","display_name":"Axenic","level":3,"score":0.6980010867118835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6641907095909119},{"id":"https://openalex.org/C2779489039","wikidata":"https://www.wikidata.org/wiki/Q188121","display_name":"Staphylococcus aureus","level":3,"score":0.6380070447921753},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.6358751654624939},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6352244019508362},{"id":"https://openalex.org/C2779920670","wikidata":"https://www.wikidata.org/wiki/Q1144013","display_name":"Streptomyces","level":3,"score":0.6225792169570923},{"id":"https://openalex.org/C2780681812","wikidata":"https://www.wikidata.org/wiki/Q22286833","display_name":"Streptomyces coelicolor","level":4,"score":0.61937415599823},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.5373512506484985},{"id":"https://openalex.org/C2775941552","wikidata":"https://www.wikidata.org/wiki/Q25212305","display_name":"Isolation (microbiology)","level":2,"score":0.4230264127254486},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3202117383480072},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20230910181999207}],"mesh":[{"descriptor_ui":"D000880","descriptor_name":"Anthraquinones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000880","descriptor_name":"Anthraquinones","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048372","descriptor_name":"Streptomyces coelicolor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048372","descriptor_name":"Streptomyces coelicolor","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.1807613115","doi":"https://doi.org/10.1073/pnas.1807613115","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1807613115","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"doi:10.1101/317362","doi":"https://doi.org/10.1101/317362","is_oa":true,"landing_page_url":"https://doi.org/10.1101/317362","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/05/08/317362.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:europepmc.org:5424516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6176635","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6176635","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6176635","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:30228116","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/30228116","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:osti.gov:1610217","doi":null,"is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1610217","pdf_url":"https://www.osti.gov/servlets/purl/1610217","source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.1101/317362","doi":"https://doi.org/10.1101/317362","is_oa":true,"landing_page_url":"https://doi.org/10.1101/317362","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2018/05/08/317362.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G134814782","display_name":"Molecular Genetics of Biofilm Formation","funder_award_id":"R01GM058213","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G222768804","display_name":null,"funder_award_id":"DE\u2010FG02\u2010","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G266182681","display_name":"NEW AWARD - THE CENTER FOR PLANT AND MICROBIAL COMPLEX CARBOHYDRATES AT THE UNIVERSITY OF GEORGIA COMPLEX CARBOHYDRATE RESEARCH CENTER","funder_award_id":"FG02-93ER20097","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3954360041","display_name":"Discovery of antibiotics active against multidrug resistant bacteria","funder_award_id":"R21AI117025","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4744438218","display_name":"Antimicrobial Drug Discovery from Coevolved Symbiotic Communities","funder_award_id":"U19AI109673","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5250662454","display_name":"TAS::89 0222::TAS CENTER FOR PLANT AND MICROBIAL COMPLEX CARBOHYDRATES","funder_award_id":"DEFG0293ER20097","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G5648016710","display_name":null,"funder_award_id":"DE-FG02","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G687642559","display_name":null,"funder_award_id":"DE\u2010FG02\u201093ER20097","funder_id":"https://openalex.org/F4320337480","funder_display_name":"Basic Energy Sciences"},{"id":"https://openalex.org/G8264628334","display_name":"Chemical biology of bacterial symbionts","funder_award_id":"R01AT009874","funder_id":"https://openalex.org/F4320337593","funder_display_name":"National Center for Complementary and Integrative Health"},{"id":"https://openalex.org/G9000862353","display_name":"Molecular and Cellular Basis for Digestive Diseases","funder_award_id":"P30DK058404","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G9000878488","display_name":"Pathobiology of heme inducible transporters in Gram positive pathogens","funder_award_id":"R01AI073843","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320309622","display_name":"Harvard University","ror":"https://ror.org/03vek6s52"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337348","display_name":"National Human Genome Research Institute","ror":"https://ror.org/00baak391"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"},{"id":"https://openalex.org/F4320337480","display_name":"Basic Energy Sciences","ror":"https://ror.org/05mg91w61"},{"id":"https://openalex.org/F4320337593","display_name":"National Center for Complementary and Integrative Health","ror":"https://ror.org/00190t495"},{"id":"https://openalex.org/F4320337744","display_name":"Chemical Sciences, Geosciences, and Biosciences Division","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2801201490.pdf","grobid_xml":"https://content.openalex.org/works/W2801201490.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1552239458","https://openalex.org/W1571611869","https://openalex.org/W1669810599","https://openalex.org/W1827213771","https://openalex.org/W1873980424","https://openalex.org/W1918381289","https://openalex.org/W1919257395","https://openalex.org/W1963492926","https://openalex.org/W1969271184","https://openalex.org/W1975610050","https://openalex.org/W1983403167","https://openalex.org/W1988815096","https://openalex.org/W1993562651","https://openalex.org/W2003147562","https://openalex.org/W2015513020","https://openalex.org/W2017343996","https://openalex.org/W2018035315","https://openalex.org/W2021354258","https://openalex.org/W2023192368","https://openalex.org/W2033102612","https://openalex.org/W2034829212","https://openalex.org/W2035983545","https://openalex.org/W2036917159","https://openalex.org/W2041001058","https://openalex.org/W2048422948","https://openalex.org/W2052569498","https://openalex.org/W2054104443","https://openalex.org/W2062232551","https://openalex.org/W2072970694","https://openalex.org/W2075000963","https://openalex.org/W2090746212","https://openalex.org/W2103600799","https://openalex.org/W2107282968","https://openalex.org/W2108163870","https://openalex.org/W2117363410","https://openalex.org/W2118062406","https://openalex.org/W2120419643","https://openalex.org/W2124351063","https://openalex.org/W2127113854","https://openalex.org/W2127681878","https://openalex.org/W2136879569","https://openalex.org/W2139516496","https://openalex.org/W2150052051","https://openalex.org/W2155342436","https://openalex.org/W2163553489","https://openalex.org/W2164622913","https://openalex.org/W2164667097","https://openalex.org/W2164859426","https://openalex.org/W2169942471","https://openalex.org/W2178324140","https://openalex.org/W2274801375","https://openalex.org/W2461723836","https://openalex.org/W2499377586","https://openalex.org/W2534382943","https://openalex.org/W2586340362","https://openalex.org/W2593795014","https://openalex.org/W2769727931","https://openalex.org/W2798416813","https://openalex.org/W2950354111","https://openalex.org/W2950436573","https://openalex.org/W2951800936","https://openalex.org/W2953328044","https://openalex.org/W3025546593","https://openalex.org/W4238994080"],"related_works":["https://openalex.org/W7164026839","https://openalex.org/W2972463857","https://openalex.org/W3206386909","https://openalex.org/W2076451725","https://openalex.org/W2562705751","https://openalex.org/W2025002850","https://openalex.org/W2133076852","https://openalex.org/W2987563786","https://openalex.org/W7171369848","https://openalex.org/W2604345476"],"abstract_inverted_index":{"Abstract":[0],"The":[1,152],"rapid":[2],"emergence":[3],"of":[4,69,78,128,154,159,177,185,197,219,247],"antibiotic-resistant":[5],"pathogenic":[6],"bacteria":[7,34],"has":[8],"accelerated":[9],"the":[10,32,66,79,85,97,157,175,198,217],"search":[11],"for":[12],"new":[13],"antibiotics.":[14,169,182],"Many":[15],"clinically":[16,179],"used":[17,60],"antibacterials":[18],"were":[19,237],"discovered":[20],"through":[21],"culturing":[22],"a":[23,55,112,123,147,195,255,282],"single":[24,231],"microbial":[25,44,220],"species":[26],"under":[27],"nutrient-rich":[28],"conditions,":[29],"but":[30],"in":[31,136,146,233,275,281],"environment,":[33],"constantly":[35],"encounter":[36],"poor":[37],"nutrient":[38],"conditions":[39],"and":[40,59,91,100,125,141,239,245,257,273],"interact":[41],"with":[42],"neighboring":[43],"species.":[45],"In":[46,202],"an":[47,105,118,133,203,213,264],"effort":[48,204],"to":[49,64,87,166,205,222,241],"recapitulate":[50],"this":[51],"environment":[52],"we":[53,211],"generated":[54],"nine-strain":[56],"Actinomycete":[57],"community":[58,86],"16S":[61],"rDNA":[62],"sequencing":[63],"deconvolute":[65],"stochastic":[67],"production":[68],"antimicrobial":[70],"activity":[71],"that":[72,189,215,225],"was":[73],"not":[74,227],"observed":[75],"from":[76],"any":[77,230],"axenic":[80],"cultures.":[81],"We":[82],"subsequently":[83],"simplified":[84],"just":[88],"two":[89],"strains":[90,187],"identified":[92,110],"Amycolatopsis":[93],"sp.":[94],"AA4":[95],"as":[96,104,122],"producing":[98],"strain":[99],"Streptomyces":[101],"coelicolor":[102],"M145":[103],"inducing":[106],"strain.":[107],"Bioassay-guided":[108],"isolation":[109],"amycomicin,":[111,254],"highly":[113],"modified":[114],"fatty":[115,137,270],"acid":[116,138,271],"containing":[117],"epoxide":[119],"isonitrile":[120],"warhead":[121],"potent":[124,256],"specific":[126,164,258],"inhibitor":[127],"Staphylococcus":[129,261],"aureus.":[130],"Amycomicin":[131,268],"targets":[132,165,269],"essential":[134],"enzyme":[135],"biosynthesis":[139,272],"(FabH)":[140],"reduces":[142],"S.":[143],"aureus":[144,262],"infection":[145,150],"mouse":[148,283],"skin":[149,279],"model.":[151,284],"discovery":[153,191],"amycomicin":[155],"demonstrates":[156],"utility":[158],"screening":[160],"complex":[161],"communities":[162,221,236],"against":[163,260,278],"discover":[167],"small-molecule":[168,181],"Significance":[170],"Bacteria,":[171],"especially":[172],"actinomycetes,":[173],"produce":[174,223],"majority":[176],"our":[178],"useful":[180],"Genomic":[183],"analyses":[184],"antibiotic-producing":[186],"indicate":[188],"earlier":[190],"efforts":[192],"found":[193],"only":[194],"fraction":[196],"likely":[199],"antibiotic":[200,248,259],"candidates.":[201],"uncover":[206],"these":[207],"previously":[208],"missed":[209],"candidates":[210],"developed":[212],"approach":[214],"utilizes":[216],"ability":[218],"antibiotics":[224],"are":[226],"produced":[228],"by":[229],"member":[232],"isolation.":[234],"Successful":[235],"established":[238],"deconvoluted":[240],"identify":[242],"both":[243],"producers":[244],"inducers":[246],"activity.":[249],"One":[250],"inducer-producer":[251],"pair":[252],"made":[253],",":[263],"important":[265],"human":[266],"pathogen.":[267],"exhibits":[274],"vivo":[276],"efficacy":[277],"infections":[280]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":16},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":16},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":2}],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2018-05-17T00:00:00"}
