{"id":"https://openalex.org/W2801197838","doi":"https://doi.org/10.1134/s1062359018030068","title":"Proliferation and Differentiation of Mouse Embryonic Stem Cells Modified by the Neural Growth Factor (NGF) Gene","display_name":"Proliferation and Differentiation of Mouse Embryonic Stem Cells Modified by the Neural Growth Factor (NGF) Gene","publication_year":2018,"publication_date":"2018-04-29","ids":{"openalex":"https://openalex.org/W2801197838","doi":"https://doi.org/10.1134/s1062359018030068","mag":"2801197838"},"language":"en","primary_location":{"id":"doi:10.1134/s1062359018030068","doi":"https://doi.org/10.1134/s1062359018030068","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1062359018030068","pdf_url":null,"source":{"id":"https://openalex.org/S4210230782","display_name":"Biology Bulletin","issn_l":"1062-3590","issn":["1062-3590","1608-3059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003766418","display_name":"Elena A. Khramtsova","orcid":"https://orcid.org/0000-0003-1104-8109","observed_orcids":["https://orcid.org/0000-0003-1104-8109"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210155801","display_name":"Institute of Cell Biophysics","ror":"https://ror.org/05gbnpz65","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210155801"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"E. A. Khramtsova","raw_affiliation_strings":["Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000141230","display_name":"Lyudmila M. Mezhevikina","orcid":"https://orcid.org/0000-0002-8011-853X","observed_orcids":["https://orcid.org/0000-0002-8011-853X"]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210155801","display_name":"Institute of Cell Biophysics","ror":"https://ror.org/05gbnpz65","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210155801"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"L. M. Mezhevikina","raw_affiliation_strings":["Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113914867","display_name":"Eugenii E. Fesenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1313323035","display_name":"Russian Academy of Sciences","ror":"https://ror.org/05qrfxd25","country_code":"RU","type":"government","lineage":["https://openalex.org/I1313323035"]},{"id":"https://openalex.org/I4210155801","display_name":"Institute of Cell Biophysics","ror":"https://ror.org/05gbnpz65","country_code":"RU","type":"facility","lineage":["https://openalex.org/I1313323035","https://openalex.org/I4210129690","https://openalex.org/I4210155801"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"E. E. Fesenko","raw_affiliation_strings":["Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow oblast, 142290, Russia","institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5003766418"],"corresponding_institution_ids":["https://openalex.org/I1313323035","https://openalex.org/I4210155801"],"apc_list":null,"apc_paid":null,"fwci":0.0793,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.36319115,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"45","issue":"3","first_page":"219","last_page":"225"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mouse-embryonic-stem-cells","display_name":"mouse embryonic stem cells","score":0.9190000295639038},{"id":"https://openalex.org/keywords/nerve-growth-factor","display_name":"nerve growth factor","score":0.9890000224113464},{"id":"https://openalex.org/keywords/embryoid-bodies","display_name":"embryoid bodies","score":0.6899999976158142},{"id":"https://openalex.org/keywords/neuroectodermal-differentiation","display_name":"neuroectodermal differentiation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.6230000257492065},{"id":"https://openalex.org/keywords/long-term-in-vitro-culture","display_name":"long-term in vitro culture","score":0.7609999775886536},{"id":"https://openalex.org/keywords/leukemia-inhibitory-factor","display_name":"leukemia inhibitory factor","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nestin","display_name":"nestin","score":0.8859999775886536},{"id":"https://openalex.org/keywords/vimentin","display_name":"vimentin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/gfp-reporter","display_name":"GFP reporter","score":0.5569999814033508},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"cell adhesion","score":0.6190000176429749},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.3109999895095825}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8685284852981567},{"id":"https://openalex.org/C143948831","wikidata":"https://www.wikidata.org/wiki/Q3384920","display_name":"Embryoid body","level":5,"score":0.8023133277893066},{"id":"https://openalex.org/C2778423431","wikidata":"https://www.wikidata.org/wiki/Q417782","display_name":"Nerve growth factor","level":3,"score":0.7227875590324402},{"id":"https://openalex.org/C135073763","wikidata":"https://www.wikidata.org/wiki/Q1271432","display_name":"Neuroectoderm","level":5,"score":0.6477949619293213},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.6446911692619324},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6439201235771179},{"id":"https://openalex.org/C2777738006","wikidata":"https://www.wikidata.org/wiki/Q14906812","display_name":"Nestin","level":4,"score":0.480409175157547},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.46641242504119873},{"id":"https://openalex.org/C136834591","wikidata":"https://www.wikidata.org/wiki/Q2944097","display_name":"Neural stem cell","level":3,"score":0.4264335632324219},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.4243243932723999},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.3866221010684967},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3746056854724884},{"id":"https://openalex.org/C20875687","wikidata":"https://www.wikidata.org/wiki/Q2642600","display_name":"Adult stem cell","level":4,"score":0.24661394953727722},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2398509979248047},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23529300093650818},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14654883742332458},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.12337902188301086},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.08080744743347168},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1134/s1062359018030068","doi":"https://doi.org/10.1134/s1062359018030068","is_oa":false,"landing_page_url":"https://doi.org/10.1134/s1062359018030068","pdf_url":null,"source":{"id":"https://openalex.org/S4210230782","display_name":"Biology Bulletin","issn_l":"1062-3590","issn":["1062-3590","1608-3059"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","norway-1","poland-20","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320267","host_organization_name":"Pleiades Publishing","host_organization_lineage":["https://openalex.org/P4310320267","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Pleiades Publishing","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biology Bulletin","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1966999821","https://openalex.org/W1977639054","https://openalex.org/W1984512384","https://openalex.org/W1987743529","https://openalex.org/W2008048796","https://openalex.org/W2012756951","https://openalex.org/W2019358245","https://openalex.org/W2030983339","https://openalex.org/W2065562585","https://openalex.org/W2083558557","https://openalex.org/W2090919248","https://openalex.org/W2133966135","https://openalex.org/W2163133855","https://openalex.org/W2598192697"],"related_works":["https://openalex.org/W2435918348","https://openalex.org/W2598192697","https://openalex.org/W881017127","https://openalex.org/W1994361112","https://openalex.org/W2380071532","https://openalex.org/W3164246730","https://openalex.org/W2359624124","https://openalex.org/W2364775025","https://openalex.org/W2161025153","https://openalex.org/W2363808516"],"abstract_inverted_index":{"The":[0],"effect":[1],"of":[2,13,33,58,92,108,110,127,136],"the":[3,9,56,72,90,93,101,106,125],"nerve":[4],"growth":[5],"factor":[6],"(NGF)":[7],"on":[8,95],"proliferation":[10],"and":[11,35,70,113,134],"differentiation":[12],"mouse":[14,59],"embryonic":[15],"stem":[16],"cells":[17,29,65],"(ESCs)":[18],"during":[19],"long-term":[20,119],"culturing":[21],"in":[22,53],"vitro":[23,54],"was":[24,47],"studied":[25],"using":[26],"genetically":[27],"modified":[28],"with":[30,55],"stable":[31],"expression":[32],"ngf":[34],"gfp":[36],"(green":[37],"fluorescent":[38],"protein)":[39],"genes":[40],"(clone":[41],"R":[42,62],"1":[43,63],"NGF":[44,64,129],").":[45],"It":[46,83],"shown":[48],"that,":[49,86],"under":[50],"standard":[51],"conditions":[52],"addition":[57],"cytokine":[60],"LIF,":[61],"lose":[66],"their":[67],"adhesive":[68],"properties":[69],"acquire":[71],"ability":[73],"to":[74,89,122],"form":[75],"cellular":[76],"conglomerates":[77],"or":[78],"embryoid":[79],"bodies":[80],"(EBs)":[81],"spontaneously.":[82],"is":[84],"noted":[85],"after":[87],"attachment":[88],"surface":[91],"culture":[94],"days":[96],"3\u20135,":[97],"EBs":[98],"differentiated":[99],"towards":[100],"neuroectoderm,":[102],"as":[103],"evidenced":[104],"by":[105],"appearance":[107],"markers":[109],"early":[111],"(nestin)":[112],"late":[114],"(vimentin)":[115],"neural":[116],"differentiation.":[117],"During":[118],"cultivation":[120],"up":[121],"22":[123],"days,":[124],"production":[126],"endogenous":[128],"protein":[130],"promotes":[131],"predominant":[132],"selection":[133],"survival":[135],"neuroectodermal":[137],"derivatives.":[138]},"counts_by_year":[{"year":2020,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2018-05-17T00:00:00"}
