{"id":"https://openalex.org/W2801059293","doi":"https://doi.org/10.2174/1567201815666180503120113","title":"Development of Curcumin-Loaded Solid Lipid Nanoparticles Utilizing Glyceryl Monostearate as Single Lipid Using QbD Approach: Characterization and Evaluation of Anticancer Activity Against Human Breast Cancer Cell Line","display_name":"Development of Curcumin-Loaded Solid Lipid Nanoparticles Utilizing Glyceryl Monostearate as Single Lipid Using QbD Approach: Characterization and Evaluation of Anticancer Activity Against Human Breast Cancer Cell Line","publication_year":2018,"publication_date":"2018-05-07","ids":{"openalex":"https://openalex.org/W2801059293","doi":"https://doi.org/10.2174/1567201815666180503120113","mag":"2801059293","pmid":"https://pubmed.ncbi.nlm.nih.gov/29732970"},"language":"en","primary_location":{"id":"doi:10.2174/1567201815666180503120113","doi":"https://doi.org/10.2174/1567201815666180503120113","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1567201815666180503120113","pdf_url":null,"source":{"id":"https://openalex.org/S16973894","display_name":"Current Drug Delivery","issn_l":"1567-2018","issn":["1567-2018","1875-5704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Delivery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089684202","display_name":"Himanshu Bhatt","orcid":"https://orcid.org/0009-0007-7268-6135","observed_orcids":["https://orcid.org/0009-0007-7268-6135"]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Himanshu Bhatt","raw_affiliation_strings":["Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024142001","display_name":"Sri Vishnu Kiran Rompicharla","orcid":"https://orcid.org/0000-0002-1059-0281","observed_orcids":["https://orcid.org/0000-0002-1059-0281"]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sri Vishnu Kiran Rompicharla","raw_affiliation_strings":["Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001344962","display_name":"Neeraja Komanduri","orcid":"https://orcid.org/0000-0002-0469-5693","observed_orcids":["https://orcid.org/0000-0002-0469-5693"]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neeraja Komanduri","raw_affiliation_strings":["Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062429772","display_name":"Aashma Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shah Aashma","raw_affiliation_strings":["Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065857402","display_name":"Sateja Paradkar","orcid":"https://orcid.org/0000-0002-0630-9792","observed_orcids":["https://orcid.org/0000-0002-0630-9792"]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sateja Paradkar","raw_affiliation_strings":["Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036638461","display_name":"Balaram Ghosh","orcid":"https://orcid.org/0000-0002-3425-2439","observed_orcids":["https://orcid.org/0000-0002-3425-2439"]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Balaram Ghosh","raw_affiliation_strings":["Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011840568","display_name":"Swati Biswas","orcid":"https://orcid.org/0000-0002-1575-4206","observed_orcids":["https://orcid.org/0000-0002-1575-4206"]},"institutions":[{"id":"https://openalex.org/I4210101034","display_name":"Birla Institute of Technology and Science - Hyderabad Campus","ror":"https://ror.org/014ctt859","country_code":"IN","type":"education","lineage":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]},{"id":"https://openalex.org/I74796645","display_name":"Birla Institute of Technology and Science, Pilani","ror":"https://ror.org/001p3jz28","country_code":"IN","type":"education","lineage":["https://openalex.org/I74796645"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Swati Biswas","raw_affiliation_strings":["Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Birla Institute of Technology & Science-Pilani, Hyderabad Campus, Shameerpet, Hyderabad, Telangana 500078, India","institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011840568"],"corresponding_institution_ids":["https://openalex.org/I4210101034","https://openalex.org/I74796645"],"apc_list":null,"apc_paid":null,"fwci":2.227,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.85650661,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"15","issue":"9","first_page":"1271","last_page":"1283"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":0.8105000257492065,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0617000013589859,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11319","display_name":"Curcumin's Biomedical Applications","score":0.05530000105500221,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/curcumin","display_name":"curcumin","score":0.949999988079071},{"id":"https://openalex.org/keywords/solid-lipid-nanoparticles","display_name":"solid lipid nanoparticles","score":1.0},{"id":"https://openalex.org/keywords/glycerol-monostearate","display_name":"glyceryl monostearate","score":0.9990000128746033},{"id":"https://openalex.org/keywords/poloxamer-188","display_name":"poloxamer 188","score":0.8970000147819519},{"id":"https://openalex.org/keywords/quality-by-design","display_name":"quality by design","score":0.8989999890327454},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.9959999918937683},{"id":"https://openalex.org/keywords/drug-encapsulation","display_name":"drug encapsulation","score":0.6380000114440918},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.9290000200271606},{"id":"https://openalex.org/keywords/cellular-uptake","display_name":"cellular uptake","score":0.8240000009536743},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9390000104904175},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C199529486","wikidata":"https://www.wikidata.org/wiki/Q7557912","display_name":"Solid lipid nanoparticle","level":3,"score":0.92037034034729},{"id":"https://openalex.org/C11432220","wikidata":"https://www.wikidata.org/wiki/Q1975334","display_name":"Dispersity","level":2,"score":0.690237820148468},{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.6813777685165405},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6454108953475952},{"id":"https://openalex.org/C101335993","wikidata":"https://www.wikidata.org/wiki/Q408943","display_name":"Poloxamer","level":4,"score":0.619016170501709},{"id":"https://openalex.org/C187530423","wikidata":"https://www.wikidata.org/wiki/Q7140503","display_name":"Particle size","level":2,"score":0.5916644930839539},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5575721859931946},{"id":"https://openalex.org/C155574463","wikidata":"https://www.wikidata.org/wiki/Q170731","display_name":"Solubility","level":2,"score":0.5032216906547546},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.4472106099128723},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4240199625492096},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.404513418674469},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3876813054084778},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.26640576124191284},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.15464496612548828},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1531398594379425},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.08810296654701233},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06945788860321045},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003474","descriptor_name":"Curcumin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005989","descriptor_name":"Glycerides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.2174/1567201815666180503120113","doi":"https://doi.org/10.2174/1567201815666180503120113","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1567201815666180503120113","pdf_url":null,"source":{"id":"https://openalex.org/S16973894","display_name":"Current Drug Delivery","issn_l":"1567-2018","issn":["1567-2018","1875-5704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Delivery","raw_type":"journal-article"},{"id":"pmid:29732970","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29732970","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug delivery","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2747909720","https://openalex.org/W4408394309","https://openalex.org/W4297464137","https://openalex.org/W7167081370","https://openalex.org/W2811214319","https://openalex.org/W4317739178","https://openalex.org/W2796654357","https://openalex.org/W2037602102","https://openalex.org/W4383187323","https://openalex.org/W4408941900"],"abstract_inverted_index":{"BACKGROUND:":[0],"Solid":[1],"lipid":[2,21,42,168],"nanoparticles":[3,93],"(SLNs)":[4],"represent":[5],"an":[6],"affordable,":[7],"easily":[8],"scalable,":[9],"stable":[10],"and":[11,50,90,106,157,206],"biocompatible":[12],"drug":[13,19,86,180],"delivery":[14],"system":[15],"with":[16,136,238],"a":[17,130,223,260,275],"high":[18],"to":[20,56,73,151,184,200,218,251,271],"ratio":[22],"which":[23],"also":[24],"improves":[25],"solubility":[26,173],"of":[27,46,54,77,133,140,145,174,225,235,266],"poorly":[28],"soluble":[29],"drugs.":[30],"OBJECTIVE:":[31],"SLNs":[32,55,113,148],"were":[33,94,114],"developed":[34,269],"by":[35,68,70],"using":[36,96,120],"glyceryl":[37],"monostearate":[38],"as":[39,274],"the":[40,44,52,58,75,161,167,172,175,185,233,252,267],"single":[41],"in":[43,182,194,248,279],"presence":[45],"surfactant":[47],"Poloxamer":[48],"188":[49],"evaluated":[51,115],"efficiency":[53],"load":[57],"therapeutic":[59],"cargo,":[60],"curcumin":[61],"(CUR).":[62],"METHOD:":[63],"The":[64,92,126,142,257],"nano-formulation":[65],"was":[66,149,163],"optimized":[67,127],"Quality":[69],"Design":[71],"approach":[72],"understand":[74],"effect":[76],"various":[78,82],"process":[79],"parameters":[80],"on":[81],"quality":[83],"attributes,":[84],"including":[85],"loadability,":[87],"particle":[88,131],"size":[89,132],"polydispersity.":[91],"characterized":[95],"Differential":[97],"scanning":[98],"calorimetry":[99],"(DSC),":[100],"Fourier":[101],"Transform":[102],"Infra-red":[103],"Spectroscopy":[104],"(FT-IR)":[105],"X-Ray":[107],"Diffraction":[108],"(XRD)":[109],"analysis.":[110],"These":[111],"novel":[112],"for":[116,240,263],"in-vitro":[117],"anticancer":[118],"activity":[119],"breast":[121,196],"adenocarcinoma":[122,197],"cells":[123,198,237,249],"(MDA-MB-231).":[124],"RESULTS:":[125],"formulation":[128],"had":[129],"226.802\u00b13.92":[134],"nm":[135],"low":[137],"polydispersity":[138],"index":[139],"0.244\u00b10.018.":[141],"%":[143],"encapsulation":[144],"CUR":[146,162,187,202,220,254],"into":[147,166],"found":[150],"be":[152,272],"67.88\u00b12.08":[153],"%.":[154],"DSC,":[155],"FT-IR":[156],"XRD":[158],"confirmed":[159],"that":[160],"encapsulated":[164],"stably":[165],"matrix,":[169],"thereby":[170],"improving":[171],"drug.":[176],"CUR-SLN":[177,270],"showed":[178],"sustained":[179],"release":[181],"comparison":[183],"free":[186,201,219,253],"solution.":[188],"CUR-SLNs":[189,211,239],"exhibited":[190],"higher":[191,245],"cellular":[192],"uptake":[193],"human":[195],"compared":[199,217,250],"at":[203,222],"both":[204],"1":[205],"4":[207],"h":[208,230,242],"time":[209],"points.":[210],"demonstrated":[212],"decreased":[213],"cell":[214],"viability":[215],"(43.97\u00b11.53%)":[216],"(59.33\u00b10.95%)":[221],"concentration":[224],"50":[226],"\u00b5g/mL":[227],"after":[228],"24":[229,241],"treatment.":[231],"Furthermore,":[232],"treatment":[234],"MDA-MB-231":[236],"induced":[243],"significantly":[244],"apoptosis":[246],"(37.28\u00b15.3%)":[247],"(21.06\u00b10.97%).":[255],"CONCLUSION:":[256],"results":[258],"provide":[259],"strong":[261],"rationale":[262],"further":[264],"exploration":[265],"newly":[268],"utilized":[273],"potent":[276],"chemotherapeutic":[277],"agent":[278],"cancer":[280],"therapy.":[281]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2018-05-17T00:00:00"}