{"id":"https://openalex.org/W2801034404","doi":null,"title":"Implications of hobnail features in anaplastic thyroid carcinoma and precursor lesions","display_name":"Implications of hobnail features in anaplastic thyroid carcinoma and precursor lesions","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2801034404","mag":"2801034404"},"language":"en","primary_location":{"id":"pmh:oai:jdc.jefferson.edu:phsrs-1035","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/phsrs/44","pdf_url":"https://jdc.jefferson.edu/phsrs/44","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Pathology Honors Program Student Research Symposium","raw_type":"abstract"},"volume":null,"type":"conference-paper","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://jdc.jefferson.edu/phsrs/44","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026884113","display_name":"Ba Dunne","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ba Dunne","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5107984632","display_name":"Stacey K. Mardekian","orcid":"https://orcid.org/0000-0001-6430-1847","observed_orcids":["https://orcid.org/0000-0001-6430-1847"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Stacey K. Mardekian","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-6430-1847","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.07257304,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10329","display_name":"Thyroid Cancer Diagnosis and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11728","display_name":"Thyroid and Parathyroid Surgery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12992","display_name":"Metastasis and carcinoma case studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/anaplastic-thyroid-carcinoma","display_name":"anaplastic thyroid carcinoma","score":0.9369999766349792},{"id":"https://openalex.org/keywords/hobnail-cells","display_name":"hobnail cells","score":0.8939999938011169},{"id":"https://openalex.org/keywords/papillary-thyroid-carcinoma","display_name":"papillary thyroid carcinoma","score":0.8790000081062317},{"id":"https://openalex.org/keywords/follicular-thyroid-carcinoma","display_name":"follicular thyroid carcinoma","score":0.8569999933242798},{"id":"https://openalex.org/keywords/precursor-lesions","display_name":"precursor lesions","score":0.7269999980926514},{"id":"https://openalex.org/keywords/tumor-aggressiveness","display_name":"tumor aggressiveness","score":0.9599999785423279},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7409999966621399},{"id":"https://openalex.org/keywords/thyroid-cancer-histopathology","display_name":"thyroid cancer histopathology","score":0.6600000262260437}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.636002779006958},{"id":"https://openalex.org/C2778981773","wikidata":"https://www.wikidata.org/wiki/Q4751574","display_name":"Anaplastic carcinoma","level":3,"score":0.6024069786071777},{"id":"https://openalex.org/C2993294228","wikidata":"https://www.wikidata.org/wiki/Q13632630","display_name":"Thyroid carcinoma","level":3,"score":0.5333971977233887},{"id":"https://openalex.org/C526584372","wikidata":"https://www.wikidata.org/wiki/Q16399","display_name":"Thyroid","level":2,"score":0.44629910588264465},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3997102677822113},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.3989446461200714},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3138622045516968}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:jdc.jefferson.edu:phsrs-1035","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/phsrs/44","pdf_url":"https://jdc.jefferson.edu/phsrs/44","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Pathology Honors Program Student Research Symposium","raw_type":"abstract"},{"id":"mag:2801034404","doi":null,"is_oa":false,"landing_page_url":"https://jdc.jefferson.edu/cgi/viewcontent.cgi?article=1035&context=phsrs","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:jdc.jefferson.edu:phsrs-1035","doi":null,"is_oa":true,"landing_page_url":"https://jdc.jefferson.edu/phsrs/44","pdf_url":"https://jdc.jefferson.edu/phsrs/44","source":{"id":"https://openalex.org/S4210178181","display_name":"The Medicine Forum","issn_l":"2325-2863","issn":["2325-2863"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Department of Pathology Honors Program Student Research Symposium","raw_type":"abstract"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"sustainable_development_goals_aurora":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.4099999964237213}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2801034404.pdf","grobid_xml":"https://content.openalex.org/works/W2801034404.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Anaplastic":[0],"thyroid":[1,10,29,34,189],"carcinoma":[2,30],"(ATC)":[3],"has":[4],"the":[5,41,68,97,144,182],"poorest":[6],"prognosis":[7],"of":[8,49,91,99,113,135,150,156,173,185],"all":[9],"cancers.":[11],"Morphologically,":[12],"it":[13],"is":[14,67,72,178],"characterized":[15,73],"by":[16,75,79],"pleomorphic":[17],"undifferentiated":[18],"cells.":[19],"In":[20],"some":[21],"cases,":[22],"a":[23,62],"differentiated":[24,132],"precursor":[25,106,145,161],"lesion,":[26],"either":[27],"papillary":[28],"(PTC)":[31],"or":[32],"follicular":[33],"carcinoma,":[35],"can":[36],"be":[37,55],"identified":[38,142],"adjacent":[39],"to":[40,54,95,180],"anaplastic":[42],"component.":[43],"There":[44],"are":[45,52,170],"certain":[46],"morphological":[47],"variants":[48],"PTC":[50,146,160],"that":[51,167],"known":[53],"associated":[56,105,163],"with":[57,81,164],"more":[58],"aggressive":[59],"behavior,":[60],"but":[61],"recently":[63],"described,":[64],"understudied":[65],"variant":[66],"hobnail":[69,100,157,168,186],"variant.":[70],"It":[71],"histologically":[74],"micropapillary":[76],"structures":[77],"lined":[78],"cells":[80,101,140,187],"abundant":[82],"eosinophilic":[83],"cytoplasm":[84],"and":[85,104,123],"apically-placed":[86],"bulging":[87],"nuclei.":[88],"The":[89,153],"aim":[90],"this":[92],"study":[93,177],"was":[94],"evaluate":[96],"frequency":[98,155],"in":[102,148,159,188],"ATC":[103,114,165],"lesions.":[107],"Microscopic":[108],"slides":[109],"from":[110],"21":[111],"cases":[112,128],"diagnosed":[115],"at":[116],"Thomas":[117],"Jefferson":[118],"University":[119],"Hospital":[120],"between":[121],"2014":[122],"2017":[124],"were":[125,137,141],"studied.":[126],"11":[127],"had":[129],"an":[130,171],"identifiable":[131],"component,":[133],"8":[134],"which":[136],"PTC.":[138],"Hobnail":[139],"within":[143],"lesion":[147],"5/8":[149],"these":[151],"cases.":[152],"high":[154],"features":[158,169],"lesions":[162],"suggests":[166],"indicator":[172],"tumor":[174],"aggressiveness.":[175],"Further":[176],"warranted":[179],"determine":[181],"prognostic":[183],"value":[184],"neoplasms.":[190]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}