{"id":"https://openalex.org/W2801024920","doi":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","title":"Abstract QS18: Adipose Derived Stem Cells Isolated from Premature Aging Mice Show Sustained Stemness: Implications for Regenerative Medicine","display_name":"Abstract QS18: Adipose Derived Stem Cells Isolated from Premature Aging Mice Show Sustained Stemness: Implications for Regenerative Medicine","publication_year":2018,"publication_date":"2018-04-01","ids":{"openalex":"https://openalex.org/W2801024920","doi":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","mag":"2801024920"},"language":"en","primary_location":{"id":"doi:10.1097/01.gox.0000534027.52458.dd","doi":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048933131","display_name":"Sudheer K. Ravuri","orcid":"https://orcid.org/0000-0002-2812-3892","observed_orcids":["https://orcid.org/0000-0002-2812-3892"]},"institutions":[{"id":"https://openalex.org/I4210128328","display_name":"Steadman Philippon Research Institute","ror":"https://ror.org/03msykc12","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210128328"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudheer K. Ravuri","raw_affiliation_strings":["Steadman Philippon Research Institute, Vail, CO, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Steadman Philippon Research Institute, Vail, CO, USA","institution_ids":["https://openalex.org/I4210128328"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023231499","display_name":"Xiaodong Mu","orcid":"https://orcid.org/0000-0002-0362-0083","observed_orcids":["https://orcid.org/0000-0002-0362-0083"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaodong Mu","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Texas Health Science Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Texas Health Science Center, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011637413","display_name":"Wanqun Chen","orcid":"https://orcid.org/0000-0003-4474-9040","observed_orcids":["https://orcid.org/0000-0003-4474-9040"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wanqun Chen","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Texas Health Science Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Texas Health Science Center, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049355169","display_name":"Johnny Huard","orcid":"https://orcid.org/0000-0002-2926-569X","observed_orcids":["https://orcid.org/0000-0002-2926-569X"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Johnny Huard","raw_affiliation_strings":["Department of Orthopaedic Surgery, University of Texas Health Science Center, Houston, TX, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, University of Texas Health Science Center, Houston, TX, USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2195,"currency":"USD","value_usd":2195},"apc_paid":{"value":2195,"currency":"USD","value_usd":2195},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"6","issue":"4S","first_page":"125","last_page":"126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11457","display_name":"Adipose Tissue and Metabolism","score":0.004900000058114529,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10937","display_name":"Telomeres, Telomerase, and Senescence","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adipose-derived-stem-cells","display_name":"adipose-derived stem cells","score":0.9670000076293945},{"id":"https://openalex.org/keywords/premature-aging","display_name":"premature aging","score":0.902999997138977},{"id":"https://openalex.org/keywords/hutchinson-gilford-progeria-syndrome","display_name":"Hutchinson-Gilford progeria syndrome","score":0.8880000114440918},{"id":"https://openalex.org/keywords/lamin-a-c","display_name":"lamin A/C","score":0.5220000147819519},{"id":"https://openalex.org/keywords/stem-cell-senescence","display_name":"stem cell senescence","score":0.8569999933242798},{"id":"https://openalex.org/keywords/stemness","display_name":"stemness","score":0.5830000042915344},{"id":"https://openalex.org/keywords/muscle-progenitor-cells","display_name":"muscle progenitor cells","score":0.75},{"id":"https://openalex.org/keywords/co-culture","display_name":"co-culture","score":0.7570000290870667},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.7279999852180481},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8309999704360962},{"id":"https://openalex.org/keywords/mtorc1","display_name":"mTORC1","score":0.7889999747276306},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.972000002861023},{"id":"https://openalex.org/keywords/regenerative-medicine","display_name":"regenerative medicine","score":0.7649999856948853},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6843820214271545},{"id":"https://openalex.org/C171089720","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Adipose tissue","level":2,"score":0.6681824326515198},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5648789405822754},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5591729879379272},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.530296802520752},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.4933761656284332},{"id":"https://openalex.org/C2909947164","wikidata":"https://www.wikidata.org/wiki/Q6139748","display_name":"Premature aging","level":2,"score":0.4476970434188843},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3502078056335449},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.18703868985176086},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.06844916939735413}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1097/01.gox.0000534027.52458.dd","doi":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:4922692","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5959686","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:5959686","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5959686","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plast Reconstr Surg Glob Open","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:ad4d92022eef4e2194634f63676fa03b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ad4d92022eef4e2194634f63676fa03b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Plastic and Reconstructive Surgery, Global Open, Vol 6, Iss 4S, Pp 125-126 (2018)","raw_type":"article"},{"id":"mag:3166919424","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC5959686","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Plastic & Reconstructive Surgery Global Open","raw_type":null}],"best_oa_location":{"id":"doi:10.1097/01.gox.0000534027.52458.dd","doi":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","is_oa":true,"landing_page_url":"https://doi.org/10.1097/01.gox.0000534027.52458.dd","pdf_url":null,"source":{"id":"https://openalex.org/S2754281505","display_name":"Plastic & Reconstructive Surgery Global Open","issn_l":"2169-7574","issn":["2169-7574"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-d","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Plastic and Reconstructive Surgery - Global Open","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2083451242","https://openalex.org/W2947479936","https://openalex.org/W4304185540","https://openalex.org/W2999281536","https://openalex.org/W7163557693","https://openalex.org/W4284988737","https://openalex.org/W2294845583","https://openalex.org/W4399686105","https://openalex.org/W4244494875","https://openalex.org/W2346605681"],"abstract_inverted_index":{"PURPOSE:":[0],"Exhaustion":[1],"of":[2,14,50,75,86,118,175,190,211,224,266,312,316,339,348,364,374],"functional":[3],"stem":[4,17,56],"cells":[5,57,197,218],"in":[6,64,72,124,166,199,244,324,342,453,459],"tissues":[7,32,134],"may":[8,21,36,298,414,446],"be":[9,415],"caused":[10],"by":[11,161],"the":[12,48,51,73,80,113,172,208,336,362,372],"effects":[13],"aging":[15,52],"and":[16,27,33,39,89,115,139,145,157,177,181,187,219,222,255,286,290,367,370,377,399,424,432,435,438,450,462],"cell":[18,237,258],"senescence,":[19,452],"which":[20,454],"ultimately":[22],"lead":[23],"to":[24,184,206,346,360,404,419,429],"decreased":[25,263,300],"rejuvenation":[26,223],"increased":[28],"age":[29],"progression.":[30],"Adipose":[31],"mature":[34,76],"adipocytes":[35],"become":[37],"dysfunctional":[38],"acquire":[40],"a":[41,68,94,200,325,343],"pro-inflammatory,":[42],"senescent-like":[43],"phenotype":[44],"with":[45,126,194,262,321,465],"aging,":[46],"but":[47,236,278,413],"influence":[49,210],"process":[53],"on":[54,111,214],"adipose":[55,133,146],"is":[58,109],"not":[59,279,394,411],"well":[60,354],"understood.":[61],"Mice":[62],"deficient":[63],"Zmpste24":[65],"(Zmpste24-/-or":[66],"Z24-/-),":[67],"zinc":[69],"metalloproteinase":[70],"involved":[71],"formation":[74],"lamin":[77],"A":[78],"for":[79,96,128,152,203,328,468],"nuclear":[81],"membrane,":[82],"demonstrate":[83],"premature":[84,122],"onset":[85],"age-related":[87],"changes":[88],"have":[90],"been":[91],"studied":[92],"as":[93,353,355,395,397],"model":[95],"human":[97],"Hutchinson-Gilford":[98],"Progeria":[99],"Syndrome":[100],"(HGPS).":[101],"Using":[102],"this":[103],"mouse":[104],"model,":[105],"our":[106],"current":[107],"study":[108],"focused":[110],"investigating":[112],"characteristics":[114,174],"rejuvenative":[116,401],"potential":[117,209,265,311,402],"ASCs":[119,158,163,193,213,228,274,297,320,334,352,357,387,408,426,445,455],"from":[120,137,388],"Z24-/-":[121,138,176,212,215,245,267,273,296,313,319,322,333,340,356,389,407,425],"mice":[123,144,392],"vitro":[125],"implications":[127,467],"regenerative":[129,310,469],"medicine.":[130,470],"METHODS:":[131],"Subcutaneous":[132],"were":[135,159,164,292,358,393,409,427],"harvested":[136],"age-matched":[140],"wild-type":[141],"(WT)":[142],"control":[143],"tissue":[147,463],"was":[148,284,306],"minced,":[149],"enzymatically":[150],"digested":[151],"1":[153],"hr":[154],"at":[155],"37\u00b0C":[156],"separated":[160],"centrifugation.":[162],"cultured":[165],"adipocyte":[167],"growth":[168],"medium.":[169],"We":[170,442],"compared":[171,418],"culture":[173],"WT":[178,234,317,349,351,405,420,423],"(wild-type)":[179],"ASCs,":[180,235],"performed":[182],"qPCR":[183],"determine":[185,207],"senescence":[186],"quiescent":[188,277,417],"properties":[189],"ASCs.":[191,246,268,314,350,406,421],"Co-cultured":[192],"muscle":[195,216],"progenitor":[196,217],"(MPCs)":[198],"Transwell":[201,326],"system":[202,327],"2":[204,329],"days":[205,330],"eventual":[220],"rescuing":[221],"defective":[225,337,396],"phenotypes.":[226],"RESULTS:Z24-/-":[227],"grew":[229],"much":[230],"slower":[231],"rate":[232],"than":[233],"senescence-associated":[238],"\u03b2-galactosidase":[239],"(SA-\u03b2-Gal)":[240],"staining":[241],"showed":[242,249,331,385],"<5%":[243],"RT-qPCR":[247],"results":[248,270,384],"mTORC1":[250],"(cell":[251],"senescence-promoting":[252],"factor)":[253],"down-regulation":[254],"p21":[256],"(negative":[257],"cycle":[259],"regulator)":[260],"upregulation":[261],"proliferation":[264],"These":[269],"suggest":[271],"that":[272,295,332,347,386,444],"are":[275],"more":[276,280,416],"senescent.":[281],"Furthermore,":[282],"TGF-\u03b21expression":[283],"upregulated":[285],"pro-inflammatory":[287,301,365,431],"factors":[288,366,376],"(IL-1\u03b2":[289],"IL-6)":[291],"downregulated,":[293],"suggesting":[294,308],"exhibit":[299],"potential.":[302],"VEGF":[303],"gene":[304],"expression":[305,363,373],"upregulated,":[307],"sustained":[309,448],"Co-culture":[315],"or":[318],"MPCs":[323,341,398],"rescued":[335],"phenotypes":[338],"manner":[344],"comparable":[345,403],"able":[359,428],"repress":[361,430],"pro-fibrogenic":[368,433],"factors,":[369,434],"increase":[371],"anti-inflammatory":[375,437],"energy":[378,439],"metabolism":[379,440],"factors.":[380,441],"CONCLUSION:":[381],"Our":[382],"preliminary":[383],"prematurely":[390],"aged":[391],"exhibited":[400],"generally":[410],"senescent,":[412],"Both":[422],"promoted":[436],"believe":[443],"show":[447],"stemness":[449],"lower":[451],"could":[456],"perform":[457],"better":[458],"anti-aging":[460],"therapy":[461],"rejuvenation,":[464],"greater":[466],"S.K.":[471],"Ravuri:":[472],"None.":[473,476,479,482],"X.":[474],"Mu:":[475],"W.":[477],"Chen:":[478],"J.":[480],"Huard:":[481]},"counts_by_year":[],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2018-05-17T00:00:00"}
