{"id":"https://openalex.org/W2801023971","doi":"https://doi.org/10.2174/1574886313666180508122332","title":"Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors: A Review of the Literature","display_name":"Musculoskeletal and Rheumatic Diseases Induced by Immune Checkpoint Inhibitors: A Review of the Literature","publication_year":2018,"publication_date":"2018-05-10","ids":{"openalex":"https://openalex.org/W2801023971","doi":"https://doi.org/10.2174/1574886313666180508122332","mag":"2801023971","pmid":"https://pubmed.ncbi.nlm.nih.gov/29745339","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/6198478"},"language":"en","primary_location":{"id":"doi:10.2174/1574886313666180508122332","doi":"https://doi.org/10.2174/1574886313666180508122332","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1574886313666180508122332","pdf_url":null,"source":{"id":"https://openalex.org/S18096204","display_name":"Current Drug Safety","issn_l":"1574-8863","issn":["1574-8863","2212-3911"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Safety","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC6198478","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022490646","display_name":"Devis Benfaremo","orcid":"https://orcid.org/0000-0002-9867-2360","observed_orcids":["https://orcid.org/0000-0002-9867-2360"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Devis Benfaremo","raw_affiliation_strings":["Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103040705","display_name":"Lucia Manfredi","orcid":"https://orcid.org/0000-0002-9313-2197","observed_orcids":["https://orcid.org/0000-0002-9313-2197"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucia Manfredi","raw_affiliation_strings":["Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079896587","display_name":"Michele Maria Luchetti","orcid":"https://orcid.org/0000-0001-9132-7401","observed_orcids":["https://orcid.org/0000-0001-9132-7401"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Michele Maria Luchetti","raw_affiliation_strings":["Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069066410","display_name":"Armando Gabrielli","orcid":"https://orcid.org/0000-0002-4509-8772","observed_orcids":["https://orcid.org/0000-0002-4509-8772"]},"institutions":[{"id":"https://openalex.org/I122534668","display_name":"Marche Polytechnic University","ror":"https://ror.org/00x69rs40","country_code":"IT","type":"education","lineage":["https://openalex.org/I122534668"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Armando Gabrielli","raw_affiliation_strings":["Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dipartimento di Scienze Cliniche e Molecolari, Universita Politecnica delle Marche, Ancona, Italy","institution_ids":["https://openalex.org/I122534668"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5079896587"],"corresponding_institution_ids":["https://openalex.org/I122534668"],"apc_list":null,"apc_paid":null,"fwci":3.9347,"has_fulltext":false,"cited_by_count":73,"citation_normalized_percentile":{"value":0.9630093,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"13","issue":"3","first_page":"150","last_page":"164"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11724","display_name":"Inflammatory Myopathies and Dermatomyositis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":1.0},{"id":"https://openalex.org/keywords/immune-related-adverse-events","display_name":"immune-related adverse events","score":0.9879999756813049},{"id":"https://openalex.org/keywords/musculoskeletal-adverse-events","display_name":"musculoskeletal adverse events","score":0.8429999947547913},{"id":"https://openalex.org/keywords/rheumatic-diseases","display_name":"rheumatic diseases","score":0.8600000143051147},{"id":"https://openalex.org/keywords/joint-pain","display_name":"joint pain","score":0.972000002861023},{"id":"https://openalex.org/keywords/myalgia","display_name":"myalgia","score":0.9990000128746033},{"id":"https://openalex.org/keywords/arthritis","display_name":"arthritis","score":0.9300000071525574},{"id":"https://openalex.org/keywords/inflammatory-myopathies","display_name":"myositis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vasculitis","display_name":"vasculitis","score":1.0},{"id":"https://openalex.org/keywords/sicca-syndrome","display_name":"sicca syndrome","score":0.9879999756813049},{"id":"https://openalex.org/keywords/polymyalgia-rheumatica","display_name":"polymyalgia rheumatica","score":0.9990000128746033},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9990000128746033},{"id":"https://openalex.org/keywords/sarcoidosis","display_name":"sarcoidosis","score":1.0}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9648920893669128},{"id":"https://openalex.org/C2780079024","wikidata":"https://www.wikidata.org/wiki/Q1752891","display_name":"Polymyalgia rheumatica","level":5,"score":0.7447972297668457},{"id":"https://openalex.org/C2780030458","wikidata":"https://www.wikidata.org/wiki/Q7041828","display_name":"Nivolumab","level":4,"score":0.7313222885131836},{"id":"https://openalex.org/C2781232998","wikidata":"https://www.wikidata.org/wiki/Q1433212","display_name":"Myositis","level":2,"score":0.6921579837799072},{"id":"https://openalex.org/C2778616394","wikidata":"https://www.wikidata.org/wiki/Q474959","display_name":"myalgia","level":2,"score":0.6870489716529846},{"id":"https://openalex.org/C2780057760","wikidata":"https://www.wikidata.org/wiki/Q13896859","display_name":"Pembrolizumab","level":4,"score":0.6767110824584961},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.6749421954154968},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.5381584763526917},{"id":"https://openalex.org/C2908795448","wikidata":"https://www.wikidata.org/wiki/Q335555","display_name":"Sicca syndrome","level":3,"score":0.5281529426574707},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43531161546707153},{"id":"https://openalex.org/C2777077863","wikidata":"https://www.wikidata.org/wiki/Q170990","display_name":"Arthritis","level":2,"score":0.4252481162548065},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42471766471862793},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.41736748814582825},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.37642431259155273},{"id":"https://openalex.org/C2776015282","wikidata":"https://www.wikidata.org/wiki/Q644318","display_name":"Vasculitis","level":3,"score":0.31843528151512146},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27228695154190063},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.1920357644557953},{"id":"https://openalex.org/C2776712624","wikidata":"https://www.wikidata.org/wiki/Q707816","display_name":"Giant cell arteritis","level":4,"score":0.09885913133621216}],"mesh":[{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000074322","descriptor_name":"Antineoplastic Agents, Immunological","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D007155","descriptor_name":"Immunologic Factors","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D009140","descriptor_name":"Musculoskeletal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D009140","descriptor_name":"Musculoskeletal Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D012216","descriptor_name":"Rheumatic Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.2174/1574886313666180508122332","doi":"https://doi.org/10.2174/1574886313666180508122332","is_oa":false,"landing_page_url":"https://doi.org/10.2174/1574886313666180508122332","pdf_url":null,"source":{"id":"https://openalex.org/S18096204","display_name":"Current Drug Safety","issn_l":"1574-8863","issn":["1574-8863","2212-3911"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320079","host_organization_name":"Bentham Science Publishers","host_organization_lineage":["https://openalex.org/P4310320079"],"host_organization_lineage_names":["Bentham Science Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Drug Safety","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:5197714","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6198478","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:6198478","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6198478","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Drug Saf","raw_type":"Text"},{"id":"pmid:29745339","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29745339","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current drug safety","raw_type":"Journal Article"},{"id":"pmh:oai:iris.univpm.it:11566/266153","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/266153","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:5197714","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC6198478","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8299999833106995}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1533005819","https://openalex.org/W1946787137","https://openalex.org/W1971989824","https://openalex.org/W2013030792","https://openalex.org/W2033009850","https://openalex.org/W2122096722","https://openalex.org/W2130085832","https://openalex.org/W2143772132","https://openalex.org/W2157174922","https://openalex.org/W2171580322","https://openalex.org/W2193769500","https://openalex.org/W2259730793","https://openalex.org/W2270309512","https://openalex.org/W2296110227","https://openalex.org/W2301262881","https://openalex.org/W2327980272","https://openalex.org/W2332091461","https://openalex.org/W2343059010","https://openalex.org/W2344884541","https://openalex.org/W2441690768","https://openalex.org/W2464216504","https://openalex.org/W2478423423","https://openalex.org/W2513710094","https://openalex.org/W2525217971","https://openalex.org/W2527106917","https://openalex.org/W2555838624","https://openalex.org/W2556486062","https://openalex.org/W2560764121","https://openalex.org/W2563735287","https://openalex.org/W2565782504","https://openalex.org/W2565826521","https://openalex.org/W2566702711","https://openalex.org/W2567514120","https://openalex.org/W2572174216","https://openalex.org/W2587959153","https://openalex.org/W2588144362","https://openalex.org/W2593872139","https://openalex.org/W2594671953","https://openalex.org/W2599224341","https://openalex.org/W2600419100","https://openalex.org/W2607191964","https://openalex.org/W2608424969","https://openalex.org/W2612299170","https://openalex.org/W2613642472","https://openalex.org/W2615532207","https://openalex.org/W2621416287","https://openalex.org/W2623054880","https://openalex.org/W2625359171","https://openalex.org/W2673218446","https://openalex.org/W2725585498","https://openalex.org/W2731014799","https://openalex.org/W2736900145","https://openalex.org/W2737654646","https://openalex.org/W2738096852","https://openalex.org/W2747028021","https://openalex.org/W2747440871","https://openalex.org/W2753413920","https://openalex.org/W2754717389","https://openalex.org/W2757709559","https://openalex.org/W2762010572","https://openalex.org/W2764116502","https://openalex.org/W2770072955","https://openalex.org/W2770404972","https://openalex.org/W2776320342","https://openalex.org/W2783137027","https://openalex.org/W2783621911","https://openalex.org/W2796327298"],"related_works":["https://openalex.org/W2996408582","https://openalex.org/W2565782504","https://openalex.org/W2994753855","https://openalex.org/W3038004647","https://openalex.org/W3023683881","https://openalex.org/W4295921486","https://openalex.org/W4300773776","https://openalex.org/W3129588953","https://openalex.org/W3046459254","https://openalex.org/W2966200698"],"abstract_inverted_index":{"BACKGROUND:":[0],"Immune":[1],"checkpoint":[2,43,54,122],"inhibitors":[3,55,123],"are":[4,57,97,114],"a":[5,17,115],"new":[6],"promising":[7],"class":[8],"of":[9,19,35,76],"antitumor":[10],"drugs":[11],"that":[12],"have":[13],"been":[14],"associated":[15,51,119],"with":[16,52,120],"number":[18],"immune-related":[20],"Adverse":[21],"Events":[22],"(AEs),":[23],"including":[24],"musculoskeletal":[25,36,47,110],"and":[26,37,48,65,79,84,90,105,111],"rheumatic":[27,38,49,112],"disease.":[28],"METHODS:":[29],"We":[30],"searched":[31],"Medline":[32],"reviewing":[33],"reports":[34],"AEs":[39,50,96],"induced":[40,109],"by":[41],"immune":[42,53,121],"inhibitors.":[44],"RESULTS:":[45],"Several":[46],"treatment":[56],"reported":[58,71,86],"in":[59,87],"the":[60,68,74],"literature.":[61],"In":[62],"particular,":[63],"arthralgia":[64],"myalgia":[66],"were":[67],"most":[69],"common":[70],"AEs,":[72],"whereas":[73],"prevalence":[75],"arthritis,":[77],"myositis":[78],"vasculitis":[80],"is":[81],"less":[82],"characterized":[83],"mainly":[85],"case":[88,91],"series":[89],"reports.":[92],"Other":[93],"occasionally":[94],"described":[95],"sicca":[98],"syndrome,":[99],"polymyalgia":[100],"rheumatica,":[101],"systemic":[102],"lupus":[103],"erythematosus":[104],"sarcoidosis.":[106],"CONCLUSION:":[107],"Newly":[108],"diseases":[113],"frequent":[116],"adverse":[117],"event":[118],"treatment.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":19},{"year":2019,"cited_by_count":13}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2018-05-17T00:00:00"}